漳州地区930例过敏患者过敏原检测结果分析
|
摘要
目的分析漳州地区皮肤过敏患者对食入性与吸入性过敏原的过敏情况以及过敏原在人群中的分布特征,作为过敏原地区流行病学的研究分析。方法选取2017年1月至12月漳州市皮肤病防治院门诊皮肤过敏患者930例,按患者性别及年龄大小进行分组,应用德国Mediwiss敏筛(Allergy Screen)过敏原免疫印迹定量检测系统对患者血清特异性过敏原sIgE进行检测。结果吸入性过敏原sIgE检出率较食入性过敏原sIgE高,检出阳性率分别为60.9%和29%,两组差异有统计学意义(P<0.05)。在吸入性过敏原sIgE中,以尘螨sIgE的检测阳性率最高,为46.56%;而在食入性过敏原sIgE中,虾sIgE检测阳性率最高,为15.48%。结论漳州地区吸入性过敏原检测阳性率高于食入性过敏原。该地区最常见的吸入性过敏原为户尘螨;最常见的食入性过敏原为虾,在儿童组鸡蛋白和牛奶为主要过敏原。
Objective To analyze the allergic condition of food allergens and inhalation allergens in allergic patients,as well as the distribution characteristics of allergens in the population for the analysis of epidemiology in areas with allergens.Methods A total of 930 allergic outpatients were selected in Skin Disease Prevention and Treatment Hospital of Zhangzhou City from January 2017 to December 2017.Included patients were divided based on gender and age.The immunoblotting quantitative detection system for allergens,made by Allergy Screen of Mediwiss(Germany),was employed to detect total IgE in serum and specific sIgE of included patients.Results Detection rate of sIgE in inhalation allergens was higher than that in food allergens,with the detection rate of 60.9% and 29%,respectively.The difference between the two groups was statistically significant(P<0.05).Among sIgE in inhalation allergens,the positive rate of sIgE in dust mites was detected to be the highest,which was46.56%.Among sIgE in food allergens,the positive rate of sIgE in shrimp was the highest of reaching 15.48%.ConclusionThe positive rate of inhalation allergens is higher than that of food allergens in Zhangzhou area.The most common inhalation allergen and food allergen is dust mites and shrimp in this area,respectively.Milk and egg whites are the main food allergens for children.
Objective To analyze the allergic condition of food allergens and inhalation allergens in allergic patients,as well as the distribution characteristics of allergens in the population for the analysis of epidemiology in areas with allergens.Methods A total of 930 allergic outpatients were selected in Skin Disease Prevention and Treatment Hospital of Zhangzhou City from January 2017 to December 2017.Included patients were divided based on gender and age.The immunoblotting quantitative detection system for allergens,made by Allergy Screen of Mediwiss(Germany),was employed to detect total IgE in serum and specific sIgE of included patients.Results Detection rate of sIgE in inhalation allergens was higher than that in food allergens,with the detection rate of 60.9% and 29%,respectively.The difference between the two groups was statistically significant(P<0.05).Among sIgE in inhalation allergens,the positive rate of sIgE in dust mites was detected to be the highest,which was46.56%.Among sIgE in food allergens,the positive rate of sIgE in shrimp was the highest of reaching 15.48%.ConclusionThe positive rate of inhalation allergens is higher than that of food allergens in Zhangzhou area.The most common inhalation allergen and food allergen is dust mites and shrimp in this area,respectively.Milk and egg whites are the main food allergens for children.
引文
[1]赵辨.中国临床皮肤病学[M].南京:江苏凤凰科学技术出版社,2017:759-783.
[2]唐瑶,徐海涛,儿童荨麻疹及特应性皮炎过敏原点刺试验结果分析[J].临床皮肤科杂志,2018,47(8):1000-4963.
[3]张冬丽,霍万学,王迪.通辽地区过敏原检测结果及与其他地区对比分析[J].现代免疫学,2018,38(5):1001-2478.
[4]付兰,杨雪松,黎奇,等.昆明地区1674例过敏原特异性IgE分析[J].皮肤病与性病,2018,40(5):1002-1310.
[5]王杰,何春峰,堵桂梅,等.兰州地区急性期泛发型湿疹患者血清总IgE及sIgE筛查结果分析[J].临床皮肤科杂志,2015,44(3):150-151.
[6]陈剑雄,刘远智,张辉,等.深圳地区过敏性疾病患者血清特异性IgE检测及分析[J].国际检验医学杂志,2018,39(11):1340-1343.
[7]路雪艳,王德旭,蒋靖,等.湿疹皮炎患者过敏原特异性IgE检测阳性结果的多中心研究[J].中华皮肤科杂志,2015,48(9):616-620.
[8]Govaere E,Van Gysel D,Massa G,et al.The influence of age and gender on sensitization to allergen in infants and young children[J].Pediatr Allergy Immunol,2007,18(8):671-678.
[9]Kim J,Hahm M I,Lee S Y,et al.Sensitization to aeroallergens in Korean children:apopulation-based study in 2010[J].J Korean Med Sci,2011,26(9):1165-1172.
[2]唐瑶,徐海涛,儿童荨麻疹及特应性皮炎过敏原点刺试验结果分析[J].临床皮肤科杂志,2018,47(8):1000-4963.
[3]张冬丽,霍万学,王迪.通辽地区过敏原检测结果及与其他地区对比分析[J].现代免疫学,2018,38(5):1001-2478.
[4]付兰,杨雪松,黎奇,等.昆明地区1674例过敏原特异性IgE分析[J].皮肤病与性病,2018,40(5):1002-1310.
[5]王杰,何春峰,堵桂梅,等.兰州地区急性期泛发型湿疹患者血清总IgE及sIgE筛查结果分析[J].临床皮肤科杂志,2015,44(3):150-151.
[6]陈剑雄,刘远智,张辉,等.深圳地区过敏性疾病患者血清特异性IgE检测及分析[J].国际检验医学杂志,2018,39(11):1340-1343.
[7]路雪艳,王德旭,蒋靖,等.湿疹皮炎患者过敏原特异性IgE检测阳性结果的多中心研究[J].中华皮肤科杂志,2015,48(9):616-620.
[8]Govaere E,Van Gysel D,Massa G,et al.The influence of age and gender on sensitization to allergen in infants and young children[J].Pediatr Allergy Immunol,2007,18(8):671-678.
[9]Kim J,Hahm M I,Lee S Y,et al.Sensitization to aeroallergens in Korean children:apopulation-based study in 2010[J].J Korean Med Sci,2011,26(9):1165-1172.