姜黄化学成分及药理作用研究进展
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摘要
姜黄是姜科姜黄属植物之一,广泛种植于热带和亚热带地区,药用价值高。目前研究发现姜黄中主要含有酚酸类和萜类等化学成分。药理研究表明,姜黄具有抗肿瘤、抗氧化、降血糖、抗炎抗菌抗病毒等作用。通过检索文献,对近年来国内外关于姜黄化学成分和药理作用相关文献进行分类归纳总结,旨在为姜黄的深入研究和广泛应用提供参考。
引文
[1]OYEMITAN I A,ELUSIYAN C A,ONIFADE A O,et al.Neuropharmacological profile and chemical analysis of fresh rhizome essential oil of Curcuma longa(turmeric)cultivated in Southwest Nigeria[J].Toxicology Reports,2017,4(1):391.
[2]付兴会,林连美.中药姜黄主要有效成分药理学研究进展[J].湖北中医药大学学报,2015,17(4):109-110.
[3]任二芳,牛德宝,谢朝敏,等.姜黄开发与应用进展[J].轻工科技,2014,30(10):10-11.
[4]RAVINDRAN P N,NIRMAL BABU K,SIVARAMAN K.Turmeric:the genus Curcuma[J].Taylor&Francis,2007,45(4):397-398.
[5]LI SHIYOU,YUAN WEI,DENG GUANGRUI,et al.Chemical composition and product quality control of turmeric(Curcuma longa L.)[J].Phytochemistry,2011,5(1):28-54.
[6]LEELA N K,TAVA A,SHAFI P M,et al.Chemical composition of essential oils of turmeric(Curcuma longa L.)[J].Indian Institute of Spices Reseach Repository,2002,52(2):137-141.
[7]CHOWDHURY J U,NANDI N C,BHUIYAN M N I,et al.Essential oil constituents of the rhizomes of two types of Curcuma longa of bangladesh[J].Bangladesh Journal of Scientific&Industrial Research,2008,43(2):259-266.
[8]GOPALAN B,GOTO M,AKIO KODAMA A,et al.Supercritical carbon dioxide extraction of turmeric(Curcuma longa)[J].Journal of Agricultural&Food Chemistry,2000,48(6):2189-2192.
[9]USMAN,LA,HAMID AA,GEORGE OC,et al.Chemical composition of rhizome essential oil of Curcuma longa L.growing in North Central Nigeria World J[J].Chem,2009,4(2):178-181.
[10]MA X,GANG D R.Metabolic profiling of turmeric(Curcuma longa L.)plants derived from in vitro micropropagation and conventional greenhouse cultivation[J].Journal of Agricultural&Food Chemistry,2006,54(25):9573-9583.
[11]ZENG Y C,LIANG J M,GE-XIA Q U,et al.Chemical constituents of Curcuma longaⅠ:bisabolane sesquiterpenes[J].Chinese Journal of Medicinal Chemistry,2007,17(4):238-242.
[12]ANGEL L C,NELIO T M,MARILENA E A,et al.Supercritical CO2 extraction of curcumins and essential oil from the rhizomes of turmeric(Curcuma longa L.)[J].Industrial&Engineering Chemistry Research,2000,39(12):4729-4733.
[13]LI W,XIAO F Y S.Three novel terpenoids from the rhizomes of Curcuma longa[J].Journal of Asian Natural Products Research,2009,11(6):569-575.
[14]MANZAN A C C M,TONIOLO F S,BREDOW E,et al.Extraction of essential oil and pigments from Curcuma longa[L]by steam distillation and extraction with volatile solvents[J].Journal of Agricultural&Food Chemistry,2003,51(23):6802-6807.
[15]AQEELAAFZAL,GHALIBORIQAT,KHAN M A,et al.Chemistry and biochemistry of terpenoids from curcuma and related species[J].Journal of Biologically Active Products from Nature,2013,3(1):1-55.
[16]MANAL H S,MANAL S A.A new acylated luteolin glycoside from Curcuma longa L.and free radical scavenging potential of its extracts[J].Journal of Medicinal Plant Research,2014,8(1):1-5.
[17]JIANG C L,TSAI S F,LEE S S.Flavonoids from Curcuma longa leaves and their NMR assignments[J].Natural Product Communications,2015,10(1):63-66.
[18]SAHU R,SAXENA J.Isolation of flavonoid derivative from Curcuma longa[J].World Journal of Pharmaceutical Research,2014,3(7):740-745.
[19]MA J H,WANG Y,LIU Y,et al.Four new sesquiterpenes from the rhizomes of curcuma phaeocaulis and their iNOS inhibitory activities[J].Journal of Asian Natural Products Research,2015,17(5):532-540.
[20]CUI Y H,WANG H F,JIAN L I,et al.Isolation and identification of chemical constituents from rhizomes of Curcuma longa L[J].Journal of Shenyang Pharmaceutical University,2016,33(3):198-201.
[21]LI J,WANG H F,CHEN G,et al.Structure determination of two new bisabolane-type sesquiterpenes from the rhizomes of Curcuma longa by NMR spectroscopy[J].Magnetic Resonance in Chemistry,2015,53(7):536-538.
[22]JIN HONG X U,YANG H P,ZHOU X D,et al.Autophagy accompanied with bisdemethoxycurcumin-induced apoptosis in non-small cell lung cancer cells[J].Biomedical and Environmental Sciences,2015,28(2):105-115.
[23]ZHANG J X,XIAO Y C,LIU M,et al.Study on the sesquiterpene constituents of Curcuma longa[J].West China Journal of Pharmaceutical Sciences,2014,29(3):260-262.
[24]严梅娣,岑雪英.姜黄素对甲状腺癌细胞SW579增殖和凋亡的影响[J].中华全科医学,2015,13(3):396-398.
[25]吴清清,陈永恒,廖芬芳,等.姜黄素和穿心莲内酯对鼻咽癌细胞CNE-2的作用及机制[J].广东医学,2015,36(15):2327-2330.
[26]杨芳,刘少琼,禹正杨,等.姜黄素调控结肠癌SW480细胞skp2-p27kip通路的研究[J].中医药导报,2014,20(16):35-39.
[27]MARTINCORDERO C,LOPEZLAZARO M,GALVEZ M,et al.Curcumin as a DNA topoisomeraseⅡpoison[J].J Enzyme Inhib Med Chem,2003,18(6):505-509.
[28]SHPITZ B,GILADI N,SAGIV E,et al.Celecoxib and curcumin additively inhibit the growth of colorectal cancer in a rat model[J].Digestion,2006,74(3-4):140-144.
[29]杜胜娟,赵伟,夏飞,等.姜黄素的临床应用及其相关作用机制[J].中国现代医药杂志,2017,19(9):93-97.
[30]TYAGI P,SINGH M,KUMARI H,et al.Bactericidal activity of curcumin I is associated with damaging of bacterial membrane[J].Plos One,2015,10(3):e121313.
[31]HUANG L,JING Z,SONG T,et al.Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii[J].International Immunopharmacology,2016,34:263-270.
[32]BAI X,OBERLEYDEEGAN R E,BAI A,et al.Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection[J].Respirology,2016,21(5):951.
[33]DE R,KUNDU P,SWARNAKAR S,et al.Antimicrobial activity of curcumin against helicobacter pylori isolates from india and during infections in Mice[J].Antimicrobial Agents&Chemotherapy,2009,53(4):1592.
[34]TEMBA B A,FLETCHER M T,FOX G P,et al.Inactivation of aspergillus flavus spores by curcumin-mediated photosensitization[J].Food Control,2016,59(16):708-713.
[35]胡晨霞,刘戈,何嘉琪,等.姜黄属常用中药对实验性RA大鼠滑膜炎症的影响[J].中华中医药学刊,2011,29(1):95-97.
[36]HAN F,LUO B,SHI R,et al.Curcumin ameliorates rat experimental autoimmune neuritis[J].Journal of Neuroscience Research,2014,92(6):743-750.
[37]SUN J,ZHAO Y,JIN H,et al.Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice[J].International Immunopharmacology,2015,25(2):235.
[38]MAU L P,CHENG W C,CHEN J K,et al.Curcumin ameliorates alveolar bone destruction of experimental periodontitis by modulating osteoclast differentiation,activation and function[J].Journal of Functional Foods,2016(22):243-256.
[39]AMMON H P T,WAHL M A.Pharmacology of Curcuma longa[J].Planta Medica,1991,57(1):1.
[40]HUANG S L,CHEN P Y,WU M J,et al.Curcuminoids modulate the PKCδ/NADPH oxidase/reactive oxygen species signaling pathway and suppress matrix invasion during monocyte-macrophage differentiation[J].Journal of Agricultural&Food Chemistry,2015,63(40):8838.
[41]YANG Y,WEIXUN D,YAN L,et al.SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury[J].Free Radic Biol Med,2013,65(4):667.
[42]SHAKERI F,SOUKHTANLOO M,BOSKABADY M H.The effect of hydro-ethanolic extract of Curcuma longa rhizome and curcumin on total and differential WBCand serum oxidant,antioxidant biomarkers in rat model of asthma[J].Iranian Journal of Basic Medical Sciences,2017,20(2):155.
[43]LEE H Y,KIM S W,LEE G H,et al.Curcumin and Curcuma longa L.extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress[J].Scientific Reports,2017,7(1):6513.
[44]UCHIO R,HIGASHI Y,KOHAMA Y,et al.A hot water extract of turmeric(Curcuma longa)suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production[J].Journal of Nutritional Science,2017,6(3):1-9.
[45]TRANCHIDA F,RAKOTONIAINA Z,SHINTU L,et al.Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats[J].Scientific Reports,2017,7(1):1-13.
[46]CAO L,DING W,DU J,et al.Effects of curcumin on antioxidative activities and cytokine production in Jian carp(cyprinus carpio var.Jian)with CCl4-induced liver damage[J].Fish&Shellfish Immunology,2015,43(1):150-157.
[47]LEKSHMI P C,ARIMBOOR R,NISHA V M,et al.In vitro antidiabetic and inhibitory potential of turmeric(Curucma longa L)rhizome against cellular and LDL oxidation and angiotensin converting enzyme[J].Journal of Food Science&Technology,2014,51(12):3910-3917.
[48]WEI SBERG,LEIBEL R,TORTORIELLO DV.Proteasome inhibitors,including curcumin,improve pancreaticβ-cell function and insulin sensitivity in diabetic mice[J].Nutr Diabetes,2016,6(4):e205.
[49]NAIJIL G,ANJU T R,JAYANARAYANAN S,et al.Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats[J].Nutrition Research,2015,35(9):823.
[50]杨耀光.大黄与姜黄配伍对实验性高脂血症小鼠降血脂作用研究[J].河北医药,2014,36(10):1456-1458.
[51]UM M Y,HWANG K H,AHN J,et al.Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase[J].Basic&Clinical Pharmacology&Toxicology,2013,113(3):152-157.
[52]CANFRANDUQUE A,PASTOR O,REINA M,et al.Curcumin mitigates the intracellular lipid deposit induced by antipsychotics in vitro[J].Plos One,2015,10(10):e141829.
[53]SINGH V,RANA M,JAIN M,et al.Curcuma oil attenuates accelerated atherosclerosis and macrophage foamcell formation by modulating genes involved in plaque stability,lipid homeostasis and inflammation[J].British Journal of Nutrition,2015,113(1):100.
[54]MERWE C V D,DYK H C V,ENGELBRECHT L,et al.Curcumin rescues a PINK1 knock down SH-SY5Y cellular model of parkinson’s disease from mitochondrial dysfunction and cell death[J].Molecular Neurobiology,2016,54(4):2752-2762.
[55]GONZA L S,GUZMA N N S,MEDINA-CAMPOS O N,et al.Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats[J].Oxid Med Cell Longev,2013,2013(12):801418.
[56]ZHANG L,LUO J,ZHANG M,et al.Effects of curcumin on chronic,unpredictable,mild,stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats[J].International Journal of Neuropsychopharmacology,2014,17(5):793.
[57]袁伟,贾常莎.姜黄消痤搽剂联合红蓝光治疗寻常痤疮疗效观察[J].中国皮肤性病学杂志,2012,26(3):217-218.
[58]KHAJEHDEHI P.Turmeric:remerging of a neglected Asian traditional remedy[J].J Nephropathol,2012,1(1):17-22.
[59]KWON Y,MAGNUSON B A.Age-related differential responses to curcumin-induced apoptosis during the initiation of colon cancer in rats[J].Food and Chemical Toxicology,2009,47(2):377-385.
[60]BAYRAK O,UZ E,BAYRAK R,et al.Curcumin protects against ischemia/reperfusion injury in rat kidneys[J].World Journal of Urology,2008,26(3):285-291.
[61]殷华峰,戴平,陈旅翼,等.姜黄降尿酸作用的实验研究[J].药学与临床研究,2011,19(2):134-135.
[62]SIVIERO A,GALLO E,MAGGINI V,et al.Curcumin,a golden spice with a low bioavailability[J].Journal of Herbal Medicine,2015,5(2):57-70.
[2]付兴会,林连美.中药姜黄主要有效成分药理学研究进展[J].湖北中医药大学学报,2015,17(4):109-110.
[3]任二芳,牛德宝,谢朝敏,等.姜黄开发与应用进展[J].轻工科技,2014,30(10):10-11.
[4]RAVINDRAN P N,NIRMAL BABU K,SIVARAMAN K.Turmeric:the genus Curcuma[J].Taylor&Francis,2007,45(4):397-398.
[5]LI SHIYOU,YUAN WEI,DENG GUANGRUI,et al.Chemical composition and product quality control of turmeric(Curcuma longa L.)[J].Phytochemistry,2011,5(1):28-54.
[6]LEELA N K,TAVA A,SHAFI P M,et al.Chemical composition of essential oils of turmeric(Curcuma longa L.)[J].Indian Institute of Spices Reseach Repository,2002,52(2):137-141.
[7]CHOWDHURY J U,NANDI N C,BHUIYAN M N I,et al.Essential oil constituents of the rhizomes of two types of Curcuma longa of bangladesh[J].Bangladesh Journal of Scientific&Industrial Research,2008,43(2):259-266.
[8]GOPALAN B,GOTO M,AKIO KODAMA A,et al.Supercritical carbon dioxide extraction of turmeric(Curcuma longa)[J].Journal of Agricultural&Food Chemistry,2000,48(6):2189-2192.
[9]USMAN,LA,HAMID AA,GEORGE OC,et al.Chemical composition of rhizome essential oil of Curcuma longa L.growing in North Central Nigeria World J[J].Chem,2009,4(2):178-181.
[10]MA X,GANG D R.Metabolic profiling of turmeric(Curcuma longa L.)plants derived from in vitro micropropagation and conventional greenhouse cultivation[J].Journal of Agricultural&Food Chemistry,2006,54(25):9573-9583.
[11]ZENG Y C,LIANG J M,GE-XIA Q U,et al.Chemical constituents of Curcuma longaⅠ:bisabolane sesquiterpenes[J].Chinese Journal of Medicinal Chemistry,2007,17(4):238-242.
[12]ANGEL L C,NELIO T M,MARILENA E A,et al.Supercritical CO2 extraction of curcumins and essential oil from the rhizomes of turmeric(Curcuma longa L.)[J].Industrial&Engineering Chemistry Research,2000,39(12):4729-4733.
[13]LI W,XIAO F Y S.Three novel terpenoids from the rhizomes of Curcuma longa[J].Journal of Asian Natural Products Research,2009,11(6):569-575.
[14]MANZAN A C C M,TONIOLO F S,BREDOW E,et al.Extraction of essential oil and pigments from Curcuma longa[L]by steam distillation and extraction with volatile solvents[J].Journal of Agricultural&Food Chemistry,2003,51(23):6802-6807.
[15]AQEELAAFZAL,GHALIBORIQAT,KHAN M A,et al.Chemistry and biochemistry of terpenoids from curcuma and related species[J].Journal of Biologically Active Products from Nature,2013,3(1):1-55.
[16]MANAL H S,MANAL S A.A new acylated luteolin glycoside from Curcuma longa L.and free radical scavenging potential of its extracts[J].Journal of Medicinal Plant Research,2014,8(1):1-5.
[17]JIANG C L,TSAI S F,LEE S S.Flavonoids from Curcuma longa leaves and their NMR assignments[J].Natural Product Communications,2015,10(1):63-66.
[18]SAHU R,SAXENA J.Isolation of flavonoid derivative from Curcuma longa[J].World Journal of Pharmaceutical Research,2014,3(7):740-745.
[19]MA J H,WANG Y,LIU Y,et al.Four new sesquiterpenes from the rhizomes of curcuma phaeocaulis and their iNOS inhibitory activities[J].Journal of Asian Natural Products Research,2015,17(5):532-540.
[20]CUI Y H,WANG H F,JIAN L I,et al.Isolation and identification of chemical constituents from rhizomes of Curcuma longa L[J].Journal of Shenyang Pharmaceutical University,2016,33(3):198-201.
[21]LI J,WANG H F,CHEN G,et al.Structure determination of two new bisabolane-type sesquiterpenes from the rhizomes of Curcuma longa by NMR spectroscopy[J].Magnetic Resonance in Chemistry,2015,53(7):536-538.
[22]JIN HONG X U,YANG H P,ZHOU X D,et al.Autophagy accompanied with bisdemethoxycurcumin-induced apoptosis in non-small cell lung cancer cells[J].Biomedical and Environmental Sciences,2015,28(2):105-115.
[23]ZHANG J X,XIAO Y C,LIU M,et al.Study on the sesquiterpene constituents of Curcuma longa[J].West China Journal of Pharmaceutical Sciences,2014,29(3):260-262.
[24]严梅娣,岑雪英.姜黄素对甲状腺癌细胞SW579增殖和凋亡的影响[J].中华全科医学,2015,13(3):396-398.
[25]吴清清,陈永恒,廖芬芳,等.姜黄素和穿心莲内酯对鼻咽癌细胞CNE-2的作用及机制[J].广东医学,2015,36(15):2327-2330.
[26]杨芳,刘少琼,禹正杨,等.姜黄素调控结肠癌SW480细胞skp2-p27kip通路的研究[J].中医药导报,2014,20(16):35-39.
[27]MARTINCORDERO C,LOPEZLAZARO M,GALVEZ M,et al.Curcumin as a DNA topoisomeraseⅡpoison[J].J Enzyme Inhib Med Chem,2003,18(6):505-509.
[28]SHPITZ B,GILADI N,SAGIV E,et al.Celecoxib and curcumin additively inhibit the growth of colorectal cancer in a rat model[J].Digestion,2006,74(3-4):140-144.
[29]杜胜娟,赵伟,夏飞,等.姜黄素的临床应用及其相关作用机制[J].中国现代医药杂志,2017,19(9):93-97.
[30]TYAGI P,SINGH M,KUMARI H,et al.Bactericidal activity of curcumin I is associated with damaging of bacterial membrane[J].Plos One,2015,10(3):e121313.
[31]HUANG L,JING Z,SONG T,et al.Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii[J].International Immunopharmacology,2016,34:263-270.
[32]BAI X,OBERLEYDEEGAN R E,BAI A,et al.Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection[J].Respirology,2016,21(5):951.
[33]DE R,KUNDU P,SWARNAKAR S,et al.Antimicrobial activity of curcumin against helicobacter pylori isolates from india and during infections in Mice[J].Antimicrobial Agents&Chemotherapy,2009,53(4):1592.
[34]TEMBA B A,FLETCHER M T,FOX G P,et al.Inactivation of aspergillus flavus spores by curcumin-mediated photosensitization[J].Food Control,2016,59(16):708-713.
[35]胡晨霞,刘戈,何嘉琪,等.姜黄属常用中药对实验性RA大鼠滑膜炎症的影响[J].中华中医药学刊,2011,29(1):95-97.
[36]HAN F,LUO B,SHI R,et al.Curcumin ameliorates rat experimental autoimmune neuritis[J].Journal of Neuroscience Research,2014,92(6):743-750.
[37]SUN J,ZHAO Y,JIN H,et al.Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice[J].International Immunopharmacology,2015,25(2):235.
[38]MAU L P,CHENG W C,CHEN J K,et al.Curcumin ameliorates alveolar bone destruction of experimental periodontitis by modulating osteoclast differentiation,activation and function[J].Journal of Functional Foods,2016(22):243-256.
[39]AMMON H P T,WAHL M A.Pharmacology of Curcuma longa[J].Planta Medica,1991,57(1):1.
[40]HUANG S L,CHEN P Y,WU M J,et al.Curcuminoids modulate the PKCδ/NADPH oxidase/reactive oxygen species signaling pathway and suppress matrix invasion during monocyte-macrophage differentiation[J].Journal of Agricultural&Food Chemistry,2015,63(40):8838.
[41]YANG Y,WEIXUN D,YAN L,et al.SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury[J].Free Radic Biol Med,2013,65(4):667.
[42]SHAKERI F,SOUKHTANLOO M,BOSKABADY M H.The effect of hydro-ethanolic extract of Curcuma longa rhizome and curcumin on total and differential WBCand serum oxidant,antioxidant biomarkers in rat model of asthma[J].Iranian Journal of Basic Medical Sciences,2017,20(2):155.
[43]LEE H Y,KIM S W,LEE G H,et al.Curcumin and Curcuma longa L.extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress[J].Scientific Reports,2017,7(1):6513.
[44]UCHIO R,HIGASHI Y,KOHAMA Y,et al.A hot water extract of turmeric(Curcuma longa)suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production[J].Journal of Nutritional Science,2017,6(3):1-9.
[45]TRANCHIDA F,RAKOTONIAINA Z,SHINTU L,et al.Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats[J].Scientific Reports,2017,7(1):1-13.
[46]CAO L,DING W,DU J,et al.Effects of curcumin on antioxidative activities and cytokine production in Jian carp(cyprinus carpio var.Jian)with CCl4-induced liver damage[J].Fish&Shellfish Immunology,2015,43(1):150-157.
[47]LEKSHMI P C,ARIMBOOR R,NISHA V M,et al.In vitro antidiabetic and inhibitory potential of turmeric(Curucma longa L)rhizome against cellular and LDL oxidation and angiotensin converting enzyme[J].Journal of Food Science&Technology,2014,51(12):3910-3917.
[48]WEI SBERG,LEIBEL R,TORTORIELLO DV.Proteasome inhibitors,including curcumin,improve pancreaticβ-cell function and insulin sensitivity in diabetic mice[J].Nutr Diabetes,2016,6(4):e205.
[49]NAIJIL G,ANJU T R,JAYANARAYANAN S,et al.Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats[J].Nutrition Research,2015,35(9):823.
[50]杨耀光.大黄与姜黄配伍对实验性高脂血症小鼠降血脂作用研究[J].河北医药,2014,36(10):1456-1458.
[51]UM M Y,HWANG K H,AHN J,et al.Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase[J].Basic&Clinical Pharmacology&Toxicology,2013,113(3):152-157.
[52]CANFRANDUQUE A,PASTOR O,REINA M,et al.Curcumin mitigates the intracellular lipid deposit induced by antipsychotics in vitro[J].Plos One,2015,10(10):e141829.
[53]SINGH V,RANA M,JAIN M,et al.Curcuma oil attenuates accelerated atherosclerosis and macrophage foamcell formation by modulating genes involved in plaque stability,lipid homeostasis and inflammation[J].British Journal of Nutrition,2015,113(1):100.
[54]MERWE C V D,DYK H C V,ENGELBRECHT L,et al.Curcumin rescues a PINK1 knock down SH-SY5Y cellular model of parkinson’s disease from mitochondrial dysfunction and cell death[J].Molecular Neurobiology,2016,54(4):2752-2762.
[55]GONZA L S,GUZMA N N S,MEDINA-CAMPOS O N,et al.Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats[J].Oxid Med Cell Longev,2013,2013(12):801418.
[56]ZHANG L,LUO J,ZHANG M,et al.Effects of curcumin on chronic,unpredictable,mild,stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats[J].International Journal of Neuropsychopharmacology,2014,17(5):793.
[57]袁伟,贾常莎.姜黄消痤搽剂联合红蓝光治疗寻常痤疮疗效观察[J].中国皮肤性病学杂志,2012,26(3):217-218.
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