制川乌炮制废水中生物碱类成分的回收利用
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摘要
目的:优化大孔吸附树脂回收制川乌炮制有毒废水中6种生物碱类成分的工艺条件,为其他药物炮制废水的处理提供参考。方法:以苯甲酰新乌头原碱、苯甲酰乌头原碱、苯甲酰次乌头原碱、新乌头碱、次乌头碱和乌头碱的吸附率和洗脱率为考察指标,利用静态吸附-洗脱试验对15种大孔吸附树脂进行筛选,并通过与动态吸附相结合的方法,优选大孔树脂的回收工艺参数。结果:D101型大孔树脂对制川乌炮制废水中6种生物碱类成分具有较好的吸附和洗脱效果,最佳工艺参数为每克大孔树脂可处理4. 3 g川乌的炮制废水,上样速度≤3. 0 m L·min-1为宜,水洗除杂用量2 BV,加70%乙醇6 BV洗脱。苯甲酰新乌头原碱、苯甲酰乌头原碱、苯甲酰次乌头原碱新、新乌头碱、次乌头碱、乌头碱的回收率依次为98. 03%,94. 09%,96. 53%,78. 15%,85. 40%,70. 57%。结论:D101型大孔树脂在进行制川乌炮制废水减毒处理的同时,还可对其所含的6种生物碱类成分进行有效回收,在解决环保问题的同时,创造了一定的经济效益,且优选的工艺条件稳定可行。
Objective: To optimize the recovery technology for 6 kinds of toxic alkaloids in the toxic wastewater from processing of Aconiti Radix with macroporous resin. Method: With the rates of adsorption and elution of benzoylmesaconine,benzoylaconine,benzoylhypaconine,mesaconitine,hypaconitine and aconitine as indexes,static and dynamic adsorption-elution tests were used to select the best one from 15 kinds of macroporous resin,and the recovery technology parameters of six toxic alkaloids in the wastewater from processing of Aconiti Radix were optimized. Result: D101 macroporous resin had a good adsorption and elution effect on 6 kinds of toxic alkaloids in the wastewater from processing of Aconiti Radix,its optimum technology conditions were as follows:each gram of macroporous resin could be used to treat processing wastewater from 4. 3 g of Aconiti Radix,the sample loading speed was not higher than 3. 0 m L·min-1,the resin column was eluted with 6 BV of 70% ethanol after removing impurities with 2 BV of water. The recoveries of benzoylmesaconine, benzoylaconine,benzoylhypaconine,mesaconitine,hypaconitine and aconitine were 98. 03%,94. 09%,96. 53%,78. 15%,85. 40% and 70. 57%,respectively. Conclusion: D101 macroporous resin can be used for detoxification treatment of processing wastewater of Aconiti Radix,at the same time,6 kinds of alkaloids are effectively recovered,which can solve the environmental problems and create certain economic benefits,and the optimized process conditions are stable and feasible.
Objective: To optimize the recovery technology for 6 kinds of toxic alkaloids in the toxic wastewater from processing of Aconiti Radix with macroporous resin. Method: With the rates of adsorption and elution of benzoylmesaconine,benzoylaconine,benzoylhypaconine,mesaconitine,hypaconitine and aconitine as indexes,static and dynamic adsorption-elution tests were used to select the best one from 15 kinds of macroporous resin,and the recovery technology parameters of six toxic alkaloids in the wastewater from processing of Aconiti Radix were optimized. Result: D101 macroporous resin had a good adsorption and elution effect on 6 kinds of toxic alkaloids in the wastewater from processing of Aconiti Radix,its optimum technology conditions were as follows:each gram of macroporous resin could be used to treat processing wastewater from 4. 3 g of Aconiti Radix,the sample loading speed was not higher than 3. 0 m L·min-1,the resin column was eluted with 6 BV of 70% ethanol after removing impurities with 2 BV of water. The recoveries of benzoylmesaconine, benzoylaconine,benzoylhypaconine,mesaconitine,hypaconitine and aconitine were 98. 03%,94. 09%,96. 53%,78. 15%,85. 40% and 70. 57%,respectively. Conclusion: D101 macroporous resin can be used for detoxification treatment of processing wastewater of Aconiti Radix,at the same time,6 kinds of alkaloids are effectively recovered,which can solve the environmental problems and create certain economic benefits,and the optimized process conditions are stable and feasible.
引文
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[12]刘艳,章诗伟,周兰,等.乌头类生物碱对心肌的毒性作用及分子毒理学研究进展[J].中国法医学杂志,2009,24(6):398-401.
[13]王峰峰,宋兆辉,张兰兰,等.乌头碱、新乌头碱、次乌头碱水解和醇解产物的研究[J].中国中药杂志,2012,37(11):1564-1569.
[2]季宗彬.中药有效成分药理与应用[M].北京:人民卫生出版社,2011:860.
[3]刘帅,李妍,李卫飞,等.乌头类中药毒性及现代毒理学研究进展[J].中草药,2016,47(22):4095-4102.
[4]王哲,谭鹏,刘红玉,等.浸泡程度对川乌炮制品传统质量及生物碱成分的影响[J].中国实验方剂学杂志,2014,20(11):7-9.
[5]张旭,王锦玉,仝燕,等.大孔树脂技术在中药提取纯化中的应用及展望[J].中国实验方剂学杂志,2012,18(6):286-290.
[6]张瑜,杨健,秦振娴,等.大孔吸附树脂富集金银花中环烯醚萜苷类成分的工艺优选[J].中国实验方剂学杂志,2016,22(24):18-21.
[7]北京市药品监督管理局.北京市中药饮片炮制规范[M].北京:化学工业出版社,2008:15-17.
[8]易剑平,迟玉明,李东影,等.絮凝法去除川乌炮制废水中生物碱类成分的可行性分析[J].中国实验方剂学杂志,2019,25(4):134-139.
[9]蔡超群,杨春华,梁敬钰,等.乌头属二萜生物碱成分构效关系研究进展[J].海峡药学,2013,25(3):1-5.
[10] Singhuber J,ZHU M,Prinz S,et al. Aconitum in traditional Chinese medicine:a valuable drug or an unpredictable risk?[J]. J Ethnopharmacol,2009,126(1):18-30.
[11]高黎明,毛学峰,魏小梅,等.二萜类生物碱的药理作用及构效关系研究概况[J].西北师范大学学报:自然科学版,1999,35(1):98-103.
[12]刘艳,章诗伟,周兰,等.乌头类生物碱对心肌的毒性作用及分子毒理学研究进展[J].中国法医学杂志,2009,24(6):398-401.
[13]王峰峰,宋兆辉,张兰兰,等.乌头碱、新乌头碱、次乌头碱水解和醇解产物的研究[J].中国中药杂志,2012,37(11):1564-1569.
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