青海地区健康人群CA72-4参考区间的建立
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摘要
目的建立青海地区健康人群CA72-4的参考区间。方法选取2015年1月～2017年12月在青海地区三甲医院体检中心进行体检的健康人群900例(含青海地区各级城乡居民),检测CA72-4水平。结果经Wilcoxon秩和检验结果显示,青海地区男女间血清CA72-4差异有统计学意义(U=-2.082,P<0.05)。经Kmskal-WallisH检验结果显示,青海地区男性与女性健康人群不同年龄段CA72-4差异均无统计学意义(H_(男性)=2.161,H_(女性)=1.931,均P>0.05)。青海地区健康人群不同性别CA72-4参考中位数男性1.92U/ml、女性2.24U/ml;男性95%参考区间0～11.24U/ml、女性5%参考区间0～12.85U/ml。结论青海地区健康人群CA72-4参考区间的建立要考虑到样本数量、当地实际情况,最好以当地健康人群为主,根据本地区实际情况建立自己的参考区间。
Objective To investigate the reference interval for CA72-4 in healthy population in Qinghai. Methods 900 healthy examinees(including urban and rural residents in Qinghai area) in the medical examination center of Grade-A Tertiary Hospital in Qinghai from January 2015 to December 2017 were selected. CA72-4 in the fasting elbow venous blood(5 ml) was detected by Roche detection system after incubation for 35 min and centrifugation for 10 min. Each detection met the internal quality control standards so as to avoid the systematic errors. Results Wilcoxon rank sum test showed that the difference of serum CA72-4 between male and female in Qinghai area was statistically significant(U=-2.082, P<0.05). Kmskal-WallisH test showed that difference in CA72-4 between different age groups was not statistic in male healthy population(H=2.161, P>0.05) and female healthy population in Qinghai(H=1.931, P>0.05). The median CA72-4 level was 1.92 U/ml for males and 2.24 U/ml for females, the 95 th percentile interval of male was 0～11.24 U/ml, and the 5 th percentile interval of female was 0～12.85 U/ml. Conclusion The establishment of the CA72-4 reference interval for healthy people in Qinghai should be based on sample size and local actual situation. The subjects should be the local healthy population.
Objective To investigate the reference interval for CA72-4 in healthy population in Qinghai. Methods 900 healthy examinees(including urban and rural residents in Qinghai area) in the medical examination center of Grade-A Tertiary Hospital in Qinghai from January 2015 to December 2017 were selected. CA72-4 in the fasting elbow venous blood(5 ml) was detected by Roche detection system after incubation for 35 min and centrifugation for 10 min. Each detection met the internal quality control standards so as to avoid the systematic errors. Results Wilcoxon rank sum test showed that the difference of serum CA72-4 between male and female in Qinghai area was statistically significant(U=-2.082, P<0.05). Kmskal-WallisH test showed that difference in CA72-4 between different age groups was not statistic in male healthy population(H=2.161, P>0.05) and female healthy population in Qinghai(H=1.931, P>0.05). The median CA72-4 level was 1.92 U/ml for males and 2.24 U/ml for females, the 95 th percentile interval of male was 0～11.24 U/ml, and the 5 th percentile interval of female was 0～12.85 U/ml. Conclusion The establishment of the CA72-4 reference interval for healthy people in Qinghai should be based on sample size and local actual situation. The subjects should be the local healthy population.
引文
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[14] 王微,王慜杰,齐军.北京地区血清肿瘤标志物SCC-Ag、CA72-4、AFP参考区间的初步建立[J].肿瘤学杂志,2018,24(4):365-369.
[15] 张梅,王刚,武青青,等.CRP联合CA72-4,CEA,CA19-9检测对胃癌早期诊断的临床价值[J].现代生物医学进展,2017,17(10):1896-1899.
[16] Du X,Ding T,Zhang H,et al.Age-Specific Normal Reference Range for Serum Anti-Müllerian Hormone in Healthy Chinese Han Women:A nationwide Population-Based Study[J].Reproductive Sciences,2016,23(8):1019.
[17] Yan X,Wang K,Lu W,et al.CdSe/ZnS Quantum Dot-Labeled Lateral Flow Strips for Rapid and Quantitative Detection of Gastric Cancer Carbohydrate Antigen 72-4[J].Nanoscale Research Letters,2016,11(1):1-8.
[18] 杨卫华,侯海东,孙红霞,等.上海市宝山区体检人群CA724结果回顾性分析[J].标记免疫分析与临床,2016,23(10):1194-1196.
[19] 汤胜君,胡敏,陈昆友,等.胃蛋白酶原联合肿瘤标志物检测对健康人群胃癌发生的预测价值[J].中国卫生检验杂志,2017(15):2217-2219.
[20] Yu LL,Yang HP.Establishment of the Reference Range of CA72-4 for Healthy People in Beijing[J].Labeled Immunoassays & Clinical Medicine,2011,18(2):115-116.
[21] 王桂玲.青海省海西地区成人红细胞及血红蛋白参考区间调查[J].检验医学,2016,31(7):590-592.
[2] 陈震,白云鹏.糖类抗原CA72-4化学发光定量免疫分析方法的建立[J].标记免疫分析与临床,2017,24(1):102-105.
[3] 肖伟欢.HE4联合CA72-4、CA19-9血清糖类抗原检测对卵巢癌患者的临床意义[J].临床血液学杂志(输血与检验),2016(5):808-810.
[4] 马天飞,唐域,邢晓静,等.胃癌患者化疗前后癌胚抗原CA19-9 CA72-4水平变化的临床意义[J].山西医药杂志,2017,46(20):2498-2501.
[5] 聂双发,李磊,胡晓峰,等.血清CEA、CA199、CA72-4和CA125水平在胃癌临床病理分期中的价值分析[J].医学临床研究,2017,34(7).:15-20.
[6] 张梅,王刚,武青青,等.CRP联合CA72-4,CEA,CA19-9检测对胃癌早期诊断的临床价值[J].现代生物医学进展,2017,17(10):1896-1899.
[7] 蔡懿婷,许慈,朱黎明.血清肿瘤标志物CEA、CA72-4、CA19-9的阳性预测值在消化肿瘤诊断中的价值[J].现代消化及介入诊疗,2016,21(4):546-549.
[8] 黄喜顺,邓立新,邱耀辉,等.血清PG、G-17联合CA72-4和13CUBT在早期胃癌的诊断价值[J].重庆医学,2017,46(10):1346-1348.
[9] 王丹丹,王敏.CA125联合CA19-9、CEA、CA72-4检测在上皮性卵巢癌诊断中的意义[J].现代肿瘤医学,2016,24(5):818-821.
[10] 何燕霞,王凯,巩姣梅,等.血清PG、CA72-4和TK1对胃癌筛查及诊断价值的研究[J].中国卫生检验杂志,2016(2):240-243.
[11] 李梅.白细胞介素-6、糖类抗原72-4、血清癌抗原125联合人附睾蛋白4对卵巢癌的诊断价值[J].安徽医药,2016,20(6):1138-1140.
[12] 李永元,刘洪杰.血清TK1、PG以及CA72-4检测在胃癌筛查以及诊断中的应用价值[J].中国实验诊断学,2017,21(10):1682-1684.
[13] 赵雯红,方艳惠,王影,等.血清CA125、CA72-4、AFP联合检测在卵巢肿瘤鉴别诊断中的作用[J].世界中医药,2017,15(a01):538-538.
[14] 王微,王慜杰,齐军.北京地区血清肿瘤标志物SCC-Ag、CA72-4、AFP参考区间的初步建立[J].肿瘤学杂志,2018,24(4):365-369.
[15] 张梅,王刚,武青青,等.CRP联合CA72-4,CEA,CA19-9检测对胃癌早期诊断的临床价值[J].现代生物医学进展,2017,17(10):1896-1899.
[16] Du X,Ding T,Zhang H,et al.Age-Specific Normal Reference Range for Serum Anti-Müllerian Hormone in Healthy Chinese Han Women:A nationwide Population-Based Study[J].Reproductive Sciences,2016,23(8):1019.
[17] Yan X,Wang K,Lu W,et al.CdSe/ZnS Quantum Dot-Labeled Lateral Flow Strips for Rapid and Quantitative Detection of Gastric Cancer Carbohydrate Antigen 72-4[J].Nanoscale Research Letters,2016,11(1):1-8.
[18] 杨卫华,侯海东,孙红霞,等.上海市宝山区体检人群CA724结果回顾性分析[J].标记免疫分析与临床,2016,23(10):1194-1196.
[19] 汤胜君,胡敏,陈昆友,等.胃蛋白酶原联合肿瘤标志物检测对健康人群胃癌发生的预测价值[J].中国卫生检验杂志,2017(15):2217-2219.
[20] Yu LL,Yang HP.Establishment of the Reference Range of CA72-4 for Healthy People in Beijing[J].Labeled Immunoassays & Clinical Medicine,2011,18(2):115-116.
[21] 王桂玲.青海省海西地区成人红细胞及血红蛋白参考区间调查[J].检验医学,2016,31(7):590-592.
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