4030例性病门诊患者沙眼衣原体、淋球菌及解脲脲原体感染情况分析
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摘要
目的了解性病门诊患者沙眼衣原体(CT)、淋球菌(NG)及解脲脲原体(UU)感染情况。方法回顾性分析2013—2016年首都医科大学附属北京地坛医院性病门诊患者CT、NG、UU核酸检测结果。结果 4 030例患者中男2 509例,女1 521例,年龄1~73岁,平均(32.73±9.06)岁。CT、NG、UU总阳性率分别为11.29%(455/4 030)、6.72%(271/4030)、26.63%(1 073/4 030)。不同年份患者NG阳性率之间差异有统计学意义,2016年NG阳性率最高。不同性别患者NG、UU阳性率之间差异有统计学意义,男性患者NG阳性率较高,女性患者UU阳性率较高。不同年龄段患者CT、NG、UU阳性率之间差异均有统计学意义。CT、NG、UU阳性患者年龄多在21~40岁,但15~20岁年龄段的患者CT、NG、UU阳性率均最高。CT阳性患者和NG阳性患者中混合感染的构成比分别为27.91%和24.72%。结论性病门诊患者CT、NG、UU核酸检测阳性率较高,建议性病门诊常规筛查患者CT等性病病原体感染,并在临床工作中注意各种性病病原体的混合感染。
Objective To investigate the prevalence of Chlamydia trachomatis(CT), Neisseria gonorrhoeae(NG) and Ureaplasma urealyticum(UU) infections in urogenital tract of patients visiting a STD clinic in Beijing Ditan Hospital Affiliated to Capital Medical University. Methods A retrospective analysis was carried out to collect the detection results of CT, NG and UU by using polymerase chain reaction(PCR) in 4030 outpatients from 2013 to 2016. Results Of the 4030 outpatients, 2509 were male, and the average age was(32.73 ± 9.06) years old, with the minimum and maximum age were 1 and 73 years old, respectively. Among all the patients, 11.29%(455/4030), 6.72%(271/4030) and 26.63%(1073/4030) were positive with CT, NG and UU infection, respectively. There was significant difference in the positive rates of CT between different age groups, of NG between different years, gender and age groups, and of UU between different gender and age groups, respectively. Patients with CT, NG and UU infections were mostly aged between 21~40 years old, but the highest positive rates were all in the age group of 15~20 years old. The highest positive rate of NG of different years was in 2016 and the positive rate of NG among male patients was higher than female patients. But the positive rate of UU among male patients was lower than female patients. Among the patients with CT or NG infection, 27.91% and 24.72% had mixed infections, respectively. Conclusion The positive rates of CT, NG and UU infections in urogenital tract of patients visiting a STD clinic in Beijing Ditan hospital was high, and usually be mixed infections, so it is essential to perform comprehensive tests of all sexually transmitted diseases for patients visiting a STD clinic.
Objective To investigate the prevalence of Chlamydia trachomatis(CT), Neisseria gonorrhoeae(NG) and Ureaplasma urealyticum(UU) infections in urogenital tract of patients visiting a STD clinic in Beijing Ditan Hospital Affiliated to Capital Medical University. Methods A retrospective analysis was carried out to collect the detection results of CT, NG and UU by using polymerase chain reaction(PCR) in 4030 outpatients from 2013 to 2016. Results Of the 4030 outpatients, 2509 were male, and the average age was(32.73 ± 9.06) years old, with the minimum and maximum age were 1 and 73 years old, respectively. Among all the patients, 11.29%(455/4030), 6.72%(271/4030) and 26.63%(1073/4030) were positive with CT, NG and UU infection, respectively. There was significant difference in the positive rates of CT between different age groups, of NG between different years, gender and age groups, and of UU between different gender and age groups, respectively. Patients with CT, NG and UU infections were mostly aged between 21~40 years old, but the highest positive rates were all in the age group of 15~20 years old. The highest positive rate of NG of different years was in 2016 and the positive rate of NG among male patients was higher than female patients. But the positive rate of UU among male patients was lower than female patients. Among the patients with CT or NG infection, 27.91% and 24.72% had mixed infections, respectively. Conclusion The positive rates of CT, NG and UU infections in urogenital tract of patients visiting a STD clinic in Beijing Ditan hospital was high, and usually be mixed infections, so it is essential to perform comprehensive tests of all sexually transmitted diseases for patients visiting a STD clinic.
引文
[1]Centers for Disease Control and Prevention.Sexually Transmitted Disease Surveillance 2016.https://www.cdc.gov/std/stats16.
[2]岳晓丽,龚向东,滕菲,等.2008-2015年中国性病监测点生殖道CT感染流行特征分析[J].中华皮肤科杂志,2016,49(5):6-11.
[3]龚向东,岳晓丽,蒋宁,等.2000-2014年中国淋病流行特征与趋势分析[J].中华皮肤科杂志,2015,48(5):301-306.
[4]Reekie J,Donovan B,Guy R,et al.Hospitalisations for pelvic inflammatory disease temporally related to a diagnosis of Chlamydia or gonorrhoea:a retrospective cohort study[J].PLo S One,2014,9(4):e94361.
[5]张静,王海滨,时宇.STD门诊患者CT、解脲支原体、淋球菌与人乳头瘤病毒感染情况分析[J].标记免疫分析与临床,2015,22(8):725-728.
[6]肖秀美,高爽,杨旭,等.2998例男性患者解脲脲原体、淋病奈瑟菌和CT感染调查分析[J].中国男科学杂志,2016,30(1):21-24.
[7]张睿,叶阿里,孔令君,等.临床患者三种性传播疾病分子生物学检测分析[J].现代检验医学杂志,2015,30(3):107-110.
[8]国家卫生计生委疾病预防控制局.2 0 1 6年全国法定传染病疫情概况.http://www.nhfpc.gov.cn/jkj/s3578/201702/38ca5990f8a54ddf9ca6308fec406157.shtml.
[9]国家卫生计生委疾病预防控制局.2015年全国法定传染病疫情概况.http://www.nhfpc.gov.cn/jkj/s3578/201602/b9217ba14e17452aad9e45a5bcce6b65.shtml.
[10]吴星,李培,袁定芬.2011-2015年上海市支原体感染及其耐药情况分析[J].实用皮肤病学杂志,2016,9(5):300-302.
[11]谭琳琳,任君,姜珂,等.2200例生殖道CT核酸扩增检测结果分析[J].重庆医学,2013,42(35):4333-4335.
[12]陆予,冼勇洪,罗希,等.1039例泌尿生殖道CT临床检测分析[J].中外医疗,2012,31(23):3-4.
[13]Rockett R,Goire N,Limnios A,et al.Evaluation of the cobas 4800CT/NG test for detecting Chlamydia trachomatis and Neisseria gonorrhoeae[J].Sex Transm Infect,2010,86(6):470-473.
[2]岳晓丽,龚向东,滕菲,等.2008-2015年中国性病监测点生殖道CT感染流行特征分析[J].中华皮肤科杂志,2016,49(5):6-11.
[3]龚向东,岳晓丽,蒋宁,等.2000-2014年中国淋病流行特征与趋势分析[J].中华皮肤科杂志,2015,48(5):301-306.
[4]Reekie J,Donovan B,Guy R,et al.Hospitalisations for pelvic inflammatory disease temporally related to a diagnosis of Chlamydia or gonorrhoea:a retrospective cohort study[J].PLo S One,2014,9(4):e94361.
[5]张静,王海滨,时宇.STD门诊患者CT、解脲支原体、淋球菌与人乳头瘤病毒感染情况分析[J].标记免疫分析与临床,2015,22(8):725-728.
[6]肖秀美,高爽,杨旭,等.2998例男性患者解脲脲原体、淋病奈瑟菌和CT感染调查分析[J].中国男科学杂志,2016,30(1):21-24.
[7]张睿,叶阿里,孔令君,等.临床患者三种性传播疾病分子生物学检测分析[J].现代检验医学杂志,2015,30(3):107-110.
[8]国家卫生计生委疾病预防控制局.2 0 1 6年全国法定传染病疫情概况.http://www.nhfpc.gov.cn/jkj/s3578/201702/38ca5990f8a54ddf9ca6308fec406157.shtml.
[9]国家卫生计生委疾病预防控制局.2015年全国法定传染病疫情概况.http://www.nhfpc.gov.cn/jkj/s3578/201602/b9217ba14e17452aad9e45a5bcce6b65.shtml.
[10]吴星,李培,袁定芬.2011-2015年上海市支原体感染及其耐药情况分析[J].实用皮肤病学杂志,2016,9(5):300-302.
[11]谭琳琳,任君,姜珂,等.2200例生殖道CT核酸扩增检测结果分析[J].重庆医学,2013,42(35):4333-4335.
[12]陆予,冼勇洪,罗希,等.1039例泌尿生殖道CT临床检测分析[J].中外医疗,2012,31(23):3-4.
[13]Rockett R,Goire N,Limnios A,et al.Evaluation of the cobas 4800CT/NG test for detecting Chlamydia trachomatis and Neisseria gonorrhoeae[J].Sex Transm Infect,2010,86(6):470-473.