微丝的信号调控机制和体内功能
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摘要
微丝是细胞骨架的主要成分之一,广泛存在于所有真核细胞中。微丝与其相关蛋白介导的信号通路几乎在所有的生物学事件中发挥重要作用,参与了细胞形态维持、细胞运动、信号转导等细胞基本生物学行为的调控。同时,微丝及其相关蛋白还在个体发育中扮演重要角色,其异常与疾病发生发展过程密切相关。该文就微丝相关蛋白、微丝相关信号通路、微丝功能及其与疾病相关的最新研究进展进行小结,并对微丝的未来研究方向进行了初步的探讨。
Actin filaments are one of the main component of the cytoskeleton, which are widely exist in all eukaryotic cells. Actin filaments and actin-associated proteins-mediated signaling pathways play important roles in many cellular biological events, including cell morphology maintain, cell motility, signal transduction. Actin filaments and actin-associated proteins also play a key role in development, and their abnormality is associated with disease. In this review, we summarized the latest advance of actin, actin-associated proteins, actin-related signaling pathways and their correlation with diseases. We also preliminarily discussed the future research direction of actin filaments.
Actin filaments are one of the main component of the cytoskeleton, which are widely exist in all eukaryotic cells. Actin filaments and actin-associated proteins-mediated signaling pathways play important roles in many cellular biological events, including cell morphology maintain, cell motility, signal transduction. Actin filaments and actin-associated proteins also play a key role in development, and their abnormality is associated with disease. In this review, we summarized the latest advance of actin, actin-associated proteins, actin-related signaling pathways and their correlation with diseases. We also preliminarily discussed the future research direction of actin filaments.
引文
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52 Saha S,Lee IH,Polley A,Groves JT,Rao M,Mayor S.Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin.Mol Biol Cell 2015;26(22):4033-45.
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2 Pollard TD,Borisy GG.Cellular motility driven by assembly and disassembly of actin filaments Cell 2003;112(4):453-65.
3 Bamburg JR,Wiggan ONP.ADF/cofilin and actin dynamics in disease.Trends Cell Biol 2002;12(12):598-605.
4 Kim S,Kwon J.Actin cytoskeletal rearrangement and dysfunction due to activation of the receptor for advanced glycation end products is inhibited by thymosin beta 4.J Physiol 2015;593(8):1873-86.
5 Suarez C,Carroll RT,Burke TA,Christensen JR,Bestul AJ,Sees JA,et al.Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.Dev Cell 2015;32(1):43-53.
6 Dos Remedios CG,Chhabra D,Kekic M,Dedova IV,Tsubakihara M,Berry DA,et al.Actin binding proteins:regulation of cytoskeletal microfilaments.Physiol Rev 2003;83(2):433-73.
7 Xue B,Leyrat C,Grimes JM,Robinson RC.Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization.Proc Natl Acad Sci USA 2014;111(43):4596-605.
8 Mullins RD,Heuser JA,Pollard TD.The interaction of Arp2/3complex with actin:nucleation,high affinity pointed end capping,and formation of branching networks of filaments.Proc Natl Acad Sci USA 1998;95(11):6181-6.
9 Farina F,Gaillard J,Guérin C,CoutéY,Sillibourne J,Blanchoin L,et al.The centrosome is an actin-organizing center.Nat Cell Biol 2016;18:65-75.
10 Loisel TP,Boujemaa R,Pantaloni D,et al.Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.Nature 1999;401(6753):613-6.
11 Skau CT,Courson DS,Bestul AJ,Carlier MF.Actin filament bundling by fimbrin is important for endocytosis,cytokinesis,and polarization in fission yeast.J Biol Chem 2011;286:26964-977.
12 Bamburg JR,Wiggan OP.ADF/cofilin and actin dynamics in disease.Trends Cell Biol 2003;12(12):598-605.
13 Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,et al.NudCregulates actin dynamics and ciliogenesis by stabilizing cofilin 1.Cell Res 2015;26:239-53.
14 Richards TA,Cavaliersmith T.Myosin domain evolution and the primary divergence of eukaryotes.Nature 2005;436(7054):1113-8.
15 Fagarasanu A,Rachubinski RA.Orchestrating organelle inheritance in Saccharomyces cerevisiae.Curr Opin Microbiol 2007;10(6):528-38.
16 Reymann AC,Blanchoin L.Actin network architecture can determine myosin motor activity.Science 2012;336(6086):1310-4.
17 Solinet S,Mahmud K,Stewman SF,Ben El Kadhi K,Decelle B,Talje L,et al.The actin-binding ERM protein moesin binds to and stabilizes microtubules at the cell cortex.J Cell Biol 2013;202(2):251-60.
18 Aoki K,Maeda F,Nagasako T,Mochizuki Y,Uchida S,Ikenouchi J.A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing.Proc Natl Acad Sci USA 2016;113(13):E1863-71.
19 Wojciak-Stothard B,Ridley AJ.Rho GTPases and the regulation of endothelial permeability.Vascul Pharmacol 2002;39(4):187-99.
20 Amano M,Nakayama M,Kaibuchi K.Rho-kinase/ROCK:Akey regulator of the cytoskeleton and cell polarity.Cytoskeleton2010;67(9):545-54.
21 Zhang W,Bhetwal BP,Gunst SJ.Rho Kinase(ROCK)collaborates with pak to regulate actin polymerization and contraction in airway smooth muscle.J Physiol 2018;596(16):3617-35.
22 Meyer Zum Buschenfelde U,Brandenstein LI,von Elsner L,Flato K,Holling T,Zenker M,et al.RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.PLoSGenet 2018;14(5):e1007370.
23 Livitsanou M,Vasilaki E,Stournaras C,Kardassis D.Modulation of TGFβ/Smad signaling by the small GTPase RhoB.Cell Signal 2018;48:54-63.
24 Hoffman L,Jensen CC,Yoshigi M,Beckerle M.Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1.Mol Biol Cell 2017;28(20):2661-75.
25 Himangshu S,Atul K,Jina B,Gogoi PK,Jaganathan BG.Inhibition of actin polymerization decreases osteogeneic differentiation of mesenchymal stem cells through p38 MAPK pathway.JBiomed Sci 2013;20(1):71.
26 Mendoza MC,Vilela M,Juarez JE,Blenis J,Danuser G.ERK reinforces actin polymerization to power persistent edge protrusion during motility.Sci Signal 2015;8(377):ra47.
27 Ballestrem C,Wehrlehaller B,Hinz B,Imhof BA.Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration.Mol Biol Cell 2000;11(9):2999-3012.
28 Corallino S,Malinverno C,Neumann B,Tischer C,Palamidessi A,Frittoli E,et al.Author correction:A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.Nat Commun 2018;9(1):1475.
29 Aguilar-Solis ED,Lee-Rivera I,álvarez-Arce A,López E,López-ColoméAM.FAK phosphorylation plays a central role in thrombin-induced RPE cell migration.Cell Signal 2017;36:56-66.
30 Akiyama T,Kawasaki Y.Wnt signalling and the actin cytoskeleton.Oncogene 2006;25(57):7538-44.
31 Wang Q,Symes AJ,Kane CA,Freeman A,Nariculam J,Munson P,et al.A novel role for Wnt/Ca2+signaling in actin cytoskeleton remodeling and cell motility in prostate cancer.PLoS One 2010;5(5):e10456.
32 Garcia AL,Udeh A,Kalahasty K,Hackam AS.A growing field:The regulation of axonal regeneration by Wnt signaling.Neu Reg Res 2018;13(1):43-52.
33 Seo J,Kim J.Regulation of Hippo signaling by actin remodeling.BMB Rep 2018;51(3):151-56.
34 Wada K,Itoga K,Okano T,Yonemura S,Sasaki H.Hippo pathway regulation by cell morphology and stress fibers.Development 2011;138(18):3907-14.
35 Qiao Y,Chen J,Lim YB,Finch-Edmondson ML,Seshachalam VP,Qin L,et al.YAP regulates actin dynamics through ARH-GAP29 and promotes metastasis.Cell Rep 2017;19(8):1495-1502.
36 Chugh P,Paluch EK.The actin cortex at a glance.J Cell Sci2018;131(14):jcs186254.
37 Fritzsche M,Erlenk?mper C,Moeendarbary E,Charras G,Kruse K.Actin kinetics shapes cortical network structure and mechanics.Sci Adv 2016;2(4):e1501337.
38 Tsankova A,Pham TT,Garcia DS,Otte F,Cabernard C.Cell polarity regulates biased myosin activity and dynamics during asymmetric cell division via Drosophila Rho kinase and Protein Kinase N.Dev Cell 2017;42(2):143-55.
39 Pelaseyed T,Bretscher A.Regulation of actin-based apical structures on epithelial cells.J Cell Sci 2018;131(20):jcs221853.
40 Doherty GJ,Mcmahon HT.Mechanisms of endocytosis.Annu Rev Biochem 2009;78:857-902.
41 Li P,Bademosi AT,Luo J,Meunier FA.Actin remodeling in regulated exocytosis:Toward a mesoscopic View.Trends Cell Biol2018;28(9):685-97.
42 Svitkina T.The actin cytoskeleton and actin-based motility.Cold Spring Harb Perspect Biol 2018;10(1):a018267.
43 Ren XD,Kiosses WB,Schwartz MA.Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton.EMBO J 1999;18(3):578-85.
44 Callan-Jones AC,Voituriez R.Actin flows in cell migration:from locomotion and polarity to trajectories.Curr Opin Cell Biol2016;38:12-7.
45 Misu S,Takebayashi M,Miyamoto K.Nuclear actin in development and transcriptional reprogramming.Frontier in Genetics2017;8:27.
46 Schrank BR,Aparicio T,Li Y,Chang W,Chait BT,Gundersen GG,et al.Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.Nature 2018;559(7712):61-6.
47 Caridi CP,D’Agostino C,Ryu T,Zapotoczny G,Delabaere L,Li X,et al.Nuclear F-actin and myosins drive relocalization of heterochromatic breaks.Nature 2018;559(7712):54-60.
48 Vasioukhin V,Bauer C,Yin M,Fuchs E.Directed actin polymerization is the driving force for epithelial cell-cell adhesion.Cell2000;100(2):209-19.
49 Ivanov AI,Hunt D,Utech M,Nusrat A,Parkos CA.Differential roles for actin polymerization and a Myosin II Motor in assembly of the epithelial apical junctional complex.Mol Biol Cell 2005;16(6):2636-50.
50 Kovacs EM,Goodwin M,Ali RG,Paterson AD,Yap AS.Cadherin-directed actin assembly:E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts.Curr Biol 2002;12(12):379-82.
51 Galkin VE,Orlova A,Egelman EH.Actin filaments as tension sensors.Curr Biol 2012;22(3):96-101.
52 Saha S,Lee IH,Polley A,Groves JT,Rao M,Mayor S.Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin.Mol Biol Cell 2015;26(22):4033-45.
53 Gurel PS,Hatch AL,Higgs HN.Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.Curr Biol 2014;24(14):R660-72.
54 Kast DJ,Dominguez R.The cytoskeleton-autophagy connection.Curr Biol 2017;27(8):R318-26.
55 Aguilera MO,Berón W,Colombo MI.The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy.Autophagy 2012;8(11):1590-1603.
56 Reggiori F,Monastyrska I,Shintani T,Klionsky DJ.The actin cytoskeleton is required for selective types of autophagy,but not nonspecific autophagy,in the yeast Saccharomyces cerevisiae.Mol Biol Cell 2005;16(12):5843-56.
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