更昔洛韦治疗病毒性口腔疱疹的有效性和安全性评价

详细信息    查看全文 | 推荐本文 |

英文篇名：Ef?cacy and Safety of Ganciclovir in the Treatment of Viral oral Herpes 作者：郭磊 ; 吴韫慧 ; 高瑞 英文作者：GUO Lei;WU Yun-hui;GAO Rui;Department of Stomatology, 7th people's Hospital of Zhengzhou; 关键词：更昔洛韦 ; 病毒性口腔疱疹 ; 有效性 ; 安全性 英文关键词：Ganciclovir;;Viral oral Herpes;;Ef?cacy;;Safety 中文刊名：YPPJ 英文刊名：Drug Evaluation 机构：郑州市第七人民医院口腔科; 出版日期：2019-03-28 出版单位：药品评价 年：2019 期：v.16 语种：中文; 页：YPPJ201906013 页数：4 CN：06 ISSN：36-1259/R 分类号：47-49+63

摘要

目的:探析更昔洛韦应用于病毒性口腔疱疹中的治疗效果和安全性。方法:2017年11月—2018年11月在我院治疗病毒性口腔疱疹患儿中选取84例,严格按照系统随机分配原则分为对照组和观察组,各42例。其中对照组采用利巴韦林治疗,观察组采用更昔洛韦治疗,观察对比两组患者治疗效果、临床症状改善时间和不良反应发生率。结果:治疗后,对照组总有效率为78.57%,观察组总有效率为95.24%,对照组总有效率低于观察组;对照组口腔疼痛时间、体温恢复时间、溃疡消失时间及疱疹消失时间均长于观察组,且对照组不良反应发生率为11.90%,观察组无不良反应发生现象,对照组不良反应发生率高于观察组,差异具有统计学意义(P<0.05)。结论:予以病毒性口腔疱疹患儿更昔洛韦进行治疗,效果显著,可有效改善临床症状时间,降低不良反应发生率。
        Objective: To explore the ef?cacy and safety of ganciclovir in the treatment of viral oral herpes. Methods: Eighty-four children with viral oral herpes were selected from November 2017 to November 2018 in our hospital, and divided into control group and observation group according to the principle of systematic random distribution, with 42 cases in each group. The control group was treated with ribavirin and the observation group with ganciclovir. Results: After treatment, the total effective rate of the control group was 78.57%, the total effective rate of the observation group was 95.24%, and the total effective rate of the control group was 95.24%. The effective rate was lower than that in the observation group. The oral pain time, temperature recovery time, ulcer disappearance time and herpes disappearance time in the control group were longer than those in the observation group, and the incidence of adverse reactions in the control group was 11.90%. There was no adverse reaction in the observation group.The incidence of adverse reactions in the control group was higher than that in the observation group, and the difference was statistically signi?cant(P<0.05). Conclusion: Ganciclovir is effective in treating children with viral oral herpes. It can effectively improve the time of clinical symptoms and reduce the incidence of adverse reactions. It is worth popularizing.

引文

[1]张琇雯,李玲,卜凤娇,等.更昔洛韦联合中药治疗单纯疱疹病毒性角膜炎的系统评价[J].国际眼科杂志,2018,18(7):1206-1210.
    [2]林忠,李卫民.更昔洛韦治疗86例带状疱疹后遗神经痛的有效性及安全性[J].中国实用神经疾病杂志,2015,18(10):117-118.
    [3]吴晓波,吕贞燕,何勇.更昔洛韦联合丙种免疫球蛋白治疗婴儿巨细胞病毒感染的系统评价[J].临床药物治疗杂志,2016,14(2):31-36.
    [4]雷兴,曾斐,李珍,等.更昔洛韦联合炎琥宁对带状疱疹病毒性角膜炎的治疗效果[J].药学与临床研究,2015,23(2):194-196.
    [5]张睿.更昔洛韦联合康复新液治疗疱疹性口腔炎的疗效分析[J].中国医药指南,2017,15(3):71-72.
    [6]姚玙,王方.中药雾化熏眼联合更昔洛韦治疗单纯疱疹性病毒性角膜炎的疗效分析[J].饮食保健,2016,3(12):90-91.
    [7]黄清珍.更昔洛韦联合热毒宁治疗小儿病毒性脑炎的疗效和安全性分析[J].医药论坛杂志,2017,38(3):168-169.
    [8]李迎晓.更昔洛韦联合康复新液治疗疱疹性口腔炎患儿的临床疗效[J].实用中西医结合临床,2017,17(9):96-97.
    [9]尹亮.更昔洛韦治疗幼儿病毒性口腔疱疹疗效观察[J].国际病毒学杂志,2015,22(1):65-67.
    [10]黄海东,陈冬,杨月丽,等.炎琥宁联合更昔洛韦对单纯疱疹病毒性角膜炎患者血清和泪液中抗氧化指标的影响[J].解放军预防医学杂志,2018,205(4):44-47.
    [11]王颖.探讨更昔洛韦治疗疱疹性咽峡炎的临床疗效和药理作用[J].中国继续医学教育,2017,9(17):174-175.
    [12]汪志美,邹雪,唐正,等.半导体激光联合更昔洛韦及前列地尔治疗恶性肿瘤并带状疱疹的疗效观察及护理[J].激光杂志,2017,38(1):163-165.