亚甲状腺功能减退在胚胎停育中的作用及二者相关性研究
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摘要
目的探讨亚甲状腺功能减退在胚胎停育中的作用及二者相关性。方法选取本院2017年6月至2018年6月收治的50例停经8～12周胚胎停育患者作为观察组,同期50例正常妊娠妇女作为对照组。比较两组亚甲状腺功能指标[血清促甲状腺激素(TSH),血清甲状腺激素(FT3,FT4)],亚甲状腺功能减退与胚胎停育的相关性采用Logistic回归分析。结果妊娠8～12周时观察组TSH水平显著高于对照组,差异具有统计学意义(P<0.05)。两组T3和T4水平比较差异无统计学意义。经多因素Logisitic分析,TSH水平是影响胚胎停育的重要因素(P<0.05),T3及T4对胚胎停育的影响较小。结论血清TSH水平与胚胎停育具有明显相关性,亚甲状腺功能减退会增加妊娠妇女胚胎停育的风险。
Objective To investigate the role of hypothyroidism in fetal arrest and the correlation between hypothyroidism and hypothyroidism.Methods From June 2017 to June 2018, 50 patients with postmenopausal fetal arrest from 8 to 12 weeks were selected as observation group. During the same period, 50 normal pregnant women served as control group. The indexes of subthyroid function [serum thyroid stimulating hormone(TSH),serum thyroid hormone(FT3, FT4)] were compared between the two groups. Logistic regression analysis was used to analyze the correlation between hypothyroidism and fetal arrest. Results The level of TSH in the observation group was significantly higher than that in the control group at 8-12 weeks of gestation(P<0.05). There was no significant difference in the levels of T3 and T4 between the two groups. Logisitic analysis showed that TSH level was an important factor affecting embryo arrest(P<0.05). T3 and T4 had little effect on embryo arrest. Conclusion Serum TSH has a significant correlation with fetal suspension. Hypothyroidism may increase the risk of fetal arrest.
Objective To investigate the role of hypothyroidism in fetal arrest and the correlation between hypothyroidism and hypothyroidism.Methods From June 2017 to June 2018, 50 patients with postmenopausal fetal arrest from 8 to 12 weeks were selected as observation group. During the same period, 50 normal pregnant women served as control group. The indexes of subthyroid function [serum thyroid stimulating hormone(TSH),serum thyroid hormone(FT3, FT4)] were compared between the two groups. Logistic regression analysis was used to analyze the correlation between hypothyroidism and fetal arrest. Results The level of TSH in the observation group was significantly higher than that in the control group at 8-12 weeks of gestation(P<0.05). There was no significant difference in the levels of T3 and T4 between the two groups. Logisitic analysis showed that TSH level was an important factor affecting embryo arrest(P<0.05). T3 and T4 had little effect on embryo arrest. Conclusion Serum TSH has a significant correlation with fetal suspension. Hypothyroidism may increase the risk of fetal arrest.
引文
[1]陈飞,黄河玲.胚胎停育相关因素研究进展[J].中国计划生育学杂志,2016,24(7):494-497.
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[5]侯大乔,敬源,张亚红,等.早孕胚胎停育与多种接触因素相关性研究及胚胎停育病因分析[J].中国妇幼保健,2018(1):142-145.
[6]焦波.妊娠期甲状腺功能异常与不良妊娠结局的临床分析[J].中国妇幼健康研究,2017,28(3):336-340.
[7]李春香,李显彬,栾磊,等.齐齐哈尔地区100例胚胎停止发育患者体内激素水平分析[J].中国卫生检验杂志,2017(15):2193-2194.
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[9]李辉,陈雪兰.孕早期女性甲状腺功能失调临床观察[J].中华实用诊断与治疗杂志,2015,29(7):720-721.
[2]刘丽娜,张丽颖.胚胎停育高危因素和并发症的探索[J].疑难病杂志,2015(2):214-217.
[3]庞东眉,李想,张丽颖.胚胎停育高危因素的相关研究[J].中国计划生育学杂志,2016,24(6):428-431.
[4]郭立燕,翟敏,王莎莎,等.胚胎停育影响因素的Meta分析[J].中国儿童保健杂志,2016,24(2):166-169.
[5]侯大乔,敬源,张亚红,等.早孕胚胎停育与多种接触因素相关性研究及胚胎停育病因分析[J].中国妇幼保健,2018(1):142-145.
[6]焦波.妊娠期甲状腺功能异常与不良妊娠结局的临床分析[J].中国妇幼健康研究,2017,28(3):336-340.
[7]李春香,李显彬,栾磊,等.齐齐哈尔地区100例胚胎停止发育患者体内激素水平分析[J].中国卫生检验杂志,2017(15):2193-2194.
[8]樊向维.妊娠期母体甲状腺功能变化及其对胎儿的影响[J].国际妇产科学杂志,2015,42(3):330-334.
[9]李辉,陈雪兰.孕早期女性甲状腺功能失调临床观察[J].中华实用诊断与治疗杂志,2015,29(7):720-721.