活血利水方辅助治疗急性脑梗死的疗效及对血栓弹力图指标、血管内皮因子水平的影响
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摘要
目的:分析活血利水方辅助治疗急性脑梗死的疗效及对血栓弹力图指标、血管内皮因子水平的影响。方法:急性脑梗死患者96例,根据治疗方法不同分为对照组和观察组。对照组患者采用常规的西医治疗,观察组患者加用活血利水方辅助治疗,分析两组患者治疗后的临床效果。结果:治疗前,两组患者中医症候积分、血栓弹力图指标、NIHSS评分、BI评分比较,差异无统计学意义(P>0.05)。治疗后,观察组患者中医症候积分、血栓弹力图指标、NIHSS评分、BI评分优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者AngⅡ、NO、ET-1、GMP-140水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者NO水平高于对照组,AngⅡ、ET-1、GMP-140水平低于对照组,差异有统计学意义(P<0.05)。结论:活血利水方辅助治疗急性脑梗死可改善患者神经功能和血栓弹力图指标,降低患者ET-1、GMP-140水平,提高患者生活能力。
Objective:To analyze the effect and effect of self-made Huoxue Lishui Recipe on thromboelastogram and vascular endothelial factor in acute cerebral infarction. Methods:Ninety-six patients with acute cerebral infarction were divided into control group and observation group according to different treatment methods. The patients in the control group were treated with routine western medicine, and the patients in the observation group were treated with self-made Huoxue Lishui Recipe. The clinical effects of the two groups were analyzed. Results:Before treatment, there was no significant difference between the two groups in TCM symptom score, thromboelastogram index and NIHSS score or BI score(P>0.05). After treatment, the scores of TCM symptoms and thromboelastograms in the observation group were better than those in the control group(P<0.05). Before treatment, there was no significant difference in the level of GMP-140 between the two groups(P>0.05). After treatment, the level of NO in the observation group was higher than that in the control group. The levels of AngⅡ,ET-1 and GMP-140 were lower than those of the control group(P<0.05). Conclusion:It can improve the patients' neurological function and thromboelastogram indexes, reduce the levels of ET-1 and GMP-140 in the patients and improve the living ability of the patients.
Objective:To analyze the effect and effect of self-made Huoxue Lishui Recipe on thromboelastogram and vascular endothelial factor in acute cerebral infarction. Methods:Ninety-six patients with acute cerebral infarction were divided into control group and observation group according to different treatment methods. The patients in the control group were treated with routine western medicine, and the patients in the observation group were treated with self-made Huoxue Lishui Recipe. The clinical effects of the two groups were analyzed. Results:Before treatment, there was no significant difference between the two groups in TCM symptom score, thromboelastogram index and NIHSS score or BI score(P>0.05). After treatment, the scores of TCM symptoms and thromboelastograms in the observation group were better than those in the control group(P<0.05). Before treatment, there was no significant difference in the level of GMP-140 between the two groups(P>0.05). After treatment, the level of NO in the observation group was higher than that in the control group. The levels of AngⅡ,ET-1 and GMP-140 were lower than those of the control group(P<0.05). Conclusion:It can improve the patients' neurological function and thromboelastogram indexes, reduce the levels of ET-1 and GMP-140 in the patients and improve the living ability of the patients.
引文
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[21] 徐文莉,钱川,陈占军.血府逐瘀汤对急性脑梗死病人CGRP,ET-1,S100-β和GFAP的影响[J].中西医结合心脑血管病杂志,2016,14(23):2737-2741.
[22] 王龙飞,韩岚,樊玲,等.桃红四物汤对实验性脑缺血大鼠血清中 ET-1,Ang-1,VEGF 的影响[J].中国实验方剂学杂志,2017,23(1):101-106.
[23] 李世英,李峥,张晋霞,等.单核细胞趋化蛋白1和血管内皮细胞钙黏蛋白水平与脑梗死进展及颈动脉粥样硬化的关系[J].中华老年心脑血管病杂志,2016,18(1):87-88.
[2] 张力文,万云高,马欣,等.伴糖尿病的心肌梗死及脑梗死对比研究进展[J].中华老年心脑血管病杂志,2017,12(8):893-896.
[3] 沈玉娇,冯方俊.中性粒细胞/淋巴细胞比值与急性脑梗死患者中医辨证分型的关系研究[J].中西医结合研究,2016,8(4):179-181.
[4] 娄卫东,李赵梅,谢紫明.中西医结合治疗急性脑梗死疗效观察及对血管内皮功能的影响[J].新中医,2016,19(3):18-20.
[5] 全国第四次脑血管病学术会议.各类脑血管病诊断要点[J].中华神经科杂志,1996,9(6):379-380.
[6] 国家中医药管理局急症协作组.中风病中医诊断疗效评定标准(试行)[S].北京中医药大学学报,1996,6(1):55-56.
[7] 郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:99-104.
[8] 李园园.丁苯酞与阿托伐他汀治疗急性脑梗死的临床疗效及对血液流变学的影响[J].神经损伤与功能重建,2017,17(1):22-24.
[9] Song SH,Kim JH,Lee JH,et al.Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke[J].BMC Neurol,2017,17(1):20.
[10] 张淑琴,范恒,邓立军,等.阿托伐他汀钙联合阿司匹林对脑梗死患者血清Hcy、NSE、UA、hs-CRP 及炎性因子水平的影响[J].海南医学院学报,2017,23(3):425-428.
[11] 丁锐,王家琳,唐晓敏.活血化瘀方治疗急性脑梗死临床观察[J].中国中医急症,2017,26(9):1678-1680.
[12] 邱敏,孙科,陶劲,等.“中风”病之“内风”病机溯源[J].中国中医基础医学杂志,2016,22(2):163-164.
[13] 田敬芹,张伟.补肾活血汤治疗急性脑梗死30例[J].河南中医,2016,36(10):1744-1745.
[14] 王宝林,杨泉,钱江,等.“清脑抗炎汤”对急性脑梗死血浆 D-二聚体及hs-CRP影响的临床研究[J].江苏中医药,2016,48(9):31-33.
[15] 陈振翼,方邦江,闫诏,等.复元醒脑法对急性脑梗死患者血栓弹力图与凝血功能相关性的影响[J].辽宁中医药大学学报,2017,19(12):69-72.
[16] 苏延玲,王红丽,张中华,等.灯盏花素注射液对急性脑梗死患者血液生化指标和血液流变学的影响[J].中国药房,2016,27(27):3802-3804.
[17] 茅国芳,王坤林,符金香,等.2型糖尿病患者血清PCSK9与动脉粥样硬化指标的相关性分析[J].南京医科大学学报(自然科学版),2016,36(1):46-50.
[18] Sirbu A,Nicolae H,Martin S,et al.IGF-1 and insulin resistance are major determinants of common carotid artery thickness in morbidly obese young patients[J].Angiology,2016,67(3):259-265.
[19] 陶黎,李花.丁苯酞联合阿托伐他汀对急性脑梗死患者血清NSE、ANGu、Hcy、炎性因子及凝血功能指标水平的影响[J].海南医学院学报,2016,22(21):2609-2612.
[20] 夏英凯,杜怡峰,韩国哲,等.急性脑梗死患者血清MCP-1水平的变化[J].山东医药,2016,56(1):79-80.
[21] 徐文莉,钱川,陈占军.血府逐瘀汤对急性脑梗死病人CGRP,ET-1,S100-β和GFAP的影响[J].中西医结合心脑血管病杂志,2016,14(23):2737-2741.
[22] 王龙飞,韩岚,樊玲,等.桃红四物汤对实验性脑缺血大鼠血清中 ET-1,Ang-1,VEGF 的影响[J].中国实验方剂学杂志,2017,23(1):101-106.
[23] 李世英,李峥,张晋霞,等.单核细胞趋化蛋白1和血管内皮细胞钙黏蛋白水平与脑梗死进展及颈动脉粥样硬化的关系[J].中华老年心脑血管病杂志,2016,18(1):87-88.
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