计算机认知矫正治疗对女性缓解期精神分裂症患者认知功能的影响
|
摘要
目的探讨计算机认知矫正治疗(CCRT)对女性缓解期精神分裂症患者认知功能的影响。方法收集2016年9月至2017年9月沈阳市精神卫生中心门诊治疗的42例女性缓解期精神分裂症患者,随机分为联合治疗组和单纯药物治疗组,联合治疗组在口服奥氮平的基础上同时采用CCRT作为认知治疗工具,单纯药物治疗组仅口服奥氮平。试验共进行12周,分别在治疗前、治疗6周后、治疗12周后应用精神分裂症认知功能成套测验共识版(MCCB)评定2组患者的认知功能。结果与治疗前比较,治疗12周后,联合治疗组中符号编码、数字序列、空间广度、语义流畅、持续操作、言语记忆、视觉记忆、迷宫以及总分的差异有统计学意义(P <0.05),单纯药物治疗组中符号编码、语义流畅、空间广度、言语记忆、视觉记忆以及总分的差异有统计学意义(P <0.05)。治疗12周后,联合治疗组MCCB各项测验的分数均高于单纯药物治疗组,其中持续操作、数字序列、言语记忆、视觉记忆、迷宫以及总分的差异有统计学意义(P <0.05)。结论 CCRT对女性缓解期精神分裂症患者的部分认知功能有明显改善作用。
Objective To investigate the effect of computerized cognitive remediation therapy(CCRT) on cognitive function in female schizophrenia patients in remission. Methods This study included 42 female schizophrenia patients in remission who were treated at Shenyang Mental Health Center between September 2016 and September 2017. Patients were randomly divided into combined therapy and simple drug treatment groups. Patients in the combined therapy group were treated with oral olanzapine plus CCRT,which was used as cognitive therapy for 12 weeks. Those in the simple drug treatment group only received oral olanzapine for 12 weeks. The MATRICS consensus cognitive battery(MCCB) was used to evaluate cognitive function before treatment and 6 and 12 weeks after treatment. Results At12 weeks after treatment,significant differences were observed in symbol coding,digital sequence,spatial span,semantic fluency,continuous operation,speech memory,visual memory,maze,and total scores in the combined therapy group,while significant differences in symbol coding,semantic fluency,spatial span,speech memory,visual memory,and total scores were observed in the simple drug treatment group(all P < 0.05). The MCCB scores in the combined therapy group were higher than those in the simple drug treatment group at 12 weeks after treatment,with statistically significant differences in continuous operation,digital sequence,speech memory,visual memory,maze,and total scores(P < 0.05). Conclusion CCRT can significantly improve cognitive function in female schizophrenia patients in remission.
Objective To investigate the effect of computerized cognitive remediation therapy(CCRT) on cognitive function in female schizophrenia patients in remission. Methods This study included 42 female schizophrenia patients in remission who were treated at Shenyang Mental Health Center between September 2016 and September 2017. Patients were randomly divided into combined therapy and simple drug treatment groups. Patients in the combined therapy group were treated with oral olanzapine plus CCRT,which was used as cognitive therapy for 12 weeks. Those in the simple drug treatment group only received oral olanzapine for 12 weeks. The MATRICS consensus cognitive battery(MCCB) was used to evaluate cognitive function before treatment and 6 and 12 weeks after treatment. Results At12 weeks after treatment,significant differences were observed in symbol coding,digital sequence,spatial span,semantic fluency,continuous operation,speech memory,visual memory,maze,and total scores in the combined therapy group,while significant differences in symbol coding,semantic fluency,spatial span,speech memory,visual memory,and total scores were observed in the simple drug treatment group(all P < 0.05). The MCCB scores in the combined therapy group were higher than those in the simple drug treatment group at 12 weeks after treatment,with statistically significant differences in continuous operation,digital sequence,speech memory,visual memory,maze,and total scores(P < 0.05). Conclusion CCRT can significantly improve cognitive function in female schizophrenia patients in remission.
引文
[1]曹爱爱,吴彦,彭代辉.精神分裂症认知功能成套测验在精神科中的应用[J].精神医学杂志,2015,28(4):314-316.DOI:10.3969/j.issn.2095-9346.2015.04.024.
[2]回秀清,王学义.精神分裂症认知功能损害特点及干预研究进展[J].神经疾病与精神卫生,2011,11(1):69-72.DOI:10.3969/j.issn.1009-6574.2011.01.025.
[3]ZANELLO A,PERRIG L,HUGUELET P.Cognitive functions related to interpersonal problem-solving skills in schizophrenic patients compared with healthy subjects[J].Psychiatry Res,2006,142(1):67-78.DOI:10.1016/j.psychres.2003.07.009.
[4]KALACHE SM,MULSANT BH,DAVIES SJ,et al.The impact of aging,cognition,and symptoms on functional competence in individuals with schizophrenia across the lifespan[J].Schizophr Bull,2015,41(2):374-381.DOI:10.1093/schbul/sbu114.
[5]ROSSI S,HALLETT M,ROSSINI PM,et al.Safety,ethical considerations,and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research[J].Clin Neurophysiol,2009,120(12):2008-2039.DOI:10.1016/j.clinph.2009.08.016.
[6]RORIGUEZJIMENEZ R,BAGNEY A,GARCIANAVARRO C,et al.The MATRICS Consensus Cognitive Battery(MCCB):co-norming and standardization in Spain[J].Schizophr Res,2012,134(2/3):279-284.DOI:10.1016/j.schres.2011.11.026.
[7]王继丰,邱玲玲.典型抗精神病药与非典型抗精神病药对精神分裂症患者生存质量影响的对照研究[J].中国民康医学,2013,25(2):17-19.DOI:10.3969/j.issn.1672-0369.2013.02.011.
[8]罗维玲,孙艳,王谦文.氯氮平和利坦塞林对精神分裂症认知功能的影响[J].临床精神医学杂志,2004,14(2):97-98.DOI:10.3969/j.issn.1005-3220.2004.02.016.
[9]MELTZER HY,MCGURK SR.The effects of clozapine,risperidone,and olanzapine on cognitive function in schizophrenia[J].Schizophr Bull,2005,25(2):233-255.DOI:10.1093/oxfordjournals.schbul.a033376.
[10]朱建忠.认知行为干预对社区慢性精神分裂症患者康复疗效评估[J].国际医药卫生导报,2011,17(5):560-563.DOI:10.3760/cma.j.issn.1007-1245.2011.05.018.
[11]安翠霞,董玲,王岚,等.计算机认知矫正治疗对精神分裂症患者认知功能的影响研究[J].神经疾病与精神卫生,2015,15(4):332-335.DOI:10.3969/j.issn.1009-6574.2015.04.003.
[12]董继承,张少丽,王晓蕾.综合心理治疗对精神分裂症患者认知功能影响的研究[J].中华行为医学与脑科学杂志,2009,18(10):891-893.DOI:10.3760/cma.j.issn.1674-6554.2009.10.010.
[2]回秀清,王学义.精神分裂症认知功能损害特点及干预研究进展[J].神经疾病与精神卫生,2011,11(1):69-72.DOI:10.3969/j.issn.1009-6574.2011.01.025.
[3]ZANELLO A,PERRIG L,HUGUELET P.Cognitive functions related to interpersonal problem-solving skills in schizophrenic patients compared with healthy subjects[J].Psychiatry Res,2006,142(1):67-78.DOI:10.1016/j.psychres.2003.07.009.
[4]KALACHE SM,MULSANT BH,DAVIES SJ,et al.The impact of aging,cognition,and symptoms on functional competence in individuals with schizophrenia across the lifespan[J].Schizophr Bull,2015,41(2):374-381.DOI:10.1093/schbul/sbu114.
[5]ROSSI S,HALLETT M,ROSSINI PM,et al.Safety,ethical considerations,and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research[J].Clin Neurophysiol,2009,120(12):2008-2039.DOI:10.1016/j.clinph.2009.08.016.
[6]RORIGUEZJIMENEZ R,BAGNEY A,GARCIANAVARRO C,et al.The MATRICS Consensus Cognitive Battery(MCCB):co-norming and standardization in Spain[J].Schizophr Res,2012,134(2/3):279-284.DOI:10.1016/j.schres.2011.11.026.
[7]王继丰,邱玲玲.典型抗精神病药与非典型抗精神病药对精神分裂症患者生存质量影响的对照研究[J].中国民康医学,2013,25(2):17-19.DOI:10.3969/j.issn.1672-0369.2013.02.011.
[8]罗维玲,孙艳,王谦文.氯氮平和利坦塞林对精神分裂症认知功能的影响[J].临床精神医学杂志,2004,14(2):97-98.DOI:10.3969/j.issn.1005-3220.2004.02.016.
[9]MELTZER HY,MCGURK SR.The effects of clozapine,risperidone,and olanzapine on cognitive function in schizophrenia[J].Schizophr Bull,2005,25(2):233-255.DOI:10.1093/oxfordjournals.schbul.a033376.
[10]朱建忠.认知行为干预对社区慢性精神分裂症患者康复疗效评估[J].国际医药卫生导报,2011,17(5):560-563.DOI:10.3760/cma.j.issn.1007-1245.2011.05.018.
[11]安翠霞,董玲,王岚,等.计算机认知矫正治疗对精神分裂症患者认知功能的影响研究[J].神经疾病与精神卫生,2015,15(4):332-335.DOI:10.3969/j.issn.1009-6574.2015.04.003.
[12]董继承,张少丽,王晓蕾.综合心理治疗对精神分裂症患者认知功能影响的研究[J].中华行为医学与脑科学杂志,2009,18(10):891-893.DOI:10.3760/cma.j.issn.1674-6554.2009.10.010.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |