DNA甲基化在肺癌中的研究进展
摘要
<正>肺癌已是发达国家和发展中国家男性癌症死亡的主要原因~([1])。中国肿瘤流行病现状显示,中国肺癌男性发病率居首位,女性发病率居第二位~([2]),但是中国肺癌男性及女性死亡率均居首位~([3])。受现有的检查方式、体检意识、医疗资源分配等相关因素的影响,大部分患者诊断肺癌时已为晚期,5年生存率不足20%~([4])。随着科技的进步、研究的深入以及研究
引文
[1] Lindsey A.Torre,Freddie Bray,Rebecca L.Global Cancer Statistics[J].Cancer J Clin,2015,65:87-108.
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[5] Gayon J.From Mendel to epigenetics:History of genetics[J].C R Biol,2016,339(7/8):225-30.
[6] Werner RJ,Kelly AD,Issa JJ.Epigenetics and precision oncology[J].Cancer Journal,2017,23(5):262-269.
[7] Yang LB,Rau R,Goodell MA.DNMT3A in haematological malignancies[J].Nature Reviews Cancer,2015,15(3):152-165.
[8] Jones PA.Functions of DNA methylation:islands,start sites,gene bodies and beyond[J].Nature Reviews Genetics,2012,13(7):484-492.
[9] Bird A.DNA methylation patterns and epigenetic memory[J].Genes & Development,2002,16(1):6-21.
[10] Liu B,Song J,Luan J,et al.Du Z promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer[J].Experimental Biology and Medicine,2016,241(14):1531-1539.
[11] Liang GN,Weisenberger DJ.DNA methylation aberrancies as a guide for surveillance and treatment of human cancers[J].Epigenetics,2017,12(6):416-432.
[12] Liu BQ,Song JF,Luan JQ,et al.Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer[J].Experimental Biology and Medicine,2016,241(14):1531-1539.
[13] Yuan S,Yu Z,Liu Q,et al.A novel epigenetically silenced tumor suppressor,inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma[J].Oncogene,2016,35(47):6120-6131.
[14] Ansari J,Shackelford RE,Ei Osta H.Epigenetics in non-small cell lung cancer:from basics to therapeutics[J].Translational lung cancer research,2016,5(2):155-171.
[15] Yang XY,Zhang J,Yu XL,et al.Death-associated protein kinase promoter methylation correlates with clinicopathological and prognostic features in nonsmall cell lung cancer patients:a cohort study[J].J Cancer Res Ther,2018,14(Supplement):65-71.
[16] Zheng Y Li X,Jiang Y,Xu Y,et al.Promoter hypermethylation of Wnt inhibitory factor-1 in patients with lung cancer:a systematic meta-analysis[J].Medicine,1994,95(49):51-52.
[17] Han Y,Shi K,Zhou SJ,et al.The clinicopathological significance of hMLH1 hypermethylation in non-small-cell lung cancer:a meta-analysis and literature review[J].Onco Targets Ther,2016,16(9):5081-90.
[18] Huang T,Chen X,Hong Q.Meta-analyses ofgene methylation and smoking behavior in non-small cell lung cancer patients[J].Sci Rep,2015,10(5):8897.
[19] Turner MC,Krewski D,Pope IC,et al.Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers[J].American Journal of Respiratory and Critical Care Medicine,2011,184(12):1374-1381.
[20] Gainetdinov IV,Kapitskaya KY,Rykova EY.Ponomaryova AA cherdyntseva NV,vlassov VV,laktionov PP,azhikina TL hypomethylation of human-specific family of LINE-1 retrotransposons in circulating DNA of lung cancer patients[J].Lung Cancer,2016,99:127-130.
[21] Yokoyama S,Higashi M,Tsutsumida H,et al.Hiraki T yonezawa S,batra SK,hollingsworth Ma,tanimoto ATET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer[J].Genes & Cancer,2017,8(3/4):517-527.
[22] Fujii S,Shinjo K,Matsumoto S,et al.Epigenetic upregulation of ARL4C,due to DNA hypomethylation in the 3’-untranslated region,promotes tumorigenesis of lung squamous cell carcinoma[J].Oncotarget,2016,7(49):81571-81587.
[23] Gao X,Zhang Y,Breitling LP,et al.Tobacco smoking and methylation of genes related to lung cancer development[J].Oncotarget,2016,7(37):59017-59028.
[24] Team Nlstr ,Aberle DR,Adams AM,et al.Reduced lung cancer mortality with Low-dose computed tomographic screening[J].N Engl J Med,2011,365:395-409.
[25] Hulbert A,Juse Torres I,Stark A,et al.Herman JG early detection of lung cancer using DNA promoter hypermethylation in plasma and sputum[J].Clinical Cancer Research,2017,23(8):1998-2005.
[26] Liu DI,Peng HL,SunUN Q,et al.The indirect efficacy comparison of DNA methylation in sputum for early screening and auxiliary detection of lung cancer:a Meta-Analysis[J].International Journal of Environmental Research and Public Health,2017,14(7):679.
[27] Ni S,Ye M.Huang T.Short stature homeobox 2 methylation as a potential noninvasive biomarker in bronchial aspirates for lung cancer diagnosis[J].Oncotarget,2017,8(37):61253-61263.
[28] Wu F,Lu M,Qu L,et al.DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer[J].International Journal of Clinical and Experimental Pathology,2015,8(5):5457-5463.
[29] Zhang XX,Yang X,Wang JL,et al.Down-regulation of PAX6 by promoter methylation is associated with poor prognosis in non small cell lung cancer[J].International Journal of Clinical and Experimental Pathology,2015,8(9):11452-11457.
[2] 曾倩,崔芳芳,宇传华,等.中国癌症发病、死亡现状与趋势分析[J].中国卫生统计,2016,33(2):321-323.
[3] 邹小农,贾漫漫,王鑫,等.中国肺癌和烟草流行及控烟现状[J].中国肺癌杂志,2017,20(8):505-510.
[4] Chen WQ,Zheng RS,Baade PD,et al.Cancer statistics in China,2015[J].Cancer Journal for Clinicians,2016,66(2):115-132.
[5] Gayon J.From Mendel to epigenetics:History of genetics[J].C R Biol,2016,339(7/8):225-30.
[6] Werner RJ,Kelly AD,Issa JJ.Epigenetics and precision oncology[J].Cancer Journal,2017,23(5):262-269.
[7] Yang LB,Rau R,Goodell MA.DNMT3A in haematological malignancies[J].Nature Reviews Cancer,2015,15(3):152-165.
[8] Jones PA.Functions of DNA methylation:islands,start sites,gene bodies and beyond[J].Nature Reviews Genetics,2012,13(7):484-492.
[9] Bird A.DNA methylation patterns and epigenetic memory[J].Genes & Development,2002,16(1):6-21.
[10] Liu B,Song J,Luan J,et al.Du Z promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer[J].Experimental Biology and Medicine,2016,241(14):1531-1539.
[11] Liang GN,Weisenberger DJ.DNA methylation aberrancies as a guide for surveillance and treatment of human cancers[J].Epigenetics,2017,12(6):416-432.
[12] Liu BQ,Song JF,Luan JQ,et al.Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer[J].Experimental Biology and Medicine,2016,241(14):1531-1539.
[13] Yuan S,Yu Z,Liu Q,et al.A novel epigenetically silenced tumor suppressor,inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma[J].Oncogene,2016,35(47):6120-6131.
[14] Ansari J,Shackelford RE,Ei Osta H.Epigenetics in non-small cell lung cancer:from basics to therapeutics[J].Translational lung cancer research,2016,5(2):155-171.
[15] Yang XY,Zhang J,Yu XL,et al.Death-associated protein kinase promoter methylation correlates with clinicopathological and prognostic features in nonsmall cell lung cancer patients:a cohort study[J].J Cancer Res Ther,2018,14(Supplement):65-71.
[16] Zheng Y Li X,Jiang Y,Xu Y,et al.Promoter hypermethylation of Wnt inhibitory factor-1 in patients with lung cancer:a systematic meta-analysis[J].Medicine,1994,95(49):51-52.
[17] Han Y,Shi K,Zhou SJ,et al.The clinicopathological significance of hMLH1 hypermethylation in non-small-cell lung cancer:a meta-analysis and literature review[J].Onco Targets Ther,2016,16(9):5081-90.
[18] Huang T,Chen X,Hong Q.Meta-analyses ofgene methylation and smoking behavior in non-small cell lung cancer patients[J].Sci Rep,2015,10(5):8897.
[19] Turner MC,Krewski D,Pope IC,et al.Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers[J].American Journal of Respiratory and Critical Care Medicine,2011,184(12):1374-1381.
[20] Gainetdinov IV,Kapitskaya KY,Rykova EY.Ponomaryova AA cherdyntseva NV,vlassov VV,laktionov PP,azhikina TL hypomethylation of human-specific family of LINE-1 retrotransposons in circulating DNA of lung cancer patients[J].Lung Cancer,2016,99:127-130.
[21] Yokoyama S,Higashi M,Tsutsumida H,et al.Hiraki T yonezawa S,batra SK,hollingsworth Ma,tanimoto ATET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer[J].Genes & Cancer,2017,8(3/4):517-527.
[22] Fujii S,Shinjo K,Matsumoto S,et al.Epigenetic upregulation of ARL4C,due to DNA hypomethylation in the 3’-untranslated region,promotes tumorigenesis of lung squamous cell carcinoma[J].Oncotarget,2016,7(49):81571-81587.
[23] Gao X,Zhang Y,Breitling LP,et al.Tobacco smoking and methylation of genes related to lung cancer development[J].Oncotarget,2016,7(37):59017-59028.
[24] Team Nlstr ,Aberle DR,Adams AM,et al.Reduced lung cancer mortality with Low-dose computed tomographic screening[J].N Engl J Med,2011,365:395-409.
[25] Hulbert A,Juse Torres I,Stark A,et al.Herman JG early detection of lung cancer using DNA promoter hypermethylation in plasma and sputum[J].Clinical Cancer Research,2017,23(8):1998-2005.
[26] Liu DI,Peng HL,SunUN Q,et al.The indirect efficacy comparison of DNA methylation in sputum for early screening and auxiliary detection of lung cancer:a Meta-Analysis[J].International Journal of Environmental Research and Public Health,2017,14(7):679.
[27] Ni S,Ye M.Huang T.Short stature homeobox 2 methylation as a potential noninvasive biomarker in bronchial aspirates for lung cancer diagnosis[J].Oncotarget,2017,8(37):61253-61263.
[28] Wu F,Lu M,Qu L,et al.DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer[J].International Journal of Clinical and Experimental Pathology,2015,8(5):5457-5463.
[29] Zhang XX,Yang X,Wang JL,et al.Down-regulation of PAX6 by promoter methylation is associated with poor prognosis in non small cell lung cancer[J].International Journal of Clinical and Experimental Pathology,2015,8(9):11452-11457.