平菇化学成分及药理活性研究进展
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摘要
平菇(Pleurotus ostreatus)是一种常见的药食两用真菌。平菇子实体中含有多糖类、甾类、挥发油类、多酚类等多种化学成分,具有抗肿瘤、抗炎、抗病毒、免疫调节、抗氧化、降血糖、降血脂、保肝、杀虫、抑菌等多种药理活性,对股骨头坏死、阿尔茨海默症也有一定疗效。本文从平菇的化学成分、药理活性等方面进行综述,以期为更好研究开发平菇资源,并将其应用到医药、保健品、食品等相关领域提供参考依据。
Pleurotus ostreatus is a common medicinal and edible fungus. The fruiting bodies of P. ostreatus contain various chemical composition such as polysaccharides,steroids,volatile oils and polyphenols,which have many pharmacological effects,such as anti-tumor,anti-inflammatory,anti-virus,immune regulation,anti-oxidation,hypoglycemia,hypolipidemia,liver protection,insecticide,bacteriostasis and so on. Additionally,there are certain curative effects noted in the treatment of femoral head necrosis and Alzheimer's disease. In this paper,the chemical composition,pharmacological activity of P. ostreatus are summarized,in order to provide reference basis for better research and development of P. ostreatus resources,and its application of medicine,health products,food and other related fields.
Pleurotus ostreatus is a common medicinal and edible fungus. The fruiting bodies of P. ostreatus contain various chemical composition such as polysaccharides,steroids,volatile oils and polyphenols,which have many pharmacological effects,such as anti-tumor,anti-inflammatory,anti-virus,immune regulation,anti-oxidation,hypoglycemia,hypolipidemia,liver protection,insecticide,bacteriostasis and so on. Additionally,there are certain curative effects noted in the treatment of femoral head necrosis and Alzheimer's disease. In this paper,the chemical composition,pharmacological activity of P. ostreatus are summarized,in order to provide reference basis for better research and development of P. ostreatus resources,and its application of medicine,health products,food and other related fields.
引文
[1]郑素月,张金霞,王贺祥,等.我国栽培平菇近缘种的多相分类[J].中国食用菌,2003,5(3):3-6.
[2]李传华,曲明清,曹晖,等.中国食用菌普通名名录[J].食用菌学报,2013,20(3):50-72.
[3]王呈玉.中国侧耳属[Pleurotus(Fr.)Kumm.]真菌系统分类学研究[D].长春:吉林农业大学,2004.
[4]戴玉成,杨祝良.中国药用真菌名录及部分名称的修订[J].菌物学报,2008,27(6):801-824.
[5]Tong H,Xia F,Feng K,et al.Structural characterization and in vitro,antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus[J].Bioresource Technology,2009,100(4):1682-1686.
[6]Xia F,Fan J,Zhu M,et al.Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus[J].Journal of the Taiwan Institute of Chemical Engineers,2011,42(3):402-407.
[7]Younis A M,Wu F S,El Shikh H H.Antimicrobial activity of extracts of the oyster culinary medicinal mushroom Pleurotus ostreatus(higher basidiomycetes)and identification of a new antimicrobial compound[J].International Journal of Medicinal Mushrooms,2015,17(6):579.
[8]张超,操海群,陈莉,等.食用菌多糖对植物病毒抑制作用的初步探究[J].安徽农业大学学报,2005,32(1):15-18.
[9]Sarangi I,Ghosh D,Bhutia S K,et al.Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans[J].International Immunopharmacology,2006,6(8):1287.
[10]Ravi B,Renitta R E,Prabha M L,et al.Evaluation of antidiabetic potential of oyster mushroom(Pleurotus ostreatus)in alloxan-induced diabetic mice[J].Immunopharmacol Immunotoxicol,2013,35(1):101-109.
[11]任清,王玢,李奇,等.平菇多糖的提取及其抗氧化保湿功效研究[J].香料香精化妆品,2008,36(4):23-26.
[12]Wang H,Gao J,Ng T B.A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus[J].Biochemical & Biophysical Research Communications,2000,275(3):810-816.
[13]Lavi I,Friesem D,Geresh S,et al.An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells[J].Cancer Letters,2006,244(1):61-70.
[14]Krishnamoorthy D,Sankaran M.Modulatory effect of Pleurotus ostreatus on oxidant/antioxidant status in 7,12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats-a dose-response study[J].Journal of Cancer Research & Therapeutics,2016,12(1):386.
[15]Jayakumar T,Ramesh E,Geraldine P.Antioxidant activity of the oyster mushroom,Pleurotus ostreatus,on CCl(4)-induced liver injury in rats[J].Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association,2006,44(12):1989-1996.
[16]梁锦锋,单乐天,李鸿文,等.平菇提取物对激素性股骨头坏死大鼠模型的药效作用研究[J].浙江中医药大学学报,2014,38(5):622-625.
[17]Zhang Y,Yang X,Jin G,et al.Polysaccharides from Pleurotus ostreatus,alleviate cognitive impairment in a rat model of Alzheimer’s disease[J].International Journal of Biological Macromolecules,2016,92:935-941.
[18]朱明洪,陈屏,王琦,等.平菇子实体化学成分的分析研究[J].食药用菌,2016,23(4):242-246,261.
[19]Bhattacharya M,Srivastav P P,Mishra H N.Optimization of process variables for supercritical fluid extraction of ergothioneine and polyphenols from Pleurotus ostreatus,and correlation to free-radical scavenging activity[J].Journal of Supercritical Fluids,2014,95:51-59.
[20]赖姗姗,陈玉青,刘媛媛,等.平菇不同状态下营养成分分析比较与品质评价[J].食品安全质量检测学报,2018,9(7):1619-1622.
[21]唐志刚.平菇的栽培以及营养价值[J].农家科技,2013,19(6):77.
[22]Tolera K D,Abera S.Nutritional quality of oyster mushroom(Pleurotus ostreatus)as affected by osmotic pretreatments and drying methods[J].Food Science & Nutrition,2017,5:989-996.
[23]于士军,何玲艳,张莹,等.六种食用菌营养和功能成分的主成分分析和聚类分析[J].阜阳师范学院学报:自然科学版,2018,35(1):37-42.
[24]张晓.平菇多糖的提取、纯化及免疫调节作用研究[D].西安:陕西师范大学,2017.
[25]胡鹏启.平菇子实体主要化学成分及其体内抗氧化活性研究[D].长春:吉林农业大学,2015.
[26]Wittig M,Krings U,Berger R G.Single-run analysis of vitamin D photoproducts in oyster mushroom(Pleurotus ostreatus)after UV-B treatment[J].Journal of Food Composition & Analysis,2013,31(2):266-274.
[27]阮鸣,霍光明,张李阳,等.新型与市售平菇香气成分的GC-MS分析与比较[J].食品工业科技,2016,38(10):72-76,81.
[28]刘学铭.我国15种常见和珍稀食用菌化学成分谱研究[A].中国菌物学会.2010年中国菌物学会学术年会论文摘要集[C].中国菌物学会,2010:2.
[29]李秦,海洋,师会勤,等.平菇与香菇挥发性香气成分的GC-MS分析比较[J].化学与生物工程,2010,27(2):87-89.
[30]Kawagishi H,Suzuki H,Watanabe H,et al.A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance[J].BBA-General Subjects,2000,1474(3):299-308.
[31]Anandhi R,Annadurai T,Anitha T S,et al.Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom,Pleurotus ostreatus,and its major constituent,chrysin,in triton WR-1339-induced hypercholesterolemic rats[J].Journal of Physiology & Biochemistry,2013,69(2):313-323.
[32]刘海英,张运峰,范永山,等.平菇、杏鲍菇和白灵菇菌丝多糖对·OH、DPPH·和NO-2的体外清除作用[J].中国农学通报,2010,26(17):26-30.
[33]Zhang Y,Dai L,Kong X,et al.Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus[J].International Journal of Biological Macromolecules,2012,51(3):259.
[34]Roy A,Sahu R K,Prasad P.Preliminary phytochemical screening and,in vitro,antioxidant properties of the,Pleurotus ostreatus,extract[J].Research Journal of Pharmacology & Pharmacodynamics,2014.
[35]Han S R,Kim K H,Lim K O,et al.Biological activity analysis of different solvent extracts from Pleurotus ostreatus[C].International Conference on Convergence Technology,2015.
[36]孔繁利,孙新,佟海滨,等.糙皮侧耳碱提水溶性多糖对肿瘤的抑制作用及其机制[J].吉林大学学报:医学版,2012,38(6):1091-1095.
[37]Kobayashi H,Motoyoshi N,Itagaki T,et al.The inhibition of human tumor cell proliferation by RNase Pol,a member of the RNase T1 family,from Pleurotus ostreatus[J].Journal of the Agricultural Chemical Society of Japan,2013,77(7):1486-1491.
[38]Ebrahimi A,Atashi A,Soleimani M,et al.Comparison of anticancer effect of Pleurotus ostreatus extract with doxorubicin hydrochloride alone and plus thermotherapy on erythroleukemia cell line[J].Journal of Complementary and Integrative Medicine,2017,15(2):1-8.
[39]Sun Y,Liu J.Purification,structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus[J].Bioresource Technology,2009,100(2):983-986.
[40]Wang H X,Ng T B.Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus,mushroom with anti-human immunodeficiency virus,translation-inhibitory,and ribonuclease activities[J].Biochem Biophys Res Commun,2000,276(2):587-593.
[41]Zhang Y,Wang Z,Jin G,et al.Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats[J].International Journal of Biological Macromolecules,2017,101:107.
[42]Zhang Y,Hu T,Zhou H,et al.Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats[J].International Journal of Biological Macromolecules,2016,83:126-132.
[43]Xiong M,Huang Y,Liu Y,et al.Antidiabetic activity of ergosterol from Pleurotus ostreatus in KK-A(y)mice with spontaneous type 2 diabetes mellitus[J].Molecular Nutrition & Food Research,2018,62(3):1700444.
[44]Gil A,Smiderle F R,Morales D,et al.Water-soluble polysaccharides extracts from oyster culinary-medicinal mushroom,Pleurotus ostreatus(Agaricomycetes)with HMGCR inhibitory activity[J].International Journal of Medicinal Mushrooms,2017,19(10):879-892.
[45]向红琼,冯志新.Pleurotus ostreatus对线虫作用机理的研究[J].植物病理学报,2000,31(4):357-363.
[46]Meza-Menchaca T,Suárez-Medellín J,Del ángel-Piňa C,et al.The amoebicidal effect of ergosterol peroxide isolated from Pleurotus ostreatus[J].Phytotherapy Research,2016,29(12):1982-1986.
[47]Ademola I O,Ojo P O,Odeniran P O.Pleurotus ostreatus extract inhibits Eimeria species development in naturally infected broiler chickens[J].Tropical Animal Health and Production,2018.
[48]Pauliuc I,Bota U D.Antibacterial activity of Pleurotus ostreatus gemmotherapic extract[J].Annals of the Romanian Society for Cell Biology,2013,18(1):178-181.
[49]王会娟.平菇降解黄曲霉毒素的研究[D].北京:中国农业科学院,2012.
[50]Nosál’Ová V,Bobek P,Cerná S,et al.Effects of pleuran(beta-glucan isolated from Pleurotus ostreatus)on experimental colitis in rats[J].Physiological Research,2001,50(6):575.
[51]Singh V,Vyas D,Pandey R,et al.Pleurotus ostreatus produces antioxidant and anti-arthritic activity in wistar albino rats[J].World Journal of Pharmacy and Pharmaceutical Sciences,2015,4(5):1230-1246.
[52]Naguib Y M,Azmy R M,Samaka R M,et al.Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury[J].Bmc Complement Altern Med,2014,14(1):494.
[53]Palli L,Castellet-Rovira F,Pérez-Trujillo,Miriam,et al.Preliminary evaluation of Pleurotus ostreatus for the removal of selected pharmaceuticals from hospital wastewater[J].Biotechnology Progress,2017,33(6):1529-1537.
[54]Ahuactzin-Pérez,Miriam,Tlecuitl-Beristain,et al.A novel biodegradation pathway of the endocrine-disruptor di(2-ethyl hexyl)phthalate by,Pleurotus ostreatus,based on quantum chemical investigation[J].Ecotoxicology and Environmental Safety,2018,147:494-499.
[2]李传华,曲明清,曹晖,等.中国食用菌普通名名录[J].食用菌学报,2013,20(3):50-72.
[3]王呈玉.中国侧耳属[Pleurotus(Fr.)Kumm.]真菌系统分类学研究[D].长春:吉林农业大学,2004.
[4]戴玉成,杨祝良.中国药用真菌名录及部分名称的修订[J].菌物学报,2008,27(6):801-824.
[5]Tong H,Xia F,Feng K,et al.Structural characterization and in vitro,antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus[J].Bioresource Technology,2009,100(4):1682-1686.
[6]Xia F,Fan J,Zhu M,et al.Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus[J].Journal of the Taiwan Institute of Chemical Engineers,2011,42(3):402-407.
[7]Younis A M,Wu F S,El Shikh H H.Antimicrobial activity of extracts of the oyster culinary medicinal mushroom Pleurotus ostreatus(higher basidiomycetes)and identification of a new antimicrobial compound[J].International Journal of Medicinal Mushrooms,2015,17(6):579.
[8]张超,操海群,陈莉,等.食用菌多糖对植物病毒抑制作用的初步探究[J].安徽农业大学学报,2005,32(1):15-18.
[9]Sarangi I,Ghosh D,Bhutia S K,et al.Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans[J].International Immunopharmacology,2006,6(8):1287.
[10]Ravi B,Renitta R E,Prabha M L,et al.Evaluation of antidiabetic potential of oyster mushroom(Pleurotus ostreatus)in alloxan-induced diabetic mice[J].Immunopharmacol Immunotoxicol,2013,35(1):101-109.
[11]任清,王玢,李奇,等.平菇多糖的提取及其抗氧化保湿功效研究[J].香料香精化妆品,2008,36(4):23-26.
[12]Wang H,Gao J,Ng T B.A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus[J].Biochemical & Biophysical Research Communications,2000,275(3):810-816.
[13]Lavi I,Friesem D,Geresh S,et al.An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells[J].Cancer Letters,2006,244(1):61-70.
[14]Krishnamoorthy D,Sankaran M.Modulatory effect of Pleurotus ostreatus on oxidant/antioxidant status in 7,12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats-a dose-response study[J].Journal of Cancer Research & Therapeutics,2016,12(1):386.
[15]Jayakumar T,Ramesh E,Geraldine P.Antioxidant activity of the oyster mushroom,Pleurotus ostreatus,on CCl(4)-induced liver injury in rats[J].Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association,2006,44(12):1989-1996.
[16]梁锦锋,单乐天,李鸿文,等.平菇提取物对激素性股骨头坏死大鼠模型的药效作用研究[J].浙江中医药大学学报,2014,38(5):622-625.
[17]Zhang Y,Yang X,Jin G,et al.Polysaccharides from Pleurotus ostreatus,alleviate cognitive impairment in a rat model of Alzheimer’s disease[J].International Journal of Biological Macromolecules,2016,92:935-941.
[18]朱明洪,陈屏,王琦,等.平菇子实体化学成分的分析研究[J].食药用菌,2016,23(4):242-246,261.
[19]Bhattacharya M,Srivastav P P,Mishra H N.Optimization of process variables for supercritical fluid extraction of ergothioneine and polyphenols from Pleurotus ostreatus,and correlation to free-radical scavenging activity[J].Journal of Supercritical Fluids,2014,95:51-59.
[20]赖姗姗,陈玉青,刘媛媛,等.平菇不同状态下营养成分分析比较与品质评价[J].食品安全质量检测学报,2018,9(7):1619-1622.
[21]唐志刚.平菇的栽培以及营养价值[J].农家科技,2013,19(6):77.
[22]Tolera K D,Abera S.Nutritional quality of oyster mushroom(Pleurotus ostreatus)as affected by osmotic pretreatments and drying methods[J].Food Science & Nutrition,2017,5:989-996.
[23]于士军,何玲艳,张莹,等.六种食用菌营养和功能成分的主成分分析和聚类分析[J].阜阳师范学院学报:自然科学版,2018,35(1):37-42.
[24]张晓.平菇多糖的提取、纯化及免疫调节作用研究[D].西安:陕西师范大学,2017.
[25]胡鹏启.平菇子实体主要化学成分及其体内抗氧化活性研究[D].长春:吉林农业大学,2015.
[26]Wittig M,Krings U,Berger R G.Single-run analysis of vitamin D photoproducts in oyster mushroom(Pleurotus ostreatus)after UV-B treatment[J].Journal of Food Composition & Analysis,2013,31(2):266-274.
[27]阮鸣,霍光明,张李阳,等.新型与市售平菇香气成分的GC-MS分析与比较[J].食品工业科技,2016,38(10):72-76,81.
[28]刘学铭.我国15种常见和珍稀食用菌化学成分谱研究[A].中国菌物学会.2010年中国菌物学会学术年会论文摘要集[C].中国菌物学会,2010:2.
[29]李秦,海洋,师会勤,等.平菇与香菇挥发性香气成分的GC-MS分析比较[J].化学与生物工程,2010,27(2):87-89.
[30]Kawagishi H,Suzuki H,Watanabe H,et al.A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance[J].BBA-General Subjects,2000,1474(3):299-308.
[31]Anandhi R,Annadurai T,Anitha T S,et al.Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom,Pleurotus ostreatus,and its major constituent,chrysin,in triton WR-1339-induced hypercholesterolemic rats[J].Journal of Physiology & Biochemistry,2013,69(2):313-323.
[32]刘海英,张运峰,范永山,等.平菇、杏鲍菇和白灵菇菌丝多糖对·OH、DPPH·和NO-2的体外清除作用[J].中国农学通报,2010,26(17):26-30.
[33]Zhang Y,Dai L,Kong X,et al.Characterization and in vitro antioxidant activities of polysaccharides from Pleurotus ostreatus[J].International Journal of Biological Macromolecules,2012,51(3):259.
[34]Roy A,Sahu R K,Prasad P.Preliminary phytochemical screening and,in vitro,antioxidant properties of the,Pleurotus ostreatus,extract[J].Research Journal of Pharmacology & Pharmacodynamics,2014.
[35]Han S R,Kim K H,Lim K O,et al.Biological activity analysis of different solvent extracts from Pleurotus ostreatus[C].International Conference on Convergence Technology,2015.
[36]孔繁利,孙新,佟海滨,等.糙皮侧耳碱提水溶性多糖对肿瘤的抑制作用及其机制[J].吉林大学学报:医学版,2012,38(6):1091-1095.
[37]Kobayashi H,Motoyoshi N,Itagaki T,et al.The inhibition of human tumor cell proliferation by RNase Pol,a member of the RNase T1 family,from Pleurotus ostreatus[J].Journal of the Agricultural Chemical Society of Japan,2013,77(7):1486-1491.
[38]Ebrahimi A,Atashi A,Soleimani M,et al.Comparison of anticancer effect of Pleurotus ostreatus extract with doxorubicin hydrochloride alone and plus thermotherapy on erythroleukemia cell line[J].Journal of Complementary and Integrative Medicine,2017,15(2):1-8.
[39]Sun Y,Liu J.Purification,structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus[J].Bioresource Technology,2009,100(2):983-986.
[40]Wang H X,Ng T B.Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus,mushroom with anti-human immunodeficiency virus,translation-inhibitory,and ribonuclease activities[J].Biochem Biophys Res Commun,2000,276(2):587-593.
[41]Zhang Y,Wang Z,Jin G,et al.Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats[J].International Journal of Biological Macromolecules,2017,101:107.
[42]Zhang Y,Hu T,Zhou H,et al.Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats[J].International Journal of Biological Macromolecules,2016,83:126-132.
[43]Xiong M,Huang Y,Liu Y,et al.Antidiabetic activity of ergosterol from Pleurotus ostreatus in KK-A(y)mice with spontaneous type 2 diabetes mellitus[J].Molecular Nutrition & Food Research,2018,62(3):1700444.
[44]Gil A,Smiderle F R,Morales D,et al.Water-soluble polysaccharides extracts from oyster culinary-medicinal mushroom,Pleurotus ostreatus(Agaricomycetes)with HMGCR inhibitory activity[J].International Journal of Medicinal Mushrooms,2017,19(10):879-892.
[45]向红琼,冯志新.Pleurotus ostreatus对线虫作用机理的研究[J].植物病理学报,2000,31(4):357-363.
[46]Meza-Menchaca T,Suárez-Medellín J,Del ángel-Piňa C,et al.The amoebicidal effect of ergosterol peroxide isolated from Pleurotus ostreatus[J].Phytotherapy Research,2016,29(12):1982-1986.
[47]Ademola I O,Ojo P O,Odeniran P O.Pleurotus ostreatus extract inhibits Eimeria species development in naturally infected broiler chickens[J].Tropical Animal Health and Production,2018.
[48]Pauliuc I,Bota U D.Antibacterial activity of Pleurotus ostreatus gemmotherapic extract[J].Annals of the Romanian Society for Cell Biology,2013,18(1):178-181.
[49]王会娟.平菇降解黄曲霉毒素的研究[D].北京:中国农业科学院,2012.
[50]Nosál’Ová V,Bobek P,Cerná S,et al.Effects of pleuran(beta-glucan isolated from Pleurotus ostreatus)on experimental colitis in rats[J].Physiological Research,2001,50(6):575.
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