固冲止崩汤对围绝经期功能性子宫出血患者雌激素分泌及炎症反应的影响
|
摘要
目的:探讨采用固冲止崩汤治疗围绝经期功能性子宫出血对患者雌激素分泌及炎症反应的影响。方法:选取2016年7月—2018年11月我院收治的围绝经期功能性子宫出血患者92例,根据随机数字表法分为两组,各46例。对照组采用米非司酮(12.5 mg,qd)治疗,观察组在对照组基础上采用固冲止崩汤(1剂/d)治疗,比较两组治疗前后雌二醇(E_2)水平、炎症反应及不良反应发生情况。结果:观察组治疗后雌二醇(E_2)水平低于对照组,差异有统计学意义(P <0.05);观察组治疗后肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6水平均低于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:固冲止崩汤可有效降低围绝经期功能性子宫出血患者炎症反应,调节雌激素分泌,且用药安全性较高。
Objective:To investigate the effect of guchong zhibeng decoction on estrogen secretion and in?ammation response in patients with peri-menopausal functional uterine hemorrhage. Methods:92 patients with peri-menopausal functional uterine hemorrhage admitted to our hospital from July 2016 to November 2018 were selected and randomly divided into two groups, 46 cases each. The patients in the control group were treated with mifepristone(12.5 mg, qd), and the patients in the observation group were treated with guchong zhibeng decoction(1 dose/d) on the basis of the control group. The levels of estradiol(E_2) before and after treatment, in?ammation response and adverse reactions were compared between the two groups. Results:The level of estradiol(E_2) in the observation group was lower than that in the control group, and the difference was statistically signi?cant(P<0.05).The levels of tumor necrosis factor(TNF)-α and interleukin(IL)-6 in the observation group were lower than those in the control group, and the differences were statistically signi?cant(P<0.05). There was no statistically signi?cant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Guchong zhibeng decoction can effectively reduce inflammatory response in the patients with peri-menopausal functional uterine hemorrhage and regulate estrogen secretion, and the safety of the medication is higher.
Objective:To investigate the effect of guchong zhibeng decoction on estrogen secretion and in?ammation response in patients with peri-menopausal functional uterine hemorrhage. Methods:92 patients with peri-menopausal functional uterine hemorrhage admitted to our hospital from July 2016 to November 2018 were selected and randomly divided into two groups, 46 cases each. The patients in the control group were treated with mifepristone(12.5 mg, qd), and the patients in the observation group were treated with guchong zhibeng decoction(1 dose/d) on the basis of the control group. The levels of estradiol(E_2) before and after treatment, in?ammation response and adverse reactions were compared between the two groups. Results:The level of estradiol(E_2) in the observation group was lower than that in the control group, and the difference was statistically signi?cant(P<0.05).The levels of tumor necrosis factor(TNF)-α and interleukin(IL)-6 in the observation group were lower than those in the control group, and the differences were statistically signi?cant(P<0.05). There was no statistically signi?cant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Guchong zhibeng decoction can effectively reduce inflammatory response in the patients with peri-menopausal functional uterine hemorrhage and regulate estrogen secretion, and the safety of the medication is higher.
引文
[1]张林.米非司酮联合妈富隆治疗功能性子宫出血的疗效观察[J].中国执业药师,2015,12(3):9-11.
[2]代学华,叶永梅,郭停.止血汤辅助治疗围绝经期功能性子宫出血临床研究[J].陕西中医,,2017,38(1):55-56.
[3]中华医学会妇产科学分会妇科内分泌学组.异常子宫出血诊断与治疗指南[J].中华妇产科杂志,2014,49(11):801-806.
[4]刘敏如.中医妇科学[M].北京:人民卫生出版社,2007:456-457.
[5]陈亚玲.米非司酮联合宫瘤消胶囊对子宫肌瘤的临床效果[J].中国合理用药探索,2018,15(3):23-25.
[6]王丽琴.去氧孕烯炔雌醇片联合补肾固冲汤治疗围绝经期功能性子宫出血疗效观察[J].现代中西医结合杂志,2016,25(11):1208-1210.
[7]万金华,许义芳.清热祛瘀汤配合黄体酮胶丸治疗围绝经期功能失调性子宫出血[J].吉林中医药,2017,37(10):1008-1011.
[8]樊延霞.中西医结合治疗围绝经期功能失调性子宫出血临床研究[J].中医学报,2016,31(12):2003-2006,2010.
[2]代学华,叶永梅,郭停.止血汤辅助治疗围绝经期功能性子宫出血临床研究[J].陕西中医,,2017,38(1):55-56.
[3]中华医学会妇产科学分会妇科内分泌学组.异常子宫出血诊断与治疗指南[J].中华妇产科杂志,2014,49(11):801-806.
[4]刘敏如.中医妇科学[M].北京:人民卫生出版社,2007:456-457.
[5]陈亚玲.米非司酮联合宫瘤消胶囊对子宫肌瘤的临床效果[J].中国合理用药探索,2018,15(3):23-25.
[6]王丽琴.去氧孕烯炔雌醇片联合补肾固冲汤治疗围绝经期功能性子宫出血疗效观察[J].现代中西医结合杂志,2016,25(11):1208-1210.
[7]万金华,许义芳.清热祛瘀汤配合黄体酮胶丸治疗围绝经期功能失调性子宫出血[J].吉林中医药,2017,37(10):1008-1011.
[8]樊延霞.中西医结合治疗围绝经期功能失调性子宫出血临床研究[J].中医学报,2016,31(12):2003-2006,2010.