负压封闭引流术联合复方四黄汤对骨科创伤患者TNF-α、IL-6、CRP水平的影响

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英文篇名：Effect of Vacuum Sealing Drainage Combined with Compound Sihuang Decoction on TNF-α,IL-6 and CRP in Patients with Orthopedic Trauma 作者：陈友银 ; 王振华 ; 吴明珑 英文作者：CHEN Youyin;WANG Zhenhua;WU Minglong;TCM Hospital of Dianjing;Tongji Medical College Affiliated to Huazhong University of Science and Technology; 关键词：骨科创伤 ; 负压封闭引流术 ; 复方四黄汤 ; 中医药治疗 ; 中医外治法 英文关键词：orthopedic trauma;;vacuum sealing drainage;;compound Sihuang Decoction;;traditional Chinese medicine treatment;;external treatment of traditional Chinese medicine 中文刊名：HNZK 英文刊名：Acta Chinese Medicine 机构：垫江县中医院;华中科技大学同济医学院; 出版日期：2019-04-04 16:39 出版单位：中医学报 年：2019 期：v.34;No.251 基金：国家自然科学基金面上项目(81573801);; 湖北省卫生和计划生育委员会科研项目(WJ2017M060) 语种：中文; 页：HNZK201904038 页数：5 CN：04 ISSN：41-1411/R 分类号：159-163

摘要

目的:观察负压封闭引流术联合复方四黄汤治疗骨科创伤患者的临床疗效,并观察对患者C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)、白细胞介素6(interleukin-6,IL-6)水平的影响。方法:将90例患者按随机数字表法分为对照组和观察组,每组45例。对照组给予常规治疗,观察组在对照组治疗基础上给予负压封闭引流术联合复方四黄汤治疗。观察治疗后两组患者的临床疗效、并发症、愈合时间、住院时间、感染控制时间,比较两组患者治疗前后TNF-α、IL-6、CRP水平。结果:观察组有效率为97.78%,高于对照组的86.67%,差异有统计学意义(P<0.05);观察组并发症发生率为2.22%,低于对照组的15.56%,差异有统计学意义(P<0.05);观察组创伤愈合时间、住院时间、感染控制时间等指标明显优于对照组,差异有统计学意义(P<0.05);治疗后,两组患者TNF-α、IL-6、CRP指标较治疗前明显改善,差异均有统计学意义(P<0.05),且观察组明显优于对照组,差异均有统计学意义(P<0.05)。结论:骨科创伤患者使用负压封闭引流术联合复方四黄汤治疗,可提高有效率,减少并发症,促进创伤改善,控制感染。
        Objective:To observe the clinical efficacy of vacuum sealing drainage combined with compound Sihuang Decoction in treatment of orthopedic trauma patients,as well as the effect on C-reactive protein(CRP),tumor necrosis factor alpha(TNF-α) and interleukin-6(IL-6) levels.Methods:90 patients were divided into control group and observation group according to random number table,with 45 cases in each group.The control group was given traditional treatment,and the observation group was treated with vacuum sealing drainage combined with compound Sihuang Decoction in addition to that of the control group.The clinical efficacy,complications,healing time,hospitalization time,and infection control time of the two groups were observed.The changes of TNF-α,IL-6 and CRP levels in the two groups were compared before and after treatment.Results:The effective rate of the observation group was 97.78%,which was significantly higher than that(86.67%) of the control group(P<0.05).The incidence of the observation group was 2.22%,which was significantly lower than that(15.56%) of the control group(P<0.05).The indexes of wound healing time,hospitalization time and infection control time in the observation group were significantly better than that of the control group(P<0.05).After treatment,The levels of TNF-α,IL-6 and the CRP index the two groups of patients were significantly improved compared with that before treatment,and the difference were statistically significant(P<0.05),and those of the observation group were significantly better than those of the control group(P<0.05).Conclusion:combined with Vacuum sealing drainage combined with compound Sihuang Decoction can improve the efficiency,reduce complications,promote the early improvement of trauma and control the infection of patients with orthopedic trauma.

引文

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