梗阻性肾积水动物模型的研究进展
摘要
<正>梗阻性肾积水是小儿常见的泌尿系统疾病,病因主要是肾盂输尿管交界处狭窄。梗阻性肾积水对肾脏发生损害的机制仍不完全清楚,梗阻性肾积水动物模型的构建,在很大程度上模拟了先天性肾积水发生的过程,为探讨梗阻性肾积水的病理及生理过程提供了良好的实验基础,本文就梗阻性肾积水动物模型的制作、研究方法、发病机制等综述如下。1梗阻性肾积水动物模型1.1动物的选择不同的实验动物使用同一实验方法,结果可能
引文
[1]ESKILD-JENSEN A,CHRISTENSEN H,LINDVIG M,et al.Renal functional outcome in unilateral hydronephrosis in newborn pigs[J].J Urol,2000,163(6):1896-1900.
[2]叶露,李琼,李宏,等.动态增强MRI测量猪单侧肾功能不全模型肾小球滤过率[J].磁共振成像,2012,3(3):204-209.
[3]MADSEN M G.Urinary biomarkers in hydronephrosis[J].Dan Med J,2013,60(2):B4582.
[4]SALLSTROM J,PEUCKERT C,GAO X,et al.Impaired EphA4signaling leads to congenital hydronephrosis,renal injury,and hypertension[J].Am J Physiol Renal Physiol,2013,305(1):F71-F79.
[5]马勇,周林,郭剑明,等.超声生物显微镜无创检测新生小鼠先天性肾积水[J].复旦学报(医学版),2014,41(3):344-347.
[6]YOSHIOKA W,KAWAGUCHI T,FUJISAWA N,et al.Predominant role of cytosolic phospholipase A2αin dioxin-induced neonatal hydronephrosis in mice[J].Sci Rep,2014,10(4):40-42.
[7]于雪馨,王常林,孙荣国,等.鼠输尿管完全梗阻后肾脏病理及足细胞表型改变的研究[J].中国医科大学学报,2010,39(1):1-3.
[8]叶达夫,张杰,姚颐.大鼠急、慢性梗阻性积水肾组织的形态学改变[J].武汉大学学报(医学版),2010,31(2):166-169.
[9]腾丽新,张璟,刘胜学,等.建立大鼠单侧输尿管梗阻模型手术方式的选择[J].重庆医学,2002,31(9):851-852.
[10]刘建民,王凤超,孟宇,等.兔单侧输尿管梗阻模型中TGF-β1变化的意义[J].实用全科医学,2004,2(5):379-380.
[11]SUMMERS S A,GAN P Y,DEWAGE L,et al.Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction[J].Kidney Int,2012,82(6):676-685.
[12]WEN J G,RINGGAARD S,JRGENSEN T M,et al.Long-term effects of partial unilateral ureteral obstruction on renal hemodynamics and morphology in newbornrats:a magnetic resonance imaging study[J].Urol Res,2002,30(4):205-212.
[13]CAO Z,YU W,LI W,et al.Acute kidney injuries induced by various irrigation pressures in rat models of mild and severe hydronephrosis[J].Urology,2013,82(6):1453.e9-e16.
[14]BOWEN J,SHARMA H,GOUGH D C.Chronic hydronephrosis:renographic drainage patterns and renal morphology in an animal model[J].Br J Urol,1994,74(1):26-30.
[15]杨洋,张潍平,彭芸,等.两种输尿管不全梗阻肾积水动物模型制作方法的比较[J].临床小儿外科杂志,2011,10(2):107-110.
[16]PENNA F J,CHOW J S,MINNILLO B J,et al.Identifying ureteropelvic junction obstruction by fluorescence imaging:a comparative study of imaging modalitiesto assess renal function and degree of obstruction in a mouse model[J].J Urol,2011,185(6):2405-2413.
[17]SHOKEIR A A,NIJMAN R J,EL-AZAB M,et al.Partial ureteral obstruction:effect of intravenous normal saline and furosemide upon the renal resistive index[J].J Urol,1997,157(3):1074-1077.
[18]LEE J Y,SHIN J H,SONG K H,et al.Expression of aquaporin-3in ipsilateral rat kidney with unilateral partial ureteral obstruction[J].Korean J Urol,2013,54(4):266-270.
[19]VAN KAMPEN M,EBLE M J,KREMPIEN R,et al.Influence of irradiated volume on ureteral injury after intraoperative radiation therapy:experimental study in dogs[J].Radiology,2003,228(1):139-143.
[20]ALBERTI C.Congenital ureteropelvic junction obstruction:physiopathology,decoupling of tout court pelvic dilatation-obstruction semantic connection,biomarkers to predict renal damage evolution[J].Eur Rev Med Pharmacol Sci,2012,16(2):213-219.
[21]WEN J G,CHEN Y,RINGGAARD S,et al.Evaluation of renal function in normal and hydronephrotic kidneys in rats using gadolinium diethylenetetramine-pentaacetic acid enhanced dynamic magnetic resonance imaging[J].J Urol,2000,163(4):1264-1270.
[22]GUERIN F,AZOULAY R,BERREBI D,et al.Partial unilateral ureteral obstruction in newborn mice:magnetic resonance imaging and pathology studies[J].J Urol,2008,179(4):1553-1563.
[23]韩文文,张潍平,彭芸,等.兔肾积水模型的建立及SPECT和CT灌注成像[J].中国实用动物学报,2009,17(6):410-414.
[24]谭大清,张杰,姚颐,等.单侧梗阻性肾积水99mTc-DTPA肾动态显像无功能状态时的肾功能评估[J].中华实验外科杂志,2008,25(4):542.
[25]张洪宪,马潞林,陆敏,等.继发性输尿管梗阻对大鼠活体输尿管蠕动规律及ICC样间质细胞的影响[J].实验动物学,2011,28(4):15-20.
[26]DECRAMER S,BASCANDS J L,SCHANSTRA J P.Non-invasive markers of ureteropelvic junction obstruction[J].World J Urol,2007,25(5):457-465.
[27]LI W Q,DONG Z Q,ZHOU X B,et al.Renovascular morphological changes in a rabbit model of hydronephrosis[J].J Huazhong Univ Sci Technolog Med Sci,2014,34(4):575-581.
[28]BOTTO N,AZOULAY R,PEUCHMAUR M,et al.Renal parenchymal fibrosis and atrophy are not correlated with upper tract dilatation:long-term study of partial unilateral ureteral obstruction in neonatal mice[J].J Pediatr Urol,2011,7(3):310-316.
[2]叶露,李琼,李宏,等.动态增强MRI测量猪单侧肾功能不全模型肾小球滤过率[J].磁共振成像,2012,3(3):204-209.
[3]MADSEN M G.Urinary biomarkers in hydronephrosis[J].Dan Med J,2013,60(2):B4582.
[4]SALLSTROM J,PEUCKERT C,GAO X,et al.Impaired EphA4signaling leads to congenital hydronephrosis,renal injury,and hypertension[J].Am J Physiol Renal Physiol,2013,305(1):F71-F79.
[5]马勇,周林,郭剑明,等.超声生物显微镜无创检测新生小鼠先天性肾积水[J].复旦学报(医学版),2014,41(3):344-347.
[6]YOSHIOKA W,KAWAGUCHI T,FUJISAWA N,et al.Predominant role of cytosolic phospholipase A2αin dioxin-induced neonatal hydronephrosis in mice[J].Sci Rep,2014,10(4):40-42.
[7]于雪馨,王常林,孙荣国,等.鼠输尿管完全梗阻后肾脏病理及足细胞表型改变的研究[J].中国医科大学学报,2010,39(1):1-3.
[8]叶达夫,张杰,姚颐.大鼠急、慢性梗阻性积水肾组织的形态学改变[J].武汉大学学报(医学版),2010,31(2):166-169.
[9]腾丽新,张璟,刘胜学,等.建立大鼠单侧输尿管梗阻模型手术方式的选择[J].重庆医学,2002,31(9):851-852.
[10]刘建民,王凤超,孟宇,等.兔单侧输尿管梗阻模型中TGF-β1变化的意义[J].实用全科医学,2004,2(5):379-380.
[11]SUMMERS S A,GAN P Y,DEWAGE L,et al.Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction[J].Kidney Int,2012,82(6):676-685.
[12]WEN J G,RINGGAARD S,JRGENSEN T M,et al.Long-term effects of partial unilateral ureteral obstruction on renal hemodynamics and morphology in newbornrats:a magnetic resonance imaging study[J].Urol Res,2002,30(4):205-212.
[13]CAO Z,YU W,LI W,et al.Acute kidney injuries induced by various irrigation pressures in rat models of mild and severe hydronephrosis[J].Urology,2013,82(6):1453.e9-e16.
[14]BOWEN J,SHARMA H,GOUGH D C.Chronic hydronephrosis:renographic drainage patterns and renal morphology in an animal model[J].Br J Urol,1994,74(1):26-30.
[15]杨洋,张潍平,彭芸,等.两种输尿管不全梗阻肾积水动物模型制作方法的比较[J].临床小儿外科杂志,2011,10(2):107-110.
[16]PENNA F J,CHOW J S,MINNILLO B J,et al.Identifying ureteropelvic junction obstruction by fluorescence imaging:a comparative study of imaging modalitiesto assess renal function and degree of obstruction in a mouse model[J].J Urol,2011,185(6):2405-2413.
[17]SHOKEIR A A,NIJMAN R J,EL-AZAB M,et al.Partial ureteral obstruction:effect of intravenous normal saline and furosemide upon the renal resistive index[J].J Urol,1997,157(3):1074-1077.
[18]LEE J Y,SHIN J H,SONG K H,et al.Expression of aquaporin-3in ipsilateral rat kidney with unilateral partial ureteral obstruction[J].Korean J Urol,2013,54(4):266-270.
[19]VAN KAMPEN M,EBLE M J,KREMPIEN R,et al.Influence of irradiated volume on ureteral injury after intraoperative radiation therapy:experimental study in dogs[J].Radiology,2003,228(1):139-143.
[20]ALBERTI C.Congenital ureteropelvic junction obstruction:physiopathology,decoupling of tout court pelvic dilatation-obstruction semantic connection,biomarkers to predict renal damage evolution[J].Eur Rev Med Pharmacol Sci,2012,16(2):213-219.
[21]WEN J G,CHEN Y,RINGGAARD S,et al.Evaluation of renal function in normal and hydronephrotic kidneys in rats using gadolinium diethylenetetramine-pentaacetic acid enhanced dynamic magnetic resonance imaging[J].J Urol,2000,163(4):1264-1270.
[22]GUERIN F,AZOULAY R,BERREBI D,et al.Partial unilateral ureteral obstruction in newborn mice:magnetic resonance imaging and pathology studies[J].J Urol,2008,179(4):1553-1563.
[23]韩文文,张潍平,彭芸,等.兔肾积水模型的建立及SPECT和CT灌注成像[J].中国实用动物学报,2009,17(6):410-414.
[24]谭大清,张杰,姚颐,等.单侧梗阻性肾积水99mTc-DTPA肾动态显像无功能状态时的肾功能评估[J].中华实验外科杂志,2008,25(4):542.
[25]张洪宪,马潞林,陆敏,等.继发性输尿管梗阻对大鼠活体输尿管蠕动规律及ICC样间质细胞的影响[J].实验动物学,2011,28(4):15-20.
[26]DECRAMER S,BASCANDS J L,SCHANSTRA J P.Non-invasive markers of ureteropelvic junction obstruction[J].World J Urol,2007,25(5):457-465.
[27]LI W Q,DONG Z Q,ZHOU X B,et al.Renovascular morphological changes in a rabbit model of hydronephrosis[J].J Huazhong Univ Sci Technolog Med Sci,2014,34(4):575-581.
[28]BOTTO N,AZOULAY R,PEUCHMAUR M,et al.Renal parenchymal fibrosis and atrophy are not correlated with upper tract dilatation:long-term study of partial unilateral ureteral obstruction in neonatal mice[J].J Pediatr Urol,2011,7(3):310-316.
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