参黄凝胶膏剂中丁香挥发油对大黄酸的经皮渗透作用
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摘要
目的探讨参黄凝胶膏剂中丁香挥发油对大黄酸的经皮渗透作用。方法采用改良Franz扩散池法,考察丁香挥发油对大黄酸透皮特性的影响。以大黄酸释放度为评价指标,立式扩散池结合透析袋法研究参黄凝胶膏剂体外释放行为。结果 3%丁香挥发油促透效果强于3%氮酮、3%薄荷挥发油,累积渗透量(120. 11±8. 84)μg/cm2,增渗倍数2. 93。体外释放行为与Weibull模型拟合度最高(r=0. 999 8)。结论丁香挥发油能显著增加参黄凝胶膏剂中大黄酸的透皮吸收。
AIM To explore the percutaneous penetration effects of Caryophylli Flos volatile oil on rhein in Shenhuang Gel Ointment. METHODS Modified Franz diffusion cell method was applied to investigating the effects of Caryophylli Flos volatile oil on rhein transdermal characteristic. With rhein release rate as an evaluation index,vertical diffusion cell combined with dialysis bag method was used to study the in vitro release behaviors of Shenhuang Gel Ointment. RESULTS Three percent Caryophylli Flos volatile oil demonstrated stronger penetration enhancement effect than 3% azone and 3% Menthae haplocalycis Herba volatile oil, with the accumulative permeation quantity and enhancement ratio of( 120. 11±8. 84) μg/cm2 and 2. 93,respectively. The in vitro release behaviors exhibited the highest fitting degree with Weibull model( r = 0. 999 8). CONCLUSION Caryophylli Flos volatile oil can significantly increase the percutaneous absorption of rhein in Shenhuang Gel Ointment.
AIM To explore the percutaneous penetration effects of Caryophylli Flos volatile oil on rhein in Shenhuang Gel Ointment. METHODS Modified Franz diffusion cell method was applied to investigating the effects of Caryophylli Flos volatile oil on rhein transdermal characteristic. With rhein release rate as an evaluation index,vertical diffusion cell combined with dialysis bag method was used to study the in vitro release behaviors of Shenhuang Gel Ointment. RESULTS Three percent Caryophylli Flos volatile oil demonstrated stronger penetration enhancement effect than 3% azone and 3% Menthae haplocalycis Herba volatile oil, with the accumulative permeation quantity and enhancement ratio of( 120. 11±8. 84) μg/cm2 and 2. 93,respectively. The in vitro release behaviors exhibited the highest fitting degree with Weibull model( r = 0. 999 8). CONCLUSION Caryophylli Flos volatile oil can significantly increase the percutaneous absorption of rhein in Shenhuang Gel Ointment.
引文
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[2]魏星,裘华森,张琪,等.参黄散贴剂对腹部术后胃肠功能不全患者的促康复作用——110例前瞻性多中心随机对照临床研究[J].中医杂志,2014,55(5):386-390.
[3]郑超.参黄膏对术后气滞血瘀型胃肠功能不全的促康复临床研究[D].杭州:浙江大学,2013.
[4]陈杰,魏星,周济春,等.参黄散敷脐对肿瘤根治术后气滞血瘀型胃肠功能不全的促康复临床初步研究[J].浙江中医药大学学报,2012,36(4):372-374.
[5]宋立华,刘淑芝.中药凝胶膏剂的研究进展分析[J].中国实验方剂学杂志,2015,21(22):133-136.
[6]丁美红,封玲,孙秋华,等.基于多指标综合评分法优化参黄散提取工艺[J].中国现代应用药学,2016,33(12):1497-1502.
[7]陈建萍,吴伟康,张敏生,等.中药复方配伍规律研究的思路与方法[J].中国实验方剂学杂志,2000,6(1):1-4.
[8]李镇,容悦莹,王淑美,等.中药组方配伍的研究进展[J].中国实验方剂学杂志,2015,21(7):223-226.
[9]徐小宏,陈友雷,魏星,等.参黄散对术后肠动力障碍大鼠胃肠功能及小肠ICAM-1、IL-10、IL-1β和i NOS表达的影响[J].浙江中医药大学学报,2015,39(11):777-781.
[10]丁美红,吴怡,万浩芳,等.参黄散经神阙穴与非穴位敷贴在新西兰兔血浆中的药代动力学比较[J].中华中医药杂志,2018,33(6):2321-2326.
[11]王晖,许卫铭,薄荷醇及其二组分系统对5-氟脲嘧啶经皮渗透和贮库效应的影响[J].中国临床药理学与治疗学,2003,8(4):422-424.
[12]王艳宏,刘书博,王锐,等.中药挥发油促透皮吸收及透皮吸收作用的研究进展[J].中国实验方剂学杂志,2017,23(3):192-199.
[13]赵婷婷,张彤,项乐源,等.当归、丁香挥发油的促透皮吸收作用[J].中成药,2016,38(9):1923-1929.
[14]封玲,丁美红,沈勤,等.大黄酸神阙穴给药经皮渗透性的影响因素研究与初步机制探讨[J].中国中药杂志,2016,41(8):1546-1552.