血清胱抑素C、尿β_2微球蛋白联合检测在糖尿病肾损害早期诊断中的价值
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摘要
目的探讨血清胱抑素C(Cys-C)、尿β_2微球蛋白(β_2-MG)联合检测在糖尿病肾脏疾病诊断中的临床意义。方法随机抽取天津中医药大学第二附属医院2014年3月～2015年3月收治的糖尿病患者100例设为观察组,按照病程的长短划分为观察组A(病程<5年)和观察组B(病程≥5年),另选同期100名健康体检者设为对照组,比较三组血清Cys-C和β_2-MG水平。结果观察组中的Cys-C阳性检出率为87.00%,β_2-MG阳性检出率为83.00%,对照组中这两项指标的阳性检出率均为0,观察组高于对照组,差异有统计学意义(P<0.05);观察组A和观察组B中血清Cys-C水平为(1.19±0.24)mg/L和(1.45±0.34)mg/L,β_2-MG水平分别为(0.39±0.09)mg/L和(0.79±0.17)mg/L;对照组中的血清Cys-C水平为(0.84±0.16)mg/L,β_2-MG水平为(0.13±0.02)mg/L;观察组血清Cys-C和β_2-MG水平高于对照组,差异均有统计学意义(P<0.05),且观察组B血清CysC和β_2-MG水平高于观察组A,差异均有统计学意义(P<0.05)。结论血清胱抑素C、尿β_2微球蛋白联合检测在糖尿病肾损害早期诊断中具有指导意义和临床价值。
Objective To investigate the clinical significance of combined detection of serum cystatin C(Cys-C) and urinary β_2microglobulin(β_2-MG)in the diagnosis of diabetic kidney disease.Methods A total of 100 patients with diabetes mellitus admitted to the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from March 2014 to March 2015 were randomly divided into observation group A(sickness <5years) and observation group B(the course of disease ≥ 5 years), another 100 healthy subjects in the same period were set as the control group, and the serum levels of Cys-C and β_2-MG were compared. Results The positive detection rate of Cys-C in the observation group was 87.00%, and the positive detection rate of β_2-MG was 83.00%. The positive detection rate of these two indicators in the control group was 0,the observation group was higher than the control group, the difference was statistically significant(P<0.05); the serum Cys-C levels in observation group A and observation group B were(1.19±0.24) mg/L and(1.45±0.34) mg/L, The β_2-MG levels were(0.39±0.09) mg/L and(0.79±0.17) mg/L, respectively; the serum Cys-C level in the control group was(0.84±0.16) mg/L, and the β_2-MG level was(0.13±0.02)mg/L;The serum levels of Cys-C and β_2-MG in the observation group were significantly higher than those in the control group(P<0.05), and the serum levels of Cys-C and β_2-MG in the observation group were higher than those in the observation group A,the differences were statistically significant(P <0.05). Conclusion The combined detection of serum cystatin C and urinary β_2 microglobulin has guiding significance and clinical value in the early diagnosis of diabetic renal damage.
Objective To investigate the clinical significance of combined detection of serum cystatin C(Cys-C) and urinary β_2microglobulin(β_2-MG)in the diagnosis of diabetic kidney disease.Methods A total of 100 patients with diabetes mellitus admitted to the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from March 2014 to March 2015 were randomly divided into observation group A(sickness <5years) and observation group B(the course of disease ≥ 5 years), another 100 healthy subjects in the same period were set as the control group, and the serum levels of Cys-C and β_2-MG were compared. Results The positive detection rate of Cys-C in the observation group was 87.00%, and the positive detection rate of β_2-MG was 83.00%. The positive detection rate of these two indicators in the control group was 0,the observation group was higher than the control group, the difference was statistically significant(P<0.05); the serum Cys-C levels in observation group A and observation group B were(1.19±0.24) mg/L and(1.45±0.34) mg/L, The β_2-MG levels were(0.39±0.09) mg/L and(0.79±0.17) mg/L, respectively; the serum Cys-C level in the control group was(0.84±0.16) mg/L, and the β_2-MG level was(0.13±0.02)mg/L;The serum levels of Cys-C and β_2-MG in the observation group were significantly higher than those in the control group(P<0.05), and the serum levels of Cys-C and β_2-MG in the observation group were higher than those in the observation group A,the differences were statistically significant(P <0.05). Conclusion The combined detection of serum cystatin C and urinary β_2 microglobulin has guiding significance and clinical value in the early diagnosis of diabetic renal damage.
引文
[1]凌雨,张翠平.五项指标联合检测对早期诊断糖尿病肾病的临床价值[J].医学检验与临床,2017,28(1):1-3.
[2]Shikata K,Makino H.Microinflammation in the pathogenesis of diabetic nephropathy[J].J Diabetes Investig,2013,4(2):142-149.
[3]张建标,马列婷.血清胱抑素C和β2-微球蛋白联合检测对糖尿病肾病的早期诊断价值[J].陕西医学杂志,2015(2):240-241.
[4]苏燕,梁伟娟.4项联合检测在糖尿病肾病早期诊断中的临床应用[J].实验与检验医学,2016,34(3):379-381,388.
[5]李艳萍.血清胱抑素C、尿微量蛋白联合检测在2型糖尿病肾损害早期诊断中的临床价值[J].中国实用医刊,2015,42(9):110-111.
[6]黄晋,刘皓.血清胱抑素C对早期肾功能损伤的诊断意义[J].中国医学创新,2013(18):102-104.
[7]刘娜.血清胱抑素C对慢性肾脏病肾功能的评定值及金水宝的干预作用研究[D].河北医科大学,2013.
[8]谢基明,冀虎岗,杨国香,等.血清胱抑素C评价早期肾功能损害的临床意义探讨[J].标记免疫分析与临床,2013,5(1):308.
[9]Kuwata K,Nakamura I,Ide M,et al.Comparison of changes in urinary and blood levels of biomarkers associated with proximal tubular injury in rat models[J].J Toxicol Pathol,2015,28(3):151-164.
[2]Shikata K,Makino H.Microinflammation in the pathogenesis of diabetic nephropathy[J].J Diabetes Investig,2013,4(2):142-149.
[3]张建标,马列婷.血清胱抑素C和β2-微球蛋白联合检测对糖尿病肾病的早期诊断价值[J].陕西医学杂志,2015(2):240-241.
[4]苏燕,梁伟娟.4项联合检测在糖尿病肾病早期诊断中的临床应用[J].实验与检验医学,2016,34(3):379-381,388.
[5]李艳萍.血清胱抑素C、尿微量蛋白联合检测在2型糖尿病肾损害早期诊断中的临床价值[J].中国实用医刊,2015,42(9):110-111.
[6]黄晋,刘皓.血清胱抑素C对早期肾功能损伤的诊断意义[J].中国医学创新,2013(18):102-104.
[7]刘娜.血清胱抑素C对慢性肾脏病肾功能的评定值及金水宝的干预作用研究[D].河北医科大学,2013.
[8]谢基明,冀虎岗,杨国香,等.血清胱抑素C评价早期肾功能损害的临床意义探讨[J].标记免疫分析与临床,2013,5(1):308.
[9]Kuwata K,Nakamura I,Ide M,et al.Comparison of changes in urinary and blood levels of biomarkers associated with proximal tubular injury in rat models[J].J Toxicol Pathol,2015,28(3):151-164.