某院左氧氟沙星注射液合理用药分析
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摘要
目的促进临床合理使用左氧氟沙星注射液。方法抽取某院2017年1月至3月使用左氧氟沙星注射液的517张急诊处方和240份住院病历,对用药的合理性进行统计与分析。结果所抽查的757例处方与病历中,涉及患者男360例,女397例; 18岁以下1例,60岁以上252例; 517张急诊处方中有503张来自内科和外科,240份住院病历中,呼吸内科占比(45. 42%)居首;给药频次以每日1次为主,单日剂量多为0. 4 g,溶剂以0. 9%氯化钠注射液250 mL最常用;住院病历微生物检测率为72. 08%。结论该院左氧氟沙星注射液的临床应用存在一定的不合理现象,需加强医务人员的合理用药培训,以减少药害事件的发生。
Objective To promote the rational use of Levofloxacin Injection in the clinic. Methods Totally 517 emergency drug prescriptions and 240 hospitalization records including Levofloxacin Injection were collected from January to March 2017 in order to analyze the rationality of drug use. Results Among 757 prescriptions and medical records,360 patients were males,397 patients were females,1 patient was under 18 years old and 252 patients were over 60 years old. Among 517 emergency prescriptions,503 prescriptions were from internal medicine and surgery,and among 240 hospitalized medical records,the records from respiratory medicine accounted for 45. 42%,ranking first. The frequency of administration was mainly once a day,and the dosage was mostly 0. 4 g per day. For the solvent,250 m L 0. 9% Sodium Chloride Injection was the most commonly used. The microbial detection rate of hospitalized medical records was72. 08%. Conclusion There were some unreasonable phenomena in the clinical application of Levofloxacin Injection in a hospital. It is necessary to strengthen the training of medical staff on rational drug use in order to reduce the occurrence of medication misadventure.
Objective To promote the rational use of Levofloxacin Injection in the clinic. Methods Totally 517 emergency drug prescriptions and 240 hospitalization records including Levofloxacin Injection were collected from January to March 2017 in order to analyze the rationality of drug use. Results Among 757 prescriptions and medical records,360 patients were males,397 patients were females,1 patient was under 18 years old and 252 patients were over 60 years old. Among 517 emergency prescriptions,503 prescriptions were from internal medicine and surgery,and among 240 hospitalized medical records,the records from respiratory medicine accounted for 45. 42%,ranking first. The frequency of administration was mainly once a day,and the dosage was mostly 0. 4 g per day. For the solvent,250 m L 0. 9% Sodium Chloride Injection was the most commonly used. The microbial detection rate of hospitalized medical records was72. 08%. Conclusion There were some unreasonable phenomena in the clinical application of Levofloxacin Injection in a hospital. It is necessary to strengthen the training of medical staff on rational drug use in order to reduce the occurrence of medication misadventure.
引文
[1]国家食品药品监督管理总局.国家药品不良反应监测年度报告(2017年)[J].中国药物评价,2018,35(2):154-160.
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[5]张菁,郁继诚,施耀国,等.左氧氟沙星药代动力学/药效学研究[J].中华医学杂志,2005,85(27):1926-1932.
[6]吴晓燕,周秋娟,瞿发林.左氧氟沙星注射液与其他药物配伍禁忌的回顾性分析[J].实用药物与临床,2013,16(1):54-56.
[7]何平,郭秀芳.静脉滴注左氧氟沙星后饮酒致酷似双硫仑样反应1例[J].临床荟萃,2010,25(8):710.
[8]张筠,卜艳丽,李成建.氢化可的松与头孢菌素类药物合用所致双硫仑样反应文献概述[J].中国药物滥用防治杂志,2014,20(3):172-173.
[9]李慧博,王丽,闫秀娥.氢化可的松注射液与甲硝唑联用致双硫仑样反应[J].临床药物治疗杂志,2018,16(2):84-87.
[2]孙岩.126例左氧氟沙星注射液不良反应病例的分析[J].中国医药指南,2015,13(13):119.
[3]严汝庆.102例左氧氟沙星临床不良反应分析[J].中国药学杂志,2013,48(10):830-831.
[4]WOODHEAD M,BLASI F,EWIG S,et al.Guidelines for the management of adult lower respiratory tract infections[J].Eur Respir J,2005,26:1138-1180.
[5]张菁,郁继诚,施耀国,等.左氧氟沙星药代动力学/药效学研究[J].中华医学杂志,2005,85(27):1926-1932.
[6]吴晓燕,周秋娟,瞿发林.左氧氟沙星注射液与其他药物配伍禁忌的回顾性分析[J].实用药物与临床,2013,16(1):54-56.
[7]何平,郭秀芳.静脉滴注左氧氟沙星后饮酒致酷似双硫仑样反应1例[J].临床荟萃,2010,25(8):710.
[8]张筠,卜艳丽,李成建.氢化可的松与头孢菌素类药物合用所致双硫仑样反应文献概述[J].中国药物滥用防治杂志,2014,20(3):172-173.
[9]李慧博,王丽,闫秀娥.氢化可的松注射液与甲硝唑联用致双硫仑样反应[J].临床药物治疗杂志,2018,16(2):84-87.
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