医用Ti-6Al-4V合金表面氟硅烷超疏水涂层的制备及生物学性能
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摘要
采用微弧氧化技术和氟硅烷修饰在医用Ti-6Al-4V合金表面构建超疏水涂层。考察微弧氧化电压对涂层表面形貌及粗糙度的影响,分析微弧氧化涂层和超疏水涂层的相组成及元素化学状态,以探讨超疏水表面的形成机制。初步研究了超疏水试样的细胞毒性和抗菌性能。结果表明,随着微弧氧化电压的增加,涂层的表面粗糙度增大,而显微结构均匀性在440 V最佳。经疏水处理后,试样的表面粗糙度较微弧氧化试样有所下降,而接触角随着电压的增加而先增大后减小,在440 V时获得最大值154.9°。微弧氧化涂层主要由锐钛矿及少量金红石TiO_2相组成,并含有大量的–OH和一些磷的化合物,而超疏水试样表面存在大量的CF_3、CF_2和Si-O基团。全氟辛基三氯硅烷通过水解和脱水反应将氟硅烷嫁接于微弧氧化涂层上而形成超疏水表面。超疏水试样属于1级无毒材料,其细胞增殖率与Ti-6Al-4V合金无显著差异。此外,超疏水试样还具有一定的抗菌性,相对微弧氧化试样,其抗菌率可达93.03%。
The superhydrophobic coatings were prepared on the surface of biomedical Ti-6Al-V alloy by micro-arc oxidation(MAO)and surface modification of fluoroalkyl silane.The effect of voltages on surface morphologies and roughness of the coatings was investigated,and the phase composition and element chemical state of the MAO and hydrophobic treated samples were analyzed to discuss the formation mechanism of the superhydrophobic coating.At the same time,the cytotoxicity and antibacterial property of the superhydrophobic samples were also preliminarily evaluated.The results show that the surface roughness of the coatings increases with increasing the voltages,and the microstructure uniformity of the coatings is optimum at 440 V.After superhydrophobic treatment,the surface roughness of samples decreases slightly compared to that of the MAO samples,and the contact angles of the samples increase first,and then decrease with increasing the voltages,reaching the maximum value of 154.9°at 440 V.The MAO coating is mainly composed of anatase TiO_2 phase and a little rutile TiO_2 phase with a large number of–OH and some phosphorus compounds.While the surface of the superhydrophobic coating contains a large number of CF_3,CF_2 and Si-O groups.The fluoroalkyl silane is grafted onto the MAO coating through the hydrolytic reaction and dehydration reaction to form the superhydrophobic surface.The superhydrophobic sample belongs to Class 1 non-toxic material,and the cell viability of the superhydrophobic sample has no significant difference from that of Ti-6Al-4V alloy.Moreover,the superhydrophobic sample also has certain antibacterial property,and the antibacterial rate can be up to 93.03%compared to that of the MAO treated sample.
The superhydrophobic coatings were prepared on the surface of biomedical Ti-6Al-V alloy by micro-arc oxidation(MAO)and surface modification of fluoroalkyl silane.The effect of voltages on surface morphologies and roughness of the coatings was investigated,and the phase composition and element chemical state of the MAO and hydrophobic treated samples were analyzed to discuss the formation mechanism of the superhydrophobic coating.At the same time,the cytotoxicity and antibacterial property of the superhydrophobic samples were also preliminarily evaluated.The results show that the surface roughness of the coatings increases with increasing the voltages,and the microstructure uniformity of the coatings is optimum at 440 V.After superhydrophobic treatment,the surface roughness of samples decreases slightly compared to that of the MAO samples,and the contact angles of the samples increase first,and then decrease with increasing the voltages,reaching the maximum value of 154.9°at 440 V.The MAO coating is mainly composed of anatase TiO_2 phase and a little rutile TiO_2 phase with a large number of–OH and some phosphorus compounds.While the surface of the superhydrophobic coating contains a large number of CF_3,CF_2 and Si-O groups.The fluoroalkyl silane is grafted onto the MAO coating through the hydrolytic reaction and dehydration reaction to form the superhydrophobic surface.The superhydrophobic sample belongs to Class 1 non-toxic material,and the cell viability of the superhydrophobic sample has no significant difference from that of Ti-6Al-4V alloy.Moreover,the superhydrophobic sample also has certain antibacterial property,and the antibacterial rate can be up to 93.03%compared to that of the MAO treated sample.
引文
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[4]Yang Y,Lai Y,Zhang Q et al.Colloid Surface B[J],2010,79:309
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[6]Jiang J Y,Xu J L,Liu Z H et al.Appl Surf Sci[J],2015,347:591
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[12]Xu B,Cai Z.Appl Surf Sci[J],2008,254:5899
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[15]Wang Y,Yu H,Chen C et al.Mater Design[J],2015,85:640
[16]Wang Shuai(王帅),Yang Chunguang(杨春光),Xu Dake(徐大可)et al.Acta Metall Sin(金属学报)[J],2014,50(12):1453
[17]Xu Jilin,Liu Fu,Luo Junming et al.J Mater Sci Technol[J],2013,29(1):22
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[27]Wang L,Shi L,Chen J et al.Mater Lett[J],2014,116:35
[28]Jin C,Jiang Y,Niu T et al.J Mater Chem[J],2012,22:12 562