乌梅丸加减联合穴位贴敷治疗寒热错杂型慢性腹泻的临床观察
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摘要
目的:观察乌梅丸加减联合穴位贴敷治疗寒热错杂型慢性腹泻的临床疗效。方法:纳入寒热错杂型慢性腹泻患者80例,随机分为对照组和观察组,每组各40例。对照组患者给予蒙脱石散口服治疗,观察组患者给予乌梅丸加减联合穴位贴敷治疗,疗程均为6周。比较两组患者的临床疗效和每日大便次数;采用SF-36量表评价患者的生活质量。结果:①治疗后,观察组患者的临床总有效率为95.0%,对照组的临床总有效率为75.0%,观察组的疗效优于对照组(P<0.05)。②治疗后,两组患者的每日大便次数均较治疗前减少(P<0.05),且观察组患者的每日大便次数少于对照组(P<0.05)。③治疗后,两组患者的SF-36量表躯体健康、总体健康、活力、社会功能、情绪角色、心理健康6个维度的评分均较治疗前升高(P<0.05),且观察组患者的躯体健康、活力、心理健康3个维度的评分高于对照组(P<0.05)。结论:乌梅丸加减联合穴位贴敷可明显改善寒热错杂型慢性腹泻患者的临床症状,提高其生活质量。
Objective: To observe the clinical efficacy of modified Wumei Pill combined with acupoint application in treating chronic diarrhea with syndrome of intermingled heat and cold. Methods: Eighty patients of chronic diarrhea with syndrome of intermingled heat and cold were included and randomly divided into the control group and observation group, 40 cases in each group. The patients in the control group were orally treated with montmorillonite powder, and the patients in the observation group were treated with modified Wumei Pill combined with acupoint application, with a course of 6 weeks. The clinical efficacy and the times of daily defecation were compared between the two groups. The quality of life was evaluated by SF-36 scale. Results: ①After treatment, the total effective rates of the observation group and the control group were 95.0% and 75.0% respectively, and the efficacy of the observation group was better than that of the control group(P<0.05). ②After treatment, the times of daily defecation in both groups were reduced compared with before treatment(P<0.05), and the times of daily defecation in the observation group were less than those in the control group(P<0.05). ③After treatment, the scores of six dimensions including physical health, general health, vitality, social function, emotional role and mental health in SF-36 scale were increased in both groups compared with before treatment(P<0.05), and the scores of three dimensions including physical health, vitality and mental health in the observation group were higher than those in the control group(P<0.05). Conclusion: Modified Wumei Pill combined with acupoint application can significantly improve the clinical symptoms in patients of chronic diarrhea with syndrome of intermingled heat and cold, and enhance the quality of life.
Objective: To observe the clinical efficacy of modified Wumei Pill combined with acupoint application in treating chronic diarrhea with syndrome of intermingled heat and cold. Methods: Eighty patients of chronic diarrhea with syndrome of intermingled heat and cold were included and randomly divided into the control group and observation group, 40 cases in each group. The patients in the control group were orally treated with montmorillonite powder, and the patients in the observation group were treated with modified Wumei Pill combined with acupoint application, with a course of 6 weeks. The clinical efficacy and the times of daily defecation were compared between the two groups. The quality of life was evaluated by SF-36 scale. Results: ①After treatment, the total effective rates of the observation group and the control group were 95.0% and 75.0% respectively, and the efficacy of the observation group was better than that of the control group(P<0.05). ②After treatment, the times of daily defecation in both groups were reduced compared with before treatment(P<0.05), and the times of daily defecation in the observation group were less than those in the control group(P<0.05). ③After treatment, the scores of six dimensions including physical health, general health, vitality, social function, emotional role and mental health in SF-36 scale were increased in both groups compared with before treatment(P<0.05), and the scores of three dimensions including physical health, vitality and mental health in the observation group were higher than those in the control group(P<0.05). Conclusion: Modified Wumei Pill combined with acupoint application can significantly improve the clinical symptoms in patients of chronic diarrhea with syndrome of intermingled heat and cold, and enhance the quality of life.
引文
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[10] 弓树德,施义.国医大师周仲瑛运用乌梅丸治疗食管癌化疗所致寒热错杂型腹泻经验浅析[J].浙江中医药大学学报,2018,42(4):287- 289.
[11] 王红霞,周正华.穴位贴敷在消化系统疾病中应用研究进展[J].内蒙古中医药,2018,37(8):111- 114.
[12] 张莎,王文,李哲,等.穴位敷贴治疗腹泻型肠易激综合征的系统评价[J].湖南中医药大学学报,2017,37(9):1002- 1007.
[13] 齐永.脐针疗法、脐全息与脐诊法[J].中国针灸,2004,24(10):732- 737.
[14] MENA BARES L M,CARMONA ASENJO E,GARCíA SáNCHEZ M V,et al.75SeHCAT scan in bile acid malabsorption in chronic diarrhoea[J].Rev Esp Med Nucl Imagen Mol,2017,36(1):37- 47.
[15] 李春波,何燕玲.健康状况调查问卷SF- 36的介绍[J].国外医学(精神病学分册),2002,29(2):116- 119.
[16] 王素华,李立明,李俊.SF- 36健康调查量表的应用[J].国外医学(社会医学分册),2001,18(1):4- 8.
[17] 任晓晖,刘朝杰,李宁秀,等.用SF- 36量表评价慢性病患者的生命质量[J].华西医科大学学报,2001,32(2):250- 253.
[2] 苏炳伟,苏建军.慢性腹泻的中西医治疗临床疗效比较[J].内蒙古中医药,2012,31(2):33- 34.
[3] THOMAS P D,FORBES A,GREEN J,et al.Guidelines for the investigation of chronic diarrhoea,2nd edition[J].Gut,2003,52 (Suppl 5):v1- v15.
[4] 陈湘君.中医内科学[M].上海:上海科学技术出版社,2004:176- 181.
[5] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:139- 143.
[6] 公方雪.刘喜明老师乌梅丸临床应用心法[J].世界中医药,2016,11(9):1814- 1816.
[7] 高振坤,王兰.乌梅丸的现代研究及其剂型改革的思路与探讨[J].陕西中医,2006,27(7):865- 866.
[8] 冯慧茹.乌梅丸治疗寒热错杂型慢性腹泻效果观察[J].双足与保健,2018(18):185- 186.
[9] 周辉霞,熊湘平,张璟宏.乌梅丸治疗慢性腹泻的临床疗效观察[J].中国民间疗法,2017,25(3):50- 51.
[10] 弓树德,施义.国医大师周仲瑛运用乌梅丸治疗食管癌化疗所致寒热错杂型腹泻经验浅析[J].浙江中医药大学学报,2018,42(4):287- 289.
[11] 王红霞,周正华.穴位贴敷在消化系统疾病中应用研究进展[J].内蒙古中医药,2018,37(8):111- 114.
[12] 张莎,王文,李哲,等.穴位敷贴治疗腹泻型肠易激综合征的系统评价[J].湖南中医药大学学报,2017,37(9):1002- 1007.
[13] 齐永.脐针疗法、脐全息与脐诊法[J].中国针灸,2004,24(10):732- 737.
[14] MENA BARES L M,CARMONA ASENJO E,GARCíA SáNCHEZ M V,et al.75SeHCAT scan in bile acid malabsorption in chronic diarrhoea[J].Rev Esp Med Nucl Imagen Mol,2017,36(1):37- 47.
[15] 李春波,何燕玲.健康状况调查问卷SF- 36的介绍[J].国外医学(精神病学分册),2002,29(2):116- 119.
[16] 王素华,李立明,李俊.SF- 36健康调查量表的应用[J].国外医学(社会医学分册),2001,18(1):4- 8.
[17] 任晓晖,刘朝杰,李宁秀,等.用SF- 36量表评价慢性病患者的生命质量[J].华西医科大学学报,2001,32(2):250- 253.