长链非编码核糖核酸及其介导的竞争内源性核糖核酸与卒中发病机制研究进展
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摘要
长链非编码核糖核酸(long noncoding RNA,lncRNA)是长度大于200碱基的非编码RNA,为竞争内源性RNA(competing endogenous RNA,ceRNA)的关键组成分子,具有重要的生物学功能。近期研究表明,lncRNA及其介导的ceRNA与卒中的发病、炎症反应及血管生成密切相关,为卒中的诊治提供了新的方向。本文对lncRNA及其介导的ceRNA与卒中关系的研究进展进行综述。
Long noncoding RNA(lncRNA) represents a class of transcripts longer than 200 nucleotides and is a vital molecular component for competing endogenous RNA(ceRNA), which has significant biological function. Recent studies indicated that lncRNA and ceRNA mediated by lncRNA are closely related to the risk of stroke, inflammation and angiogenesis in stroke, which provides a new direction for the diagnosis and treatment of stroke. This article reviewed that the research progress of lncRNA and ceRNA mediated by lncRNA in stroke.
Long noncoding RNA(lncRNA) represents a class of transcripts longer than 200 nucleotides and is a vital molecular component for competing endogenous RNA(ceRNA), which has significant biological function. Recent studies indicated that lncRNA and ceRNA mediated by lncRNA are closely related to the risk of stroke, inflammation and angiogenesis in stroke, which provides a new direction for the diagnosis and treatment of stroke. This article reviewed that the research progress of lncRNA and ceRNA mediated by lncRNA in stroke.
引文
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[13]WANG J,ZHAO H,FAN Z,et al.Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization[J].Stroke,2017,48(8):2211-2221.
[14]WEN Y,YU Y,FU X.LncRNA Gm4419contributes to OGD/R injury of cerebral microglial cells via IkappaB phosphorylation and NF-kappaBactivation[J].Biochem Biophys Res Commun,2017,487(4):923-929.
[15]XU Q,DENG F,XING Z,et al.Long non-coding RNA C2dat1 regulates CaMKIIδexpression to promote neuronal survival through the NF-κBsignaling pathway following cerebral ischemia[J/OL].Cell Death Dis,2016,7:e2173.https://doi.org/10.1038/cddis.2016.57.
[16]YANG L,LU Z N.Long non-coding RNA HOTAIRpromotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2[J].Biochem Biophys Res Commun,2016,479(2):186-191.
[17]ZANG Y,ZHOU X,WANG Q,et al.LncRNAFIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells[J].Biochem Biophys Res Commun,2018,501(1):131-138.
[18]ZHANG X,TANG X,LIU K,et al.Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke[J].J Neurosci,2017,37(7):1797-1806.
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[22]PENG J H,WU Y,TIAN X C,et al.HighThroughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage[J/OL].Sci Rep,2017,7:46 577.https://doi.org/10.1038/srep46577.
[23]WEN J,YANG C Y,LU J,et al.Ptprj-as1 mediates inflammatory injury after intracerebral hemorrhage by activating NF-κB pathway[J].Eur Rev Med Pharmacol Sci,2018,22(9):2817-2823.
[24]CHEN F,ZHANG L,WANG E,et al.LncRNAGAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway[J].Biochem Biophys Res Commun,2018,496(1):184-190.
[25]CHEN S,WANG M,YANG H,et al.LncRNATUG1 sponges microRNA-9 to promote neurons apoptosis by up-regulated Bcl2l11 under ischemia[J].Biochem Biophys Res Commun,2017,485(1):167-173.
[26]GUO D,MA J,YAN L,et al.Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke[J].Cell Physiol Biochem,2017,43(1):182-194.
[27]LI Z,LI J,TANG N.Long noncoding RNA Malat1is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygenglucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2expression[J/OL].Neuroscience,2017,354:1-10.https://doi.org/10.1016/j.neuroscience.2017.04.017.
[28]LI L,WANG M,MEI Z,et al.lncRNAs HIF1A-AS2 facilitates the up-regulation of HIF-1αby sponging to miR-153-3p,whereby promoting angiogenesis in HUVECs in hypoxia[J/OL].Biomed Pharmacother,2017,96:165-172.https://doi.org/10.1016/j.biopha.2017.09.113.
[29]WANG Z,WANG R,WANG K,et al.Upregulated long non-coding RNA Snhg1 promotes the angiogenesis of brain microvascular endothelial cells after oxygen-glucose deprivation treatment by targeting miR-199a[J].Can J Physiol Pharmacol,2018,96(9):909-915.
[30]ZHANG L,LUO X,CHEN F,et al.LncRNASNHG1 regulates cerebrovascular pathologies as a competing endogenous RNA through HIF-1alpha/VEGF signaling in ischemic stroke[J].J Cell Biochem,2018,119(7):5460-5472.
[31]QI X,SHAO M,SUN H,et al.Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction[J/OL].Neuroscience,2017,348:98-106.https://doi.org/10.1016/j.neuroscience.2017.02.002.
[32]YAN H,RAO J,YUAN J,et al.Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway[J].Cell Death Dis,2017,8(12):3211.
[33]DONG B,ZHOU B,SUN Z,et al.LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage[J/OL].Microcirculation,2018,25(8):e12499.https://doi.org/10.1111/micc.12499.
[2]FATICA A,BOZZONI I.Long non-coding RNAs:new players in cell differentiation and development[J].Nat Rev Genet,2014,15(1):7-21.
[3]TAY Y,RINN J,PANDOLFI PP.The multilayered complexity of ceRNA crosstalk and competition.Nature[J].2014,505(7483):344-352.
[4]MEHTA S L,MANHAS N,RAGHUBIR R.Molecular targets in cerebral ischemia for developing novel therapeutics[J].Brain Res Rev,2007,54(1):34-66.
[5]HE W Z,WEI D C,CAI D,et al.Altered Long NonCoding RNA Transcriptomic Profiles in Ischemic Stroke[J].Hum Gene Ther,2018,29(6):719-732.
[6]ZHANG J,YUAN L,ZHANG X,et al.Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia[J/OL].Exp Neurol,2016,277:162-170.https://doi.org/10.1016/j.expneurol.2015.12.014.
[7]ZHU M,LI N,LUO P,et al.Peripheral Blood Leukocyte Expression of lncRNA MIAT and Its Diagnostic and Prognostic Value in Ischemic Stroke[J].J Stroke Cerebrovasc Dis,2018,27(2):326-337.
[8]YANG J,GU L,GUO X,et al.LncRNA ANRILExpression and ANRIL Gene Polymorphisms Contribute to the Risk of Ischemic Stroke in the Chinese Han Population[J].Cell Mol Neurobiol,2018,38(6):1253-1269.
[9]WANG J,CAO B,HAN D,et al.Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy[J].Aging Dis,2017,8(1):71-84.
[10]ZHANG B,WANG D,JI T F,et al.Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model[J].Oncotarget,2017,8(10):17 347-17 359.
[11]LIU J,LI Q,ZHANG K S,et al.Downregulation of the Long Non-Coding RNA Meg3 Promotes Angiogenesis After Ischemic Brain Injury by Activating Notch Signaling[J].Mol Neurobiol,2017,54(10):8179-8190.
[12]ZHAN R,XU K,PAN J,et al.Long noncoding RNA MEG3 mediated angiogenesis after cerebral infarction through regulating p53/NOX4 axis[J].Biochem Biophys Res Commun,2017,490(3):700-706.
[13]WANG J,ZHAO H,FAN Z,et al.Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization[J].Stroke,2017,48(8):2211-2221.
[14]WEN Y,YU Y,FU X.LncRNA Gm4419contributes to OGD/R injury of cerebral microglial cells via IkappaB phosphorylation and NF-kappaBactivation[J].Biochem Biophys Res Commun,2017,487(4):923-929.
[15]XU Q,DENG F,XING Z,et al.Long non-coding RNA C2dat1 regulates CaMKIIδexpression to promote neuronal survival through the NF-κBsignaling pathway following cerebral ischemia[J/OL].Cell Death Dis,2016,7:e2173.https://doi.org/10.1038/cddis.2016.57.
[16]YANG L,LU Z N.Long non-coding RNA HOTAIRpromotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2[J].Biochem Biophys Res Commun,2016,479(2):186-191.
[17]ZANG Y,ZHOU X,WANG Q,et al.LncRNAFIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells[J].Biochem Biophys Res Commun,2018,501(1):131-138.
[18]ZHANG X,TANG X,LIU K,et al.Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke[J].J Neurosci,2017,37(7):1797-1806.
[19]MEHTA S L,KIM T,VEMUGANTI R.Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins[J].J Neurosci,2015,35(50):16 443-16 449.
[20]JIA J,ZHANG M,LI Q,et al.Long noncoding ribonucleic acid NKILA induces the endoplasmic reticulum stress/autophagy pathway and inhibits the nuclear factor-k-gene binding pathway in rats after intracerebral hemorrhage[J].J Cell Physiol,2018,233(11):8839-8849.
[21]LIANG Z,CHI Y J,LIN G Q,et al.LncRNAMEG3 participates in neuronal cell injury induced by subarachnoid hemorrhage via inhibiting the Pi3k/Akt pathway[J].Eur Rev Med Pharmacol Sci,2018,22(9):2824-2831.
[22]PENG J H,WU Y,TIAN X C,et al.HighThroughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage[J/OL].Sci Rep,2017,7:46 577.https://doi.org/10.1038/srep46577.
[23]WEN J,YANG C Y,LU J,et al.Ptprj-as1 mediates inflammatory injury after intracerebral hemorrhage by activating NF-κB pathway[J].Eur Rev Med Pharmacol Sci,2018,22(9):2817-2823.
[24]CHEN F,ZHANG L,WANG E,et al.LncRNAGAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway[J].Biochem Biophys Res Commun,2018,496(1):184-190.
[25]CHEN S,WANG M,YANG H,et al.LncRNATUG1 sponges microRNA-9 to promote neurons apoptosis by up-regulated Bcl2l11 under ischemia[J].Biochem Biophys Res Commun,2017,485(1):167-173.
[26]GUO D,MA J,YAN L,et al.Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke[J].Cell Physiol Biochem,2017,43(1):182-194.
[27]LI Z,LI J,TANG N.Long noncoding RNA Malat1is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygenglucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2expression[J/OL].Neuroscience,2017,354:1-10.https://doi.org/10.1016/j.neuroscience.2017.04.017.
[28]LI L,WANG M,MEI Z,et al.lncRNAs HIF1A-AS2 facilitates the up-regulation of HIF-1αby sponging to miR-153-3p,whereby promoting angiogenesis in HUVECs in hypoxia[J/OL].Biomed Pharmacother,2017,96:165-172.https://doi.org/10.1016/j.biopha.2017.09.113.
[29]WANG Z,WANG R,WANG K,et al.Upregulated long non-coding RNA Snhg1 promotes the angiogenesis of brain microvascular endothelial cells after oxygen-glucose deprivation treatment by targeting miR-199a[J].Can J Physiol Pharmacol,2018,96(9):909-915.
[30]ZHANG L,LUO X,CHEN F,et al.LncRNASNHG1 regulates cerebrovascular pathologies as a competing endogenous RNA through HIF-1alpha/VEGF signaling in ischemic stroke[J].J Cell Biochem,2018,119(7):5460-5472.
[31]QI X,SHAO M,SUN H,et al.Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction[J/OL].Neuroscience,2017,348:98-106.https://doi.org/10.1016/j.neuroscience.2017.02.002.
[32]YAN H,RAO J,YUAN J,et al.Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway[J].Cell Death Dis,2017,8(12):3211.
[33]DONG B,ZHOU B,SUN Z,et al.LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage[J/OL].Microcirculation,2018,25(8):e12499.https://doi.org/10.1111/micc.12499.