重庆市儿童母亲人乳头瘤病毒疫苗接种意愿和影响因素研究
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摘要
目的了解重庆市儿童母亲对人乳头瘤病毒(HPV)疫苗的接种意愿和影响因素。方法采用分层抽样方法选择重庆市8个区县6月龄-6岁儿童的母亲进行HPV相关知识和HPV疫苗接种意愿问卷调查,采用Logistic回归分析接种意愿的影响因素。结果在802名调查对象中,149名(18.58%)知晓导致宫颈癌的主要HPV型别,128名(15.95%)知晓HPV感染途径,623名(77.68%)愿意接种HPV疫苗,671名(83.67%)愿意为子女接种HPV疫苗。Logistic回归分析显示,职业、家庭收入、HPV和HPV疫苗知晓情况、疫苗价格、第二类疫苗接种史是影响调查对象接受HPV疫苗的显著性因素。结论儿童母亲对HPV疫苗的接受率高但HPV相关知晓率低。建议加强健康教育、降低疫苗价格以提高HPV疫苗的可及性。
Objective To assess acceptance of human papillomavirus(HPV) vaccine among children's mothers in Chongqing city and factors influencing acceptance. Methods We used a stratified random sampling method to recruit mothers of children aged 6 months to 6 years from 8 counties of Chongqing to participate in a questionnaire-based survey of HPV vaccine acceptance. We used logistic regression to determine factors influencing acceptance. Results Among 802 participants, 149(18.58%) knew the HPV types causing cervical cancer; 128(15.95%) knew HPV transmission routes; 623(77.68%) would like to receive HPV vaccination; and 671(83.67%)would like to have their children vaccinated with HPV vaccine. Logistic regression showed that education, family income, knowledge about HPV and HPV vaccine, vaccine price, and history of receiving Category II vaccines were factors significantly influencing acceptance of HPV vaccine. Conclusions Children's mothers were highly accepting of HPV vaccine but had little knowledge about the vaccine. We recommend enhancing health education and reducing vaccine price to improve knowledge about and access to HPV vaccine.
Objective To assess acceptance of human papillomavirus(HPV) vaccine among children's mothers in Chongqing city and factors influencing acceptance. Methods We used a stratified random sampling method to recruit mothers of children aged 6 months to 6 years from 8 counties of Chongqing to participate in a questionnaire-based survey of HPV vaccine acceptance. We used logistic regression to determine factors influencing acceptance. Results Among 802 participants, 149(18.58%) knew the HPV types causing cervical cancer; 128(15.95%) knew HPV transmission routes; 623(77.68%) would like to receive HPV vaccination; and 671(83.67%)would like to have their children vaccinated with HPV vaccine. Logistic regression showed that education, family income, knowledge about HPV and HPV vaccine, vaccine price, and history of receiving Category II vaccines were factors significantly influencing acceptance of HPV vaccine. Conclusions Children's mothers were highly accepting of HPV vaccine but had little knowledge about the vaccine. We recommend enhancing health education and reducing vaccine price to improve knowledge about and access to HPV vaccine.
引文
[1]DEMPSEY A,COHN L,DALTON VA,et al.Pat ient and clinic factors associated wi th adolescent human papillomavirus vaccine utilization within a universitybased health system[J].Vaccine,2010,28(4):989-995.
[2]TORRE LA,BRAY F,SIEGEL RL,et al.Global cancer statistics,2012[J].Ca:a Cancer Journal for Clinicians,2015,65(2):87-108.
[3]CHEN WQ,ZHENG RS,BAADE PD,et al.Cancer statistics in China,2015[J].Ca:a Cancer Journal for Clinicians,2016,66(2):115-132.
[4]谢建渝,余娟,董国强.762例妇女宫颈高危型HPV感染与宫颈病变的相关性研究[J].检验医学与临床,2012,9(20):2533-2535.XIE J ianyu,YU J uan,DONG Guoqiang.Study on correlation between cervical high-risk HPV infection and cervical lesions in 762 women[J].Laboratory Medicine and Clinic,2012,9(20):2533-2535.
[5]PITTS M,SMITH A,CROY S,et al.Singaporean women's knowledge of human papillomavirus(HPV)and attitudes toward HPV vaccination[J].Women Health,2009,49(4):2989-2993.
[6]陈奕,许国章.预防性人乳头瘤病毒疫苗的应用进展[J].国际流行病学传染病学杂志,2014,41(1):54-56.CHEN Yi,XU Guozhang.Progress in applicat ion of preventive human papillomavirus vaccine[J].International Journal of Epidemiology and Inf ectious Disease,2014,41(1):54-56.
[7]刘智华,王蓉,万艳平,等.高中生对人乳头瘤病毒的认知调查[J].中国护理研究,2012,26(4):314-316.LIU Zhihua,WANG Rong,WAN Yanping,et al.Survey of recognition of senior high school students to human papillomavirus[J].Chinese Nursing Research,2012,26(4):314-316.
[8]CAPOGROSSO P,VENTIMIGLIA E,MATLOOB R,et al.Awareness and knowledge of human papillomavirusrelated diseases are still dramatically insufficient in the era of high-coverage vaccination programs[J].World JUrol,2015,33(6):873-880.
[9]梁伟坚,郭练,李曼,等.广州市妇女参加宫颈癌筛查影响因素的结构方程模型分析[J].中华疾病控制杂志,2014,18(5):411-414.LIANG Wei jian,GUO Lian,LI Man,et al.Analysis of the factors af fecting cervical cancer screening in the community population of Guangzhou city via a structural equation model[J].Chinese Journal of Disease Control&Prevention,2014,18(5):411-414.
[10]LAU M,LIN H,FLORES G.Factors associated with human papilloma-vi rus vaccine-ser ies ini t iat ion and healthcare provider recommendation in US adolescent females:2007 national survey of children’s health[J].Vaccine,2012,30(20):3112-3118.
[11]杨丽,何艳,马彩玲.人乳头瘤病毒疫苗预防宫颈癌及其相关感染有效性及安全性的Meta分析[J].中国全科医学,2015,18(12):1415-1424.YANG Li,HE Yan,MA Cailing.Efficacy and saf ety of prophylactic human papillomavirus vaccine in preventing cervical cancer and HPV-related infection prevention:a meta-analysis[J].Chinese General Practice,2015,18(12):1415-1424.
[12]JOURA EA,GIULIANO AR,IVERSEN OE,et al.A9-valent HPV vaccine against infection and intraepithelial neoplasia in women[J].New England Journal of Medicine,2015,372(8):711-723.
[13]KATOULIS AC,LIAKOU A,BOZI E,et al.Erythema multi form following vaccination for human papillomavirus[J].Dermatology,2010,220(1):60-72.
[2]TORRE LA,BRAY F,SIEGEL RL,et al.Global cancer statistics,2012[J].Ca:a Cancer Journal for Clinicians,2015,65(2):87-108.
[3]CHEN WQ,ZHENG RS,BAADE PD,et al.Cancer statistics in China,2015[J].Ca:a Cancer Journal for Clinicians,2016,66(2):115-132.
[4]谢建渝,余娟,董国强.762例妇女宫颈高危型HPV感染与宫颈病变的相关性研究[J].检验医学与临床,2012,9(20):2533-2535.XIE J ianyu,YU J uan,DONG Guoqiang.Study on correlation between cervical high-risk HPV infection and cervical lesions in 762 women[J].Laboratory Medicine and Clinic,2012,9(20):2533-2535.
[5]PITTS M,SMITH A,CROY S,et al.Singaporean women's knowledge of human papillomavirus(HPV)and attitudes toward HPV vaccination[J].Women Health,2009,49(4):2989-2993.
[6]陈奕,许国章.预防性人乳头瘤病毒疫苗的应用进展[J].国际流行病学传染病学杂志,2014,41(1):54-56.CHEN Yi,XU Guozhang.Progress in applicat ion of preventive human papillomavirus vaccine[J].International Journal of Epidemiology and Inf ectious Disease,2014,41(1):54-56.
[7]刘智华,王蓉,万艳平,等.高中生对人乳头瘤病毒的认知调查[J].中国护理研究,2012,26(4):314-316.LIU Zhihua,WANG Rong,WAN Yanping,et al.Survey of recognition of senior high school students to human papillomavirus[J].Chinese Nursing Research,2012,26(4):314-316.
[8]CAPOGROSSO P,VENTIMIGLIA E,MATLOOB R,et al.Awareness and knowledge of human papillomavirusrelated diseases are still dramatically insufficient in the era of high-coverage vaccination programs[J].World JUrol,2015,33(6):873-880.
[9]梁伟坚,郭练,李曼,等.广州市妇女参加宫颈癌筛查影响因素的结构方程模型分析[J].中华疾病控制杂志,2014,18(5):411-414.LIANG Wei jian,GUO Lian,LI Man,et al.Analysis of the factors af fecting cervical cancer screening in the community population of Guangzhou city via a structural equation model[J].Chinese Journal of Disease Control&Prevention,2014,18(5):411-414.
[10]LAU M,LIN H,FLORES G.Factors associated with human papilloma-vi rus vaccine-ser ies ini t iat ion and healthcare provider recommendation in US adolescent females:2007 national survey of children’s health[J].Vaccine,2012,30(20):3112-3118.
[11]杨丽,何艳,马彩玲.人乳头瘤病毒疫苗预防宫颈癌及其相关感染有效性及安全性的Meta分析[J].中国全科医学,2015,18(12):1415-1424.YANG Li,HE Yan,MA Cailing.Efficacy and saf ety of prophylactic human papillomavirus vaccine in preventing cervical cancer and HPV-related infection prevention:a meta-analysis[J].Chinese General Practice,2015,18(12):1415-1424.
[12]JOURA EA,GIULIANO AR,IVERSEN OE,et al.A9-valent HPV vaccine against infection and intraepithelial neoplasia in women[J].New England Journal of Medicine,2015,372(8):711-723.
[13]KATOULIS AC,LIAKOU A,BOZI E,et al.Erythema multi form following vaccination for human papillomavirus[J].Dermatology,2010,220(1):60-72.