高危产妇临产期血浆D-二聚体和凝血四项的变化
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摘要
目的探究高危产妇临产期血浆凝血四项和D-二聚体(DD)的变化。方法选取2016年6月1日~8月31日我院收治的120例临产期产妇作为研究对象,按不同产妇分为观察组(高危产妇)与对照组(正常临产期产妇),每组60例,比较两组DD和凝血四项的变化。结果观察组患者的血清APTT显著低于对照组,且观察组患者的PT、TT、FIB、D-二聚体显著高于对照组,差异均有统计学意义(P<0.05)。结论高危产妇临产期的纤溶、凝血功能均发生改变,其中以DD、FIB、TT升高,PT、APTT降低为主,虽然能在一定程度上对产后出血症状进行缓解,但会加重妊娠并发症症状,因此,应对妊娠孕妇进行密切观察,了解动态变化,避免出现严重并发症。
Objective To observe the change of four coagulation indices and plasma D-Dimer(DD)in high-risk parturient women.Methods 120 parturients admitted to our hospital from June 1 st,2016 to August 31 st,2016 were selected as research objects.According to different parturients,they were divided into observation group(high-risk parturients) and control group(normal parturients),there were 60 cases in each group,and the changes of D-D and blood coagulation of two kinds of parturients were compared.Results The serum thromboplastin time(APTT) of patients in the observation group was significantly lower than that of the control group,and the the D-D,prothrombin time(PT),prothrombin time(TT) and fibrinogen(FIB) in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion For high parturient women,the fibrinolysis and coagulation function are changed in resulting the increasing DD,FIB and TT and decreasing PT and APTT.Although the postpartum hemorrhage is partially relieved,the complications are exacerbated.The close and dynamic monitoring can avoid the severe complications.
Objective To observe the change of four coagulation indices and plasma D-Dimer(DD)in high-risk parturient women.Methods 120 parturients admitted to our hospital from June 1 st,2016 to August 31 st,2016 were selected as research objects.According to different parturients,they were divided into observation group(high-risk parturients) and control group(normal parturients),there were 60 cases in each group,and the changes of D-D and blood coagulation of two kinds of parturients were compared.Results The serum thromboplastin time(APTT) of patients in the observation group was significantly lower than that of the control group,and the the D-D,prothrombin time(PT),prothrombin time(TT) and fibrinogen(FIB) in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion For high parturient women,the fibrinolysis and coagulation function are changed in resulting the increasing DD,FIB and TT and decreasing PT and APTT.Although the postpartum hemorrhage is partially relieved,the complications are exacerbated.The close and dynamic monitoring can avoid the severe complications.
引文
[1]田宇,马梦影,徐妍妍,等.孕产妇产前凝血四项、D-二聚体和血小板的检测分析[J].国际检验医学杂志,2014,35(16):2156-2158.
[2]曾辛,袁霞.孕妇妊娠不同时期血浆D-二聚体和凝血四项变化及其检验价值分析[J].中国生化药物杂志,2017,37(9):429-430.
[3]吴世园.孕中期、临产期凝血四项与D二聚体的变化和临床意义[J].国际检验医学杂志,2015,36(12):1713-1714,1717.
[4]冯颖,郑建霞,轩维清,等.凝血四项及D-二聚体检测对于妊娠晚期妇女的临床意义[J].中国妇幼保健,2016,31(10):2064-2065.
[5]葛虹,朱晶,王爱红,等.动态监测孕妇D-二聚体和凝血四项指标的临床价值[J].西部医学,2016,28(8):1154-1156,1164.
[6]赵秀萍.妊娠晚期孕妇检测凝血四项、FDP、D-二聚体的临床意义[J].中国妇幼保健,2017,32(5):941-943.
[7]史际华,崔建娇.凝血四项及D-二聚体对早期诊断妊娠期高血压特异性、敏感性及其意义分析[J].中国生化药物杂志,2017,37(10):427-429.
[8]刘小书.妊娠晚期女性凝血四项、纤维蛋白(原)降解产物及D-二聚体水平变化及临床意义[J].中国妇幼保健,2017,32(15):3454-3456.
[9]徐晓燕,李晓红,郗爱喜,等.凝血功能和D-二聚体与妊娠高血压疾病严重程度的相关性[J].河北医学,2017,23(6):997-999.
[10]张莉,李晓丽,兰远霞,等.妊娠期肝内胆汁淤积症孕妇血液流变学、凝血功能和细胞因子的变化及临床意义[J].海南医学院学报,2015,21(8):1088-1090.
[11]张红胜,张敏.研究凝血四项和血小板相关指标检测在妊娠期高血压妊娠晚期的临床应用价值[J].血栓与止血学,2017,23(3):406-408.
[12]邵秀兰,张锋英,王巧岭,等.血浆凝血参数及尿γ-GT、NAG在妊高症中的临床诊断价值[J].标记免疫分析与临床,2017,24(2):207-209.
[13]毕秀敏,王坤,张彩英,等.妊娠期中重度OSAHS患者血凝参数变化及临床意义[J].中国中西医结合耳鼻咽喉科杂志,2015,23(3):169-171.
[14]Onishi H,Kaniyu K,Iwashita M,et al.Fibrin monomer complex in normal pregnant women:a potential thrombotic marker in pregnancy[J].Ann Clin Biochem,2013,44(5):449-454.
[15]Antovic A,Blomback M,Bremme K,et al.The assay of overall haemostasis potential used to monitor the low molecular mass(weight)heparin,dalteparin,treatment in pregnant women with previous thromboembolism[J].Blood Coagul Fibrinolysis,2002,13(3):181-186.
[2]曾辛,袁霞.孕妇妊娠不同时期血浆D-二聚体和凝血四项变化及其检验价值分析[J].中国生化药物杂志,2017,37(9):429-430.
[3]吴世园.孕中期、临产期凝血四项与D二聚体的变化和临床意义[J].国际检验医学杂志,2015,36(12):1713-1714,1717.
[4]冯颖,郑建霞,轩维清,等.凝血四项及D-二聚体检测对于妊娠晚期妇女的临床意义[J].中国妇幼保健,2016,31(10):2064-2065.
[5]葛虹,朱晶,王爱红,等.动态监测孕妇D-二聚体和凝血四项指标的临床价值[J].西部医学,2016,28(8):1154-1156,1164.
[6]赵秀萍.妊娠晚期孕妇检测凝血四项、FDP、D-二聚体的临床意义[J].中国妇幼保健,2017,32(5):941-943.
[7]史际华,崔建娇.凝血四项及D-二聚体对早期诊断妊娠期高血压特异性、敏感性及其意义分析[J].中国生化药物杂志,2017,37(10):427-429.
[8]刘小书.妊娠晚期女性凝血四项、纤维蛋白(原)降解产物及D-二聚体水平变化及临床意义[J].中国妇幼保健,2017,32(15):3454-3456.
[9]徐晓燕,李晓红,郗爱喜,等.凝血功能和D-二聚体与妊娠高血压疾病严重程度的相关性[J].河北医学,2017,23(6):997-999.
[10]张莉,李晓丽,兰远霞,等.妊娠期肝内胆汁淤积症孕妇血液流变学、凝血功能和细胞因子的变化及临床意义[J].海南医学院学报,2015,21(8):1088-1090.
[11]张红胜,张敏.研究凝血四项和血小板相关指标检测在妊娠期高血压妊娠晚期的临床应用价值[J].血栓与止血学,2017,23(3):406-408.
[12]邵秀兰,张锋英,王巧岭,等.血浆凝血参数及尿γ-GT、NAG在妊高症中的临床诊断价值[J].标记免疫分析与临床,2017,24(2):207-209.
[13]毕秀敏,王坤,张彩英,等.妊娠期中重度OSAHS患者血凝参数变化及临床意义[J].中国中西医结合耳鼻咽喉科杂志,2015,23(3):169-171.
[14]Onishi H,Kaniyu K,Iwashita M,et al.Fibrin monomer complex in normal pregnant women:a potential thrombotic marker in pregnancy[J].Ann Clin Biochem,2013,44(5):449-454.
[15]Antovic A,Blomback M,Bremme K,et al.The assay of overall haemostasis potential used to monitor the low molecular mass(weight)heparin,dalteparin,treatment in pregnant women with previous thromboembolism[J].Blood Coagul Fibrinolysis,2002,13(3):181-186.