止带方治疗湿热体质型复发性外阴阴道假丝酵母菌病的有效性研究
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摘要
目的:研究止带方治疗湿热体质型复发性外阴阴道假丝酵母菌病(RVVC)的有效性。方法:选取2016年7月-2018年7月本院收治的湿热体质型RVVC患者120例。按先后序列号(1～120)随机分为治疗组(止带方+保妇康栓+补中益气汤)和对照组(氟康唑+克霉唑栓),各60例。比较两组疗效、复发情况及治疗前后的体质分数。结果:两组总有效率比较,差异无统计学意义(P>0.05);治疗后1、3、6个月,治疗组的复发率分别为0、3.3%、13.3%,均低于对照组的8.3%、20.0%、28.3%,差异均有统计学意义(P<0.05);治疗后,治疗组体质分数均低于治疗前及对照组,差异均有统计学意义(P<0.05)。结论:止带方+保妇康栓+补中益气汤治疗湿热体质型RVVC的效果较好,且复发率较低,可改善患者的体质分数,值得推广。
Objective:To study the efficacy of Zhidai Decoction in treatment of recurrent vulvovaginal candidiasis(RVVC)with damp-heat constitution.Method:120 cases of RVVC with damp-heat constitution from July 2016 to July 2018 in our hospital were selected.According to the serial number(1-120),they were randomly divided into treatment group(Zhidai Decoction+Baofukang Suppository+Buzhong Yiqi Decoction)and control group(Fluconazol+Clotrimazole Suppositories),60 cases in each group.The curative effect,recurrence and body mass score before and after treatment between two groups were compared.Result:The total effective rate of two groups was compared,the difference was not statistically significant(P>0.05).After treatment 1,3 and 6 months,the recurrence rates of treatment group were 0,3.3% and 13.3% respectively,which were lower than 8.3%,20.0%,28.3% of control group,the differences were statistically significant(P<0.05).After treatment,the body mass score of treatment group were lower than those of control group and before treatment,the differences were statistically significant(P<0.05).Conclusion:The effect of Zhidai Decoction+Baofukang Suppository+Buzhong Yiqi Decoction in treatment of RVVC with damp-heat constitution is better and the recurrence rate is lower,it can improve the body mass fraction of patients and is worth popularizing.
Objective:To study the efficacy of Zhidai Decoction in treatment of recurrent vulvovaginal candidiasis(RVVC)with damp-heat constitution.Method:120 cases of RVVC with damp-heat constitution from July 2016 to July 2018 in our hospital were selected.According to the serial number(1-120),they were randomly divided into treatment group(Zhidai Decoction+Baofukang Suppository+Buzhong Yiqi Decoction)and control group(Fluconazol+Clotrimazole Suppositories),60 cases in each group.The curative effect,recurrence and body mass score before and after treatment between two groups were compared.Result:The total effective rate of two groups was compared,the difference was not statistically significant(P>0.05).After treatment 1,3 and 6 months,the recurrence rates of treatment group were 0,3.3% and 13.3% respectively,which were lower than 8.3%,20.0%,28.3% of control group,the differences were statistically significant(P<0.05).After treatment,the body mass score of treatment group were lower than those of control group and before treatment,the differences were statistically significant(P<0.05).Conclusion:The effect of Zhidai Decoction+Baofukang Suppository+Buzhong Yiqi Decoction in treatment of RVVC with damp-heat constitution is better and the recurrence rate is lower,it can improve the body mass fraction of patients and is worth popularizing.
引文
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[13]张甜甜,朱玉霞,樊尚荣,等.外阴阴道假丝酵母菌病来源的热带假丝酵母菌多位点序列分型[J].现代妇产科进展,2017,26(8):564-568,573.
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[16]段渭云,王冬梅,史志艳,等.复发性外阴阴道假丝酵母菌病患者心理健康状况及个性疏导干预效果分析[J].海南医学,2017,28(11):1764-1767.
[17]郑琦,邹前健.口服碳酸氢钠调节内环境治疗复发性外阴阴道假丝酵母菌病的疗效分析[J].中国妇幼保健,2016,31(17):3467-3469.
[18]许晓芬,曹馨宇,于艳红,等.清热除湿止带汤治疗复发性外阴阴道假丝酵母菌病28例[J].河南中医,2018,38(7):1070-1073.
[19]吴芳,高淑萍.阴道用乳杆菌活菌胶囊与硝呋太尔制霉素阴道软胶囊联合治疗复发性外阴阴道假丝酵母菌病的临床观察[J].中国医刊,2017,52(6):43-45.
[20]聂莹.中西医结合治疗复发性外阴阴道念珠菌病疗效观察[J].新中医,2014,46(6):143-145.
[2]刘东平.《傅青主女科》带下病浅谈[J].天津中医药,2011,28(3):227-229.
[3]晁亚萍.乳酸菌阴道胶囊联合硝酸咪康唑栓治疗复发性外阴阴道假丝酵母菌病的临床效果[J/OL].中国医学前沿杂志(电子版),2015,7(12):10-12.
[4]吕荣伟,张李钱,赵玲萍.乳杆菌活菌胶囊联合甲硝唑栓治疗细菌性阴道病的疗效及预防复发作用[J].中国微生态学杂志,2014,26(3):345-347.
[5]陈娟,李卫.乳酸菌阴道胶囊联合常规用药治疗复发性外阴阴道假丝酵母菌病的作用[J].中国临床医生杂志,2018,46(4):482-484.
[6]中华中医药学会.中医体质分类与判定[M].北京:中国中医药出版社,2009:7.
[7]马啸,蔡慧华,何彦,等.复发性外阴阴道假丝酵母菌病患者阴道微生物的物种组成及其动态变化[J].南方医科大学学报,2017,37(2):192-198.
[8]陈颐,梁颖,冉青珍,等.复发性外阴阴道假丝酵母菌病的中医证候分布规律研究[J].辽宁中医杂志,2012,39(8):1448-1450.
[9]罗兰兰,李卫,陈娟.复发性外阴阴道假丝酵母菌病诊治研究进展[J].现代医学,2017,45(12):1844-1847.
[10]罗幼兰,饶永红,汪海华,等.复发性外阴阴道假丝酵母菌病的菌种分布及发病相关危险因素分析[J].中国妇幼保健,2017,32(13):2988-2990.
[11]陈妮妮,郑燕飞,魏爱平.复发性外阴阴道假丝酵母菌病的中医证候与体质相关性探讨[J].中华中医药杂志,2013,28(3):829-831.
[12]段渭云,王冬梅,史志艳,等.复发性外阴阴道假丝酵母菌病发病危险因素与治疗分析[J].海南医学,2017,28(21):3475-3478.
[13]张甜甜,朱玉霞,樊尚荣,等.外阴阴道假丝酵母菌病来源的热带假丝酵母菌多位点序列分型[J].现代妇产科进展,2017,26(8):564-568,573.
[14]薛凤霞,岳莹利.女性下生殖道混合感染[J].国际妇产科学杂志,2011,38(6):472-474.
[15]杨建新.两种巩固治疗方法对复发性外阴阴道假丝酵母菌病的效果比较[J].中国计划生育和妇产科,2017,9(6):66-68.
[16]段渭云,王冬梅,史志艳,等.复发性外阴阴道假丝酵母菌病患者心理健康状况及个性疏导干预效果分析[J].海南医学,2017,28(11):1764-1767.
[17]郑琦,邹前健.口服碳酸氢钠调节内环境治疗复发性外阴阴道假丝酵母菌病的疗效分析[J].中国妇幼保健,2016,31(17):3467-3469.
[18]许晓芬,曹馨宇,于艳红,等.清热除湿止带汤治疗复发性外阴阴道假丝酵母菌病28例[J].河南中医,2018,38(7):1070-1073.
[19]吴芳,高淑萍.阴道用乳杆菌活菌胶囊与硝呋太尔制霉素阴道软胶囊联合治疗复发性外阴阴道假丝酵母菌病的临床观察[J].中国医刊,2017,52(6):43-45.
[20]聂莹.中西医结合治疗复发性外阴阴道念珠菌病疗效观察[J].新中医,2014,46(6):143-145.