醒脑静联合盐酸法舒地尔在高血压脑出血术后的效果分析
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摘要
目的探究醒脑静联合盐酸法舒地尔在高血压脑出血术后的效果。方法选取2017年4月至2018年6月在本院接受治疗的高血压脑出血患者74例,采用随机数字表法将其分为观察组和对照组,每组37例患者,对照组患者在常规治疗的基础上采用醒脑静注射液进行静脉滴注治疗,观察组在对照组的基础上采用醒脑静注射液联合盐酸法舒地尔注射液静脉滴注治疗,对比两组患者术后并发症的发生率、病死率、治疗效果和生活质量。结果观察组的并发症发生率为2.7%,对照组为21.6%,观察组显著低于对照组(P<0.05),观察组的病死率为2.7%,对照组为24.3%,观察组明显低于对照组(P<0.05),观察组患者的治疗有效率为97.3%,对照组为72.9%,观察组显著高于对照组,两组差异具有统计学意义(P<0.05)。观察组的生活质量总评分为(89.1±16.5)分,对照组(71.7±12.5)分,观察组显著高于对照组,两组差异具有统计学意义(P<0.05)。结论醒脑静联合盐酸法舒地尔在高血压脑出血术后的效果显著,可以降低其手术并发症的发生率,降低患者病死率,提高治疗的有效率,改善患者的生活质量,整体提升治疗效果,建议临床上进一步推广。
Objective To investigate the effect of Xingnaojing combined with fasudil hydrochloride on postoperative hypertensive intracerebral hemorrhage. Methods From April 2017 to June 2018, 74 patients with hypertensive intracerebral hemorrhage who were treated in our hospital were divided into observation group(n=37) and control group(n=37). Patients in the control group were treated by intravenous drip with Xingnaojing injection on the basis of routine treatment, while those in the observation group were treated with xingnaojing injection combined with fasudil hydrochloride intravenous drip on the basis of the control group. The incidence, mortality, therapeutic effect and quality of life were compared between the two groups. The incidence of complications in the observation group was 2.7% and that in the control group was 21.6%. It was significantly lower in the observation group than in the control group(P<0.05). The mortality was 2.7% in the observation group and 24.3% in the control group. The effective rate of treatment was 97.3% in the observation group and 72.9% in the control group, which was significantly higher in the observation group than in the control group(P<0.05). The difference between the two groups was statistically significant(P<0.05). The total score of quality of life was(89.1±16.5) in the observation group and(71.7±12.5) in the control group, which was significantly higher in the observation group than in the control group. The difference between the two groups was statistically significant(P<0.05). Conclusion Xingnaojing combined with fasudil hydrochloride has a significant effect on postoperative hypertensive intracerebral hemorrhage. It can reduce the incidence of operative complications, reduce the mortality of patients, improve the effective rate of treatment and improve the quality of life of the patients. It is suggested that the treatment should be further popularized clinically.
Objective To investigate the effect of Xingnaojing combined with fasudil hydrochloride on postoperative hypertensive intracerebral hemorrhage. Methods From April 2017 to June 2018, 74 patients with hypertensive intracerebral hemorrhage who were treated in our hospital were divided into observation group(n=37) and control group(n=37). Patients in the control group were treated by intravenous drip with Xingnaojing injection on the basis of routine treatment, while those in the observation group were treated with xingnaojing injection combined with fasudil hydrochloride intravenous drip on the basis of the control group. The incidence, mortality, therapeutic effect and quality of life were compared between the two groups. The incidence of complications in the observation group was 2.7% and that in the control group was 21.6%. It was significantly lower in the observation group than in the control group(P<0.05). The mortality was 2.7% in the observation group and 24.3% in the control group. The effective rate of treatment was 97.3% in the observation group and 72.9% in the control group, which was significantly higher in the observation group than in the control group(P<0.05). The difference between the two groups was statistically significant(P<0.05). The total score of quality of life was(89.1±16.5) in the observation group and(71.7±12.5) in the control group, which was significantly higher in the observation group than in the control group. The difference between the two groups was statistically significant(P<0.05). Conclusion Xingnaojing combined with fasudil hydrochloride has a significant effect on postoperative hypertensive intracerebral hemorrhage. It can reduce the incidence of operative complications, reduce the mortality of patients, improve the effective rate of treatment and improve the quality of life of the patients. It is suggested that the treatment should be further popularized clinically.
引文
[1]余波,史楠,崔建忠,等.醒脑静联合盐酸法舒地尔在高血压脑出血术后的疗效观察[J].中国医院药学杂志,2014,34(18):1589-1592.
[2]杨平石.盐酸法舒地尔对高血压脑出血血肿周围组织血流量的影响[J].南昌大学学报(医学版),2017,57(1):66-68.
[3]张松坡,高玉松,胡承啸,等.醒脑静注射液联合穿刺碎吸术治疗高血压脑出血的疗效观察[J].中国实用神经疾病杂志,2016,19(13):121-122.
[4]刘红栓,田立学,孙卫东.醒脑静联合盐酸钠美芬治疗急性高血压脑出血的早期疗效观察[J].中国民间疗法,2014,22(10):77-78.
[5]张振芳,窦荣花,黄静,等.醒脑静联合法舒地尔治疗后循环缺血性眩晕的临床观察[J].临床医药实践,2017,26(2):91-93.
[6]双跃华,毛振立,于林.醒脑静注射液在高血压脑出血患者微创血肿清除术后康复中的应用效果观察[J].山东医药,2017,57(12):93-95.
[7]夏志强,杜彦挺,杜光勇,等.穿刺碎吸术后辅以醒脑静注射液治疗高血压脑出血的疗效观察[J].医学临床研究,2016,33(10):2051-2053.
[8]李永峰,李伟.微创血肿清除术联合醒脑静治疗对高血压脑出血患者神经功能损伤及细胞因子含量的影响[J].海南医学院学报,2017,23(6):827-830.
[9]钟波,刘艳红,田烜.立体定向血肿穿刺抽吸术联合醒脑静注射液治疗高血压脑出血的临床研究[J].中国现代医学杂志,2015,25(4):60-63.
[10]姚书燕,刘海花,韩文颖,等.肌氨肽苷联合不同剂量醒脑静对高血压脑出血的疗效及对神经功能缺损的改善效果[J].中国实用神经疾病杂志,2016,19(13):51-53.
[2]杨平石.盐酸法舒地尔对高血压脑出血血肿周围组织血流量的影响[J].南昌大学学报(医学版),2017,57(1):66-68.
[3]张松坡,高玉松,胡承啸,等.醒脑静注射液联合穿刺碎吸术治疗高血压脑出血的疗效观察[J].中国实用神经疾病杂志,2016,19(13):121-122.
[4]刘红栓,田立学,孙卫东.醒脑静联合盐酸钠美芬治疗急性高血压脑出血的早期疗效观察[J].中国民间疗法,2014,22(10):77-78.
[5]张振芳,窦荣花,黄静,等.醒脑静联合法舒地尔治疗后循环缺血性眩晕的临床观察[J].临床医药实践,2017,26(2):91-93.
[6]双跃华,毛振立,于林.醒脑静注射液在高血压脑出血患者微创血肿清除术后康复中的应用效果观察[J].山东医药,2017,57(12):93-95.
[7]夏志强,杜彦挺,杜光勇,等.穿刺碎吸术后辅以醒脑静注射液治疗高血压脑出血的疗效观察[J].医学临床研究,2016,33(10):2051-2053.
[8]李永峰,李伟.微创血肿清除术联合醒脑静治疗对高血压脑出血患者神经功能损伤及细胞因子含量的影响[J].海南医学院学报,2017,23(6):827-830.
[9]钟波,刘艳红,田烜.立体定向血肿穿刺抽吸术联合醒脑静注射液治疗高血压脑出血的临床研究[J].中国现代医学杂志,2015,25(4):60-63.
[10]姚书燕,刘海花,韩文颖,等.肌氨肽苷联合不同剂量醒脑静对高血压脑出血的疗效及对神经功能缺损的改善效果[J].中国实用神经疾病杂志,2016,19(13):51-53.