二甲双胍治疗联合护理干预多囊卵巢综合征患者的效果
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摘要
目的探究护理干预联合二甲双胍治疗多囊卵巢综合征患者对代谢指标、激素水平及治疗效果的影响。方法选择多囊卵巢综合征患者152例为研究对象,采用随机数字表法分为观察组和对照组,各76例。对照组口服二甲双胍治疗,观察组采用护理干预联合二甲双胍治疗。3个月后比较2组患者糖代谢指标、性激素水平变化;随访1年,比较2组排卵率及妊娠结局。结果治疗3个月后,观察组空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)均低于对照组(P<0.05);黄体生成素(LH)及睾酮(T)水平低于对照组(P<0.05);随访1年,观察组排卵率、自然妊娠率、足月分娩率均高于对照组(P<0.05)。结论护理干预联合二甲双胍治疗可显著改善多囊卵巢综合征患者糖代谢指标和性激素水平,提高治疗效果。
Objective To explore effect of nursing intervention combined with metformin in the treatment of patients with polycystic ovary syndrome(PCOS). Methods A total of 152 PCOS were enrolled in the study,and were randomly divided into observation group and control group,with76 cases in each group. The control group was treated with metformin orally,and the observation group was given nursing intervention combined with metformin. After 3 months,the glucose metabolism index and sex hormone levels of two groups were compared. After one-year follow-up,the ovulation rate and pregnancy outcomes of two groups were compared. Results After 3 months,the level of fasting blood glucose(FBG),fasting insulin(FINS),insulin resistance index(HOMA-IR) of observation group were lower than that in the control group(P < 0. 05). The luteinizing hormone(LH)and testosterone(T) levels were lower than that in the control group(P < 0. 05). After 1 year of follow-up,the ovulation rate,natural pregnancy rate,and full-term delivery rate were higher in the observation group than that in the control group(P < 0. 05). Conclusion Nursing intervention combined with metformin can significantly improve glucose metabolism index and sex hormone levels in patients with PCOS and improve clinical efficacy.
Objective To explore effect of nursing intervention combined with metformin in the treatment of patients with polycystic ovary syndrome(PCOS). Methods A total of 152 PCOS were enrolled in the study,and were randomly divided into observation group and control group,with76 cases in each group. The control group was treated with metformin orally,and the observation group was given nursing intervention combined with metformin. After 3 months,the glucose metabolism index and sex hormone levels of two groups were compared. After one-year follow-up,the ovulation rate and pregnancy outcomes of two groups were compared. Results After 3 months,the level of fasting blood glucose(FBG),fasting insulin(FINS),insulin resistance index(HOMA-IR) of observation group were lower than that in the control group(P < 0. 05). The luteinizing hormone(LH)and testosterone(T) levels were lower than that in the control group(P < 0. 05). After 1 year of follow-up,the ovulation rate,natural pregnancy rate,and full-term delivery rate were higher in the observation group than that in the control group(P < 0. 05). Conclusion Nursing intervention combined with metformin can significantly improve glucose metabolism index and sex hormone levels in patients with PCOS and improve clinical efficacy.
引文
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[5]王洁.综合护理干预对多囊卵巢综合征治疗效果的影响[J].河南医学杂志,2016,25(2):378-379.
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[8]Wang Q Y,Song Y,Huang W,et al.Comparison of Drospirenone-with Cyproterone Acetate-Containing Oral Contraceptives,Combined with Metformin and Lifestyle Modifications in Women with Polycystic Ovary Syndrome and Metabolic Disorders:A Prospective Randomized Control Trial[J].Chin Med J(Engl),2016,129(8):883-890.
[9]Naderpoor N,Shorakae S,de Courten B,et al.Metformin and lifestyle modification in polycystic ovary syndrome:systematic review and meta-analysis[J].Hum Reprod Update,2015,21(5):560-571.
[10]钟凯,张瑞女.自我体重管理在育龄期肥胖多囊卵巢综合征患者中的应用[J].现代临床护理,2014,16(12):19-23.
[11]张君,王国军,安淑银,等.生活方式干预对多囊卵巢综合征的影响[J].长春中医药大学学报,2013,29(31):496-497.
[12]Conway G,Dewailly D,Diamanti-Kanarakis E,et al.European survey of diagnosis and management of the polycystic ovary syndrome:results of the ESE PCOS Special Interest Group's Questionnaire[J].Eur J Endocrinol,2014,171(4):489-498.
[13]艾艳敏,杨菁.左旋甲状腺素对采用二甲双胍产生胰岛素抵抗的多囊卵巢综合征伴甲减患者的影响[J].海南医学院学报,2015,21(7):964-966.
[14]范丽珍.育龄期多囊卵巢综合征患者卵巢超声影像学特征分析[J].黑龙江医药科学,2016,39(1):141-142.
[15]甘奇晔.腹腔镜卵巢电凝术治疗难治性多囊卵巢综合征的效果[J].实用临床医药杂志,2014,18(19):143-145.
[16]黄李芸,饶红超,罗梅莲.护理干预对肥胖型多囊卵巢综合征不孕患者的影响[J].实用临床医药杂志,2014,18(8):61-62.
[17]于云.联合治疗在多囊卵巢综合症治疗中的价值[J].实用临床医药杂志,2014,18(E01):84-85.
[18]唐静.二甲双胍对多囊卵巢综合征患者排卵效果的影响及其机制[J].实用临床医药杂志,2016,20(7):195-196.
[19]陈新华,田德明,肖娴静,等.多囊卵巢综合征应用二甲双胍片及炔雌醇环丙孕酮的临床研究[J].实用临床医药杂志,2016,20(21):157-158.
[2]卢斋,陈华,陈曼玲,等.多囊卵巢综合征患者血清肌肉生长抑素与肥胖、胰岛素抵抗的相关性研究[J].海南医学院学报,2015,21(9):1242-1244,1247-1247.
[3]付雪梅,郝鹏锴,王丹.优思明联合二甲双胍及生活方式干预治疗青春期多囊卵巢综合征临床疗效的观察[J].中国妇幼保健,2015,30(30):5108-5110.
[4]The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS)[J].Hum Reprod,2004,19(1):41-47.
[5]王洁.综合护理干预对多囊卵巢综合征治疗效果的影响[J].河南医学杂志,2016,25(2):378-379.
[6]Ibrahim,Alanbay Cihangir Mutlu,Ercan Mehmet,Sakinci Hakan,et al.A macrophage activation marker chitotriosidase in women with PCOS:does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity[J].Archives of gynecology and obstetrics,2012,286(4):1065-1071.
[7]黄红艺,何冰,莫云,等.多囊卵巢综合征不孕患者血清生长素水平变化及其与胰岛素抵抗的关系[J].中国临床新医学,2014,12(10):902-904.
[8]Wang Q Y,Song Y,Huang W,et al.Comparison of Drospirenone-with Cyproterone Acetate-Containing Oral Contraceptives,Combined with Metformin and Lifestyle Modifications in Women with Polycystic Ovary Syndrome and Metabolic Disorders:A Prospective Randomized Control Trial[J].Chin Med J(Engl),2016,129(8):883-890.
[9]Naderpoor N,Shorakae S,de Courten B,et al.Metformin and lifestyle modification in polycystic ovary syndrome:systematic review and meta-analysis[J].Hum Reprod Update,2015,21(5):560-571.
[10]钟凯,张瑞女.自我体重管理在育龄期肥胖多囊卵巢综合征患者中的应用[J].现代临床护理,2014,16(12):19-23.
[11]张君,王国军,安淑银,等.生活方式干预对多囊卵巢综合征的影响[J].长春中医药大学学报,2013,29(31):496-497.
[12]Conway G,Dewailly D,Diamanti-Kanarakis E,et al.European survey of diagnosis and management of the polycystic ovary syndrome:results of the ESE PCOS Special Interest Group's Questionnaire[J].Eur J Endocrinol,2014,171(4):489-498.
[13]艾艳敏,杨菁.左旋甲状腺素对采用二甲双胍产生胰岛素抵抗的多囊卵巢综合征伴甲减患者的影响[J].海南医学院学报,2015,21(7):964-966.
[14]范丽珍.育龄期多囊卵巢综合征患者卵巢超声影像学特征分析[J].黑龙江医药科学,2016,39(1):141-142.
[15]甘奇晔.腹腔镜卵巢电凝术治疗难治性多囊卵巢综合征的效果[J].实用临床医药杂志,2014,18(19):143-145.
[16]黄李芸,饶红超,罗梅莲.护理干预对肥胖型多囊卵巢综合征不孕患者的影响[J].实用临床医药杂志,2014,18(8):61-62.
[17]于云.联合治疗在多囊卵巢综合症治疗中的价值[J].实用临床医药杂志,2014,18(E01):84-85.
[18]唐静.二甲双胍对多囊卵巢综合征患者排卵效果的影响及其机制[J].实用临床医药杂志,2016,20(7):195-196.
[19]陈新华,田德明,肖娴静,等.多囊卵巢综合征应用二甲双胍片及炔雌醇环丙孕酮的临床研究[J].实用临床医药杂志,2016,20(21):157-158.