增材制造在金属多孔植入物中的应用及展望
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摘要
多孔金属有着优异的抗腐蚀性、生物相容性和与人骨相匹配的力学性能,并且内部有着高度互通的孔隙结构,可促进体液的传输和新骨组织的内长入,是人体理想的替代植入物。增材制造技术因其自身的精确性、快速性在金属多孔植入物中变得日益重要。简述了主流的两种增材制造技术在植入物制备中的应用、增材制造用金属植入物材料和多孔植入物的表面拓扑优化方法,并对其在金属多孔植入物中的应用前景进行了展望。
Porous metal has excellent corrosion resistance, biocompatibility and mechanical properties matched with human bone, and it has highly interconnected pore structure inside, which can promote the transmission of body fluids and the incorporation of new bone tissue, and it is an ideal substitute implant for human body. The additive manufacturing technology becomes increasingly important in porous metal implants due to its own accuracy and rapidity. The application of two mainstream additive manufacturing technologies in implant preparation, metal implant material used for dditive manufacturing and the surface topology optimization method of porous implants were briefly described, and their application prospects in the metal porous implants were prospected.
Porous metal has excellent corrosion resistance, biocompatibility and mechanical properties matched with human bone, and it has highly interconnected pore structure inside, which can promote the transmission of body fluids and the incorporation of new bone tissue, and it is an ideal substitute implant for human body. The additive manufacturing technology becomes increasingly important in porous metal implants due to its own accuracy and rapidity. The application of two mainstream additive manufacturing technologies in implant preparation, metal implant material used for dditive manufacturing and the surface topology optimization method of porous implants were briefly described, and their application prospects in the metal porous implants were prospected.
引文
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[36]Ng C C,Savalani M M,Lau M L,et al.Microstructure and mechanical properties of selective laser melted magnesium[J].Applied Surface Science,2011,257(17):7447-7454.
[37]Nguyen T L,Staiger M P,Dias G J,et al.A novel manufacturing route for fabrication of topologically‐ordered porous magnesium scaffolds[J].Advanced Engineering Materials,2011,13(9):872-881.
[38]Giannitelli S M,Accoto D,Trombetta M,et al.Current trends in the design of scaffolds for computer-aided tissue engineering.[J].Acta Biomaterialia,2014,10(2):580-94.
[39]Kirkland N T,Kolbeinsson I,Woodfield T,et al.Synthesis and properties of topologically ordered porous magnesium[J].Materials Science&Engineering B,2011,176(20):1666-1672.
[40]肖冬明,杨永强,苏旭彬,等.Topology optimization of microstructure and selective laser melting fabrication for metallic biomaterial scaffolds[J].Transactions of Nonferrous Metals Society of China,2012,22(10):2554-2561.
[41]徐仰立,张冬云,曹玄扬,等.基于选区激光熔化成型生物医用Ti-6Al-4V合金的工艺与性能研究[J].应用激光,2017(2):199-206.
[42]Chang C L,Chen C S,Huang C H,et al.Finite element analysis of the dental implant using a topology optimizati on method[J].Medical Engineering&Physics,2012,34(7):999-1008.
[2]Wang Q,Tang H,Xi Z,et al.Study on asymmetry stainless steel filtration membrane used in juice industry[J].Rare Metal Materials&Engineering,2015,44(3):544-547.
[3]Wang C,Jia Chengchang,Karima B,et al.Research on Cu Sn10 porous material prepared by non-aqueous gelcasting process[J].Powder Metallurgy Technology,2015,33(1):29-34.
[4]Wang J,Yang J,Zhang J.Research progress in preparation techniques of porous metal materials[J].Ordnance Material Science&Engineering,2013,06:134-137
[5]李虎,虞奇峰,张波,等.浆料发泡法制备生物活性多孔钛及其性能[J].稀有金属材料与工程,2006,35(1):154-157.
[6]Kaplan R B.Open cell tantalum structures for cancellous bone implants and cell and tissue receptors:EP0560279[P].1993-09-15.
[7]胡紫英,李美姮,徐威,等.多孔钛的粉末冶金法制备及其力学性能[J].钛工业进展,2010,27(4):12-15.
[8]石博,刘颖,连利仙,等.放电等离子烧结制备生物医用多孔钛及其性能研究[J].功能材料,2009,40(11):1892-1894.
[9]吴玉博,郝俊杰,郭志猛.自蔓延高温合成钴-钛系多孔合金[J].中国材料进展,2007,26(7):25-28.
[10]卢秉恒,李涤尘.增材制造(3D打印)技术发展[J].机械制造与自动化,2013,42(4):1-4.
[11]Jardini A L,Larosa M A,Filho R M,et al.Cranial reconstruction:3D biomodel and custom-built implant created using additive manufacturing[J].J Craniomaxillofac Surg.,2014,42(8):1877-1884.
[12]Xiao D M,Yang Y Q,Xu S U,et al.Topology optimization of microstructure and selective laser melting fabrication for metallic biomaterial scaffolds[J].Transactions of Nonferrous Metals Society of China,2012,22(10):2554-2561.
[13]杨永强,陈杰,宋长辉,等.金属零件激光选区熔化技术的现状及进展[J].激光与光电子学进展,2018,55(1):3-15.
[14]Vandenbroucke B,Kruth J.Selective laser melting of biocompatible metals for rapid manufacturing of medical parts[J].Rapid Prototyping Journal,2013,13(4):196-203.
[15]Bai Yuchao,Fan Fu,Xiao Zefeng,et al.激光选区熔化设备及生物医学金属材料的研究与应用进展[J].Journal of Zhejiang University-Science A:Applied Physics&Engineering,2018,19(2):122-136.
[16]杨文静,乌日开西·艾依提,王娟,等.基于SLM制备的Ti-6Al-4V人工骨支架的结构设计与力学性能分析[J].稀有金属材料与工程,2017(10):2993-2998.
[17]汤慧萍,王建,逯圣路,等.电子束选区熔化成形技术研究进展[J].中国材料进展,2015,34(3):225-235.
[18]Cronsk覿r M,R覿nnar L,B覿ckstr觟m M.Production of customized hip stem prostheses-a comparison between conventional machining and electron beam melting(EBM)[J].Rapid Prototyping Journal,2013,19(5):365-372.
[19]Jardini A L,Larosa M A,Bernardes L F,et al.Customised titanium implant fabricated in additive manufacturing for craniomaxillofacial surgery[J].Virtual&Physical Prototyping,2014,9(2):115-125.
[20]Sing S L,An J,Yeong W Y,et al.Laser and electron-beam powder-bed additive manufacturing of metallic implants:Areview on processes,materials and designs[J].Journal of Orthopaedic Research,2016,34(3):369-385.
[21]Yang Y,Lu J,Luo Z,et al.Accuracy and density optimization in directly fabricating customized orthodontic production by selective laser melting[J].Rapid Prototyping Journal,2012,18(6):482-489.
[22]Bocca A,Eggbeer D,Bibb R,et al.Rapid manufacture of custom-fitting surgical guides[J].Rapid Prototyping Journal,2009,15(5):346-354.
[23]李洋,陈长军,王晓南,等.选区激光熔化技术制备316L多孔不锈钢工艺及性能研究[J].应用激光,2015,35(3):319-323.
[24]Li R,Liu J,Shi Y,et al.316L Stainless steel with gradient porosity fabricated by selective laser melting[J].Journal of Materials Engineering&Performance,2010,19(5):666-671.
[25]魏青松,韩昌骏,冯新宇,等.3D打印多孔支架及性能评测[C]//全国特种加工学术会议.2015.
[26]Biemond J E,Hannink G,Verdonschot N,et al.Bone ingrowth potential of electron beam and selective laser melting produced trabecular-like implant surfaces with and without a biomimetic coating[J].Journal of Materials Science Materials in Medicine,2013,24(3):745-753.
[27]杨广宇,汤慧萍,刘楠,等.Ti-5Ta-30Nb-7Zr合金医用多孔材料的电子束选区熔化成形及表征[J].钛工业进展,2017,34(1):33-36.
[28]李天威.3D打印多孔钛合金材料修复兔胫骨平台负重区骨缺损的实验研究[D].沈阳:中国医科大学,2017.
[29]张曼慧.膝关节假体优化设计及激光选区熔化制造研究[D].广州:华南理工大学,2013.
[30]Takaichi A,Suyalatu,Nakamoto T,et al.Microstructures and mechanical properties of Co-29Cr-6Mo alloy fabricated by selective laser melting process for dental applications[J].Journal of the Mechanical Behavior of Biomedical Materials,2013,21(3):67.
[31]麦淑珍.个性化Co Cr合金牙冠固定桥激光选区熔化制造工艺及性能研究[D].广州:华南理工大学,2016.
[32]田杰,戚文军,黄正华,等.SLM打印成形CoCrMo合金牙冠的表面粗糙度和硬度优化[J].钢铁研究学报,2018(5):79-83.
[33]Shah F A,Omar O,Suska F,et al.Long-term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting[J].Acta Biomaterialia,2016,36:296-309.
[34]Witte F,Ulrich H,Rudert M,et al.Biodegradable magnesium scaffolds:Part 1:appropriate inflammatory response[J].Journal of Biomedical Materials Research Part A,2007,81(3):748.
[35]Med F W,Reifenrath J,Müller P P,et al.Cartilage repair on magnesium scaffolds used as a subchondral bone replacement[J].Materialwissenschaft Und Werkstofftechnik,2006,37(6):504-508.
[36]Ng C C,Savalani M M,Lau M L,et al.Microstructure and mechanical properties of selective laser melted magnesium[J].Applied Surface Science,2011,257(17):7447-7454.
[37]Nguyen T L,Staiger M P,Dias G J,et al.A novel manufacturing route for fabrication of topologically‐ordered porous magnesium scaffolds[J].Advanced Engineering Materials,2011,13(9):872-881.
[38]Giannitelli S M,Accoto D,Trombetta M,et al.Current trends in the design of scaffolds for computer-aided tissue engineering.[J].Acta Biomaterialia,2014,10(2):580-94.
[39]Kirkland N T,Kolbeinsson I,Woodfield T,et al.Synthesis and properties of topologically ordered porous magnesium[J].Materials Science&Engineering B,2011,176(20):1666-1672.
[40]肖冬明,杨永强,苏旭彬,等.Topology optimization of microstructure and selective laser melting fabrication for metallic biomaterial scaffolds[J].Transactions of Nonferrous Metals Society of China,2012,22(10):2554-2561.
[41]徐仰立,张冬云,曹玄扬,等.基于选区激光熔化成型生物医用Ti-6Al-4V合金的工艺与性能研究[J].应用激光,2017(2):199-206.
[42]Chang C L,Chen C S,Huang C H,et al.Finite element analysis of the dental implant using a topology optimizati on method[J].Medical Engineering&Physics,2012,34(7):999-1008.