广泛型侵袭性牙周炎患者非手术治疗的远期临床疗效和血液指标的变化
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摘要
目的:探讨非手术治疗对广泛型侵袭性牙周炎患者的远期临床疗效和血液指标的影响。方法:选取2010年1月至2015年4月于本院口腔科就诊的32例广泛型侵袭性牙周炎患者为研究对象,所有病例均符合1999年牙周病分类研讨会所制定相关诊断标准,根据是否进行牙周维护治疗,分为定期维护组和不定期维护组。观察两组治疗效果。结果:治疗后定期维护组患者的探诊深度、附着丧失、出血指数低于治疗前(P<0. 05),同时治疗后患者的牙齿松动度低于治疗前(P<0. 05)。治疗后患者的白细胞计数、中性粒细胞计数及中性粒细胞百分比均低于治疗前(P<0. 05),淋巴细胞计数与治疗前比较无统计学差异(P>0. 05),淋巴细胞百分比高于治疗前(P<0. 05)。经治疗患者血清总蛋白水平低于治疗前(P<0. 05);治疗后患者血清白蛋白、A/G值高于治疗前,球蛋白低于治疗前(P<0. 05)。不定期维护组的牙周指标治疗后与治疗前比较,无统计学意义(P>0. 05),血生化指标及血细胞指标与治疗前比较,无统计学意义(P>0. 05)。两组血生化指标及血细胞指标比较,差异有统计学意义(P<0. 05)。结论:积极的牙周非手术治疗可显著改善广泛型侵袭性牙周炎患者的血细胞计数及生化指标,抑制炎症反应,增强机体免疫力,有利于治疗效果的维护与提高。
Objective: To study the long-term clinical effect of non-surgical treatment in generalized aggressive periodontitis(GAgP) patients and their blood index changes.Methods: Thirty - two GAgP patients treated from January 2010 to April 2015 in our stomatology department were selected. Accord-ing to the periodontal maintenance therapy, the patients were divided into regular treatment group and irregular treatment group. The effect of two groups was observed.Results: After treatment, PD,AL, and bleeding index of the regular treatment group decreased(P<0. 05); the incidence of gomphia-sis decreased(P<0. 05); the white blood cell count, neutrophil count, and neutrophilic granulocyte percentage decreased too(P<0. 05); the lymphocyte count showed no significant change(P>0. 05),but the percentage of lymphocyte increased(P<0. 05); the serum biochemical indicators such as total protein and globulin decreased(P<0. 05), while serum albumin level and A/G ratio increased(P<0. 05); the periodontal index of irregular treatment group reduced(P<0. 05). In irregular treament group, no significant changes were found(all P>0. 05).Conclusion: For GAgP patients, the active non-surgical treatment can greatly improve the blood cell count and biochemical indexex, control the inflammatory response, improve the immunity and be good for the maintenance and improvement of treatment effect.
Objective: To study the long-term clinical effect of non-surgical treatment in generalized aggressive periodontitis(GAgP) patients and their blood index changes.Methods: Thirty - two GAgP patients treated from January 2010 to April 2015 in our stomatology department were selected. Accord-ing to the periodontal maintenance therapy, the patients were divided into regular treatment group and irregular treatment group. The effect of two groups was observed.Results: After treatment, PD,AL, and bleeding index of the regular treatment group decreased(P<0. 05); the incidence of gomphia-sis decreased(P<0. 05); the white blood cell count, neutrophil count, and neutrophilic granulocyte percentage decreased too(P<0. 05); the lymphocyte count showed no significant change(P>0. 05),but the percentage of lymphocyte increased(P<0. 05); the serum biochemical indicators such as total protein and globulin decreased(P<0. 05), while serum albumin level and A/G ratio increased(P<0. 05); the periodontal index of irregular treatment group reduced(P<0. 05). In irregular treament group, no significant changes were found(all P>0. 05).Conclusion: For GAgP patients, the active non-surgical treatment can greatly improve the blood cell count and biochemical indexex, control the inflammatory response, improve the immunity and be good for the maintenance and improvement of treatment effect.
引文
[1]张连志.非手术方法治疗侵袭性牙周炎临床疗效研究[J].中国继续医学教育,2015,7(7):43-44.Zhang LZ. To explore the effect of nonsurgical treat-ment foe aggressire periodontitis[J]. China Continuing Medical Education, 2015,7(7):43-44.
[2]洪青梅.广泛型侵袭性牙周炎非手术治疗的疗效及对血液指标的影响[J].赣南医学院学报,2015,35(1):59-62.Hong QM. Curative effect of non-operative treatment ingeneralized aggressive periodontitis and its effects on blood indexes[J]. Journal of Gannan Medical Universi-ty,2015,35(1):59-62.
[3]陈慧芝,陈惠敏,周折冲,等.侵袭性牙周炎患者非手术治疗的临床疗效和血液指标的远期观察[J].中国处方药,2015,13(1):83-84.Chen HZ,Chen HM, Zhou ZC,et al. Long-term obser-vation of clinical efficacy and blood parameters in pa-tients with invasive periodontitis treated with non-surgi-cal treatment[J]. Journal of China Prescription Drug,2015,13(1):83-84.
[4]路瑞芳,冯向辉,徐莉,等.侵袭性牙周炎在非手术治疗后不同治疗反应位点的临床和可疑致病微生物特性[J].北京大学学报:医学版,2015,47(1):13-18.Lu RF,Feng XH,Xu L,et al. Clinical and putative peri-odontal pathogens,features of different sites with prob-ing depth reduction after non-surgical periodontal treat-ment in patients with aggressive periodontitis[J]. Jour-nal of Peking University:Health Scinces, 2015, 47(1):13-18.
[5]肖艳,谭小兵,徐静舒.米诺环素辅助治疗侵袭性牙周炎对血清炎性因子的影响[J].重庆医学,2015,44(9):1208-1 210.Xiao Y,Tan XB,Xu JS. Effect of serum inflammatory cytokine by adjuvant minocycline ointment in the treat-ment of aggressive periodontitis[J]. Chongqing Medi-cine, 2015,44(9):1 208-1 210.
[6]梁洁,吕达,方珍,等.牙周非手术治疗对侵袭性牙周炎疾病风险等级的干预[J].中华口腔医学研究杂志:电子版,2013,7(6):498-500.Liang J,Lv D,Fang Z,et al. Non-surgical periodontal treatment decreases the risk level of patients with ag-gressive periodontitis[J]. Chin J Stomatol Res:Elec-tronic Edition, 2013,7(6):498-500.
[7]周金敏,李永凯,向学熔. Nd:YAG水激光在广泛型侵袭性牙周炎非手术治疗的应用[J].激光杂志,2013,34(5):68-69.Zhou JM, Li YK, Xiang XR. Effect of a water-cooled Nd:YAG laser in the non-surgical treatment of general-ized aggresive periodontitis[J]. Laser Journal, 2013,34(5):68-69.
[8]张浙丹.侵袭性牙周炎基础治疗前后全身炎症标志物的变化[J].实用口腔医学杂志,2013,29(5):710-713.Zhang ZD. The changes of systemic inflammation markers after basic periodontal therapy in patients with aggressiveperiodontitis[J]. J Pract Stomatol,2013,29(5):710-713.
[9]康岐山.非手术方法治疗侵袭性牙周炎临床疗效观察[J].贵阳中医学院学报,2013,35(3):90-91.Kang QS. Clinical observation of non-surgical treat-ment of invasive periodontitis[J]. J Guiyang Coll Tradit Chin Med, 2013,35(3):90-91.
[10]徐琛蓉,张雄,江丽.非手术方法治疗侵袭性牙周炎临床疗效观察[J].广东牙病防治,2010,18(2):59-63.Xu CR,Zhang X,Jiang L. Clinical Observation of non-surgical periodontal therapyon patients with generalized aggressive periodontitis[J]. Journal of Dental Preven-tion and Treatment, 2010,18(2):59-63.
[11]江川.局限性侵袭性牙周炎患者早期全身应用抗生素的临床意义[J].陕西医学杂志,2014,43(6):679-680.Jiang C. Benfits of early systemic antibiotics in local-ized aggressive periodontitis[J]. Shaanxi Medical Jour-nal, 2014,43(6):679-680.
[2]洪青梅.广泛型侵袭性牙周炎非手术治疗的疗效及对血液指标的影响[J].赣南医学院学报,2015,35(1):59-62.Hong QM. Curative effect of non-operative treatment ingeneralized aggressive periodontitis and its effects on blood indexes[J]. Journal of Gannan Medical Universi-ty,2015,35(1):59-62.
[3]陈慧芝,陈惠敏,周折冲,等.侵袭性牙周炎患者非手术治疗的临床疗效和血液指标的远期观察[J].中国处方药,2015,13(1):83-84.Chen HZ,Chen HM, Zhou ZC,et al. Long-term obser-vation of clinical efficacy and blood parameters in pa-tients with invasive periodontitis treated with non-surgi-cal treatment[J]. Journal of China Prescription Drug,2015,13(1):83-84.
[4]路瑞芳,冯向辉,徐莉,等.侵袭性牙周炎在非手术治疗后不同治疗反应位点的临床和可疑致病微生物特性[J].北京大学学报:医学版,2015,47(1):13-18.Lu RF,Feng XH,Xu L,et al. Clinical and putative peri-odontal pathogens,features of different sites with prob-ing depth reduction after non-surgical periodontal treat-ment in patients with aggressive periodontitis[J]. Jour-nal of Peking University:Health Scinces, 2015, 47(1):13-18.
[5]肖艳,谭小兵,徐静舒.米诺环素辅助治疗侵袭性牙周炎对血清炎性因子的影响[J].重庆医学,2015,44(9):1208-1 210.Xiao Y,Tan XB,Xu JS. Effect of serum inflammatory cytokine by adjuvant minocycline ointment in the treat-ment of aggressive periodontitis[J]. Chongqing Medi-cine, 2015,44(9):1 208-1 210.
[6]梁洁,吕达,方珍,等.牙周非手术治疗对侵袭性牙周炎疾病风险等级的干预[J].中华口腔医学研究杂志:电子版,2013,7(6):498-500.Liang J,Lv D,Fang Z,et al. Non-surgical periodontal treatment decreases the risk level of patients with ag-gressive periodontitis[J]. Chin J Stomatol Res:Elec-tronic Edition, 2013,7(6):498-500.
[7]周金敏,李永凯,向学熔. Nd:YAG水激光在广泛型侵袭性牙周炎非手术治疗的应用[J].激光杂志,2013,34(5):68-69.Zhou JM, Li YK, Xiang XR. Effect of a water-cooled Nd:YAG laser in the non-surgical treatment of general-ized aggresive periodontitis[J]. Laser Journal, 2013,34(5):68-69.
[8]张浙丹.侵袭性牙周炎基础治疗前后全身炎症标志物的变化[J].实用口腔医学杂志,2013,29(5):710-713.Zhang ZD. The changes of systemic inflammation markers after basic periodontal therapy in patients with aggressiveperiodontitis[J]. J Pract Stomatol,2013,29(5):710-713.
[9]康岐山.非手术方法治疗侵袭性牙周炎临床疗效观察[J].贵阳中医学院学报,2013,35(3):90-91.Kang QS. Clinical observation of non-surgical treat-ment of invasive periodontitis[J]. J Guiyang Coll Tradit Chin Med, 2013,35(3):90-91.
[10]徐琛蓉,张雄,江丽.非手术方法治疗侵袭性牙周炎临床疗效观察[J].广东牙病防治,2010,18(2):59-63.Xu CR,Zhang X,Jiang L. Clinical Observation of non-surgical periodontal therapyon patients with generalized aggressive periodontitis[J]. Journal of Dental Preven-tion and Treatment, 2010,18(2):59-63.
[11]江川.局限性侵袭性牙周炎患者早期全身应用抗生素的临床意义[J].陕西医学杂志,2014,43(6):679-680.Jiang C. Benfits of early systemic antibiotics in local-ized aggressive periodontitis[J]. Shaanxi Medical Jour-nal, 2014,43(6):679-680.
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