耳复康口服液治疗突发性耳聋150例
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摘要
目的:观察耳复康口服液治疗突发性耳聋的临床疗效。方法:选取600例突发性耳聋患者,随机分为治疗组、对照组A、对照组B和对照组C,每组150例。对照组A采用西医规范治疗方案,采用低分子右旋糖酐、三磷酸腺苷、辅酶A等进行静脉滴注,口服甲钴胺分散片及醋酸泼尼松片,对照组B在对照组A的基础上加用耳聋左慈丸,对照组C在对照组A的基础上加用注射用红花黄色素,治疗组在对照组A的基础上联合耳复康口服液治疗。比较各组患者的临床疗效及治疗前后耳聋、耳闷及眩晕等症状缓解情况。结果:治疗组有效率为80. 7%,对照组A有效率为64. 0%,对照组B有效率为68. 7%,对照组C有效率为67. 3%,对照组A、对照组B、对照组C组间比较,差异无统计学意义(P> 0. 05),治疗组与各对照组比较,差异有统计学意义(P <0. 05)。各组患者治疗后耳鸣、耳闷及眩晕等症状发生例数少于治疗前,差异具有统计学意义(P <0. 05),治疗后各对照组组间比较,差异无统计学意义(P> 0. 05),治疗组与各对照组比较,差异具有统计学意义(P <0. 05)。结论:耳复康口服液治疗突发性耳聋有较好的临床疗效,可改善患者的临床症状。
Objective: To observe the clinical curative effect of Erfukang Oral Liquid( EFKOL) on sudden deafness. Methods: Six hundred cases of sudden deafness were chosen and randomly divided into the treatment group,the control group A,the control group B,and the control group C,with 150 cases in each group. The control group A was treated with standard western medicine.Low molecular weight dextran,adenosine triphosphate and coenzyme A were intravenously dripped. Mecobalamin dispersible tablets and prednisone acetate tablets were orally administered. The ones in the control group B were treated with Zuoci Pill for Deafness( ZCPD) on the basis of control group A. The ones in the control group C were treated with safflower yellow for injection on the basis of the control group A,while the ones in the treatment group were treated with EFKOL on the basis of control group A.The clinical efficacy and relief of deafness,tightness and vertigo before and after the treatment were compared between the two groups. Results: The effective rate of treatment group was 80. 7%,that of the control group A was 64. 0%,that of the control group B was 68. 7%,and that of the control group C was 64. 0%. There was no significant difference among control group A,control group B and control group C( P > 0. 05). There was significant difference between the treatment group and each of the control group( P < 0. 05). After the treatment,the case number of tinnitus,ear tightness and vertigo symptoms in each group was less than that before the treatment,and the difference was statistically significant( P < 0. 05). After the treatment,there was no significant difference between each of the control group( P > 0. 05). The difference between the treatment group and each of the control group was statistically significant( P < 0. 05). Conclusion: EFKOL has a remarkable clinical curative effect on sudden deafness,can improve the clinical symptoms of patients.
Objective: To observe the clinical curative effect of Erfukang Oral Liquid( EFKOL) on sudden deafness. Methods: Six hundred cases of sudden deafness were chosen and randomly divided into the treatment group,the control group A,the control group B,and the control group C,with 150 cases in each group. The control group A was treated with standard western medicine.Low molecular weight dextran,adenosine triphosphate and coenzyme A were intravenously dripped. Mecobalamin dispersible tablets and prednisone acetate tablets were orally administered. The ones in the control group B were treated with Zuoci Pill for Deafness( ZCPD) on the basis of control group A. The ones in the control group C were treated with safflower yellow for injection on the basis of the control group A,while the ones in the treatment group were treated with EFKOL on the basis of control group A.The clinical efficacy and relief of deafness,tightness and vertigo before and after the treatment were compared between the two groups. Results: The effective rate of treatment group was 80. 7%,that of the control group A was 64. 0%,that of the control group B was 68. 7%,and that of the control group C was 64. 0%. There was no significant difference among control group A,control group B and control group C( P > 0. 05). There was significant difference between the treatment group and each of the control group( P < 0. 05). After the treatment,the case number of tinnitus,ear tightness and vertigo symptoms in each group was less than that before the treatment,and the difference was statistically significant( P < 0. 05). After the treatment,there was no significant difference between each of the control group( P > 0. 05). The difference between the treatment group and each of the control group was statistically significant( P < 0. 05). Conclusion: EFKOL has a remarkable clinical curative effect on sudden deafness,can improve the clinical symptoms of patients.
引文
[1]黄选兆,汪吉宝,孔维佳,等.实用耳鼻咽喉头颈外科学[M]. 2版.北京:人民卫生出版社,2008:88-89.
[2]牛亚玲,贾艳萍.固肾化瘀聪耳汤配合西药治疗突发性耳聋的疗效观察及护理[J].陕西中医,2011,32(3):342-343.
[3]中华耳鼻喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻喉头颈外科杂志,2011,23(41):569-570.
[4]中华人民共和国中医药行业标准.中医病证诊断疗效标准[S].北京:中国标准出版社,2010:94.
[5]熊大经,刘蓬.中医耳鼻咽喉科学[M]. 3版.北京:中国中医药出版社,2012:93-97.
[6] JACK KATZ.临床听力学[M].韩德民,译. 5版.北京:人民卫生出版社,2006:92-93.
[7] SCHREIBER B E. AGRUP C,HASKARD D O,et al. Sudden sen-sorinrural hearing loss[J]. Lancet,2010,375(3):1203-1211.
[8] STACHLER R J,CHANDRASEKHAR S S,ARCHER S M,et al.Clini-cal practice guideline:sudden hearing loss[J]. Otolaryn-gol Head and Neck Surgery,2016,33(1):87.
[9] DESAI P,DEJOIE-BREWER M,BALLAS S K. Deafness andsickle cell disease:three case reports and review of the literature[J]. J Clin Med Res,2015,7(3):189.
[10]赖闻,钟时勋,钱怡,等.双侧突发性耳聋的临床特征与治疗(附8例分析)[J].中华耳科学杂志,2014,12(4):597-602.
[11] LI H,ZHAO D,DIAO M,et al. Hyperbaric Oxygen TreatmentsAttenuate the Neutrophil-to-Lymphocyte Ratio in Patients withIdiopathic Sudden sensorineural Hearing Loss[J]. OtolaryngolHead Neck Surg,2015,153(4):606-612.
[12] KIM S,LEE J,NAM S I. Dicer Is down-regulated and correlatedwith Drosha in idiopathic sudden sensorineural hearing loss[J]. JKorean Med Sci,2015,30(8):1183-1188.
[13]李小娇.突发性耳聋患者耳鸣转归与一些因素的相关性探讨[D].广州:广州中医药大学,2011.
[14]杨明杰,李丽.行滞化瘀汤治疗突发性耳聋60例[J].中国中医药现代远程教育,2010,8(6):25.
[15]冷辉,孙海波,王爱平,等.泻火化瘀通窍法对耳蜗微循环障碍毛细胞凋亡的实验研究[J].中国中西医结合耳鼻喉科杂志,2014,22(1):5-6.
[2]牛亚玲,贾艳萍.固肾化瘀聪耳汤配合西药治疗突发性耳聋的疗效观察及护理[J].陕西中医,2011,32(3):342-343.
[3]中华耳鼻喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻喉头颈外科杂志,2011,23(41):569-570.
[4]中华人民共和国中医药行业标准.中医病证诊断疗效标准[S].北京:中国标准出版社,2010:94.
[5]熊大经,刘蓬.中医耳鼻咽喉科学[M]. 3版.北京:中国中医药出版社,2012:93-97.
[6] JACK KATZ.临床听力学[M].韩德民,译. 5版.北京:人民卫生出版社,2006:92-93.
[7] SCHREIBER B E. AGRUP C,HASKARD D O,et al. Sudden sen-sorinrural hearing loss[J]. Lancet,2010,375(3):1203-1211.
[8] STACHLER R J,CHANDRASEKHAR S S,ARCHER S M,et al.Clini-cal practice guideline:sudden hearing loss[J]. Otolaryn-gol Head and Neck Surgery,2016,33(1):87.
[9] DESAI P,DEJOIE-BREWER M,BALLAS S K. Deafness andsickle cell disease:three case reports and review of the literature[J]. J Clin Med Res,2015,7(3):189.
[10]赖闻,钟时勋,钱怡,等.双侧突发性耳聋的临床特征与治疗(附8例分析)[J].中华耳科学杂志,2014,12(4):597-602.
[11] LI H,ZHAO D,DIAO M,et al. Hyperbaric Oxygen TreatmentsAttenuate the Neutrophil-to-Lymphocyte Ratio in Patients withIdiopathic Sudden sensorineural Hearing Loss[J]. OtolaryngolHead Neck Surg,2015,153(4):606-612.
[12] KIM S,LEE J,NAM S I. Dicer Is down-regulated and correlatedwith Drosha in idiopathic sudden sensorineural hearing loss[J]. JKorean Med Sci,2015,30(8):1183-1188.
[13]李小娇.突发性耳聋患者耳鸣转归与一些因素的相关性探讨[D].广州:广州中医药大学,2011.
[14]杨明杰,李丽.行滞化瘀汤治疗突发性耳聋60例[J].中国中医药现代远程教育,2010,8(6):25.
[15]冷辉,孙海波,王爱平,等.泻火化瘀通窍法对耳蜗微循环障碍毛细胞凋亡的实验研究[J].中国中西医结合耳鼻喉科杂志,2014,22(1):5-6.