艾司西酞普兰联合奥卡西平治疗癫痫合并抑郁的临床疗效

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英文篇名：Effect of escitalopram combined with oxcarbazepine for patients with epilepsy complicated with depression 作者：卜豪英 ; 王冰 英文作者：PU Hao-ying;WANG Bing;Department of Neurology, Henan Provincial People's Hospital of Henan University;College of Medicine of Henan University; 关键词：艾司西酞普兰 ; 奥卡西平 ; 癫痫 ; 抑郁 ; 肿瘤坏死因子-α ; 不良反应 英文关键词：escitalopram;;oxcarbazepine;;epilepsy;;depression;;tumor necrosis factor-α;;adverse reactions 中文刊名：LCYX 英文刊名：Chinese Journal of Clinical Medicine 机构：河南大学河南省人民医院神经内科;河南大学医学院; 出版日期：2019-04-25 出版单位：中国临床医学 年：2019 期：v.26;No.138 基金：2014年河南省普通科技攻关项目(142102310410)~~ 语种：中文; 页：LCYX201902019 页数：4 CN：02 ISSN：31-1794/R 分类号：88-91

摘要

目的:探讨艾司西酞普兰联合奥卡西平治疗癫痫合并抑郁的疗效及安全性。方法:选择癫痫合并抑郁患者126例,采用随机字母表法将其分为观察组与对照组,每组63例。对照组采用艾司西酞普兰治疗;观察组在对照组基础上联合奥卡西平治疗。观察两组临床疗效,比较两组患者治疗前后抑郁、焦虑情绪变化和血清5-羟色胺1A(5-HT_(1A))受体、多巴胺(DA)、肿瘤坏死因子-α(TNF-α)水平变化,统计不良反应发生率。结果:观察组患者总有效率为96.83%,显著高于对照组(77.78%,P<0.01)。观察组汉密尔顿抑郁量表(HAMD)与汉密尔顿焦虑量表(HAMA)评分均低于对照组(P<0.001)。观察组5-HT_(1A)受体、DA水平高于对照组,TNF-α水平低于对照组(P<0.001)。观察组患者总不良反应发生率为7.94%,低于对照组(14.29%),但差异无统计学意义。结论:艾司西酞普兰联合奥卡西平可明显缓解癫痫合并抑郁患者的抑郁、焦虑症状,提高5-HT_(1A)受体、DA水平,降低TNF-α水平,安全性较好,优于单用艾司西酞普兰。
        Objective: To explore the effect and safety of escitalopram combined with oxcarbazepine in treatment of patients with epilepsy complicated with depression. Methods: A total of 126 patients with epilepsy complicated with depression were randomly divided into the observation group and the control group( 63 patients in each group). Patients in the control group were treated with escitalopram, and patients in the observation group were treated with escitalopram and oxcarbazepine. The clinical efficacy was observed, and the changes of depression, anxiety, and the levels of serum 5-hydroxytryptamine 1 A(5-HT_(1 A)) receptor, dopamine(DA), and tumor necrosis factor-α(TNF-α) before and after treatment were compared in the two groups. The incidence of adverse reactions was statistically analyzed. Results: The total effective rate of the observation group was 96.83%, which was higher than that in the control group(77.78%, P<0.01). The scores of Hamilton depression scale(HAMD) and Hamilton anxiety scale(HAMA) were lower in the observation group than those in the control group(P<0.001). The levels of 5-HT_(1 A) receptor and DA in the observation group were higher than those in the control group, and the level of TNF-α was lower than that in the control group(P<0.001). The incidence of adverse reactions in the observation group was 7.94%, which was lower than that in the control group(14.29%), but the difference had not statistic significance. Conclusions: Escitalopram combined with oxcarbazepine can relieve depression and anxiety of patients with epilepsy complicated with depression, and improve the levels of 5-HT_(1 A) receptor and DA, and decrease the TNF-α level, with an acceptable security, which might be superior to the escitalopram alone.

引文

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