丹参川芎嗪联合稳心颗粒治疗不稳定型心绞痛合并心律失常临床观察
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摘要
目的探讨不稳定型心绞痛合并心律失常采用丹参川芎嗪与稳心颗粒联合治疗的临床效果。方法选择2016年4月—2017年4月收治的不稳定型心绞痛合并心律失常患者72例,根据随机数字法分为2组,其中对照组行常规治疗,而观察组则运用稳心颗粒联合丹参川芎嗪治疗,对比分析2组疗效。结果治疗前,2组的心肌耗氧量、心率、心绞痛持续时间以及发作频率比较差异无统计学意义(P<0.05);治疗后,观察组的心率、心绞痛发作频率、持续时间以及心肌耗氧量均优于对照组(P<0.05);观察组的治疗有效率高于对照组(P<0.05);同时,2组患者的LDL-C、HDL-C、TC、TG水平比较有统计学意义(P<0.05)。结论临床上给予不稳定型心绞痛合并心律失常患者丹参川芎嗪联合稳心颗粒治疗效果显著。
Objective To investigate the clinical effect of Danshen Ligustrazine and Wenxin granule in the treatment of unstable angina pectoris complicated with arrhythmia. Methods 72 patients with unstable angina pectoris complicated with arrhythmia who were treated in our hospital from April 2016 to April 2017 were divided into two groups according to random numbers. The control group was given routine treatment, while the observation group was given Wenxin granule combined with Salvia miltiorrhiza and Ligustrazine. Results Before treatment, there was no significant difference in myocardial oxygen consumption, heart rate, angina duration and attack frequency between the two groups(P < 0.05). After treatment, the heart rate, angina attack frequency, duration and myocardial oxygen consumption of the observation group were better than those of the control group( P < 0.05). The curative effect of the observation group was higher than that of the control group( P < 0.05). 5). At the same time, the levels of LDL-C, HDLC, TC and TG in the two groups were statistically significant(P <0.05). Conclusion Danshen Ligustrazine combined with Wenxin granule is effective in treating unstable angina pectoris with arrhythmia.
Objective To investigate the clinical effect of Danshen Ligustrazine and Wenxin granule in the treatment of unstable angina pectoris complicated with arrhythmia. Methods 72 patients with unstable angina pectoris complicated with arrhythmia who were treated in our hospital from April 2016 to April 2017 were divided into two groups according to random numbers. The control group was given routine treatment, while the observation group was given Wenxin granule combined with Salvia miltiorrhiza and Ligustrazine. Results Before treatment, there was no significant difference in myocardial oxygen consumption, heart rate, angina duration and attack frequency between the two groups(P < 0.05). After treatment, the heart rate, angina attack frequency, duration and myocardial oxygen consumption of the observation group were better than those of the control group( P < 0.05). The curative effect of the observation group was higher than that of the control group( P < 0.05). 5). At the same time, the levels of LDL-C, HDLC, TC and TG in the two groups were statistically significant(P <0.05). Conclusion Danshen Ligustrazine combined with Wenxin granule is effective in treating unstable angina pectoris with arrhythmia.
引文
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[13]苏轮,刘冰,陈昕,等.丹红注射液治疗老年不稳定型心绞痛的临床观察[J].实用心脑肺血管病杂志,2008,16(4):25-26.
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[2]张璞玉.丹参川芎嗪联合稳心颗粒治疗不稳定型心绞痛合并心律失常疗效观察[J].中医临床研究,2016,8(24):39-40.
[3]中华医学会心血管病学分会,中华心血管病杂志编辑委员.不稳定型心绞痛诊断和治疗建议[J].中华心血管病杂志,2000,28(6):409-412.
[4]中华人民共和国卫生部.中药新药临床研究指导原则(第一辑)[S].1993:41-45.
[5]宋桂敏,李一,高月.丹参川芎嗪辅助治疗不稳定型心绞痛患者的疗效及其对实验室指标的影响[J].中国生化药物杂志,2015,35(12):102-104,107.
[6]吴平勇,曾宪涛,王学军,等.川芎嗪对心肌缺血再灌注损伤防治作用的系统评价与Meta分析[J].中国循证心血管医学杂志,2014,6(6):653-657.
[7]肖志刚.丹参川芎嗪注射液配合稳心颗粒治疗不稳定型心绞痛合并心律失常[J].湖北中医杂志,2014,36(9):31.
[8]许白生.曲美他嗪联合丹参川芎嗪注射液治疗不稳定心绞痛的疗效评价[J].西部医学,2010,22(1):90-92.
[9]姚晓东.瑞舒伐他汀联合丹参川芎嗪注射液治疗不稳定型心绞痛的疗效及对CRP和血脂的影响[J].中西医结合心脑血管病杂志,2015,13(12):1367-1369.
[10]刘凤娥.丹红注射液治疗不稳定型心绞痛38例临床观察[J].中国社区医师(医学专业),2011,13(13):226.
[11]王妍焱,李洪宇,齐红梅.丹红注射液治疗不稳定型心绞痛的临床观察[J].当代医学,2009,15(16):126,129.
[12]刘宏斌,王爱东.丹红注射液治疗老年不稳定型心绞痛40例疗效分析[J].山西医药杂志(下半月刊),2008,37(3):224-225.
[13]苏轮,刘冰,陈昕,等.丹红注射液治疗老年不稳定型心绞痛的临床观察[J].实用心脑肺血管病杂志,2008,16(4):25-26.
[14]李存富,杨振伟.丹红注射液治疗不稳定型心绞痛50例临床观察[J].中国医药科学,2012,2(17):54-55.
[15]程坚.丹红注射液治疗不稳定型心绞痛疗效观察[J].现代中西医结合杂志,2008,16(1):19.