地黄饮子联合艾司唑仑治疗肾阴阳两虚型老年失眠症患者的临床疗效观察
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摘要
目的探讨地黄饮子联合艾司唑仑对肾阴阳两虚型老年失眠症患者的临床疗效。方法将2017年6月至2018年10月期间收治的肾阴阳两虚型老年失眠症患者100例,按照随机数字表法分为对照组和治疗组,每组50例。对照组患者给予艾司唑仑片治疗,治疗组在对照组治疗基础上给地黄饮子治疗,两组均连续服用4周。观察两组患者的临床疗效,中医证候积分,血清中血常规肝肾功能及不良反应发生率。结果经过治疗后治疗组患者显效率62%明显高于对照组44%(P<0.05);治疗组治疗后中医证候积分降低明显(P<0.05),治疗组中医证候积分(8.80±2.00)分显著低于对照组(15.73±1.26)分(P<0.05);治疗组患者不良反应发生率2%显著低于对照组20%,差异具有统计学意义(P<0.05)。两组患者治疗前后血常规及肝肾功能比较差异无统计学意义(P>0.05)。结论地黄饮子联合艾司唑仑治疗肾阴阳两虚型老年性失眠的疗效优于单纯口服艾司唑仑片,不良反应发生率较低,是一种针对性强且安全有效的中药治疗方法,有助于指导失眠的临床治疗。
Objective To explore the clinical effect on senile insomnia of kidney yin and yang deficiency treated with dihuangyinzi and estazolam.Methods From June 2017 through to October 2018,100 cases of senile insomnia of kidney yin and yang deficiency were collected.According to the random number table,they were divided into a control group and a treatment group,50 cases in each one.In the control group,estazolam tablets were prescribed.In the treatment group,on the base of the treatment as the control group,dihuangyinzi was added.The medication lasted for 4 weeks for oral administration in the two groups.The clinical effect,TCM symptom score,blood routine,liver and kidney functions and the incidence of adverse reaction were observed in the two groups.Results After treatment,the remarkably effective rate was62% in the treatment group,obviously higher than 44% in the control group(P<0.05).After treatment,TCM symptom score was reduced obviously in the treatment group(P<0.05).The score(8.80 ± 2.00) in the treatment group was lower significantly than(15.73 ± 1.26) in the control group(P<0.05).The incidence of adverse reaction was 2% in the treatment group,lower significantly than 20% in the control group(P<0.05).Before and after treatment,the differences were not significant in blood routine and liver and kidney functions in the two groups(P>0.05).Conclusion The combined medication of dihuangyinzi and estazolam achieves the superior effect on senile insomnia of kidney yin and yang deficiency as compared with simple oral administration of estazolam tablets.Such combined medication is low in the incidence of adverse reaction.It is safe and effective Chinese herbal medicine and conductive to the guidance of clinical treatment of insomnia.
Objective To explore the clinical effect on senile insomnia of kidney yin and yang deficiency treated with dihuangyinzi and estazolam.Methods From June 2017 through to October 2018,100 cases of senile insomnia of kidney yin and yang deficiency were collected.According to the random number table,they were divided into a control group and a treatment group,50 cases in each one.In the control group,estazolam tablets were prescribed.In the treatment group,on the base of the treatment as the control group,dihuangyinzi was added.The medication lasted for 4 weeks for oral administration in the two groups.The clinical effect,TCM symptom score,blood routine,liver and kidney functions and the incidence of adverse reaction were observed in the two groups.Results After treatment,the remarkably effective rate was62% in the treatment group,obviously higher than 44% in the control group(P<0.05).After treatment,TCM symptom score was reduced obviously in the treatment group(P<0.05).The score(8.80 ± 2.00) in the treatment group was lower significantly than(15.73 ± 1.26) in the control group(P<0.05).The incidence of adverse reaction was 2% in the treatment group,lower significantly than 20% in the control group(P<0.05).Before and after treatment,the differences were not significant in blood routine and liver and kidney functions in the two groups(P>0.05).Conclusion The combined medication of dihuangyinzi and estazolam achieves the superior effect on senile insomnia of kidney yin and yang deficiency as compared with simple oral administration of estazolam tablets.Such combined medication is low in the incidence of adverse reaction.It is safe and effective Chinese herbal medicine and conductive to the guidance of clinical treatment of insomnia.
引文
[1]李帅帅.人口老龄化对当前社会影响及对策研究[J].戏剧之家,2018,11(20):2238.
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[3]索艳风.不同年龄睡眠质量对健康相关生命质量影响的差异研究[D].北京:北京中医药大学,2017.
[4]滑宏巨,戴秀英,余建强,等.小剂量多塞平与艾司唑仑治疗老年性失眠临床疗效比较[J].宁夏医科大学学报,2014,36(12):1414-1417.
[5]刘利利,马忠金,焦晓杰.血府逐瘀汤加减治疗老年女性失眠的疗效观察[J].中西医结合心脑血管病杂志,2018,16(20):3062-3064.
[6]李焕芹.“周氏调神针刺法”治疗原发性失眠睡眠质量和日间疲劳状态的临床研究[D].北京:北京中医药大学,2017.
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[8]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:168-173.
[9]国家技术监督局.中华人民共和国国家标准《中医临床诊疗术语》(GB/T16751—1997)[S].北京:中国标准出版社,1997.
[10]中华医学会精神科分会.中国精神障碍分类与诊断标准[M]. 3版.济南:山东科学技术出版社,2001:118-119.
[11]齐冲,姚美英,高玉霞.不同居住方式社区老年人生活质量及影响因素[J].中国老年学杂志,2018,38(22):5579-5581.
[12]周芳,李智杰.李智杰教授辨证论治老年期痴呆相关性睡眠障碍[J].世界中西医结合杂志,2014,9(1):23-24.
[13]曲捷,任军,胡中伟,等.高血压老人睡眠质量现状及与孤独感的关系[J].中国健康心理学杂志,2019,27(1):78-82.
[14]Rodriguez JC,Dzierzewski JM,Alessi CA. Sleep problems in the elderly[J]. Med Clin North Am,2015,99(2):431-439.
[15]刘帅,李志鹏.老年失眠症中医证治浅探[J].江苏中医药,2015,47(2):10-13.
[16]许彩儒,阮金玉,李柳骥,等.加味逍遥丸治疗妇女绝经后情绪障碍及对患者睡眠质量、血清性激素水平的影响[J].世界中西医结合杂志,2017,12(3):418-421.
[17]杨帆.老年人失眠的睡眠特点与中医证候的相关性研究[D].北京:北京中医药大学,2018.
[18]高凤智.习练八段锦联合穴位按摩疗法对社区中老年失眠患者睡眠质量影响的研究[D].北京:北京中医药大学,2018.
[19]张志聪.黄帝内经集注[M].哈尔滨:北方文艺出版社,2007:55-58.
[2]傅瑜弘.积极心理学视域下老龄人口生活质量提升研究[J].北华大学学报(社会科学版),2018,19(6):71-77.
[3]索艳风.不同年龄睡眠质量对健康相关生命质量影响的差异研究[D].北京:北京中医药大学,2017.
[4]滑宏巨,戴秀英,余建强,等.小剂量多塞平与艾司唑仑治疗老年性失眠临床疗效比较[J].宁夏医科大学学报,2014,36(12):1414-1417.
[5]刘利利,马忠金,焦晓杰.血府逐瘀汤加减治疗老年女性失眠的疗效观察[J].中西医结合心脑血管病杂志,2018,16(20):3062-3064.
[6]李焕芹.“周氏调神针刺法”治疗原发性失眠睡眠质量和日间疲劳状态的临床研究[D].北京:北京中医药大学,2017.
[7]中华医学会精神科分会.中国精神障碍分类与诊断标准(CCMD-3)[S].济南:山东科学技术出版社,2001:68-69.
[8]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:168-173.
[9]国家技术监督局.中华人民共和国国家标准《中医临床诊疗术语》(GB/T16751—1997)[S].北京:中国标准出版社,1997.
[10]中华医学会精神科分会.中国精神障碍分类与诊断标准[M]. 3版.济南:山东科学技术出版社,2001:118-119.
[11]齐冲,姚美英,高玉霞.不同居住方式社区老年人生活质量及影响因素[J].中国老年学杂志,2018,38(22):5579-5581.
[12]周芳,李智杰.李智杰教授辨证论治老年期痴呆相关性睡眠障碍[J].世界中西医结合杂志,2014,9(1):23-24.
[13]曲捷,任军,胡中伟,等.高血压老人睡眠质量现状及与孤独感的关系[J].中国健康心理学杂志,2019,27(1):78-82.
[14]Rodriguez JC,Dzierzewski JM,Alessi CA. Sleep problems in the elderly[J]. Med Clin North Am,2015,99(2):431-439.
[15]刘帅,李志鹏.老年失眠症中医证治浅探[J].江苏中医药,2015,47(2):10-13.
[16]许彩儒,阮金玉,李柳骥,等.加味逍遥丸治疗妇女绝经后情绪障碍及对患者睡眠质量、血清性激素水平的影响[J].世界中西医结合杂志,2017,12(3):418-421.
[17]杨帆.老年人失眠的睡眠特点与中医证候的相关性研究[D].北京:北京中医药大学,2018.
[18]高凤智.习练八段锦联合穴位按摩疗法对社区中老年失眠患者睡眠质量影响的研究[D].北京:北京中医药大学,2018.
[19]张志聪.黄帝内经集注[M].哈尔滨:北方文艺出版社,2007:55-58.