水貂阿留申病诊断技术研究进展
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摘要
水貂阿留申病是水貂养殖业的重要疫病,目前无疫苗预防,主要通过发展诊断技术,淘汰感染貂防控该病。论文总结了在貂场应用的基因与抗体检测技术,基因检测具有高灵敏度和特异性,能够检测到动物带毒感染,不同类型的基因检测技术对变异性强的阿留申病毒检测各有所长;抗体检测是水貂阿留申病的主要检测方式,研究者不断创新和改进原有技术,趋向对阿留申病的规模化精准检测,但单一的抗体检测方法淘汰感染貂具有局限性。论文通过对两类检测技术分析,建议采用基因与抗体的联合检测方法,从感染貂群中区分耐受貂或抗性貂,期望为国内高感染率貂场的检测和选种提供参考。
Aleutian mink disease is the most important disease in the mink breeding industry,no effective vaccine to prevent as yet,mainly controlled by developing diagnosis techniques and eliminate minks infected with the Aleutian mink disease virus.The main gene and antibody detection methods applied in mink farms were summarized in this report.The gene detection techniques can detect the amdoparvoviral carriers with high sensitivity and specificity.Different types of techniques play distinct roles in detecting Aleutian mink disease virus with strong variability.The antibody detection method is the major testing of Aleutian mink disease,and it has been continuously innovated and improved by researchers,with the tendency of large-scale accurate detection of the Aleutian disease.Some studies have shown that single antibody testing is not enough to detect mink infected with Aleutian mink disease virus.Therefore,by analyzing two kinds of detection technologies,this paper suggests that combination of amdoparvoviral gene and antibody testing can be used to screen the minks which tolerate or resist the Aleutian mink disease virus infection,hoping to provide reference for detection and selection of domestic mink stock with high prevalent rate.
Aleutian mink disease is the most important disease in the mink breeding industry,no effective vaccine to prevent as yet,mainly controlled by developing diagnosis techniques and eliminate minks infected with the Aleutian mink disease virus.The main gene and antibody detection methods applied in mink farms were summarized in this report.The gene detection techniques can detect the amdoparvoviral carriers with high sensitivity and specificity.Different types of techniques play distinct roles in detecting Aleutian mink disease virus with strong variability.The antibody detection method is the major testing of Aleutian mink disease,and it has been continuously innovated and improved by researchers,with the tendency of large-scale accurate detection of the Aleutian disease.Some studies have shown that single antibody testing is not enough to detect mink infected with Aleutian mink disease virus.Therefore,by analyzing two kinds of detection technologies,this paper suggests that combination of amdoparvoviral gene and antibody testing can be used to screen the minks which tolerate or resist the Aleutian mink disease virus infection,hoping to provide reference for detection and selection of domestic mink stock with high prevalent rate.
引文
[1] Bloom M E,Best S M,Hayes S F,et al.Identification of Aleutian mink disease parvovirus capsid sequences mediating antibody-dependent enhancement of infection,virus neutralization,and immune complex formation[J].J Virol,2001,75 (22):11116-11127.
[2] Dworak L J,Wolfinbarger J B,Bloom M E.Aleutian mink disease parvovirus infection of K562 cells is antibody-dependent and is mediated via an Fc (gamma) RII receptor[J].Arch Virol,1997,142 (2):363-373.
[3] 邵西群,章秀婷,岳志刚,等.水貂血液阿留申病病毒及其抗体的检测与分析[J].中国兽医学报,2014,34(12):1893-1905.
[4] Liu D,Li J,Shi K,et al.Construction and immunogenicity analysis of whole-gene mutation DNA vaccine of Aleutian mink virus isolated virulent strain[J].Viral Immunol,2018,31(1):69-77.
[5] King A M Q,Adams M J,Lefkowitz E J,et al.Virus Taxonomy:Ninth Report of the International Committee on Taxonomy of Viruses[M].Elsevier Academic Press,San Diego,2011,405-425.
[6] Li L,Pesavento P A,Woods L,et al.Novel amdovirus in gray foxes[J].Emerg Infect Dis,2011,17 (10):1876-1878.
[7] Shao X Q,Wen Y J,Ba H X,et al.Novel amdoparvovirus infecting farmed raccoon dogs and arctic foxes[J].Emerg Infect Dis,2014,20 (12):2085-2088.
[8] Canuti M,Doyle H E,A P B,et al.Full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (Mephitis mephitis)[J].Emerg Mecrobes Infec,2017,6 (5):e30.
[9] Alex C E,Kubiski S V,Li L,et al.Amdoparvovirus infection in red pandas (Ailurus fulgens)[J].Vet Pathol,2018,55 (4):552-561.
[10] Ryt-Hansen P,Hagberg E E,Chriel M,et al.Global phylogenetic analysis of contemporary aleutian mink disease viruses (AMDVs)[J].Virol J,2017,14 (1):231.
[11] Prieto A,Diaz-Cao J M,Fernandez-Antonio R,et al.Application of real-time PCR to detect Aleutian mink disease virus on environmental farm sources[J].Vet Microbiol,2014,173 (3-4):355-359.
[12] Prieto A,Fernandez-Antonio R,Diaz-Cao J M,et al.Distribution of Aleutian mink disease virus contamination in the environment of infected mink farms[J].Vet Microbiol,2017,204:59-63.
[13] 庄金秋,梅建国,王玉茂,等.水貂阿留申病毒最新检测方法研究进展[J].现代畜牧兽医,2017,(11):53-58.
[14] Qiu J,Cheng F,Burger L R,et al.The transcription profile of Aleutian mink disease virus in CRFK cells is generated by alternative processing of pre-mRNAs produced from a single promoter[J].J Virol,2006,80 (2):654-662.
[15] Farid A H,Rupasinghe P P.A fast and accurate method of detecting Aleutian mink disease virus in blood and tissues of chronically infected mink[J].Can J Microbiol,2017,63 (4):341-349.
[16] Yager P,Edwards T,Fu E,et al.Microfluidic diagnostic technologies for global public health[J].Nature,2006,442 (7101):412-418.
[17] An S H,Ingaram D G.Detection of inapparent Aleutian disease virus infection in mink[J].Am J Vet Res,1977,38 (10):1619-1624.
[18] 籍玉林,曲维江,赵元楷,等.阿留申病抗体消长规律的研究[J].畜牧兽医学报,1995,(01):42-46.
[19] Farid A H,Ferns L E.Reduced severity of histopathological lesions in mink selected for tolerance to Aleutian mink disease virus infection[J].Res Vet Sci,2017,111:127-134.
[20] 王振军,王春霞,倪佳,等.水貂阿留申病毒抗体胶体金检测试纸条及其制备方法[P].吉林:CN105181964A,2015-12-23.
[21] Taranin A V,Maerova A L,Volkova O Y,et al.Dot immunoenzyme assay for the diagnosis of Aleutian mink disease[C].Helsinki:Asko Mki-Tanila,2016,94-99.
[22] 李晶.检测水貂阿留申病Dot-ELISA方法的建立及初步验证[D].吉林长春:吉林农业大学,2015.
[23] Andersson A M,Wallgren P.Evaluation of two enzyme-linked immunosorbent assays for serodiagnosis of Aleutian mink disease virus infection in mink[J].Acta Vet Scand,2013,55:86.
[24] Yi L,Cheng Y,Zhang M,et al.Identification of a novel Aleutian mink disease virus B-cell epitope using a monoclonal antibody against VP2 protein[J].Virus Res,2016,223:39-42.
[25] Lu T,Wang Y,Ge J,et al.Identification and characterization of a novel B-cell epitope on Aleutian mink disease virus capsid protein VP2 using a monoclonal antibody[J].Virus Res,2018,248:74-79.
[26] Chen X,Song C,Liu Y,et al.Development of an enzyme-linked immunosorbent assay based on fusion VP2332-452 antigen for detecting antibodies against Aleutian mink disease virus[J].J Clin Microbiol,2016,54 (2):439-442.
[27] Ma F,Zhang L,Wang Y,et al.Development of a peptide ELISA for the diagnosis of Aleutian mink disease[J].PLoS One,2016,11(11):e016793.
[28] Knuuttila A,Aronen P,Eerola M,et al.Validation of an automated ELISA system for detection of antibodies to Aleutian mink disease virus using blood samples collected in filter paper strips[J].Virol J,2014,11:141.
[29] Farid A H,Rupasinghe P P.Accuracy of enzyme-linked immunosorbent assays for quantification of antibodies against Aleutian mink disease virus[J].J Virol Methods,2016,235:144-151.
[30] Andersson A M,Nyman A K,Wallgren P.A retrospective cohort study estimating the individual Aleutian disease progress in female mink using a VP2 ELISA and its association to reproductive performance[J].Prev Vet Med,2017,140:60-66.
[2] Dworak L J,Wolfinbarger J B,Bloom M E.Aleutian mink disease parvovirus infection of K562 cells is antibody-dependent and is mediated via an Fc (gamma) RII receptor[J].Arch Virol,1997,142 (2):363-373.
[3] 邵西群,章秀婷,岳志刚,等.水貂血液阿留申病病毒及其抗体的检测与分析[J].中国兽医学报,2014,34(12):1893-1905.
[4] Liu D,Li J,Shi K,et al.Construction and immunogenicity analysis of whole-gene mutation DNA vaccine of Aleutian mink virus isolated virulent strain[J].Viral Immunol,2018,31(1):69-77.
[5] King A M Q,Adams M J,Lefkowitz E J,et al.Virus Taxonomy:Ninth Report of the International Committee on Taxonomy of Viruses[M].Elsevier Academic Press,San Diego,2011,405-425.
[6] Li L,Pesavento P A,Woods L,et al.Novel amdovirus in gray foxes[J].Emerg Infect Dis,2011,17 (10):1876-1878.
[7] Shao X Q,Wen Y J,Ba H X,et al.Novel amdoparvovirus infecting farmed raccoon dogs and arctic foxes[J].Emerg Infect Dis,2014,20 (12):2085-2088.
[8] Canuti M,Doyle H E,A P B,et al.Full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (Mephitis mephitis)[J].Emerg Mecrobes Infec,2017,6 (5):e30.
[9] Alex C E,Kubiski S V,Li L,et al.Amdoparvovirus infection in red pandas (Ailurus fulgens)[J].Vet Pathol,2018,55 (4):552-561.
[10] Ryt-Hansen P,Hagberg E E,Chriel M,et al.Global phylogenetic analysis of contemporary aleutian mink disease viruses (AMDVs)[J].Virol J,2017,14 (1):231.
[11] Prieto A,Diaz-Cao J M,Fernandez-Antonio R,et al.Application of real-time PCR to detect Aleutian mink disease virus on environmental farm sources[J].Vet Microbiol,2014,173 (3-4):355-359.
[12] Prieto A,Fernandez-Antonio R,Diaz-Cao J M,et al.Distribution of Aleutian mink disease virus contamination in the environment of infected mink farms[J].Vet Microbiol,2017,204:59-63.
[13] 庄金秋,梅建国,王玉茂,等.水貂阿留申病毒最新检测方法研究进展[J].现代畜牧兽医,2017,(11):53-58.
[14] Qiu J,Cheng F,Burger L R,et al.The transcription profile of Aleutian mink disease virus in CRFK cells is generated by alternative processing of pre-mRNAs produced from a single promoter[J].J Virol,2006,80 (2):654-662.
[15] Farid A H,Rupasinghe P P.A fast and accurate method of detecting Aleutian mink disease virus in blood and tissues of chronically infected mink[J].Can J Microbiol,2017,63 (4):341-349.
[16] Yager P,Edwards T,Fu E,et al.Microfluidic diagnostic technologies for global public health[J].Nature,2006,442 (7101):412-418.
[17] An S H,Ingaram D G.Detection of inapparent Aleutian disease virus infection in mink[J].Am J Vet Res,1977,38 (10):1619-1624.
[18] 籍玉林,曲维江,赵元楷,等.阿留申病抗体消长规律的研究[J].畜牧兽医学报,1995,(01):42-46.
[19] Farid A H,Ferns L E.Reduced severity of histopathological lesions in mink selected for tolerance to Aleutian mink disease virus infection[J].Res Vet Sci,2017,111:127-134.
[20] 王振军,王春霞,倪佳,等.水貂阿留申病毒抗体胶体金检测试纸条及其制备方法[P].吉林:CN105181964A,2015-12-23.
[21] Taranin A V,Maerova A L,Volkova O Y,et al.Dot immunoenzyme assay for the diagnosis of Aleutian mink disease[C].Helsinki:Asko Mki-Tanila,2016,94-99.
[22] 李晶.检测水貂阿留申病Dot-ELISA方法的建立及初步验证[D].吉林长春:吉林农业大学,2015.
[23] Andersson A M,Wallgren P.Evaluation of two enzyme-linked immunosorbent assays for serodiagnosis of Aleutian mink disease virus infection in mink[J].Acta Vet Scand,2013,55:86.
[24] Yi L,Cheng Y,Zhang M,et al.Identification of a novel Aleutian mink disease virus B-cell epitope using a monoclonal antibody against VP2 protein[J].Virus Res,2016,223:39-42.
[25] Lu T,Wang Y,Ge J,et al.Identification and characterization of a novel B-cell epitope on Aleutian mink disease virus capsid protein VP2 using a monoclonal antibody[J].Virus Res,2018,248:74-79.
[26] Chen X,Song C,Liu Y,et al.Development of an enzyme-linked immunosorbent assay based on fusion VP2332-452 antigen for detecting antibodies against Aleutian mink disease virus[J].J Clin Microbiol,2016,54 (2):439-442.
[27] Ma F,Zhang L,Wang Y,et al.Development of a peptide ELISA for the diagnosis of Aleutian mink disease[J].PLoS One,2016,11(11):e016793.
[28] Knuuttila A,Aronen P,Eerola M,et al.Validation of an automated ELISA system for detection of antibodies to Aleutian mink disease virus using blood samples collected in filter paper strips[J].Virol J,2014,11:141.
[29] Farid A H,Rupasinghe P P.Accuracy of enzyme-linked immunosorbent assays for quantification of antibodies against Aleutian mink disease virus[J].J Virol Methods,2016,235:144-151.
[30] Andersson A M,Nyman A K,Wallgren P.A retrospective cohort study estimating the individual Aleutian disease progress in female mink using a VP2 ELISA and its association to reproductive performance[J].Prev Vet Med,2017,140:60-66.