NMOSD患者脑脊液中神经丝蛋白轻链浓度的影响因素分析

详细信息    查看全文 | 推荐本文 |

英文篇名：Influencing factors on neurofilament light chain concentration in cerebrospinal fluid of patients with NMOSD 作者：张秀娟 ; 千超 ; 高喜松 英文作者：Zhang Xiujuan;Qian Chao;Gao Xisong;Department of Neurology, Xi'an No.3 Hospital;Department of Neurosurgery, No.215 Hospital of Shaanxi Nuclear Industry; 关键词：视神经脊髓炎谱系疾病 ; 神经丝蛋白 ; 影响因素 英文关键词：neuromyelitis optica spectrum disorder;;neurofilament protein;;influencing factors 中文刊名：XNGF 英文刊名：Medical Journal of National Defending Forces in Southwest China 机构：西安市第三医院神经内科;陕西省核工业215医院神经外科; 出版日期：2019-01-20 出版单位：西南国防医药 年：2019 期：v.29 语种：中文; 页：XNGF201901005 页数：3 CN：01 ISSN：51-1361/R 分类号：17-19

摘要

目的分析视神经脊髓炎谱系疾病(NMOSD)患者脑脊液中神经丝蛋白轻链(NFL)浓度的影响因素,为NMOSD的临床诊治提供参考。方法选取NMOSD患者52例,检测其脑脊液中NFL的浓度,并收集患者的其他临床和影像学资料,分析脑脊液NFL浓度的影响因素。结果 NMOSD患者年龄大小、病灶强化与否、扩展残疾状况量表(EDSS)评分高低是脑脊液NFL浓度的影响因素(P <0.05),而性别、病程长短、血水通道蛋白抗体(AQP4)阳性率对NMOSD脑脊液NFL浓度无明显影响(P>0.05)。结论 NMOSD患者年龄、EDSS评分和病灶强化情况是影响其脑脊液NFL浓度的独立因素。检测脑脊液NFL水平,可能对患者病情严重程度和进展有重要的参考意义。
        Objective To analyze the influencing factors on neurofilament light chain(NFL) concentration in cerebrospinal fluid of patients with neuromyelitis optica spectrum disorder(NMOSD), and to provide reference for clinical diagnosis and treatment of NMOSD. Methods A total of 52 patients with NMOSD were selected to detect the NFL concentration in cerebrospinal fluid, and other clinical and imaging data of the patients were collected to analyze the influencing factors on the NFL concentration in cerebrospinal fluid. Results The age, lesion enhancement and Expanded Disability Status Scale(EDSS) score were the influencing factors on the NFL concentration in cerebrospinal fluid(P < 0.05), while the gender, duration of disease and AQP4 positive rate had no significant effect on the NFL concentration in cerebrospinal fluid(P > 0.05). Conclusion The age,EDSS score and lesion enhancement are independent factors influencing the NFL concentration in cerebrospinal fluid of patients with NMOSD; detection of cerebrospinal fluid NFL level may have great reference significance for determining the severity and progress of patients.

引文

[1]徐雁,王维治.视神经脊髓炎谱系疾病2015新诊断标准解读[J].中华神经科杂志, 2016, 49(6):499-501.
    [2]杨志华,韩雷,李青,等.颈脊柱损伤与挥鞭性损伤后脑脊液中神经组织损伤标记物变化对评估神经组织损伤程度的影响[J].现代实用医学, 2016, 28(9):1159-1160.
    [3] Kuhle J, Plattner K, Bestwick JP, et al. A comparative study of CSF neurofilament light and heavy chain protein in MS[J].Multiple Sclerosis, 2013, 19(12):1597-1603.
    [4] Wingerchuk DM, Banwell B, Bennett JL, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders[J]. Neurology, 2015, 85(2):177.
    [5]耿嘉,朱晓斐,马舒,等.多发性硬化患者脑脊液组胺水平与EDSS评分的相关性分析[J].疑难病杂志, 2016, 15(5):441-444.
    [6] Cruz CD, Coelho A, Antuneslopes T, et al. Biomarkers of spinal cord injury and ensuing bladder dysfunction[J]. Adv Drug Deliv Rev, 2015, 82:153-159.
    [7]汤超,张刚,秦新月.视神经脊髓炎谱系疾病的临床特点及复发影响因素[J].实用医学杂志, 2017, 33(6):963-966.
    [8]苗晓慧,耿丹,石紫燕,等.视神经脊髓炎患者生活质量调查[J].中国神经免疫学和神经病学杂志, 2016, 23(4):240-243.
    [9] Wang H, Wang C, Qiu W, et al. Cerebrospinal fluid light and heavy neurofilaments in neuromyelitis optica[J]. Neurochemistry International, 2013, 63(8):805-808.
    [10]彭丽君,钱海蓉,毛琳玲,等.神经丝蛋白轻链在视神经脊髓炎谱系疾病诊断和预后中的意义[J].中华神经科杂志, 2017, 50(6):430-434.
    [11]于鹭,李梅,仲星星,等.视神经脊髓炎谱系疾病患者脑脊液蛋白水平与致残状况的相关性研究[J].中风与神经疾病, 2017, 34(1):31-33.
    [12]厉向,童巧文,柯建明,等.血清水通道蛋白4抗体测定对视神经脊髓炎的诊断及预后判断价值[J].中国病理生理杂志, 2014,30(11):1974-1979.