Febuxostat对痛风伴高尿酸血症患者的血液流变学和血小板活化功能的影响
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摘要
目的探讨febuxostat(非布司他)对痛风伴高尿酸血症患者血液流变学及血小板活化功能的影响。方法选取滨海县人民医院2015年4月至2017年3月收治的痛风伴高尿酸血症患者68例,随机分为对照组(35例)(给予别嘌醇治疗)和观察组(33例)(给予febuxostat治疗)。比较两组患者的临床疗效、血液流变学变化以及血小板活化功能的变化。结果治疗总有效率,观察组患者高于对照组患者(P<0. 05),与对照组相比,观察组患者在治疗后的血液流变学指标改善和血小板活化功能改善方面均更为明显(P<0. 05)。结论 Febuxostat治疗能有效地降低痛风伴高尿酸血症患者的高尿酸状态,改善患者的血液流变学与血小板活化功能,疗效优于别嘌醇。
Objective To investigate the effect of febuxostat on blood rheology and platelet activation in patients with gout and hyperuricemia. Methods Sixty-eight cases of patients with gout and hyperuricemia were collected in Binhai People's Hospital from April 2015 to March 2017. They were randomly divided into the control group( 35 cases),received allopurinol treatment,and the observation group( 33 cases) treated with febuxostat. The clinical effects,blood rheology and the change of platelet activation function were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group( P<0. 05). Compared with the control group,the improvement of blood rheology and platelet activation function in the observation group were more significant than those in the control group( P < 0. 05). Conclusions Febuxostat therapy can effectively reduce uric acid level in patients with gout and hyperuricemia; improve blood rheology and platelet activation function in patients with gout and hyperuricemia,and the curative effect is better than that of allopurinol.
Objective To investigate the effect of febuxostat on blood rheology and platelet activation in patients with gout and hyperuricemia. Methods Sixty-eight cases of patients with gout and hyperuricemia were collected in Binhai People's Hospital from April 2015 to March 2017. They were randomly divided into the control group( 35 cases),received allopurinol treatment,and the observation group( 33 cases) treated with febuxostat. The clinical effects,blood rheology and the change of platelet activation function were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group( P<0. 05). Compared with the control group,the improvement of blood rheology and platelet activation function in the observation group were more significant than those in the control group( P < 0. 05). Conclusions Febuxostat therapy can effectively reduce uric acid level in patients with gout and hyperuricemia; improve blood rheology and platelet activation function in patients with gout and hyperuricemia,and the curative effect is better than that of allopurinol.
引文
[1] Kim CS,Jin DC,Yun YC,et al. Relationship between serum uric acid and mortality among hemodialysis patients:Retrospective analysis of Korean end-stage renal disease registry data[J]. Kidney Res Clin Pract,2017,36:368-376.
[2] Guttmann A,Krasnokutsky S,Pillinger MH,et al. Pegloticase in gout treatment-safety issues,latest evidence and clinical considerations[J]. Ther Adv Drug Saf,2017,8:379-388.
[3]张涛,王芳,张文涛,等.非布司他治疗痛风伴高尿酸血症患者的效果及其对血尿酸、TNF-α和s ICAM-1水平的影响[J].广西医科大学学报,2017,34:1224-1226.
[4] Madala ND,Dubula T,Assounga AGH,et al. Association of kidney function and waist circumference with uric acid levels in south Africans[J]. Metab Syndr Relat Disord,2017,15:500-506.
[5]曾荣南,吴启富,接红宇,等.痛风清冲剂对痛风性关节炎患者血脂与血液流变学影响的临床研究[J].世界中西医结合杂志,2012,7:596-598.
[6]曲娜.滋肾祛湿化瘀中药治疗颈动脉不稳定斑块疗效及对血管内皮功能、血小板活化指标的影响[J].现代中西医结合杂志,2017,26:1847-1853.
[7]吕明恩,李洋,吕翠翠,等.原发免疫性血小板减少症患者出血风险与血小板活化功能的相关性分析[J].中华血液学杂志,2017,38:33-38.
[8] Nomura J,Busso N,Ives A,et al. Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice[J]. Sci Rep,2014,4:4554.
[9] Sezai A, Soma M, Nakata K,et al. Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients with chronic kidney disease(NU-FLASH trial for CKD)[J]. J Cardiol,2015,66:298-303.
[2] Guttmann A,Krasnokutsky S,Pillinger MH,et al. Pegloticase in gout treatment-safety issues,latest evidence and clinical considerations[J]. Ther Adv Drug Saf,2017,8:379-388.
[3]张涛,王芳,张文涛,等.非布司他治疗痛风伴高尿酸血症患者的效果及其对血尿酸、TNF-α和s ICAM-1水平的影响[J].广西医科大学学报,2017,34:1224-1226.
[4] Madala ND,Dubula T,Assounga AGH,et al. Association of kidney function and waist circumference with uric acid levels in south Africans[J]. Metab Syndr Relat Disord,2017,15:500-506.
[5]曾荣南,吴启富,接红宇,等.痛风清冲剂对痛风性关节炎患者血脂与血液流变学影响的临床研究[J].世界中西医结合杂志,2012,7:596-598.
[6]曲娜.滋肾祛湿化瘀中药治疗颈动脉不稳定斑块疗效及对血管内皮功能、血小板活化指标的影响[J].现代中西医结合杂志,2017,26:1847-1853.
[7]吕明恩,李洋,吕翠翠,等.原发免疫性血小板减少症患者出血风险与血小板活化功能的相关性分析[J].中华血液学杂志,2017,38:33-38.
[8] Nomura J,Busso N,Ives A,et al. Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice[J]. Sci Rep,2014,4:4554.
[9] Sezai A, Soma M, Nakata K,et al. Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients with chronic kidney disease(NU-FLASH trial for CKD)[J]. J Cardiol,2015,66:298-303.