脑脊液促进间充质干细胞神经元样分化的特点
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摘要
背景:目前研究表明对内源神经干细胞进行调控,或进行外源神经干细胞移植,是治疗痴呆等神经系统疾病最新和最有希望的方法。其中外源其他组织来源干细胞向神经干细胞定向分化的成功,为神经干细胞的来源增加了新途径。近年研究表明脑脊液既可营养神经细胞,又可成为一种有效、适宜的诱导剂,为神经干细胞的获得增加新的途径。目的:文章将对国内外脑脊液对干细胞影响的相关研究进行综述,以期为将来神经干细胞临床应用提供帮助。方法:以"Cerebrospinal fluid,Stem cells,Induced differentiation,Neural stem cells,Stem cell transplantation therapy"为英文关键词,通过计算机检索PubMed数据库与Embase数据库;以"脑脊液、干细胞、诱导分化、增殖、分化、神经干细胞、间充质干细胞、胚胎干细胞、银杏叶提取物、干细胞移植治疗、神经变性疾病"为中文关键词,计算机检索CNKI数据库,万方数据库,维普数据库等科技期刊数据库;检索时间为1998-12-10至2018-12-10。对脑脊液对间充质干细胞、胚胎干细胞及神经干细胞等的影响进行总结分析,为将来神经干细胞临床应用提供帮助。结果与结论:①"脑脊液-干细胞"相互作用是治疗神经系统疾病的希望;②脑脊液也能促进间充质干细胞分化成为神经元样细胞;③脑脊液能诱导人胚胎源干细胞分化为神经样细胞,但所得不同类型细胞的比例不同;④脑脊液能诱导内源性神经干细胞的增殖分化。
BACKGROUND: Current research indicates that regulation of endogenous neural stem cells or transplantation of exogenous neural stem cells is the latest and most promising method for the treatment of neurological diseases such as dementia. The success of the differentiation of stem cells from other sources into neural stem cells has provided a new way for the source of neural stem cells. Recent studies have shown that cerebrospinal fluid cannot only nourish nerve cells, but also become an effective and suitable inducer to add new ways for the acquisition of neural stem cells. OBJECTIVE: To review the effects of cerebrospinal fluid on stem cells at home and abroad, in order to provide assistance for the clinical application of neural stem cells in the future. METHODS: "Cerebrospinal fluid, stem cells, induced differentiation, neural stem cells, stem cell transplantation therapy" were used as English keywords to search the PubMed database and the Embase database by computer. "Cerebrospinal fluid, stem cells, induced differentiation, proliferation, differentiation, neural stem cells, mesenchymal stem cells, embryonic stem cells, ginkgo biloba extract, stem cell transplantation therapy, neurodegenerative diseases" were used as Chinese keywords to search CNKI database, WanFang database, VIP database and other scientific journal databases. The search time was from December 10~(th), 1998 to December 10~(th), 2018. The effects of cerebrospinal fluid on mesenchymal stem cells, embryonic stem cells, and neural stem cells were summarized and analyzed, providing assistance for the clinical use of neural stem cells in the future. RESULTS AND CONCLUSION:(1) Interaction of cerebrospinal fluid and stem cells is the hope of treating nervous system diseases.(2) Cerebrospinal fluid can promote the differentiation of mesenchymal stem cells into neuron-like cells.(3) Cerebrospinal fluid can induce human embryonic stem cells to differentiate into neuron-like cells, but the proportion of different types of cells obtained is different.(4) Cerebrospinal fluid can induce the proliferation and differentiation of endogenous neural stem cells.
BACKGROUND: Current research indicates that regulation of endogenous neural stem cells or transplantation of exogenous neural stem cells is the latest and most promising method for the treatment of neurological diseases such as dementia. The success of the differentiation of stem cells from other sources into neural stem cells has provided a new way for the source of neural stem cells. Recent studies have shown that cerebrospinal fluid cannot only nourish nerve cells, but also become an effective and suitable inducer to add new ways for the acquisition of neural stem cells. OBJECTIVE: To review the effects of cerebrospinal fluid on stem cells at home and abroad, in order to provide assistance for the clinical application of neural stem cells in the future. METHODS: "Cerebrospinal fluid, stem cells, induced differentiation, neural stem cells, stem cell transplantation therapy" were used as English keywords to search the PubMed database and the Embase database by computer. "Cerebrospinal fluid, stem cells, induced differentiation, proliferation, differentiation, neural stem cells, mesenchymal stem cells, embryonic stem cells, ginkgo biloba extract, stem cell transplantation therapy, neurodegenerative diseases" were used as Chinese keywords to search CNKI database, WanFang database, VIP database and other scientific journal databases. The search time was from December 10~(th), 1998 to December 10~(th), 2018. The effects of cerebrospinal fluid on mesenchymal stem cells, embryonic stem cells, and neural stem cells were summarized and analyzed, providing assistance for the clinical use of neural stem cells in the future. RESULTS AND CONCLUSION:(1) Interaction of cerebrospinal fluid and stem cells is the hope of treating nervous system diseases.(2) Cerebrospinal fluid can promote the differentiation of mesenchymal stem cells into neuron-like cells.(3) Cerebrospinal fluid can induce human embryonic stem cells to differentiate into neuron-like cells, but the proportion of different types of cells obtained is different.(4) Cerebrospinal fluid can induce the proliferation and differentiation of endogenous neural stem cells.
引文
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[23]Ye Y,Zeng YM,Wan MR,et al.Induction of human bone marrow mesenchymal stem cells differentiation into neural-like cells using cerebrospinal fluid.Cell Biochem Biophys.2011;59(3):179-184.
[24]Ren C,Liu X,Wan M,et al.A comparative study on inducing non-homologous mesenchymal stem cells to differentiate into neural stem cells using non-homologous cerebrospinal fluid.JBiomed Eng.2013;30(6):1290-1297
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[27]Farivar S,Mohamadzade Z,Shiari R,et al.Neural differentiation of human umbilical cord mesenchymal stem cells by cerebrospinal fluid.Iran J Child Neurol.2015;9(1):87-93.
[28]沈忆新,王鹏,石恩东.脑脊液体外培养骨髓间充质干细胞[J].中国组织工程研究,2011,15(36):6802-6806.
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[30]Glage S,Klinge PM,Miller MC,et al.Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid following cell-based delivery into the cerebral ventricles of cats.Fluids Barriers CNS.2011;8(1):1-7.
[31]杨海云,顾锐,王文军,等.移植骨髓间充质干细胞后的脑脊液促进神经干细胞的分化[J].中国实验诊断学,2009,13(3):300-302.
[32]Wu S,Suzuki Y,Ejiri Y,et al.Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord.J Neurosci Res.2003;72(3):343-351.
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