瓜蒌皮注射液治疗冠心病稳定型心绞痛的临床疗效和安全性分析
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摘要
目的探索瓜蒌皮注射液治疗冠心病稳定型心绞痛的临床疗效和安全性。方法计算机检索CNKI、PubMed、VIP和万方数据库,查找瓜蒌皮注射液治疗冠心病稳定型心绞痛的随机对照试验(RCT),自建库至2018年8月31日时限内文献均纳入检索范围。并对纳入文献的参考文献进行手工检索。按纳入排除标准由两人独立进行RCT的筛选、资料提取和质量评价后,采用RevMan5.3软件进行Meta分析。结果共纳入研究8个,包含865例患者。Meta分析结果显示,瓜蒌皮注射液治疗冠心病稳定型心绞痛在心绞痛和心电图的改善上优于常规治疗。结论瓜蒌皮注射液治疗冠心病稳定型心绞痛临床疗效确切,且安全性高。
Objective To investigate the clinical efficacy and safety of trichosanthis pericarpium injection in the treatment of stable angina.Methods Such databases as CNKI,PubMed,VIP and Wanfang were searched from their establishment to August 2018 for collecting the randomized controlled trials(RCTs)about trichosanthis pericarpium injection in the treatment of stable angina.The references of those RCTs were also searched by hands.After studying selection, assessment and data extraction conducted by two reviewers independently, meta-analyses were performed by RevMan5.3 software.Results Totally 8 studies invovlving 865 patients were included.The results of meta-analyses showed that: The improvement of angina pectoris and electrocardiogram in the treatment of stable angina pectoris is better than that of conventional treatment.Conclusion The clinical efficacy of trichosanthis pericarpium injection in the treatment of stable angina pectoris is exact and safety.
Objective To investigate the clinical efficacy and safety of trichosanthis pericarpium injection in the treatment of stable angina.Methods Such databases as CNKI,PubMed,VIP and Wanfang were searched from their establishment to August 2018 for collecting the randomized controlled trials(RCTs)about trichosanthis pericarpium injection in the treatment of stable angina.The references of those RCTs were also searched by hands.After studying selection, assessment and data extraction conducted by two reviewers independently, meta-analyses were performed by RevMan5.3 software.Results Totally 8 studies invovlving 865 patients were included.The results of meta-analyses showed that: The improvement of angina pectoris and electrocardiogram in the treatment of stable angina pectoris is better than that of conventional treatment.Conclusion The clinical efficacy of trichosanthis pericarpium injection in the treatment of stable angina pectoris is exact and safety.
引文
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[20] 郑辉.血府逐瘀汤合栝楼薤白半夏汤治疗稳定型心绞痛并高脂血症疗效分析[J].中国实用医药,2011,6(12):142-143.
[21] 邵春丽,王世久.瓜蒌皮抗缺氧作用的研究[J].沈阳药科大学学报,1997(4):38-40.
[22] 张弢,沈文芳,朱俊.瓜蒌对心血管系统的药理作用及临床应用[J].中国乡村医药,2007,14(11):52-52.
[23] 史永堂.新通注射液联合低分子肝素治疗不稳定型心绞痛及对血脂的疗效观察[J].中华中医药杂志,2007,22(11):804-805.
[24] 刘岱琳,曲戈霞,王乃利,等.瓜蒌的抗血小板聚集活性成分研究[J].中草药,2004,35(12):1334-1336.
[25] 罗革灵,陈伟利,谷彬,等.瓜蒌皮提取物对糖尿病大鼠血管内皮的保护作用[J].中国心血管病研究,2009,7(7):549-551.
[2] 姜利琼,陈兵,张春海,等.瓜蒌皮注射液对老年冠心病心绞痛治疗的临床观察[J].临床医学专集,2017,631-632.
[3] 刘莉,牛新萍.瓜蒌皮注射液对稳定型心绞痛痰瘀互结证血管内皮功能的影响[J].中西医结合心脑血管病杂志,2014,12(1):3-5.
[4] 杨丽君.瓜蒌皮注射液联合西药治疗痰瘀互结冠心病心绞痛随机平行对照研究[J].实用中医内科杂志,2016,30(12):61-63.
[5] 王令谆.瓜蒌皮注射液治疗冠心病患者的临床观察[J].中西医结合心脑血管病杂志,2016,4(29):65-66.
[6] 莫子明,张志广,廖尚宇.瓜篓皮注射液治疗冠心病稳定型心绞痛的临床观察[J].国外医学内科学分册,2005,32(8):357-359.
[7] 赵然尊,石蓓,王冬梅,等.瓜蒌皮注射液治疗冠心病稳定型心绞痛合并2型糖尿病的临床观察[J].中国新药杂志,2010,19(20):1871-1874.
[8] 刘宇,李慧.益气复脉注射液联合瓜篓皮注射液治疗气阴两虚型冠心病心绞痛临床疗效观察[J].内蒙古中医药,2013(12):16-17.
[9] 肖香群.寒凝心脉型胸痹证治初探[J].辽宁中医药大学学报,2008,10(4):14.
[10] 龙伯坚.黄帝内经集释·素问[M].北京:人民卫生出版社,2004:1.
[11] 赵佶.圣济总录[M].北京:人民卫生出版社,1962:773.
[12] 巢元方.诸病源候论校释[M].北京:人民卫生出版社,1983.
[13] 朱丹溪.丹溪心法校释[M].北京:人民卫生出版社,1983.
[14] 岳美中.岳美中论医案[D].北京:人民卫生出版社,2005:120.
[15] 孙爱军,郭明冬,于英奇,等.郭士魁活血化瘀学术思想探析[J].天津中医药,2017,34(2):82-85.
[16] 吴伟海,邓铁涛.邓老“痰瘀相关”理论与冠心病防治[J].深圳中西医结合杂志,2006,16(1):42-43.
[17] 卢红蓉,胡镜清.病邪兼化理论探讨[J].中国中医基础医学杂志,2016(10):1300-1301.
[18] 张琦.金匮要略讲义[J].上海:上海科学技术出版社,2008:100.
[19] 张晋,郭全.周文泉运用生脉散合丹参饮合瓜蒌薤白半夏汤治疗冠心病心绞痛经验[J].中医杂志,2011,6(52):48-50.
[20] 郑辉.血府逐瘀汤合栝楼薤白半夏汤治疗稳定型心绞痛并高脂血症疗效分析[J].中国实用医药,2011,6(12):142-143.
[21] 邵春丽,王世久.瓜蒌皮抗缺氧作用的研究[J].沈阳药科大学学报,1997(4):38-40.
[22] 张弢,沈文芳,朱俊.瓜蒌对心血管系统的药理作用及临床应用[J].中国乡村医药,2007,14(11):52-52.
[23] 史永堂.新通注射液联合低分子肝素治疗不稳定型心绞痛及对血脂的疗效观察[J].中华中医药杂志,2007,22(11):804-805.
[24] 刘岱琳,曲戈霞,王乃利,等.瓜蒌的抗血小板聚集活性成分研究[J].中草药,2004,35(12):1334-1336.
[25] 罗革灵,陈伟利,谷彬,等.瓜蒌皮提取物对糖尿病大鼠血管内皮的保护作用[J].中国心血管病研究,2009,7(7):549-551.