氨氯地平阿托伐他汀钙片治疗高血压患者的疗效及对血压、血脂的影响
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摘要
目的:探讨氨氯地平阿托伐他汀钙片治疗高血压患者的疗效。方法:选择我院收治的高血压患者112例,被随机均分为氨氯地平组(使用氨氯地平治疗)和氨氯地平阿托伐他汀组(使用氨氯地平阿托伐他汀钙片治疗),治疗8周后,对比两组患者疗效及不良反应发生率,治疗前后血压,血脂变化。结果:治疗后,两组血压、血脂(除高密度脂蛋白-胆固醇显著升高外)水平均较治疗前显著降低,P<0.05或<0.01;且与氨氯地平组比较,氨氯地平阿托伐他汀组总有效率(62.5%比96.4%)显著提高(P=0.001),不良反应发生率(28.5%比3.5%)显著降低(P=0.003);血压[(147.5±10.1)/(90.7±8.2) mmHg比(133.2±9.4)/(86.9±8.2) mmHg]、血总胆固醇[(5.7±1.3) mmol/L比(5.2±0.8) mmol/L]、甘油三酯[(2.5±1.2) mmol/L比(1.9±0.5) mmol/L]和低密度脂蛋白-胆固醇[(4.1±0.7) mmol/L比(3.1±0.6) mmol/L]水平均显著下降(P<0.05或<0.01)。结论:氨氯地平阿托伐他汀钙片可显著改善高血压患者血压、血脂水平,且不良反应少,值得临床推广。
Objective: To explore therapeutic effect of amlodipine atorvastatin calcium tablet on hypertensive patients. Methods:A total of 112 hypertensive patients treated in our hospital were randomly and equally divided into amlodipine group(received amlodipine 5 mg/d) and amlodipine atorvastatin group(received amlodipine atorvastatin calcium tablet 15 mg/d), both groups were treated for eight weeks. Therapeutic effect and incidence of adverse reactions, blood pressure and blood lipids before and after treatment were compared between two groups. Results:Compared with before treatment, there were significant reduction in levels of blood pressure and blood lipids(except significant rise in HDL-C level) in two groups after treatment, P<0.05 or <0.01; compared with amlodipine group, there was significant rise in total effective rate(62.5% vs. 96.4%, P=0.001), and significant reduction in incidence rate of adverse reactions(28.5% vs. 3.5%), P=0.003; significant reductions in levels of blood pressure [(147.5±10.1)/(90.7±8.2) mmHg vs.(133.2±9.4)/(86.9±8.2) mmHg], total cholesterol [(5.7±1.3) mmol/L vs.(5.2±0.8) mmol/L], triglyceride [(2.5±1.2) mmol/L vs.(1.9±0.5) mmol/L]and low density lipoprotein cholesterol [(4.1±0.7) mmol/L vs.(3.1±0.6) mmol/L]in amlodipine atorvastatin group, P<0.05 or <0.01. Conclusion:Amlodipine atorvastatin calcium tablet can significantly improve blood pressure and blood lipids with few adverse reactions in hypertensive patients, which is worth extending.
Objective: To explore therapeutic effect of amlodipine atorvastatin calcium tablet on hypertensive patients. Methods:A total of 112 hypertensive patients treated in our hospital were randomly and equally divided into amlodipine group(received amlodipine 5 mg/d) and amlodipine atorvastatin group(received amlodipine atorvastatin calcium tablet 15 mg/d), both groups were treated for eight weeks. Therapeutic effect and incidence of adverse reactions, blood pressure and blood lipids before and after treatment were compared between two groups. Results:Compared with before treatment, there were significant reduction in levels of blood pressure and blood lipids(except significant rise in HDL-C level) in two groups after treatment, P<0.05 or <0.01; compared with amlodipine group, there was significant rise in total effective rate(62.5% vs. 96.4%, P=0.001), and significant reduction in incidence rate of adverse reactions(28.5% vs. 3.5%), P=0.003; significant reductions in levels of blood pressure [(147.5±10.1)/(90.7±8.2) mmHg vs.(133.2±9.4)/(86.9±8.2) mmHg], total cholesterol [(5.7±1.3) mmol/L vs.(5.2±0.8) mmol/L], triglyceride [(2.5±1.2) mmol/L vs.(1.9±0.5) mmol/L]and low density lipoprotein cholesterol [(4.1±0.7) mmol/L vs.(3.1±0.6) mmol/L]in amlodipine atorvastatin group, P<0.05 or <0.01. Conclusion:Amlodipine atorvastatin calcium tablet can significantly improve blood pressure and blood lipids with few adverse reactions in hypertensive patients, which is worth extending.
引文
[1]陈慧敏,许逸飞.苯磺酸氨氯地平联合阿托伐他汀钙治疗老年高血压伴血脂异常的临床研究[J].中国临床药理学杂志,2016,32(12):1072-1074.
[2]樊彩妮,赵海鹰,蒋玲,等.苯磺酸氨氯地平和氨氯地平阿托伐他汀钙片治疗轻中度原发性高血压合并颈动脉粥样硬化患者的疗效[J].中华高血压杂志,2016,2(7):674-677.
[3]Gao X.Preliminary evaluation of the effect of amlodipine besylate and atorvastatin calcium tablets in the treatment of patients with hypertension combined with coronary heart disease[J].Chinese Community Doctors,2017,1(4):120-123.
[4]曲凯.氨氯地平阿托伐他汀钙片治疗高血压合并冠心病疗效观察[J].重庆医学,2017,1(2):295-296.
[5]Lin J,Pharmacy DO.Investigation of Clinical Effect of Amlodipine Besylate and Atorvastatin Calcium Tablets in Treatment of Hypertension Complicated With Coronary Heart Disease[J].China Health Standard Management,2017,2(5):19-20.
[6]李锐锋.阿托伐他汀钙对高血压视网膜病变的治疗作用[J].临床心血管病杂志,2016,2(10):1024-1030.
[7]裴芳,黄骥,李锐锋,等.阿托伐他汀钙对高血压视网膜病变的治疗作用[J].临床心血管病杂志,2016,1(10):1024-1030.
[8]Wei H,Ling Y,Ling X.Clinical efficacy of amlodipine besylate and atorvastatin calcium tablets in treatment of hypertension and hyperlipidemia[J].China Med Pharmacy,2016,3(2):12-14.
[9]董晓柳,徐士军,张秀清,等.阿托伐他汀联合普罗布考对高血压患者血管弹性的影响[J].中国药房,2016,27(23):3243-3245.
[10]左莉莉,张旭刚,苏辉,等.阿托伐他汀钙联合硝苯地平缓释片治疗老年高血压合并心律失常的疗效及对肝肾功能影响[J].中国地方病防治杂志,2017,1(3):326-327.
[11]Yang Z,Department G.Analysis on Effect of Amlodipine Besylate Combined With Atorvastatin Calcium in the Treatment of Hypertension and High Cholesterol[J].China Continuing Med Education,2016,2(4):10-12.
[12]刘俊燕,栗娜.苯磺酸氨氯地平联合赖诺普利氢氯噻嗪与阿托伐他汀治疗重度原发性高血压合并颈动脉粥样硬化的临床观察[J].中国药房,2017,28(9):1207-1210.
[13]Wang X.Clinical effect observation of amlodipine besylate and atorvastatin calcium tablets in the treatment of hypertension combined with coronary heart disease[J].Chinese Community Doctors,2017,2(1):102-103.
[14]国政,邓长金.长春西汀治疗急性冠脉综合征合并高血压的临床观察[J].中国药房,2016,27(33):4638-4640.
[15]郑炜平,陈海峰,林开阳,等.阿托伐他汀对高血压合并高低密度脂蛋白胆固醇血症患者肾功能的影响[J].中华高血压杂志,2016,2(1):56-60.
[2]樊彩妮,赵海鹰,蒋玲,等.苯磺酸氨氯地平和氨氯地平阿托伐他汀钙片治疗轻中度原发性高血压合并颈动脉粥样硬化患者的疗效[J].中华高血压杂志,2016,2(7):674-677.
[3]Gao X.Preliminary evaluation of the effect of amlodipine besylate and atorvastatin calcium tablets in the treatment of patients with hypertension combined with coronary heart disease[J].Chinese Community Doctors,2017,1(4):120-123.
[4]曲凯.氨氯地平阿托伐他汀钙片治疗高血压合并冠心病疗效观察[J].重庆医学,2017,1(2):295-296.
[5]Lin J,Pharmacy DO.Investigation of Clinical Effect of Amlodipine Besylate and Atorvastatin Calcium Tablets in Treatment of Hypertension Complicated With Coronary Heart Disease[J].China Health Standard Management,2017,2(5):19-20.
[6]李锐锋.阿托伐他汀钙对高血压视网膜病变的治疗作用[J].临床心血管病杂志,2016,2(10):1024-1030.
[7]裴芳,黄骥,李锐锋,等.阿托伐他汀钙对高血压视网膜病变的治疗作用[J].临床心血管病杂志,2016,1(10):1024-1030.
[8]Wei H,Ling Y,Ling X.Clinical efficacy of amlodipine besylate and atorvastatin calcium tablets in treatment of hypertension and hyperlipidemia[J].China Med Pharmacy,2016,3(2):12-14.
[9]董晓柳,徐士军,张秀清,等.阿托伐他汀联合普罗布考对高血压患者血管弹性的影响[J].中国药房,2016,27(23):3243-3245.
[10]左莉莉,张旭刚,苏辉,等.阿托伐他汀钙联合硝苯地平缓释片治疗老年高血压合并心律失常的疗效及对肝肾功能影响[J].中国地方病防治杂志,2017,1(3):326-327.
[11]Yang Z,Department G.Analysis on Effect of Amlodipine Besylate Combined With Atorvastatin Calcium in the Treatment of Hypertension and High Cholesterol[J].China Continuing Med Education,2016,2(4):10-12.
[12]刘俊燕,栗娜.苯磺酸氨氯地平联合赖诺普利氢氯噻嗪与阿托伐他汀治疗重度原发性高血压合并颈动脉粥样硬化的临床观察[J].中国药房,2017,28(9):1207-1210.
[13]Wang X.Clinical effect observation of amlodipine besylate and atorvastatin calcium tablets in the treatment of hypertension combined with coronary heart disease[J].Chinese Community Doctors,2017,2(1):102-103.
[14]国政,邓长金.长春西汀治疗急性冠脉综合征合并高血压的临床观察[J].中国药房,2016,27(33):4638-4640.
[15]郑炜平,陈海峰,林开阳,等.阿托伐他汀对高血压合并高低密度脂蛋白胆固醇血症患者肾功能的影响[J].中华高血压杂志,2016,2(1):56-60.