小剂量多巴胺联合呋塞米静脉泵入治疗顽固性心力衰竭的疗效观察
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摘要
目的:探讨小剂量多巴胺联合呋塞米静脉泵入治疗顽固性心力衰竭的临床疗效。方法:选取2016年1月至2018年2月天津医科大学总医院滨海医院收治的顽固性心力衰竭患者60例,以随机抽取形式分为观察组和对照组,每组30例。对照组患者给予呋塞米静脉泵入治疗,观察组患者在对照组的基础上加用小剂量多巴胺。比较两组患者的临床疗效、心功能指标的差异。结果:观察组患者的总有效率为90.00%(27/30),明显高于对照组的66.67%(20/30),差异有统计学意义(P<0.05);治疗后,观察组患者左心室射血分数、左心室舒张末期内径及血浆N末端B型脑钠肽原水平明显优于对照组,差异均有统计学意义(P<0.05)。结论:采用小剂量多巴胺联合呋塞米静脉泵入治疗顽固性心力衰竭,在有效提高疗效的同时有利于患者心功能的改善。
OBJECTIVE: To probe into the clinical efficacy of low-dose dopamine combined with intravenous infusion of furacemi on refractory heart failure. METHODS: 60 patients with refractory heart failure admitted into Tianjin Medical University General Hospital Binhai Hospital from Jan. 2016 to Feb. 2018 were extracted to be randomly divided observation group and control group,with 30 cases in each. The control group was given intravenous infusion of furacemi,while the observation group additionally received low-dose dopamine based on the control group.Differences of clinical efficacy,cardiac parameters of two groups were compared. RESULTS: The total effective rate of observation group was 90. 00%( 27/30),significantly higher than that of control group( 66. 67%,20/30),with statistically significant difference( P < 0. 05). After treatment,the left ventricular ejection fraction,left ventricular end diastolic diameter and plasma N-terminal B-type pro-brain natriuretic peptide in observation group were significantly better than those in control group, and the differences were statistically significant( P < 0. 05).CONCLUSIONS: Low-dose dopamine combined with intravenous infusion of furacemi on refractory heart failure can not only improve the efficiency of treatment but also improve the cardiac function.
OBJECTIVE: To probe into the clinical efficacy of low-dose dopamine combined with intravenous infusion of furacemi on refractory heart failure. METHODS: 60 patients with refractory heart failure admitted into Tianjin Medical University General Hospital Binhai Hospital from Jan. 2016 to Feb. 2018 were extracted to be randomly divided observation group and control group,with 30 cases in each. The control group was given intravenous infusion of furacemi,while the observation group additionally received low-dose dopamine based on the control group.Differences of clinical efficacy,cardiac parameters of two groups were compared. RESULTS: The total effective rate of observation group was 90. 00%( 27/30),significantly higher than that of control group( 66. 67%,20/30),with statistically significant difference( P < 0. 05). After treatment,the left ventricular ejection fraction,left ventricular end diastolic diameter and plasma N-terminal B-type pro-brain natriuretic peptide in observation group were significantly better than those in control group, and the differences were statistically significant( P < 0. 05).CONCLUSIONS: Low-dose dopamine combined with intravenous infusion of furacemi on refractory heart failure can not only improve the efficiency of treatment but also improve the cardiac function.
引文
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[2]刘远水.多巴酚丁胺联合硝酸甘油治疗慢性顽固性心力衰竭的临床分析[J].当代医学,2016,22(9):140-141.
[3]邵明凤.小剂量多巴胺联合呋塞米静脉泵入治疗顽固性心力衰竭80例观察[J].中国实用医药,2016,11(10):149-150.
[4]王京,赵莉.微量泵持续泵入硝普钠和多巴胺治疗顽固性心力衰竭的临床疗效观察[J].基层医学论坛,2016,20(13):1745-1746.
[5]史明娟,於华敏,何海英,等.多巴胺联合米力农对老年顽固性心力衰竭临床疗效、心功能和N-末端B型利钠肽前体水平的影响[J].中国生化药物杂志,2016,36(4):164-166.
[6]廖诚红,许小强,罗满芳.托伐普坦片联合左西孟旦注射液治疗顽固性心力衰竭的疗效观察[J].中国医院用药评价与分析,2016,16(9):1178-1180.
[7]李旭,刘加明,李玉琴,等.连续性血液透析滤过改善顽固性心力衰竭患者心功能的机制探讨[J].中国血液净化,2015,14(11):662-666
[8]王志娥,杨海燕,张海娜,等.肠内营养干预治疗老年顽固性心力衰竭患者的临床研究[J].东南大学学报:医学版,2015,34(2):243-246.
[9]赵娇,谭章华.多巴胺联合多巴酚丁胺治疗顽固性心力衰竭疗效观察[J].现代中西医结合杂志,2014,23(4):401-403.
[10]汪亚芸,陈曼华.新活素对老年顽固性心力衰竭患者无创血流动力学参数的影响[J].实用药物与临床,2015,18(04):406-408.
[11]袁方,刘华,戴锦杰,等.参附注射液对顽固性心力衰竭合并低血压患者心肾功能的影响[J].中华中医药杂志,2014,29(10):3295-3297.
[12]何庆勇.《金匮要略》“血不利则为水”理论与顽固性心力衰竭的治疗[J].中华中医药杂志,2015,30(1):120-122.
[13]白冬阳,肖普,白瑞莉.小剂量多巴胺静脉持续泵入联合利尿剂治疗顽固性心力衰竭[J].医药论坛杂志,2014,35(3):134,136.
[14]蔡俊岭.呋塞米联合小剂量多巴胺间歇静脉泵入治疗终末期心力衰竭合并利尿剂抵抗[J].内科,2013,8(3):237-238,236.
[15]张静,黄敏,刘芸.多巴胺联合呋塞米静脉泵入配合延续护理治疗顽固性心力衰竭80例疗效观察[J].中国药业,2017,26(23):56-58.