血清SPAG9抗体诊断乳腺良恶性病变患者的价值分析
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摘要
目的:探讨血清精子相关抗原9(SPAG9)抗体诊断乳腺良恶性病变的价值。方法:回顾性分析乳腺病变患者76例的临床资料。将乳腺癌患者44例作为研究组,将乳腺良性疾病患者32例作为对照组。比较两组血清SPAG9抗体表达情况。结果:研究组血清SPAG9抗体阳性率显著高于对照组,差异有统计学意义(P<0.05)。血清SPAG9抗体诊断乳腺癌的敏感度61.36%,特异度81.25%,准确度69.74%,阳性预测值81.82%,阴性预测值60.47%。随乳腺癌病理分级、TNM分期升高,血清SPAG9抗体水平呈上升趋势(P<0.05)。结论:血清SPAG9抗体在乳腺良恶性病变诊断过程中有较高的准确度、灵敏度、特异度,且可反映乳腺癌严重程度。
Objective:To explore the value of serum sperm associated antigen 9(SPAG9) antibody in the diagnosis of benign and malignant breast lesions.Methods:The clinical data of 76 cases of patients with breast lesions were analyzed retrospectively.44 cases of patients with breast cancer were as the research group,and 32 cases of patients with benign breast diseases were as the control group.The expression of serum SPAG9 antibody between the two groups was compared.Results:The positive rate of SPAG9 antibody in the research group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).With the increase of pathological grade and TNM stage of breast cancer,serum SPAG9 antibody level showed an upward trend(P<0.05).Conclusion:The serum SPAG9 antibody had high accuracy,sensitivity and specificity in the diagnosis of breast benign and malignant lesions,and could reflect the severity of breast cancer.
Objective:To explore the value of serum sperm associated antigen 9(SPAG9) antibody in the diagnosis of benign and malignant breast lesions.Methods:The clinical data of 76 cases of patients with breast lesions were analyzed retrospectively.44 cases of patients with breast cancer were as the research group,and 32 cases of patients with benign breast diseases were as the control group.The expression of serum SPAG9 antibody between the two groups was compared.Results:The positive rate of SPAG9 antibody in the research group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).With the increase of pathological grade and TNM stage of breast cancer,serum SPAG9 antibody level showed an upward trend(P<0.05).Conclusion:The serum SPAG9 antibody had high accuracy,sensitivity and specificity in the diagnosis of breast benign and malignant lesions,and could reflect the severity of breast cancer.
引文
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[9]任碧琼,李勇,邹国英,等.抗SPAG9自身抗体在肿瘤患者外周血中表达分析[J].重庆医学,2012,41(30):3141-3142.
[2]熊孟祥.抗SPAG9自身抗体在肿瘤患者外周血中的表达分析[J].现代中西医结合杂志,2014,23(3):261-262.
[3]林国鸿,农文伟.乳腺癌复发影响因素的研究进展[J].广西医学,2017,39(8):1231-1234.
[4]崔梦瑶,岑尧,马玉珍.癌-睾丸抗原在肿瘤诊断和治疗中的研究进展[J].中国临床研究,2015,28(12):1675-1677.
[5]董志伟,王健,穆苍山,等.恶性纤维组织细胞瘤中肿瘤睾丸抗原相关基因的表达[J].实用骨科杂志,2016,22(5):425-427.
[6]徐秀平,王亚男,董学君.精子相关抗原9(SPAG9)在乳腺癌中的表达及其临床意义[J].医学研究杂志,2016,45(11):78-81.
[7]曹敏敏,张璐,李春艳,等.精子相关抗原9在宫颈腺癌中的表达及其临床意义[J].中华实验外科杂志,2015,32(12):333-336.
[8]徐婷,谢晨烨,程卉,等.新藤黄酸联合阿霉素通过JNK信号通路诱导人乳腺癌细胞凋亡的相关机制研究[J].中华中医药杂志,2017,31(6):2721-2726.
[9]任碧琼,李勇,邹国英,等.抗SPAG9自身抗体在肿瘤患者外周血中表达分析[J].重庆医学,2012,41(30):3141-3142.