核壳结构Fe_3O_4@SiO_2纳米粒子的制备及表征
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摘要
为丰富Fe_3O_4磁性纳米粒子在生物医学领域的应用,通过共沉淀法制备Fe_3O_4纳米粒子,经柠檬酸三钠修饰后,采用改进的Stber法成功在Fe_3O_4纳米粒子表面包覆上SiO_2,制备出核壳结构Fe_3O_4@SiO_2纳米粒子。使用扫描式电子显微镜、X射线衍射仪、傅里叶变换红外光谱仪、振动样品磁强计对制备的Fe_3O_4@SiO_2纳米粒子进行表征。结果表明:制备的Fe_3O_4@SiO_2纳米粒子较Fe_3O_4纳米粒子分散性有明显的提高,平均粒径在65 nm左右,饱和比磁化强度为10.26 A·m~2/kg,仍具有良好的超顺磁性。
In the paper, emphasis is put on the synthesis and characterization of Fe_3O_4@SiO_2 core/shell structured nanoparticles. Superparamagnetic Fe_3O_4 nanoparticles are prepared by co-precipitation method and then, silica is coated on the surface of the magnetite nanoparticles by modified Stber method. Subsequently, the nanocomposite samples are characterized by scanning electron microscope, fourier transform infrared spectroscopy, X-ray diffraction and vibrating sample magnetometer. The results reveal that the Fe_3O_4 and Fe_3O_4@SiO_2 nanoparticles have an average size of 15 nm and 65 nm diameters, respectively. Moreover, the nanocomposites are monodisperse and uniformly spherical with well-defined shell-core structures and exhibit superparamagnetic characteristics. Meanwhile, spinel structure for the magnetite particles coated by silica is revealed by powder X-ray diffraction measurements.
In the paper, emphasis is put on the synthesis and characterization of Fe_3O_4@SiO_2 core/shell structured nanoparticles. Superparamagnetic Fe_3O_4 nanoparticles are prepared by co-precipitation method and then, silica is coated on the surface of the magnetite nanoparticles by modified Stber method. Subsequently, the nanocomposite samples are characterized by scanning electron microscope, fourier transform infrared spectroscopy, X-ray diffraction and vibrating sample magnetometer. The results reveal that the Fe_3O_4 and Fe_3O_4@SiO_2 nanoparticles have an average size of 15 nm and 65 nm diameters, respectively. Moreover, the nanocomposites are monodisperse and uniformly spherical with well-defined shell-core structures and exhibit superparamagnetic characteristics. Meanwhile, spinel structure for the magnetite particles coated by silica is revealed by powder X-ray diffraction measurements.
引文
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[14] Guo S, Li D L, Li J, et al. Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery[J]. Biomaterials, 2009, 30(10): 1881-1889.
[15] Yudhisthira Sahoo, Alireza Goodarzi, Swihart M T, et al. Aqueous ferrofluid of magnetite nanoparticles: Fluorescence labeling and magnetophoretic control[J]. Journal of Physical Chemistry B, 2005, 109(9): 3879-3885.
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[18] 王鹏程,柳松,刘梦溪.单分散纳米二氧化硅的制备与分散性研究[J].无机盐工业,2011,43(2):40-43.Wang P C, Liu S, Liu M X. Study on preparation and dispersivity of monodisperse silica nanoparticles[J]. Inorganic Chemicals Industry, 2011, 43(2): 40-43. (in Chinese)
[19] Chang Q, Zhu L, Yu C, et al. Synthesis and properties of magnetic and luminescent Fe3O4/SiO2/Dye/SiO2, nanoparticles[J]. Journal of Luminescence, 2008, 128(12): 1890-1895.
[20] Liu H M, Wu S H, Lu C W, et al. Mesoporous silica nanoparticles improve magnetic labeling efficiency in human stem cells[J]. Small, 2008, 4(5): 619-626.
[2] Chifiriuc C M, Dan E M, Saviuc C, et al. Biocompatible magnetic hollow silica microspheres for drug delivery[J]. Current Organic Chemistry, 2013, 17(10): 1029-1033.
[3] Lia S, Yu-Ho W, Mallikarjunarao G, et al. Magnetic particle — Based hybrid platforms for bioanalytical sensors[J]. Sensors, 2009, 9(4): 2976-2999.
[4] Tamer U, Gündogdu Y, Ismail Hakki Boyaci, et al. Synthesis of magnetic core-shell Fe3O4-Au nanoparticle for biomolecule immobilization and detection[J]. Journal of Nanoparticle Research, 2010, 12(4): 1187-1196.
[5] Gupta A K, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications[J]. Biomaterials, 2005, 26(18): 3995-4021.
[6] Atta A M, El-Mahdy G A, Al-Lohedan H A, et al. Preparation and application of cross linked poly (sodium acrylate)-coated magnetite nanoparticles as corrosion inhibitors for carbon steel alloy[J]. Molecules, 2015, 20(1): 1244-1261.
[7] Wang Y, Zhang M, Wang L, et al. Synthesis of hierarchical nickel anchored on Fe3O4@SiO2 and its successful utilization to remove the abundant proteins (BHb) in bovine blood[J]. New Journal of Chemistry, 2015, 39(6): 4876-4881.
[8] Liu H L, Wu J H, Min J H, et al. One-pot synthesis and characterization of bifunctional Au-Fe3O4, hybrid core-shell nanoparticles[J]. Journal of Alloys & Compounds, 2012, 537(26): 60-64.
[9] Qu H O, Tong S, Song K J, et al. Controllable in-situ synthesis of magnetite coated silica-core water-dispersible hybrid nanomaterials[J]. Langmuir the ACS Journal of Surfaces & Colloids, 2013, 29(33): 10573-10578.
[10] Lu Y, Yin Y, Mayers B T, et al. Modifying the surface properties of super paramagnetic iron oxide nanoparticles through A Sol-Gel Approach[J]. Nano Letters, 2002, 2(3): 183-186.
[11] St?ber W, Fink A, Ernst Bohn. Controlled growth of monodisperse silica spheres in the micron size range[J]. Journal of Colloid & Interface Science, 1968, 26(1): 62-69.
[12] Narita A, Naka K, Chujo Y. Facile control of silica shell layer thickness on hydrophilic iron oxide nanoparticles via reverse micelle method[J]. Colloids & Surfaces A: Physicochemical & Engineering Aspects, 2009, 336(1): 46-56.
[13] Philipse A P, Bruggen M P B V, Pathmamanoharan C. Magnetic silica dispersions: Preparation and stability of surface-modified silica particles with a magnetic core[J]. Langmuir, 1994, 10(1): 92-99.
[14] Guo S, Li D L, Li J, et al. Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery[J]. Biomaterials, 2009, 30(10): 1881-1889.
[15] Yudhisthira Sahoo, Alireza Goodarzi, Swihart M T, et al. Aqueous ferrofluid of magnetite nanoparticles: Fluorescence labeling and magnetophoretic control[J]. Journal of Physical Chemistry B, 2005, 109(9): 3879-3885.
[16] Wang L, Luo J, Maye M M, et al. Iron oxide-gold core-shell nanoparticles and thin film assembly[J]. Journal of Materials Chemistry, 2005, 15(18): 1821-1832.
[17] Wang L, Bao J, Lun W P, et al. One-pot synthesis and bioapplication of amine-functionalized magnetite nanoparticles and hollow nanospheres[J]. Chemistry-A European Journal, 2006, 12(24): 6341-6347.
[18] 王鹏程,柳松,刘梦溪.单分散纳米二氧化硅的制备与分散性研究[J].无机盐工业,2011,43(2):40-43.Wang P C, Liu S, Liu M X. Study on preparation and dispersivity of monodisperse silica nanoparticles[J]. Inorganic Chemicals Industry, 2011, 43(2): 40-43. (in Chinese)
[19] Chang Q, Zhu L, Yu C, et al. Synthesis and properties of magnetic and luminescent Fe3O4/SiO2/Dye/SiO2, nanoparticles[J]. Journal of Luminescence, 2008, 128(12): 1890-1895.
[20] Liu H M, Wu S H, Lu C W, et al. Mesoporous silica nanoparticles improve magnetic labeling efficiency in human stem cells[J]. Small, 2008, 4(5): 619-626.