浙江省高危HPV基因型分布热力图分析
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摘要
目的采用热力图分析浙江省高危型人乳头瘤病毒(HPV)主要基因型分布。方法收集2016年在浙江省肿瘤医院接受宫颈部高危型HPV检查的基因型分布资料,按常住地址绘制热力图,分析浙江省高危型HPV感染的基因型分布。结果 4 159名女性高危型HPV总感染率为26.63%,以HPV16、HPV58、HPV52和HPV18感染率最高,分别为17.43%、5.95%、3.63%和2.81%。对1 926名女性进行热力图分析显示,杭州市HPV16、HPV58、HPV52和HPV18的感染率均较高;温州市HPV16、HPV18的感染率较高,温州市东部地区HPV52感染率较高;绍兴市、金华市和台州市的HPV16、HPV18和HPV58的感染率较高;嘉兴市HPV18感染率高;衢州市、宁波市和丽水市这4种高危型HPV感染率均较低。城市女性HPV感染率高于城郊及农村,杭州市HPV感染率明显高于其他临近地区。结论浙江省流行的HPV基因型主要为HPV16、HPV52、HPV58和HPV18,HPV各个高危基因型在省内各地的流行分布呈多样性。
引文
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[2]BURCHELL A N,WINER R L,DE SANJOSE S,et al.Chapter6:Epidemiology and transmission dynamics of genital HPV infection[J].Vaccine,2006,24(S3):52-61.
[3]MUNOZ N,BOSCH F X,DE SANJOSE S,et al.Epidemiologic classification of human papillomavirus types associated with cervical cancer[J].N Engl J Med,2003,348(6):518-527.
[4]BRUNI L,DIAZ M,CASTELLSAGUE X,et al.Cervical human papillomavirus prevalence in 5 continents:meta-analysis of 1 million women with normal cytological findings[J].J Infect Dis,2010,202(12):1789-1799.
[5]BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[6]CROW J M.HPV:the global burden[J].Nature,2012,488:2-3.
[7]吴云燕,裘明利.女性高危型人乳头瘤病毒感染分布情况研究[J].中国实用妇科与产科杂志,2017,9(1):122-124.
[8]鄢春晖,陈林,袁蔓莉,等.重庆地区12 196例妇科门诊患者HPV亚型感染情况分析[J].重庆医学,2014,21(35):4746-4748.
[9]张胜,李凌佳,王杨,等.门诊疑似患者人乳头瘤病毒检测及基因亚型分布[J].中国皮肤性病学杂志,2016,15(10):1033-1036.
[10]HUANG S,AFONINA I,MILLER B A,et al.Human papillomavirus types 52 and 58 are prevalent in cervical cancers from Chinese women[J].Int J Cancer,1997,70(4):408-411.
[11]LIU J,ROSE B,HUANG X,et al.Comparative analysis of characteristics of women with cervical cancer in high-versus low-incidence regions[J].Gynecol Oncol,2004,94(3):803-810.
[12]BALOCH Z,LI Y,YUAN T,et al.Epidemiologic characterization of human papillomavirus(HPV)infection in various regions of Yunnan Province of China[J].BMC Infect Dis,2016,16(1):228.
[13]TANG Y,ZHENG L,YANG S,et al.Epidemiology and genotype distribution of human papillomavirus(HPV)in Southwest China:a cross-sectional five years study in non-vaccinated women[J].Virol J,2017,14(1):84.
[14]AGENIS A,DUFIT V,DOUINE M,et al.High prevalence of HPVinfection in the remote villages of French Guiana:an epidemiological study[J].Epidemiol Infect,2017,145(6):1276-1284.
[15]LYNGE E,CLAUSEN L B,GUIGNARD R,et al.What happens when organization of cervical cancer screening is delayed or stopped[J].J Med Screen,2006,13(1):41-46.