同型半胱氨酸、hs-CRP在冠心病患者血液检测中的推广意义
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摘要
目的探讨同型半胱氨酸(Hcy)和超敏C-反应蛋白(hs-CRP)在冠心病患者血液中的表达及检测意义。方法选取2016年10月～2018年4月我院收治的冠心病患者100例为观察组,另选取同期健康体检者50例为对照组。以水解酶法和免疫比浊法分别测定患者血液中Hcy和hs-CRP水平。结果观察组患者血液Hcy、hs-CRP水平均较对照组升高,差异均有统计学意义(P <0.05);冠心病患者随着其冠状动脉狭窄程度的加重,血液Hcy、hs-CRP水平亦随之升高,差异有统计学意义(P <0.05);不同冠状动脉狭窄程度的冠心病患者血液Hcy、hs-CRP水平联合检出率与单独检出率相比,差异均有统计学意义(P <0.05)。结论冠心病患者血液Hcy、hs-CRP呈现异常状态,且二者联合检测对冠心病的诊断及预后的判断具有重要意义。
Objective To explore the expression and significance of homocysteine(Hcy) and hypersensitive C-reactive protein(hs-CRP) in the blood of patients with coronary heart disease. Methods 100 patients with coronary heart disease who were admitted and treated in our hospital from October 2016 to April 2018 were selected as the observation group, and 50 people who received physical examinations during the same period were selected as the control group. Hcy and hs-CRP levels in the blood of patients were respectively detected by hydrolase method and immuno turbidimetry method. Results The levels of Hcy and hs-CRP in the blood of patients in the observation group were all higher than those in the control group, and the difference was statistically significant(P < 0.05). The level of Hcy and hs-CRP in blood increased with the severity of coronary artery stenosis in patients with coronary heart disease, and the difference was statistically significant(P < 0.05). The combined detection rate and the separate detection rate of blood Hcy and hs-CRP levels in patients with coronary artery disease with different degrees of coronary artery stenosis were statistically significant different(P < 0.05). Conclusion Hcy and hs-CRP in blood are abnormal in patients with coronary heart disease and the combined detection is of great significance in the diagnosis and prognosis of coronary heart disease.
Objective To explore the expression and significance of homocysteine(Hcy) and hypersensitive C-reactive protein(hs-CRP) in the blood of patients with coronary heart disease. Methods 100 patients with coronary heart disease who were admitted and treated in our hospital from October 2016 to April 2018 were selected as the observation group, and 50 people who received physical examinations during the same period were selected as the control group. Hcy and hs-CRP levels in the blood of patients were respectively detected by hydrolase method and immuno turbidimetry method. Results The levels of Hcy and hs-CRP in the blood of patients in the observation group were all higher than those in the control group, and the difference was statistically significant(P < 0.05). The level of Hcy and hs-CRP in blood increased with the severity of coronary artery stenosis in patients with coronary heart disease, and the difference was statistically significant(P < 0.05). The combined detection rate and the separate detection rate of blood Hcy and hs-CRP levels in patients with coronary artery disease with different degrees of coronary artery stenosis were statistically significant different(P < 0.05). Conclusion Hcy and hs-CRP in blood are abnormal in patients with coronary heart disease and the combined detection is of great significance in the diagnosis and prognosis of coronary heart disease.
引文
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[12]隋利军,桑建,朝亚.叶酸、维生素B12对老年高血压患者血浆同型半胱氨酸水平及血管内皮功能的影响[J].中国生化药物杂志,2015,35(1):125-127.
[13]李有中,郑重,谢康.动脉粥样硬化性脑梗死病人胱抑素C、同型半胱氨酸、超敏C反应蛋白和D-二聚体联合检测的临床意义[J].蚌埠医学院学报,2018,43(5):589-591.
[14]纪昕,李昕,岳晓乐,等.同型半胱氨酸、超敏C反应蛋白和纤维蛋白原联合检测对冠心病的风险评估价值[J].标记免疫分析与临床,2018,25(9):1268-1271,1285.
[15]孟伟.同型半胱氨酸、hs-CRP、D-二聚体和eNOS在冠心病患者血液中的检测意义[J].标记免疫分析与临床,2018,25(3):325-328.
[2]孙杰,邓又斌,刘琨,等.超声造影定量评价动脉粥样硬化斑块新生血管及其与组织病理学的相关性[J].中国医学影像技术,2013,29(8):1233-1236.
[3]包颖,王宝忠.臭氧大自血疗法对颈动脉粥样硬化患者超敏C反应蛋白影响的研究[J].中国实用内科杂志,2013,33(S1):145-146.
[4]叶胜,杨凌飞,周家砚,等.颈动脉粥样硬化与冠心病的相关性研究及危险因素分析[J].皖南医学院学报,2015,34(3):232-235.
[5]李明.血清Lp-PLA2、hs-CRP和D-二聚体在冠心病患者冠脉病变程度中的评估价值[J].重庆医学,2015,44(9):1215-1217.
[6]黄晖,严宁,王义勇,等.冠心病患者血浆同型半胱氨酸水平与冠状动脉病变SYNTAX积分的相关性研究[J].中国全科医学,2017,20(10):1208-1213.
[7]杨迅,王智彬,任志杰.慢性感染及炎症反应与冠状动脉病变程度的相关性研究[J].中华医院感染学杂志,2017,27(9):1971-1974.
[8]赵春滔,张志强,王志军.颈动脉内中膜厚度、颈动脉斑块总积分及P选择素水平与急性冠状动脉综合征患者冠状动脉病变的关系[J].中国心血管杂志,2015,20(6):447-451.
[9]高鹏,何平.高敏C反应蛋白与冠心病病变程度的相关性分析[J].中国医学创新,2010,7(14):44-45.
[10]陈锋,乔晋,张力.叶酸对老年高血压病患者的临床疗效及对血浆同型半胱氨酸与血管内皮功能的影响[J].河北医学,2016,22(10):1607-1610.
[11]晏晶晶,褚俊,黄文胜.原发性高血压患者颈动脉斑块与血压及血浆同型半胱氨酸的相关性[J].中国老年学杂志,2016,36(11):2656-2658.
[12]隋利军,桑建,朝亚.叶酸、维生素B12对老年高血压患者血浆同型半胱氨酸水平及血管内皮功能的影响[J].中国生化药物杂志,2015,35(1):125-127.
[13]李有中,郑重,谢康.动脉粥样硬化性脑梗死病人胱抑素C、同型半胱氨酸、超敏C反应蛋白和D-二聚体联合检测的临床意义[J].蚌埠医学院学报,2018,43(5):589-591.
[14]纪昕,李昕,岳晓乐,等.同型半胱氨酸、超敏C反应蛋白和纤维蛋白原联合检测对冠心病的风险评估价值[J].标记免疫分析与临床,2018,25(9):1268-1271,1285.
[15]孟伟.同型半胱氨酸、hs-CRP、D-二聚体和eNOS在冠心病患者血液中的检测意义[J].标记免疫分析与临床,2018,25(3):325-328.