石榴籽油研究进展
|
摘要
石榴籽油具有很好的药用级营养价值,本文就石榴籽油的组成成分、快速提取和药理活性等方面进行了综述,探讨了石榴籽油的应用前景,为石榴籽油的开发利用提供参考.
Pomegranate seed oil has good medicinal grade nutritional value,The research progresses on chemical constituents,extraction methods and pharmacological actions of pomegranate seed oil are reviewed. The application prospects of pomegranate seed oil are discussed with the purpose of providing references for the development and utilization of pomegranate seed oil.
Pomegranate seed oil has good medicinal grade nutritional value,The research progresses on chemical constituents,extraction methods and pharmacological actions of pomegranate seed oil are reviewed. The application prospects of pomegranate seed oil are discussed with the purpose of providing references for the development and utilization of pomegranate seed oil.
引文
[1]杨笑笑.石榴中活性物质的提取及应用研究[D].江南大学,2014.
[2]杜洁,曹庸,戴伟杰,等.石榴籽油低温连续相变萃取工艺优化及其脂肪酸分析[J].食品与机械,2017,02:148-151.
[3]马齐,秦涛,王丽娥,等.石榴籽油的提取及成分分析[J].粮油食品科技,2008,01:28-30.
[4]高忠梅,刘邻渭,李旋,等.3种石榴籽的主要成分分析[J].食品研究与开发,2015,22:138-141.
[5]杨万政,周瑜,杨晓霞等.石榴籽油脂的提取及脂肪酸组成研究[J].内蒙古工业大学学报(自然科学版),2013,02:96-100.
[6]赵淑娟,叶天,敬璞.石榴籽油中的石榴酸分析方法研究[J].食品工业,2012,07:89-91.
[7]Pande G,Akoh C C.Antioxidant capacity and lipid characterization of six georgia-grownpomegranate cultivars[J].Journal of Agricultural and Food Chemistry,2009,57(20):9427-9436.
[8]Kralan M,G lükcüM,Tokg z H.Oil and conjugated linolenic acid contents of seeds from important pomegranate cultivars(Punica granatum L.)grown in turkey[J].Journal of the American Oil Chemists'Society,2009,86(10):985-990.
[9]Abd E I,Wahab S M,Fiki N M E I,et al.Characterization of certainsteroid hormones in punica granatum L.seeds[J].Bull Fac Pharm Cario Univ,1998,36(1):11.
[10]Caligiani A,Bonzanini F,Palla G,et al.Characterization of a potential nutraceutical ingredient:pomegranate(Punica granatum L.)seed oil unsaponifiable fraction[J].Plant Foods Hum Nutr,2010,65(3):277-283.
[11]Moneam N M,Sharaky A S,Badredin M M.Estrogen content of pomegranate seeds.J Chromatogr,1988,438(2):438.
[12]Gasmi J,Sanderson J T.Growth inhibitory,antiandrogenic,andpro-apoptotic effects of punicic acid in LNCa P human prostatecancer cells[J].J Agric Food Chem,2010,58(23):12149-12156.
[13]Golmakani T M,Rezaei K.Comparison of microwave-assisted hydrodistillation with the traditional hydrodistillation method in the extraction of essential oils from thymus vulgaris L[J].Food Chem,2008,109:925-930.
[14]Viana M A,Fernandez X,Visinoni F,et al.Microwave hydrodiffusion and gravity,a new technique or extraction of essential oils[J].J Chromatogr A,2008,1190:14-17.
[15]李文敏,敖明章,余龙江,等.石榴籽油的微波提取和体外抗氧化作用研究[J].天然产物研究与开发,2006,03:378-380+377.
[16]朱丽莉,童军茂,李疆,等.微波辅助有机溶剂提取石榴籽油工艺的研究[J].中国油脂,2010,04:11-13.
[17]黄爱妮,李丽,刘祥龙.微波辅助法与酶解法对石榴籽油提取的比较研究[J].粮食与油脂,2016,04:20-23.
[18]方立.超临界萃取技术及其应用[J].化学推进剂与高分子材料,2009,7(4):34-36.
[19]杨万政,路静,杜晓鸣,等.石榴种籽油提取方法的比较[J].现代中药研究与实践,2011,05:61-62+45.
[20]Liu G M,Xu X,Hao Q F,et al.Supercritical CO2 extraction optimization of pomegranate(Punica granatum L.)seed oil using response surface methodology[J].Food Science and Technology,2009,42:1491-1495.
[21]臧红霞.新疆石榴籽油超临界萃取工艺条件研究[J].安徽农业科学,2011,15:9138-9139.
[22]赵武奇,谷如祥,周晨.响应面分析法优化石榴籽油超临界萃取工艺研究[J].食品工业科技,2013,08:236-239.
[23]涂洪强,刘东波,熊兴耀.石榴籽油的提取及成分分析[J].现代生物医学进展,2008,11:2107-2108+2125.
[24]张嫱,李薇薇.响应面法优化石榴籽油的超临界CO2萃取工艺[J].食品工业,2015,10:152-155.
[25]焦静,郭康权,贾小辉,等.超临界二氧化碳萃取石榴籽油的研究[J].食品科技,2007,01:199-202.
[26]李杨,江连洲,杨柳.水酶法制取植物油的国内外发展动态[J].食品工业科技,2009,06:383-387.
[27]Rosenthal A,Pyle D I,Niranjan K.Aqueous and enzymatic processes for edible oil extraction[J].Enzyme and Microbial Technology,1996,19(11):402-420.
[28]阿依姑丽·艾合麦提,韩海霞,戴小华,等.石榴籽油的提取及其体外抗氧化作用的研究[J].西北药学杂志,2011,01:37-39.
[29]金婷,谭胜兵.水酶法提取石榴籽油工艺条件探究[J].农产品加工(学刊),2014,19:42-44.
[30]苗利利.Alcalase蛋白酶水酶法提取石榴籽油的条件及功能性评价[D].陕西师范大学,2010.
[31]Patist A,Bates D.Ultrasonic innovations in the food industry:From the laboratory to commercial production[J].Innovative Food Science&Emerging Technologies,2008,9(2):147-154.
[32]袁妍,李懋鸣,李成倍,等.响应面法优化石榴籽油超声波提取工艺及成分分析[J].食品科技,2013,04:179-184.
[33]高振鹏,岳田利,袁亚宏,等.超声波强化有机溶剂提取石榴籽油的工艺优化[J].农业机械学报,2008,05:77-80.
[34]刘花花,康健,欧荣,等.新疆石榴籽油的超声辅助提取工艺及GC-MS分析[J].中国油脂,2015,01:6-9.
[35]Han Y,Ma Q,Wang L,et al.Extraction of astaxanthin from euphausia pacific using subcritical 1,1,1,2-tetrafluoroethane[J].Journal of Ocean University of China,2012,11(4):562-568.
[36]王林林,祁鲲,杨倩,等.不同制油方法对石榴籽油品质的影响[J].中国油脂,2016,06:35-38.
[37]Banihani S,Swedan S,Alguraan Z.Pomegranate and type 2 diabetes[J].Nutr Res,2013,33(5):341-348.
[38]李艳,荣向路,高英,等.石榴籽油调节2型糖尿病小鼠糖脂质代谢的药理研究[J].中药新药与临床药理,2013,06:533-537.
[39]Keisuke A,Wang M Y,Nao L.Dietary effect of pomegranate seed oil rich in 9cis,11trans,13cis conjugated linolenic acid on lipid metabolism in obese,hyperlipidemic OLETF Rats[J].Lipids in Health and Disease,2004,3(24):1-7.
[40]杨静.共轭亚麻酸(石榴酸)的油脂载体选择和生物功能的研究[D].浙江:浙江大学,2014.
[41]Rosenstock J,Inzucchi S E,Seufert J,et al.Initial combination therapy with alogliptin and pioglitazone in drug-naive patients with type 2 diabetes[J].Diabetes Care,2010,33(11):2406-2408.
[42]Bosi E,Ellis G C,Wilson CA,et al.Alogliptin as a third oralantidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone:a 52-week,randomized,double-blind,active-controlled,parallel-group study[J].Diabetes Obes Metab,2011,13(12):1088-1096.
[43]Ji Q,Han P,Li C.Efficacy and safety of alogliptin in subjects with type 2 diabetes:a randomised,double-blind,placebo-controlled,phase 3 study in mainland China,Taiwan and Hong Kong[J].United European Gastroenterol J,2013,1(1 Suppl):A135-A587.
[44]Colombo E,Sangiovanni E,Dell'Agli M.A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract[J].Evidence-Based Complementary and Alternative Medicine,2013,2013.
[45]王逢春,王敏.石榴籽油的成分及药理活性研究进展[J].中国药物与临床,2013,12(12):1590-1593.
[46]Minaiyan M,Zolfaghari B,Taheri D,et al.Preventive Effect of Three Pomegranate(Punica granatum L.)Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice[J].Int J Prev Med,2014,5(4):394-404.
[47]Coursodon-Boyiddle C F,Snarrenberg C L,Adkins-Rieck C K,et al.Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2012,303(6):G744-G751.
[48]Bassaganya-Riera J,Di Guardo M,Climent M,et al.Activation of PPARγandδby dietary punicic acid ameliorates intestinal inflammation in mice[J].Br J Nutr,2011,106(6):878-886.
[49]Viladomiu M,Hontecillas R,Lu P,et al.Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents[J].Evid Based Complement Alternat Med,2013(2013):789764.
[50]袁高峰.共轭亚麻酸的分析,代谢和功能研究[D].浙江:浙江大学,2008.
[51]王雁.石榴籽油提取工艺及抗氧化性研究[D].西华大学,2014.
[52]Shay Y S,Ephraim P L,Ishak N.Antioxldant and eicosanoid enzyme inhibition properties of pomeganate seed oil and fermented juice lavonoids[J].Journal of Ethnopharmacology,1999,66:11-17.
[53]Singh R P,Mushy K N C,Jayapakasha G K.Studies On the antioxidant activity of pomegranate peeland seed extracts using in vitro models[J].Journal of Agricultural and Food Chemistry,2002,50:81-86.
[54]王毓宁,何静,李鹏霞,等.石榴籽油自由基清除能力及对H2O2诱导PC12细胞损伤的保护作用[J].中国食品学报,2016,05:32-37.
[55]Kim N D,Mehta R,Yu W,et al.Chemopreventive and adjuvant therapeutic potential of pomegranate for human breast cancer[J].Breast Cancer Research and Treatment,2002,71(3):203-217.
[56]Lyndon M G,Albrecht M,Jiang W G,et al.Pomegranate extracts potently suppress proliferation,xenograft growth and invasion of human prostate cancer cells[J].European Urology Supplements,2003,2(6):158.
[57]Kohno H,Suzuki R,Yasui Y,et al.Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats[J].Cancer Science,2004,95(6):481-486.
[58]Koba K,Matsuoka A,Osada K,et al.Effect of loquat(Eriobotrya japonica)extracts on LDL oxidation[J].Food Chemistry,2009,104:308-316.
[59]Hora J J,Maydew E R,Lansky E P,et al.Chemopreventive effect of pomegranate seed oil on skin tumor development in CD1 mice[J].Journal of Medicinal Food,2003,6(3):157-161.
[60]李雪梅,张颖,王枫.石榴籽油对高脂膳食大鼠血脂的影响[J].公共卫生与预防医学,2009,20(5):39-41.
[61]Arao K,Yotsumoto H,Seo-Young H,et al.The 9-cis,11-trans,13-cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in Hep G2 cells[J].Biosci Biotechnol Biochem,2004,68:2634-2645.
[62]李文敏,敖明章,汪俊汉,等.石榴籽油对实验性高脂血症大鼠血脂及脂质过氧化的影响[J].食品科学,2007,28(2):309-312.
[63]Tran H N,Bae S Y,Song B H,et al.Pomegranate(Punica granatum)seed linolenic acid isomers:concentration-dependent modulation of estrogen receptor activity.Endocr Res,2010,35(1):1-16.
[64]许文胜,张涛,邵国,等.石榴籽油对雌激素相关骨质疏松症小鼠软骨代谢的保护作用及对相关蛋白表达影响的探究[J].贵州医药,2017,04:351-354.
[65]李海霞,王钊,刘延泽.石榴科植物化学成分及药理活性研究进展.中草药,2002,33(8):765.
[66]Aslam M N,Lansky E P,Varani J.Pomegranate as a cosmeceutical source:pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells[J].Journal of Ethnopharmacology,2005,103(3):311-318.
[67]王田,王文心.石榴籽油对小鼠抗抑郁作用的影响[J].河南中医,2016,03:417-419.
[2]杜洁,曹庸,戴伟杰,等.石榴籽油低温连续相变萃取工艺优化及其脂肪酸分析[J].食品与机械,2017,02:148-151.
[3]马齐,秦涛,王丽娥,等.石榴籽油的提取及成分分析[J].粮油食品科技,2008,01:28-30.
[4]高忠梅,刘邻渭,李旋,等.3种石榴籽的主要成分分析[J].食品研究与开发,2015,22:138-141.
[5]杨万政,周瑜,杨晓霞等.石榴籽油脂的提取及脂肪酸组成研究[J].内蒙古工业大学学报(自然科学版),2013,02:96-100.
[6]赵淑娟,叶天,敬璞.石榴籽油中的石榴酸分析方法研究[J].食品工业,2012,07:89-91.
[7]Pande G,Akoh C C.Antioxidant capacity and lipid characterization of six georgia-grownpomegranate cultivars[J].Journal of Agricultural and Food Chemistry,2009,57(20):9427-9436.
[8]Kralan M,G lükcüM,Tokg z H.Oil and conjugated linolenic acid contents of seeds from important pomegranate cultivars(Punica granatum L.)grown in turkey[J].Journal of the American Oil Chemists'Society,2009,86(10):985-990.
[9]Abd E I,Wahab S M,Fiki N M E I,et al.Characterization of certainsteroid hormones in punica granatum L.seeds[J].Bull Fac Pharm Cario Univ,1998,36(1):11.
[10]Caligiani A,Bonzanini F,Palla G,et al.Characterization of a potential nutraceutical ingredient:pomegranate(Punica granatum L.)seed oil unsaponifiable fraction[J].Plant Foods Hum Nutr,2010,65(3):277-283.
[11]Moneam N M,Sharaky A S,Badredin M M.Estrogen content of pomegranate seeds.J Chromatogr,1988,438(2):438.
[12]Gasmi J,Sanderson J T.Growth inhibitory,antiandrogenic,andpro-apoptotic effects of punicic acid in LNCa P human prostatecancer cells[J].J Agric Food Chem,2010,58(23):12149-12156.
[13]Golmakani T M,Rezaei K.Comparison of microwave-assisted hydrodistillation with the traditional hydrodistillation method in the extraction of essential oils from thymus vulgaris L[J].Food Chem,2008,109:925-930.
[14]Viana M A,Fernandez X,Visinoni F,et al.Microwave hydrodiffusion and gravity,a new technique or extraction of essential oils[J].J Chromatogr A,2008,1190:14-17.
[15]李文敏,敖明章,余龙江,等.石榴籽油的微波提取和体外抗氧化作用研究[J].天然产物研究与开发,2006,03:378-380+377.
[16]朱丽莉,童军茂,李疆,等.微波辅助有机溶剂提取石榴籽油工艺的研究[J].中国油脂,2010,04:11-13.
[17]黄爱妮,李丽,刘祥龙.微波辅助法与酶解法对石榴籽油提取的比较研究[J].粮食与油脂,2016,04:20-23.
[18]方立.超临界萃取技术及其应用[J].化学推进剂与高分子材料,2009,7(4):34-36.
[19]杨万政,路静,杜晓鸣,等.石榴种籽油提取方法的比较[J].现代中药研究与实践,2011,05:61-62+45.
[20]Liu G M,Xu X,Hao Q F,et al.Supercritical CO2 extraction optimization of pomegranate(Punica granatum L.)seed oil using response surface methodology[J].Food Science and Technology,2009,42:1491-1495.
[21]臧红霞.新疆石榴籽油超临界萃取工艺条件研究[J].安徽农业科学,2011,15:9138-9139.
[22]赵武奇,谷如祥,周晨.响应面分析法优化石榴籽油超临界萃取工艺研究[J].食品工业科技,2013,08:236-239.
[23]涂洪强,刘东波,熊兴耀.石榴籽油的提取及成分分析[J].现代生物医学进展,2008,11:2107-2108+2125.
[24]张嫱,李薇薇.响应面法优化石榴籽油的超临界CO2萃取工艺[J].食品工业,2015,10:152-155.
[25]焦静,郭康权,贾小辉,等.超临界二氧化碳萃取石榴籽油的研究[J].食品科技,2007,01:199-202.
[26]李杨,江连洲,杨柳.水酶法制取植物油的国内外发展动态[J].食品工业科技,2009,06:383-387.
[27]Rosenthal A,Pyle D I,Niranjan K.Aqueous and enzymatic processes for edible oil extraction[J].Enzyme and Microbial Technology,1996,19(11):402-420.
[28]阿依姑丽·艾合麦提,韩海霞,戴小华,等.石榴籽油的提取及其体外抗氧化作用的研究[J].西北药学杂志,2011,01:37-39.
[29]金婷,谭胜兵.水酶法提取石榴籽油工艺条件探究[J].农产品加工(学刊),2014,19:42-44.
[30]苗利利.Alcalase蛋白酶水酶法提取石榴籽油的条件及功能性评价[D].陕西师范大学,2010.
[31]Patist A,Bates D.Ultrasonic innovations in the food industry:From the laboratory to commercial production[J].Innovative Food Science&Emerging Technologies,2008,9(2):147-154.
[32]袁妍,李懋鸣,李成倍,等.响应面法优化石榴籽油超声波提取工艺及成分分析[J].食品科技,2013,04:179-184.
[33]高振鹏,岳田利,袁亚宏,等.超声波强化有机溶剂提取石榴籽油的工艺优化[J].农业机械学报,2008,05:77-80.
[34]刘花花,康健,欧荣,等.新疆石榴籽油的超声辅助提取工艺及GC-MS分析[J].中国油脂,2015,01:6-9.
[35]Han Y,Ma Q,Wang L,et al.Extraction of astaxanthin from euphausia pacific using subcritical 1,1,1,2-tetrafluoroethane[J].Journal of Ocean University of China,2012,11(4):562-568.
[36]王林林,祁鲲,杨倩,等.不同制油方法对石榴籽油品质的影响[J].中国油脂,2016,06:35-38.
[37]Banihani S,Swedan S,Alguraan Z.Pomegranate and type 2 diabetes[J].Nutr Res,2013,33(5):341-348.
[38]李艳,荣向路,高英,等.石榴籽油调节2型糖尿病小鼠糖脂质代谢的药理研究[J].中药新药与临床药理,2013,06:533-537.
[39]Keisuke A,Wang M Y,Nao L.Dietary effect of pomegranate seed oil rich in 9cis,11trans,13cis conjugated linolenic acid on lipid metabolism in obese,hyperlipidemic OLETF Rats[J].Lipids in Health and Disease,2004,3(24):1-7.
[40]杨静.共轭亚麻酸(石榴酸)的油脂载体选择和生物功能的研究[D].浙江:浙江大学,2014.
[41]Rosenstock J,Inzucchi S E,Seufert J,et al.Initial combination therapy with alogliptin and pioglitazone in drug-naive patients with type 2 diabetes[J].Diabetes Care,2010,33(11):2406-2408.
[42]Bosi E,Ellis G C,Wilson CA,et al.Alogliptin as a third oralantidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone:a 52-week,randomized,double-blind,active-controlled,parallel-group study[J].Diabetes Obes Metab,2011,13(12):1088-1096.
[43]Ji Q,Han P,Li C.Efficacy and safety of alogliptin in subjects with type 2 diabetes:a randomised,double-blind,placebo-controlled,phase 3 study in mainland China,Taiwan and Hong Kong[J].United European Gastroenterol J,2013,1(1 Suppl):A135-A587.
[44]Colombo E,Sangiovanni E,Dell'Agli M.A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract[J].Evidence-Based Complementary and Alternative Medicine,2013,2013.
[45]王逢春,王敏.石榴籽油的成分及药理活性研究进展[J].中国药物与临床,2013,12(12):1590-1593.
[46]Minaiyan M,Zolfaghari B,Taheri D,et al.Preventive Effect of Three Pomegranate(Punica granatum L.)Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice[J].Int J Prev Med,2014,5(4):394-404.
[47]Coursodon-Boyiddle C F,Snarrenberg C L,Adkins-Rieck C K,et al.Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2012,303(6):G744-G751.
[48]Bassaganya-Riera J,Di Guardo M,Climent M,et al.Activation of PPARγandδby dietary punicic acid ameliorates intestinal inflammation in mice[J].Br J Nutr,2011,106(6):878-886.
[49]Viladomiu M,Hontecillas R,Lu P,et al.Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents[J].Evid Based Complement Alternat Med,2013(2013):789764.
[50]袁高峰.共轭亚麻酸的分析,代谢和功能研究[D].浙江:浙江大学,2008.
[51]王雁.石榴籽油提取工艺及抗氧化性研究[D].西华大学,2014.
[52]Shay Y S,Ephraim P L,Ishak N.Antioxldant and eicosanoid enzyme inhibition properties of pomeganate seed oil and fermented juice lavonoids[J].Journal of Ethnopharmacology,1999,66:11-17.
[53]Singh R P,Mushy K N C,Jayapakasha G K.Studies On the antioxidant activity of pomegranate peeland seed extracts using in vitro models[J].Journal of Agricultural and Food Chemistry,2002,50:81-86.
[54]王毓宁,何静,李鹏霞,等.石榴籽油自由基清除能力及对H2O2诱导PC12细胞损伤的保护作用[J].中国食品学报,2016,05:32-37.
[55]Kim N D,Mehta R,Yu W,et al.Chemopreventive and adjuvant therapeutic potential of pomegranate for human breast cancer[J].Breast Cancer Research and Treatment,2002,71(3):203-217.
[56]Lyndon M G,Albrecht M,Jiang W G,et al.Pomegranate extracts potently suppress proliferation,xenograft growth and invasion of human prostate cancer cells[J].European Urology Supplements,2003,2(6):158.
[57]Kohno H,Suzuki R,Yasui Y,et al.Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats[J].Cancer Science,2004,95(6):481-486.
[58]Koba K,Matsuoka A,Osada K,et al.Effect of loquat(Eriobotrya japonica)extracts on LDL oxidation[J].Food Chemistry,2009,104:308-316.
[59]Hora J J,Maydew E R,Lansky E P,et al.Chemopreventive effect of pomegranate seed oil on skin tumor development in CD1 mice[J].Journal of Medicinal Food,2003,6(3):157-161.
[60]李雪梅,张颖,王枫.石榴籽油对高脂膳食大鼠血脂的影响[J].公共卫生与预防医学,2009,20(5):39-41.
[61]Arao K,Yotsumoto H,Seo-Young H,et al.The 9-cis,11-trans,13-cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in Hep G2 cells[J].Biosci Biotechnol Biochem,2004,68:2634-2645.
[62]李文敏,敖明章,汪俊汉,等.石榴籽油对实验性高脂血症大鼠血脂及脂质过氧化的影响[J].食品科学,2007,28(2):309-312.
[63]Tran H N,Bae S Y,Song B H,et al.Pomegranate(Punica granatum)seed linolenic acid isomers:concentration-dependent modulation of estrogen receptor activity.Endocr Res,2010,35(1):1-16.
[64]许文胜,张涛,邵国,等.石榴籽油对雌激素相关骨质疏松症小鼠软骨代谢的保护作用及对相关蛋白表达影响的探究[J].贵州医药,2017,04:351-354.
[65]李海霞,王钊,刘延泽.石榴科植物化学成分及药理活性研究进展.中草药,2002,33(8):765.
[66]Aslam M N,Lansky E P,Varani J.Pomegranate as a cosmeceutical source:pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells[J].Journal of Ethnopharmacology,2005,103(3):311-318.
[67]王田,王文心.石榴籽油对小鼠抗抑郁作用的影响[J].河南中医,2016,03:417-419.