抗β_2GPⅠ抗体/β_2GPⅠ与PLT活化
摘要
<正>近年来,血栓性疾病发病率不断上升,严重威胁人类健康和生命,血小板(PLT)活化是血栓形成的始动因素,在血栓形成中起到关键作用。研究发现抗β2糖蛋白I(β2GPⅠ)抗体出现在多种血栓性疾病中,常见于抗磷脂综合征,能使体内PLT活化并和纤维蛋白结合,引起PLT聚集,与血栓形成关系非常密切。抗β2GPⅠ抗体如何诱导
引文
[1]Pennings MT,Derksen RH,van Lummel M,et al.Platelet adhesion to dimeric beta-glycoprotein I underconditions of flow is mediated by at least tworeceptors:glycoprotein Ibalpha and apolipoprotein Ereceptor 2'[J].J Thromb Haemost,2007,5(2):369-377.
[2]Urbanus RT,Siegerink B,Roest M,et al.Anti-phospholipid antibodies and risk of myocardial infarc-tion and ischaemic stroke in young women in the RA-TIO study:a case-control study[J].Lancet Neurol,2009,8(11):998-1005.
[3]Van Lummel M,Pennings MT,Derksen RH,et al.The binding site in{beta}2-glycoprotein I for Apo-ER2'on platelets is located in domain V[J].J BiolChem,2005,280(44):36729-36736.
[4]Agar C,van Os GM,Mrgelin M,et al.Beta2-glycoprotein I can exist in 2 conformations:implica-tions for our understanding of the antiphospholipidsyndrome[J].Blood,2010,116(8):1336-1343.
[5]Ioannou Y,Zhang JY,Passam FH,et al.Naturallyoccurring free thiols within beta 2-glycoprotein I invivo:nitrosylation,redox modification by endothelialcells,and regulation of oxidative stress-induced cellinjury[J].Blood,2010,116(11):1961-1970.
[6]Passam FH,Giannakopoulos B,Miarabshahi P,etal.Molecular pathophysiology of the antiphospholipidsyndrome:the role of oxidative post-translationalmodification of beta 2 glycoprotein I[J].J ThrombHaemost,2011,9(Suppl1):275-282.
[7]Rahgozar S,Giannakopoulos B,Yan X,et al.Beta2-glycoproteinⅠprotects thrombin from inhibition byheparin cofactorⅡ:potentiation of this effect in thepresence of anti-beta2-glycoproteinⅠautoantibodies[J].Arthritis Rheum,2008,58(4):1146-1155.
[8]Kuwana M,Matsuura E,Kobayashi K,et al.Bind-ing of 2-glycoprotein I to anionic phospholipidsfacilitates processing and presentation of a crypticepitope that activates pathogenic autoreactive T cells[J].Blood,2005,105(4):1552-1557.
[9]De Laat BD,Derksen RH,Lummel MV,et al.Patho-genic anti-beta2-glycoprotein I antibodies recognizedomain I of beta-glycoprotein I only after a conforma-tional change[J].Blood,2006,107(5):1916-1924.
[10]Rand JH.A new fish for theβ2GPⅠhook:LPS[J].Blood,2011,117(25):6743-6744.
[11]White-Adams TC,Berny MA,Tucker EI,et al.Identification of coagulation factor XI as a ligand forplatelet apolipoprotein E receptor 2(ApoER2)[J].Arterioscler Thromb Vasc Biol,2009,29(10):1602-1607.
[12]Romay-Penabad Z,Aguilar-Valenzuela R,UrbanusRT,et al.Apolipoprotein E receptor 2 is involved inthe thrombotic complications in a murine model of theantiphospholipid syndrome[J].Blood,2011,117(4):1408-1414.
[13]Urbanus RT,Pennings MT,Derksen RH,et al.Platelet activation by dimeric beta2-glycoprotein Irequires signaling via both glycoprotein Ibalpha andapolipoprotein E receptor 2'[J].J Thromb Haemost,2008,6(8):1405-1412.
[14]White TC,Berny MA,Tucker EI,et al.Protein Csupports platelet binding and activation under flow:role of glycoprotein Ib and apolipoprotein E receptor2'[J].J Thromb Haemost,2008,6(6):995-1002.
[15]Stolt PC,Bock HH.Modulation of lipoproteinreceptor functions by intracellular adaptor proteins[J].Cell Signal,2006,18(10):1560-1571.
[16]Pennings MT,van Lummel MV,Derksen RH,etal.Interaction of beta2-glycoprotein I with membersof the low density lipoprotein receptor family[J].JThromb Haemost,2006,4(8):1680-1690.
[17]Sikara MP,Routsias JG,Samiotaki M,et al.{beta}2 glycoprotein I({beta}2GPI)binds platelet factor 4(PF4):implications for the pathogenesis of anti-phospholipid syndrome[J].Blood,2010,115(3):713-723.
[18]Hulstein JJ,de Lenting PJ,de Laat BD,et al.Be-ta2-glycoprotein I inhibits von Willebrand factor de-pendent platelet adhesion and aggregation[J].Blood,2007,110(5):1483-1491.
[19]Passam FH,Rahgozar S,Qi M,et al.Redox controlof beta2-glycoprotein I-von Willebrand factor inter-action by thioredoxin-1[J].J Thromb Haemost,2010,8(8):1754-1762.
[20]Vega-Ostertag ME,Ferrara DE,Romay-Penabad Z,et al.Role of p38 mitogen-activated protein kinase inantiphospholipid antibody-mediated thrombosis andendothelial cell activation[J].J Thromb Haemost,2007,5(9):1828-1834.
[21]Montiel-Manzano G,Romay-Penabad Z,Papalardode Martinez E,et al.In vivo effects of an inhibitor ofnuclear factor-kappa B on thrombogenic properties ofantiphospholipid antibodies[J].Ann N Y Acad Sci,2007,1108:540-553.
[2]Urbanus RT,Siegerink B,Roest M,et al.Anti-phospholipid antibodies and risk of myocardial infarc-tion and ischaemic stroke in young women in the RA-TIO study:a case-control study[J].Lancet Neurol,2009,8(11):998-1005.
[3]Van Lummel M,Pennings MT,Derksen RH,et al.The binding site in{beta}2-glycoprotein I for Apo-ER2'on platelets is located in domain V[J].J BiolChem,2005,280(44):36729-36736.
[4]Agar C,van Os GM,Mrgelin M,et al.Beta2-glycoprotein I can exist in 2 conformations:implica-tions for our understanding of the antiphospholipidsyndrome[J].Blood,2010,116(8):1336-1343.
[5]Ioannou Y,Zhang JY,Passam FH,et al.Naturallyoccurring free thiols within beta 2-glycoprotein I invivo:nitrosylation,redox modification by endothelialcells,and regulation of oxidative stress-induced cellinjury[J].Blood,2010,116(11):1961-1970.
[6]Passam FH,Giannakopoulos B,Miarabshahi P,etal.Molecular pathophysiology of the antiphospholipidsyndrome:the role of oxidative post-translationalmodification of beta 2 glycoprotein I[J].J ThrombHaemost,2011,9(Suppl1):275-282.
[7]Rahgozar S,Giannakopoulos B,Yan X,et al.Beta2-glycoproteinⅠprotects thrombin from inhibition byheparin cofactorⅡ:potentiation of this effect in thepresence of anti-beta2-glycoproteinⅠautoantibodies[J].Arthritis Rheum,2008,58(4):1146-1155.
[8]Kuwana M,Matsuura E,Kobayashi K,et al.Bind-ing of 2-glycoprotein I to anionic phospholipidsfacilitates processing and presentation of a crypticepitope that activates pathogenic autoreactive T cells[J].Blood,2005,105(4):1552-1557.
[9]De Laat BD,Derksen RH,Lummel MV,et al.Patho-genic anti-beta2-glycoprotein I antibodies recognizedomain I of beta-glycoprotein I only after a conforma-tional change[J].Blood,2006,107(5):1916-1924.
[10]Rand JH.A new fish for theβ2GPⅠhook:LPS[J].Blood,2011,117(25):6743-6744.
[11]White-Adams TC,Berny MA,Tucker EI,et al.Identification of coagulation factor XI as a ligand forplatelet apolipoprotein E receptor 2(ApoER2)[J].Arterioscler Thromb Vasc Biol,2009,29(10):1602-1607.
[12]Romay-Penabad Z,Aguilar-Valenzuela R,UrbanusRT,et al.Apolipoprotein E receptor 2 is involved inthe thrombotic complications in a murine model of theantiphospholipid syndrome[J].Blood,2011,117(4):1408-1414.
[13]Urbanus RT,Pennings MT,Derksen RH,et al.Platelet activation by dimeric beta2-glycoprotein Irequires signaling via both glycoprotein Ibalpha andapolipoprotein E receptor 2'[J].J Thromb Haemost,2008,6(8):1405-1412.
[14]White TC,Berny MA,Tucker EI,et al.Protein Csupports platelet binding and activation under flow:role of glycoprotein Ib and apolipoprotein E receptor2'[J].J Thromb Haemost,2008,6(6):995-1002.
[15]Stolt PC,Bock HH.Modulation of lipoproteinreceptor functions by intracellular adaptor proteins[J].Cell Signal,2006,18(10):1560-1571.
[16]Pennings MT,van Lummel MV,Derksen RH,etal.Interaction of beta2-glycoprotein I with membersof the low density lipoprotein receptor family[J].JThromb Haemost,2006,4(8):1680-1690.
[17]Sikara MP,Routsias JG,Samiotaki M,et al.{beta}2 glycoprotein I({beta}2GPI)binds platelet factor 4(PF4):implications for the pathogenesis of anti-phospholipid syndrome[J].Blood,2010,115(3):713-723.
[18]Hulstein JJ,de Lenting PJ,de Laat BD,et al.Be-ta2-glycoprotein I inhibits von Willebrand factor de-pendent platelet adhesion and aggregation[J].Blood,2007,110(5):1483-1491.
[19]Passam FH,Rahgozar S,Qi M,et al.Redox controlof beta2-glycoprotein I-von Willebrand factor inter-action by thioredoxin-1[J].J Thromb Haemost,2010,8(8):1754-1762.
[20]Vega-Ostertag ME,Ferrara DE,Romay-Penabad Z,et al.Role of p38 mitogen-activated protein kinase inantiphospholipid antibody-mediated thrombosis andendothelial cell activation[J].J Thromb Haemost,2007,5(9):1828-1834.
[21]Montiel-Manzano G,Romay-Penabad Z,Papalardode Martinez E,et al.In vivo effects of an inhibitor ofnuclear factor-kappa B on thrombogenic properties ofantiphospholipid antibodies[J].Ann N Y Acad Sci,2007,1108:540-553.