基于灰色关联分析法辨识中药生产过程关键工艺参数
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摘要
目的应用灰色关联分析法辨识中药生产过程关键工艺参数。方法以热毒宁注射液生产过程中金银花、青蒿(金青)萃取工段为例,采用灰色关联分析法计算比较该工段各工艺参数对质量指标影响的重要性大小,并结合层次分析法与Spearman等级相关分析法相互验证。结果灰色关联分析法得出工艺参数对质量指标影响重要性的排序为萃取平均体积流量(X4)>调酸后pH值(X2)>萃取浓缩出膏温度(X7)>醇沉浓缩浸膏质量(X1)>盐酸质量(X3)>萃取时间(X6)>体积流量相对标准偏差(X5),与层次分析法得到的工艺参数排序的相关系数为0.893。根据工艺参数影响重要性大小,确定萃取平均体积流量、调酸后pH值、萃取浓缩出膏温度为金青萃取工段关键工艺参数。结论灰色关联分析法用于分析筛选中药生产过程关键工艺参数具有可行性,并能为下一步建立过程预测模型以及在线反馈调控提供理论参考依据。
Objective To identify the key process parameters of the Chinese materia medica(CMM) production process by using grey relation analysis(GRA) method. Methods Taking Lonicerae Japonicae Flos and Artemisiae Annuae Herba extraction section of Reduning Injection as an example, GRA was adopted to calculate and compare the influence of the process parameters on the quality index. Meanwhile, analytic hierarchy process(AHP) combined with Spearman rank correlation analysis was used to validate mutually. Results According to GRA results, the relative importance of process parameters was ranked as follows: average volume flow rate of extraction(X4) > pH after acid adjustment(X2) > the paste temperature of extracting concentration(X7) > alcohol precipitation concentrated extract weight(X1) > hydrochloric acid weight(X3) > extraction time(X6) > relative standard deviation of flow rate(X5). The correlation coefficient between the order by GRA and that by AHP was 0.893. According to the importance of process parameters, the average volume flow rate of extraction, the pH after acid adjustment, and the paste temperature of extracting concentration were identified as the key process parameters. Conclusion The results obtained in this study show the feasibility of GRA in selecting key process parameters, which can provide theoretical reference for the establishment of prediction model as well as online feedback regulation.
Objective To identify the key process parameters of the Chinese materia medica(CMM) production process by using grey relation analysis(GRA) method. Methods Taking Lonicerae Japonicae Flos and Artemisiae Annuae Herba extraction section of Reduning Injection as an example, GRA was adopted to calculate and compare the influence of the process parameters on the quality index. Meanwhile, analytic hierarchy process(AHP) combined with Spearman rank correlation analysis was used to validate mutually. Results According to GRA results, the relative importance of process parameters was ranked as follows: average volume flow rate of extraction(X4) > pH after acid adjustment(X2) > the paste temperature of extracting concentration(X7) > alcohol precipitation concentrated extract weight(X1) > hydrochloric acid weight(X3) > extraction time(X6) > relative standard deviation of flow rate(X5). The correlation coefficient between the order by GRA and that by AHP was 0.893. According to the importance of process parameters, the average volume flow rate of extraction, the pH after acid adjustment, and the paste temperature of extracting concentration were identified as the key process parameters. Conclusion The results obtained in this study show the feasibility of GRA in selecting key process parameters, which can provide theoretical reference for the establishment of prediction model as well as online feedback regulation.
引文
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[9]沈金晶,龚行楚,潘坚扬,等.基于质量源于设计理念的金银花水提液石灰乳沉淀工艺优化研究[J].中国中药杂志,2017,42(6):1074-1082.
[10]崔雅华,王茜,徐冰,等.质量源于设计:基于知识组织的中药生产潜在关键工艺参数的辨识[J].中国实验方剂学杂志,2016,22(15):1-8.
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[13]Jiang H,He W W.Grey relational grade in local support vector regression for financial time series prediction[J].Expert Syst Appl,2012,39(3):2256-2262.
[14]Sehgal A K,Meenu.Grey relational analysis coupled with principal component analysis to optimize the machining process of ductile iron[J].Mater Today:Proc,2018,5(1):1518-1529.
[15]Patil P J,Patil C R.Analysis of process parameters in surface grinding using single objective Taguchi and multi-objective grey relational grade[J].Perspect Sci,2016,8:367-369.
[16]林梦雅,张玉萍,李雅,等.基于灰色关联度分析的丹参提取物抗炎作用谱效关系研究[J].中草药,2017,48(16):3447-3452.
[17]李倩,梁宗锁,董娟娥,等.丹参品质与主导气候因子的灰色关联度分析[J].生态学报,2010,30(10):2569-2575.
[18]Acharya V,Sharma S K,Gupta S K,et al.Analyzing the factors in industrial automation using analytic hierarchy process[J].Comput Electr Eng,2018,71:877-886.
[19]Fabjanowicz M,Bystrzanowska M,Namiesnik J,et al.An analytical hierarchy process for selection of the optimal procedure for resveratrol determination in wine samples[J].Microchem J,2018,142:126-134.
[20]Agapova M,Bresnahan B W,Linnau K F,et al.Using the analytic hierarchy process for prioritizing imaging tests in diagnosis of suspected appendicitis[J].Acad Radiol,2017,24(5):530-537.
[21]孙铭忆,李冰韶,王永洁,等.基于模糊层次分析法优选复方黄芪水浸膏提取工艺路线[J].中草药,2018,49(2):325-329.
[22]Nie Y,Yao W F.A comprehensive quality evaluation method based on C30-HPLC and an analytic hierarchy process for Chinese herbal formula,Erzhiwan[J].Molecules,2018,23(8):2045-2055.
[23]金磁力,胡建星,金宏威,等.基于支持向量机与层次分析法的中药方剂配伍分析[J].中国中药杂志,2018,43(13):2817-2823.
[24]Ishizaka A,Labib A.Review of the main developments in the analytic hierarchy process[J].Expert Syst Appl,2011,38(11):14336-14345.
[25]张卫华,赵铭军.指标无量纲化方法对综合评价结果可靠性的影响及其实证分析[J].统计与信息论坛,2005,20(3):33-36.
[26]朱鹏,苗潇磊,陈勇.绿原酸、隐绿原酸和新绿原酸在中性和碱性pH条件下的降解动力学[J].药学学报,2016,51(1):122-126.
[27]Narita Y,Inouye K.Degradation kinetics of chlorogenic acid at various pH values and effects of ascorbic acid and epigallocatechin gallate on its stability under alkaline conditions[J].J Agr Food Chem,2013,61(4):966-972.
[2]厉瑶.质量源于设计理念在丹红提取和醇沉过程分析中的应用研究[D].杭州:浙江大学,2014.
[3]韩天燕,付亭亭,费文玲,等.基于质量源于设计理念的仙曲片薄膜包衣工艺研究[J].中草药,2018,49(11):2564-2570.
[4]张俊鸿,何雁,许燕,等.基于质量源于设计理念的风咳颗粒喷雾干燥工艺研究[J].中草药,2017,48(10):2061-2066.
[5]张娟娟,孙巍,王萍,等.基于分析方法质量源于设计(AQb D)的复方丹参滴丸皂苷指纹图谱开发方法初步研究[J].中草药,2017,48(19):3992-3997.
[6]张小飞,邢传峰,果秋婷.基于质量源于设计(Qb D)理念优化穿心莲内酯固体脂质纳米粒[J].中草药,2015,46(2):194-200.
[7]Van Bockstal P J,Mortier S T F C,Corver J,et al.Quantitative risk assessment via uncertainty analysis in combination with error propagation for the determination of the dynamic design space of the primary drying step during freeze-drying[J].Eur J Pharm Biopharm,2017,121:32-41.
[8]王磊.热毒宁注射液关键生产工段智能放行若干技术的研究[D].杭州:浙江大学,2018.
[9]沈金晶,龚行楚,潘坚扬,等.基于质量源于设计理念的金银花水提液石灰乳沉淀工艺优化研究[J].中国中药杂志,2017,42(6):1074-1082.
[10]崔雅华,王茜,徐冰,等.质量源于设计:基于知识组织的中药生产潜在关键工艺参数的辨识[J].中国实验方剂学杂志,2016,22(15):1-8.
[11]邓聚龙.灰理论基础[M].武汉:华中科技大学出版社,2002.
[12]You M L,Shu C M,Chen W T,et al.Analysis of cardinal grey relational grade and grey entropy on achievement of air pollution reduction by evaluating air quality trend in Japan[J].J Clean Prod,2017,142(4):3883-3889.
[13]Jiang H,He W W.Grey relational grade in local support vector regression for financial time series prediction[J].Expert Syst Appl,2012,39(3):2256-2262.
[14]Sehgal A K,Meenu.Grey relational analysis coupled with principal component analysis to optimize the machining process of ductile iron[J].Mater Today:Proc,2018,5(1):1518-1529.
[15]Patil P J,Patil C R.Analysis of process parameters in surface grinding using single objective Taguchi and multi-objective grey relational grade[J].Perspect Sci,2016,8:367-369.
[16]林梦雅,张玉萍,李雅,等.基于灰色关联度分析的丹参提取物抗炎作用谱效关系研究[J].中草药,2017,48(16):3447-3452.
[17]李倩,梁宗锁,董娟娥,等.丹参品质与主导气候因子的灰色关联度分析[J].生态学报,2010,30(10):2569-2575.
[18]Acharya V,Sharma S K,Gupta S K,et al.Analyzing the factors in industrial automation using analytic hierarchy process[J].Comput Electr Eng,2018,71:877-886.
[19]Fabjanowicz M,Bystrzanowska M,Namiesnik J,et al.An analytical hierarchy process for selection of the optimal procedure for resveratrol determination in wine samples[J].Microchem J,2018,142:126-134.
[20]Agapova M,Bresnahan B W,Linnau K F,et al.Using the analytic hierarchy process for prioritizing imaging tests in diagnosis of suspected appendicitis[J].Acad Radiol,2017,24(5):530-537.
[21]孙铭忆,李冰韶,王永洁,等.基于模糊层次分析法优选复方黄芪水浸膏提取工艺路线[J].中草药,2018,49(2):325-329.
[22]Nie Y,Yao W F.A comprehensive quality evaluation method based on C30-HPLC and an analytic hierarchy process for Chinese herbal formula,Erzhiwan[J].Molecules,2018,23(8):2045-2055.
[23]金磁力,胡建星,金宏威,等.基于支持向量机与层次分析法的中药方剂配伍分析[J].中国中药杂志,2018,43(13):2817-2823.
[24]Ishizaka A,Labib A.Review of the main developments in the analytic hierarchy process[J].Expert Syst Appl,2011,38(11):14336-14345.
[25]张卫华,赵铭军.指标无量纲化方法对综合评价结果可靠性的影响及其实证分析[J].统计与信息论坛,2005,20(3):33-36.
[26]朱鹏,苗潇磊,陈勇.绿原酸、隐绿原酸和新绿原酸在中性和碱性pH条件下的降解动力学[J].药学学报,2016,51(1):122-126.
[27]Narita Y,Inouye K.Degradation kinetics of chlorogenic acid at various pH values and effects of ascorbic acid and epigallocatechin gallate on its stability under alkaline conditions[J].J Agr Food Chem,2013,61(4):966-972.
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