慢性乙型肝炎患者血清中透明质酸、前白蛋白的水平与HBV-DNA载量的相关性分析
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摘要
目的探讨慢性乙型肝炎患者血清中透明质酸、前白蛋白的水平与HBV-DNA载量的相关性。方法选取2015年4月至2016年5月在肇庆市第二人民医院门诊和住院的慢性乙肝患者200例为观察组,同期于肇庆市第二人民医院行健康体检的肝脏功能正常者120例为对照组,检测两组血清HBV-DNA水平与透明质酸及前白蛋白水平,分析其相关性。结果观察组患者的血清前白蛋白水平(125.66±23.45)mg/L,低于对照组的(311.43±28.56)mg/L,差异有统计学意义(t=58.779,P<0.001)。观察组患者的血清HBV-DNA水平与肝纤维化指标透明质酸均高于对照组,差异有统计学意义(P<0.05)。3组不同血清HBV-DNA水平患者的透明质酸浓度对比,差异有统计学意义(P<0.05);且随着患者血清HBV-DNA水平的增高,透明质酸逐渐增高。3组不同血清HBV-DNA水平患者的前白蛋白浓度对比,差异有统计学意义(P<0.05);且随着患者血清HBV-DNA水平的增高,前白蛋白逐渐降低。慢性乙型肝炎患者血清HBV-DNA水平与透明质酸正相关,与前白蛋白呈负相关(P<0.05)。结论慢性乙型肝炎患者血清HBV-DNA水平与透明质酸、前白蛋白存在相关性,有效控制患者血清HBV-DNA水平能延缓肝纤维化的发展。
Objective To investigate the correlation between serum hyaluronic acid and prealbumin levels and HBV-DNAload in patients with chronic hepatitis B. Methods A total of 200 patients with chronic hepatitis B who were admitted to the out-patient clinic and ward of Zhaoqing City Second People's Hospital from April 2015 to May 2016 were selected as observationgroup. 120 patients with normal liver function in our hospital during the same period were used as controls. In the group,serumHBV-DNA levels and hyaluronic acid and prealbumin levels were measured and analyzed for correlation. Results Serum prealbu-min levels(125.66±23.45)mg/L were observed in the observation group,which was lower than that in the control group(311.43±28.56)mg/L. The difference was statistically significant(t=58.779,P<0.001). The serum HBV-DNA level and the liver fibrosis indexhyaluronic acid were higher in the observation group than in the control group,and the difference was statistically significant(P<0.05). The difference of hyaluronic acid concentration between the three groups of patients with different serum HBV-DNA levelswas statistically significant(P<0.05);and with the increase of serum HBV-DNA levels,hyaluronic acid gradually increased. The dif-ference in prealbumin concentration between the three groups of patients with different serum HBV-DNA levels was statisticallysignificant(P<0.05);and with the increase of serum HBV-DNA levels,prealbumin decreased gradually. Serum HBV-DNA levels inpatients with chronic hepatitis B were positively correlated with hyaluronic acid and negatively correlated with prealbumin(P<0.05).Conclusion Serum HBV-DNA levels in patients with chronic hepatitis B have a certain correlation with hyaluronic acid and pre-albumin. Therefore,effective control of serum HBV-DNA levels can delay the development of liver fibrosis.
Objective To investigate the correlation between serum hyaluronic acid and prealbumin levels and HBV-DNAload in patients with chronic hepatitis B. Methods A total of 200 patients with chronic hepatitis B who were admitted to the out-patient clinic and ward of Zhaoqing City Second People's Hospital from April 2015 to May 2016 were selected as observationgroup. 120 patients with normal liver function in our hospital during the same period were used as controls. In the group,serumHBV-DNA levels and hyaluronic acid and prealbumin levels were measured and analyzed for correlation. Results Serum prealbu-min levels(125.66±23.45)mg/L were observed in the observation group,which was lower than that in the control group(311.43±28.56)mg/L. The difference was statistically significant(t=58.779,P<0.001). The serum HBV-DNA level and the liver fibrosis indexhyaluronic acid were higher in the observation group than in the control group,and the difference was statistically significant(P<0.05). The difference of hyaluronic acid concentration between the three groups of patients with different serum HBV-DNA levelswas statistically significant(P<0.05);and with the increase of serum HBV-DNA levels,hyaluronic acid gradually increased. The dif-ference in prealbumin concentration between the three groups of patients with different serum HBV-DNA levels was statisticallysignificant(P<0.05);and with the increase of serum HBV-DNA levels,prealbumin decreased gradually. Serum HBV-DNA levels inpatients with chronic hepatitis B were positively correlated with hyaluronic acid and negatively correlated with prealbumin(P<0.05).Conclusion Serum HBV-DNA levels in patients with chronic hepatitis B have a certain correlation with hyaluronic acid and pre-albumin. Therefore,effective control of serum HBV-DNA levels can delay the development of liver fibrosis.
引文
[1]邓峥,柳枝,黄欣.乙型肝炎病毒基因型检测对诊断感染程度的临床价值研究[J].江西医药,2016,51(7):720-721.
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[9]石之驎,戴炜,曾辉,等.血常规、Child-Pugh分级、肝功能、HBV-DNA在HBe Ag阴性及阳性乙肝肝硬化患者中的对比分析[J].临床和实验医学杂志,2016,15(10):984-986.
[10]王宇,王瑞烈.替比夫定治疗乙型肝炎相关慢加急性肝衰竭患者疗效分析[J].内科,2016,11(4):585-587.
[11]张文峰,张一,何玉麟,等.肝脏体积变化与重型乙型病毒性肝炎预后的关系[J].江西医药,2016,51(9):865-867.
[12]张晓燕,吴博.乙肝患者肝纤维化相关指标与HBV-DNA水平的相关性分析[J].海南医学院学报,2017,23(1):82-84.
[13]慢性乙型肝炎防治指南(2015年版)[J].中华实验和临床感染病杂志(电子版),2015,19(5):1-18.
[14]韩晓颖,陈秀记,闫泽强,等.血清HBsAg与HBV DNA水平与乙肝患者肝纤维化程度的相关性分析[J].国际病毒学杂志,2016,23(1):50-52.
[15]李保君,李凯杰.慢性乙型肝炎患者HBV-DNA水平与肝纤维化相关指标的相关性分析[J].海南医学院学报,2016,22(3):248-249.
[2]张丹,王允野.恩替卡韦治疗失代偿期乙肝肝硬化的疗效观察[J].中国继续医学教育,2016,8(33):191-192.
[3]刘典勋,邹先雄,朱兴,等.断流术对乙型肝炎肝硬化患者血清PDGF、CTGF及肝纤四项的影响[J].医学综述,2016,22(6):1237-1239.
[4]邱自辉,邓勇,邱艳,等.脾脏增大的慢性乙型肝炎病毒携带者肝组织病理学特点研究[J].江西医药,2016,51(2):131-133.
[5]陈柯颖,吴健林,张芬芬,等.替比夫定治疗HBe Ag阳性慢性乙型肝炎患者HBe Ag血清学转换的预测因素分析[J].广西医科大学学报,2017,34(12):1741-1743.
[6]陈安凤,谈勇,袁林杰,等.肝病退黄汤直肠滴入治疗慢性乙型病毒性肝炎高胆红素血症的临床疗效观察[J].中药药理与临床,2016,32(6):214-217.
[7]刘志莹,郑卫民,彭晓杰,等.肝细胞生长因子在乙型肝炎病毒相关肾炎患儿肾组织的表达情况[J].江西医药,2017,52(1):30-33.
[8]谷少杰,孟菁菁,张琳,等.血清前白蛋白、总胆汁酸、a-L-岩藻糖苷酶及自身抗体联合检测在乙型病毒性肝炎中的应用[J].中外女性健康研究,2016,9(13):93-94.
[9]石之驎,戴炜,曾辉,等.血常规、Child-Pugh分级、肝功能、HBV-DNA在HBe Ag阴性及阳性乙肝肝硬化患者中的对比分析[J].临床和实验医学杂志,2016,15(10):984-986.
[10]王宇,王瑞烈.替比夫定治疗乙型肝炎相关慢加急性肝衰竭患者疗效分析[J].内科,2016,11(4):585-587.
[11]张文峰,张一,何玉麟,等.肝脏体积变化与重型乙型病毒性肝炎预后的关系[J].江西医药,2016,51(9):865-867.
[12]张晓燕,吴博.乙肝患者肝纤维化相关指标与HBV-DNA水平的相关性分析[J].海南医学院学报,2017,23(1):82-84.
[13]慢性乙型肝炎防治指南(2015年版)[J].中华实验和临床感染病杂志(电子版),2015,19(5):1-18.
[14]韩晓颖,陈秀记,闫泽强,等.血清HBsAg与HBV DNA水平与乙肝患者肝纤维化程度的相关性分析[J].国际病毒学杂志,2016,23(1):50-52.
[15]李保君,李凯杰.慢性乙型肝炎患者HBV-DNA水平与肝纤维化相关指标的相关性分析[J].海南医学院学报,2016,22(3):248-249.