不同分型过敏性紫癜患者外周血Th1/Th2型细胞因子的相关性研究
|
摘要
目的:探讨Th1/Th2免疫失衡与不同分型过敏性紫癜之间的相关性。方法:收集承德医学院附属医院皮肤科2016年12月至2017年12月收治过敏性紫癜患者90例,其中肾型紫癜患者30例、腹型紫癜患者30例作为研究对象,并选取单纯型紫癜患者30例作为对照组。采用酶联免疫吸附法(ELISA)测定患者血清中白细胞介素-2(IL-2)、白细胞介素-4(IL-4)水平。结果:肾型紫癜组、腹型紫癜组患者血清IL-2水平均明显低于单纯型紫癜组,差异有统计学意义(P<0.05)。肾型紫癜组、腹型紫癜组患者血清IL-4水平均明显高于单纯型紫癜组,差异有统计学意义(P<0.05)。肾型紫癜组与腹型组紫癜组相比,两组患者血清中IL-2、IL-4水平无明显差异(P>0.05)。结论:过敏性紫癜临床分型与外周血清Th1/Th2失衡存在相关性,可为过敏性紫癜的临床治疗及预后判断提供新的依据。
Objective: To explore the correlation between Th1/Th2 immune imbalance and different types of Henoch-Schonlein purpura. Methods: A total of 90 patients with Henoch-Schonlein purpura who were treated in department of dermatology of the Affliated hospital of Chengde Medical College between December 2016 and December 2017 were collected. Thirty patients with allergic purpura who have renal injury and Thirty patients who have gastrointestinal injury were selected as the research object,which were named as purpura nephritis group and purpura abdominal type group. While 30 cases of simple purpura patients were used as the control group in the same period. IL-2, IL-4 were detected and the datas were compared. Results: The level of IL-2 in the purpura nephritis group and the purpura abdominal type group, was significantly lower than control group(P<0.05), the level of IL-4 was significantly higher than control group(P<0.05).The purpura nephritis group compared with the purpura abdominal type group,the difference both was not statistically significant(P>0.05). Conclusion: The different types of Henoch Schonlein purpura is correlated with the imbalance of Th1/Th2, which can provide new evidence for the clinical treatment and prognosis of Henoch Schonlein purpura.
Objective: To explore the correlation between Th1/Th2 immune imbalance and different types of Henoch-Schonlein purpura. Methods: A total of 90 patients with Henoch-Schonlein purpura who were treated in department of dermatology of the Affliated hospital of Chengde Medical College between December 2016 and December 2017 were collected. Thirty patients with allergic purpura who have renal injury and Thirty patients who have gastrointestinal injury were selected as the research object,which were named as purpura nephritis group and purpura abdominal type group. While 30 cases of simple purpura patients were used as the control group in the same period. IL-2, IL-4 were detected and the datas were compared. Results: The level of IL-2 in the purpura nephritis group and the purpura abdominal type group, was significantly lower than control group(P<0.05), the level of IL-4 was significantly higher than control group(P<0.05).The purpura nephritis group compared with the purpura abdominal type group,the difference both was not statistically significant(P>0.05). Conclusion: The different types of Henoch Schonlein purpura is correlated with the imbalance of Th1/Th2, which can provide new evidence for the clinical treatment and prognosis of Henoch Schonlein purpura.
引文
[1] 訾广芹,付元,陈秀霞,等.过敏性紫癜患儿外周血单个核细胞TLR6表达及其与Thl、Th2和Th17细胞免疫应答相关性研究[J].中华临床医师杂志(电子版),2014,9(21):3789～3794.
[2] Del Prete GF,De Carli M,Almerigogna F,et al.PrEferential expression of CD30 by human CD4+ T cells producing TH2-typecytokines[J].FASEB,1995,9:81～86.
[3] 吴小川.儿童过敏性紫癜的诊治进展[J].实用儿科临床杂志,2013,28(21):1605～1608.
[4] 解德琼,甘华,杜晓刚,等.终末期肾病患者Th1/Th2型细胞因子的特征与外周血T细胞凋亡的关系[J].细胞与分子免疫学杂志,2006,22(6):763～766.
[5] Li YY,Li CR,Wang GB,et al.Investigation of the change in CD4 + T cell subset in children with henoch-schonlein purpura[J].Rheumatol Int,2012,32(12):3785 ～3792.
[2] Del Prete GF,De Carli M,Almerigogna F,et al.PrEferential expression of CD30 by human CD4+ T cells producing TH2-typecytokines[J].FASEB,1995,9:81～86.
[3] 吴小川.儿童过敏性紫癜的诊治进展[J].实用儿科临床杂志,2013,28(21):1605～1608.
[4] 解德琼,甘华,杜晓刚,等.终末期肾病患者Th1/Th2型细胞因子的特征与外周血T细胞凋亡的关系[J].细胞与分子免疫学杂志,2006,22(6):763～766.
[5] Li YY,Li CR,Wang GB,et al.Investigation of the change in CD4 + T cell subset in children with henoch-schonlein purpura[J].Rheumatol Int,2012,32(12):3785 ～3792.