新生儿及婴儿TORCH感染血清学检测分析
|
摘要
目的了解青岛地区新生儿及婴儿TORCH感染状况和感染特点。方法应用间接化学发光免疫分析法(CLIA)检测1 196例新生儿和婴儿血清中的TORCH特异性抗体,并进行统计分析。结果受检患儿中TORCH-IgM阳性率为1.67%,其中以CMV和HSV感染为主;患儿中TORCH-IgG抗体阳性率为99.16%,其中以CMV感染最常见,阳性率为94.31%;患儿混合感染率达到93.31%,以HSV和CMV混合感染为最多,阳性率达85.45%;新生儿及婴儿IgG抗体检测均以CMV-IgG抗体阳性率最高,分别为96.28%、82.76%;男性和女性患儿CMV-IgG阳性率均为最高,分别为94.36%、94.27%。结论青岛地区TORCH感染以CMV、HSV感染及二者混合感染为主,既往感染阳性率较高,新近感染阳性率较低,新近感染患儿并发症主要是呼吸系统和消化系统疾病,因此,加强新生儿和婴儿TORCH抗体检测筛查,对辅助临床鉴别和治疗具有重要的意义。
Objective To investigate the condition and characteristics of TORCH infection in neonates and infants in Qingdao.Methods TORCH specific antibodies in serum samples from 1 196 neonates and infants were tested by the Indirect chemiluminescent immunoassay(CLIA),and did statistical analysis.Results Among the infected neonates and infants,positive rate of TORCH-IgM was 1.67%,and the most common pathogenic virus was CMV and HSV;positive rate of TORCH-IgG in patients was 99.16%,CMV was the most common pathogenic virus,positive rate of CMV-IgG was 94.31%.In multiple infections,the multiple infection rate of patients was 93.31%,The most common multiple infection model were HSV and CMV,the positive ate of was 85.45%.IgG antibody detection in neonates and infants in different groups,the CMV-IgG positive rate were highest in both neonates and infants,which were 96.28% and 82.76%,the CMV-IgG positive rate were highest in both male and female,which were 94.36% and 94.27%.Conclusion TORCH infection in Qingdao was mainly based on CMV and HSV infection and multiple infection between the two,higher previous infection rates and lower recent infection rates,complications in recent infection patients are mainly respiratory and digestive diseases.So it makes sense to pay special attention to testing and screening TORCH specific antibodies,it has clinical significance to the identification and treatment.
Objective To investigate the condition and characteristics of TORCH infection in neonates and infants in Qingdao.Methods TORCH specific antibodies in serum samples from 1 196 neonates and infants were tested by the Indirect chemiluminescent immunoassay(CLIA),and did statistical analysis.Results Among the infected neonates and infants,positive rate of TORCH-IgM was 1.67%,and the most common pathogenic virus was CMV and HSV;positive rate of TORCH-IgG in patients was 99.16%,CMV was the most common pathogenic virus,positive rate of CMV-IgG was 94.31%.In multiple infections,the multiple infection rate of patients was 93.31%,The most common multiple infection model were HSV and CMV,the positive ate of was 85.45%.IgG antibody detection in neonates and infants in different groups,the CMV-IgG positive rate were highest in both neonates and infants,which were 96.28% and 82.76%,the CMV-IgG positive rate were highest in both male and female,which were 94.36% and 94.27%.Conclusion TORCH infection in Qingdao was mainly based on CMV and HSV infection and multiple infection between the two,higher previous infection rates and lower recent infection rates,complications in recent infection patients are mainly respiratory and digestive diseases.So it makes sense to pay special attention to testing and screening TORCH specific antibodies,it has clinical significance to the identification and treatment.
引文
[1]NAHMIAS A J,WALLS K W,STEWART J A,et al.The TORCH complex-perinatal infections associated with toxoplasma and rubella,cytomegol-and herpes simplex viruses[J].Pediatr Res,1971,5(8):405-406.
[2]陈玉昆,杨亚晓,魏世锦,等.孕早期妇女弓形虫感染对妊娠结局的影响[J].中国血吸虫病防治杂志,2014,26(3):308-310.
[3]闻良珍.TORCH感染与出生缺陷[J].中国实用妇科与产科杂志,2008,24(2):110-113.
[4]左江成,曾一芹,向希映,等.母乳期婴儿巨细胞病毒感染现状与传播途径分析[J].实用医学杂志,2015,31(1):140-143.
[5]张欠欠,成俊珍,王逢会.TORCH感染与不良妊娠结局的相关性分析[J].中国血吸虫病防治杂志,2013,25(2):209-210.
[6]谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:108-111.
[7]VINIKOOR-IMLER L C,STEWART T G,LUBEN T J,et al.An exploratory analysis of he relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas[J].Environ Pollut,2015(202):1-6.
[8]LIU Z,YU Y,LI X,et al.Maternal lead exposure and risk of congenital heart defects occurrence in offspring[J].Reprod Toxicol,2015(51):1-6.
[9]王芳,韩美艳,姜楠.多种产前诊断技术联合应用防控出生缺陷的探讨[J].中国优生与遗传杂志,2018,26(3),79-81.
[10]中华人民共和国卫生部.中国出生缺陷防治报告(2012)[R].北京:中华人民共和国卫生部,2012:2.
[11]鲁燕.二胎孕妇TORCH感染影响因素与不良妊娠结局研究[D].济南:山东大学,2018.
[12]郑辉,虞玉群.杭州地区新生儿及婴儿TORCH感染情况的调查分析[J].中国卫生检验杂志,2015,25(15):2610-2612.
[13]刘文渊,卢文波.宁波地区新生儿TORCH感染状况分析[J].中国卫生检验杂志,2011,21(1):189-191.
[14]陈艳.1876份TORCH检测结果分析[J].中国实验诊断学,2014,18(12):2052-2054.
[15]薛爱国,丁伟,孙霞,等.青岛地区1694例妊娠早期孕妇TORCH感染状况的调查分析[J].中国优生与遗传杂志,2014,22(10):80-81.
[16]王芳.多种产前诊断技术联合应用防控出生缺陷的探讨[D].青岛:青岛大学,2018.
[17]刘震忠,吴凤琪,闫静,等.2015~2016年天津地区新生儿TORCH血清学筛查及感染特点[J].现代检验医学杂志,2017,32(4):133-136.
[18]HENDRIKS G,MCPARTLAND J,EI-MATARY W.Gastrointestinal presentation and outcome of perinatal cytomegalovirus infection[J].BMJ Case Rep,2013(2013):bcr2012007671.
[19]吴春燕,李泽泳.广州婴幼儿TORCH检测结果及感染病例分析[J].检验医学与临床,2016,13(2):250-252.
[20]黄斌,杜靖.儿童血清TORCH病原IgG与IgM抗体阳性率比较[J].浙江预防医学,2016,28(3):313-315.
[21]王菊英,周立荣,唐秀英,等.1781例新生儿至学龄期患儿TORCH检测结果分析[J].中国免疫学杂志,2014,30(2):263-265.
[2]陈玉昆,杨亚晓,魏世锦,等.孕早期妇女弓形虫感染对妊娠结局的影响[J].中国血吸虫病防治杂志,2014,26(3):308-310.
[3]闻良珍.TORCH感染与出生缺陷[J].中国实用妇科与产科杂志,2008,24(2):110-113.
[4]左江成,曾一芹,向希映,等.母乳期婴儿巨细胞病毒感染现状与传播途径分析[J].实用医学杂志,2015,31(1):140-143.
[5]张欠欠,成俊珍,王逢会.TORCH感染与不良妊娠结局的相关性分析[J].中国血吸虫病防治杂志,2013,25(2):209-210.
[6]谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:108-111.
[7]VINIKOOR-IMLER L C,STEWART T G,LUBEN T J,et al.An exploratory analysis of he relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas[J].Environ Pollut,2015(202):1-6.
[8]LIU Z,YU Y,LI X,et al.Maternal lead exposure and risk of congenital heart defects occurrence in offspring[J].Reprod Toxicol,2015(51):1-6.
[9]王芳,韩美艳,姜楠.多种产前诊断技术联合应用防控出生缺陷的探讨[J].中国优生与遗传杂志,2018,26(3),79-81.
[10]中华人民共和国卫生部.中国出生缺陷防治报告(2012)[R].北京:中华人民共和国卫生部,2012:2.
[11]鲁燕.二胎孕妇TORCH感染影响因素与不良妊娠结局研究[D].济南:山东大学,2018.
[12]郑辉,虞玉群.杭州地区新生儿及婴儿TORCH感染情况的调查分析[J].中国卫生检验杂志,2015,25(15):2610-2612.
[13]刘文渊,卢文波.宁波地区新生儿TORCH感染状况分析[J].中国卫生检验杂志,2011,21(1):189-191.
[14]陈艳.1876份TORCH检测结果分析[J].中国实验诊断学,2014,18(12):2052-2054.
[15]薛爱国,丁伟,孙霞,等.青岛地区1694例妊娠早期孕妇TORCH感染状况的调查分析[J].中国优生与遗传杂志,2014,22(10):80-81.
[16]王芳.多种产前诊断技术联合应用防控出生缺陷的探讨[D].青岛:青岛大学,2018.
[17]刘震忠,吴凤琪,闫静,等.2015~2016年天津地区新生儿TORCH血清学筛查及感染特点[J].现代检验医学杂志,2017,32(4):133-136.
[18]HENDRIKS G,MCPARTLAND J,EI-MATARY W.Gastrointestinal presentation and outcome of perinatal cytomegalovirus infection[J].BMJ Case Rep,2013(2013):bcr2012007671.
[19]吴春燕,李泽泳.广州婴幼儿TORCH检测结果及感染病例分析[J].检验医学与临床,2016,13(2):250-252.
[20]黄斌,杜靖.儿童血清TORCH病原IgG与IgM抗体阳性率比较[J].浙江预防医学,2016,28(3):313-315.
[21]王菊英,周立荣,唐秀英,等.1781例新生儿至学龄期患儿TORCH检测结果分析[J].中国免疫学杂志,2014,30(2):263-265.