原花青素防治Ⅱ型糖尿病的研究进展
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摘要
糖尿病是一种常见的慢性代谢性疾病,已成为继恶性肿瘤和心脑血管疾病之后的第三大疾病,其中Ⅱ型糖尿病发病最为普遍,其发病机制目前尚不明确。原花青素是一种来源广泛、安全度高、生物活性优良的天然植物化学物,具有良好的抗糖尿病作用。本文系统综述了原花青素对Ⅱ型糖尿病防治作用的研究进展及潜在的作用机制。
Diabetes mellitus, one of the most common chronic metabolic diseases, has become the third major disease after malignant tumor and cardiovascular and cerebrovascular diseases. Type Ⅱ diabetes mellitus(T2DM) is the most prevalent form of diabetes. However, the pathogenesis of T2DM is still unclear so far. Procyanidins, a group of natural phytochemicals with a wide range of sources, high safety and good biological activity, can exert antidiabetic effect. The potential mechanism of action of procyanidins in the prevention and control of T2DM is systematically reviewed in this article.
Diabetes mellitus, one of the most common chronic metabolic diseases, has become the third major disease after malignant tumor and cardiovascular and cerebrovascular diseases. Type Ⅱ diabetes mellitus(T2DM) is the most prevalent form of diabetes. However, the pathogenesis of T2DM is still unclear so far. Procyanidins, a group of natural phytochemicals with a wide range of sources, high safety and good biological activity, can exert antidiabetic effect. The potential mechanism of action of procyanidins in the prevention and control of T2DM is systematically reviewed in this article.
引文
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[5]HAJAVI J,MOMTAZI A A,JOHNSTON T P,et al.Curcumin:a naturally occurring modulator of adipokines in diabetes[J].Journal of Cellular Biochemistry,2017,118(12):4170-4182.DOI:10.1002/jcb.26121.
[6]ZHU X Y,WU C H,QIU S H,et al.Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes:systematic review and meta-analysis[J].Nutrition and Metabolism,2017,14:1-10.DOI:10.1186/s12986-017-0217-z.
[7]DOWNING L E,EDGAR D,ELLISON P A,et al.Mechanistic insight into nuclear receptor-mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract(GSPE)[J].Cell Biochemistry and Function,2017,35(1):12-32.DOI:10.1002/cbf.3247.
[8]OGURA K,OGURA M,SHOJI T,et al.Oral administration of apple procyanidins ameliorates insulin resistance via suppression of proinflammatory cytokine expression in liver of diabetic ob/ob mice[J].Journal of Agricultural and Food Chemistry,2016,64(46):8857-8865.DOI:10.1021/acs.jafc.6b03424.
[9]RAMOS S,MARTIN M A,GOYA L.Effects of cocoa antioxidants in type 2 diabetes mellitus[J].Antioxidants,2017,6:1-16.DOI:10.3390/antiox6040084.
[10]YANG H,XIAO L,YUAN Y,et al.Procyanidin B2 inhibits NLRP3inflammasome activation in human vascular endothelial cells[J].Biochemical Pharmacology,2014,92(4):599-606.DOI:10.1016/j.bcp.2014.10.001.
[11]YAMASHITA Y,WANG L,NANBA F,et al.Procyanidin promotes translocation of glucose transporter 4 in muscle of mice through activation of insulin and AMPK signaling pathways[J].PLoS ONE,2016,11(9):e0161704.DOI:10.1371/journal.pone.0161704.
[12]TSAI H Y,WU L Y,HWANG L S.Effect of a proanthocyanidinrich extract from longan flower on markers of metabolic syndrome in fructose-fed rats[J].Journal of Agricultural and Food Chemistry,2008,56(22):11018-11024.DOI:10.1021/jf801966y.
[13]KURIMOTO Y,SHIBAYAMA Y,INOUE S,et al.Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice[J].Journal of Agricultural and Food Chemistry,2013,61(23):5558-5564.DOI:10.1021/jf401190y.
[14]LI X,SUI Y,LI S,et al.A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin(STZ)-induced diabetic mice fed with high fat diet[J].Journal of Functional Foods,2016,27:711-722.DOI:10.1016/j.jff.2016.08.010.
[15]YAMASHITA Y,OKABE M,NATSUME M,et al.Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice[J].Archives of Biochemistry and Biophysics,2012,527(2):95-104.DOI:10.1016/j.abb.2012.03.018.
[16]ZHAO P J,ALAM M B,LEE S H,et al.Spatholobus suberectus exhibits antidiabetic activity in vitro and in vivo through activation of Akt-AMPK pathway[J].Evidence-based Complementary and Alternative Medicine,2017,2017:6091923.DOI:10.1155/2017/6091923.
[17]KRSSAK M,BREHM A,BERNROIDER E,et al.Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes[J].Diabetes,2004,53(12):3048-3056.DOI:10.2337/diabetes.53.12.3048.
[18]BOWSER S M,MOORE W T,MCMILLAN R P,et al.Highmolecular-weight cocoa procyanidins possess enhanced insulinenhancing and insulin mimetic activities in human primary skeletal muscle cells compared to smaller procyanidins[J].The Journal of Nutritional Biochemistry,2017,39:48-58.DOI:10.1016/j.jnutbio.2016.10.001.
[19]SUNDARAM R,NARESH R,SHANTHI P,et al.Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats[J].Phytomedicine,2013,20(7):577-584.DOI:10.1016/j.phymed.2013.01.006.
[20]KANAMOTO Y,YAMASHITA Y,NANBA F,et al.A black soybean seed coat extract prevents obesity and glucose intolerance by upregulating uncoupling uroteins and down-regulating inflammatory cytokines in high-fat diet-fed mice[J].Journal of Agricultural and Food Chemistry,2011,59(16):8985-8993.DOI:10.1021/jf201471p.
[21]LI X,SUI Y,WU Q,et al.Attenuated mTOR signaling and enhanced glucose homeostasis by dietary supplementation with lotus seedpod oligomeric procyanidins in streptozotocin(STZ)-induced diabetic mice[J].Journal of Agricultural and Food Chemistry,2017,65(19):3801-3810.DOI:10.1021/acs.jafc.7b00233.
[22]ARDEN C,PETRIE J L,TUDHOPE S J,et al.Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis[J].Diabetes,2011,60(12):3110-3120.DOI:10.2337/db11-0061.
[23]LENZEN S.A fresh view of glycolysis and glucokinase regulation:history and current status[J].Journal of Biological Chemistry,2014,289(18):12189-12194.DOI:10.1074/jbc.R114.557314.
[24]CAO W,COLLINS Q F,BECKER T C,et al.p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis[J].The Journal of Biological Chemistry,2005,280(52):42731-42737.DOI:10.1074/jbc.M506223200.
[25]覃香.血脂康干预治疗空腹血糖受损并血脂异常的疗效[J].中国老年学杂志,2011,31(13):2550-2551.DOI:10.3969/j.issn.1005-9202.2011.13.075.
[26]YIN M,ZHANG P,YU F,et al.Grape seed procyanidin B2ameliorates hepatic lipid metabolism disorders in db/db mice[J].Molecular Medicine Reports,2017,16(3):2844-2850.DOI:10.3892/mmr.2017.6900.
[27]YOKOZAWA T,KIM H J,CHO E J.Gravinol ameliorates highfructose-induced metabolic syndrome through regulation of lipid metabolism and proinflammatory state in rats[J].Journal of Agricultural and Food Chemistry,2008,56(13):5026-5032.DOI:10.1021/jf800213f.
[28]BAIGES I,PALMFELDT J,BLADE C,et al.Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet[J].Molecular and Cellular Proteomics,2010,9(7):1499-1513.DOI:10.1074/mcp.M000055-MCP201.
[29]QUESADA H,DEL B J,PAJUELO D,et al.Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver[J].International Journal of Obesity,2009,33(9):1007-1012.DOI:10.1038/ijo.2009.136.
[30]SHIMADA T,TOKUHARA D,TSUBATA M,et al.Flavangenol(pine bark extract)and its major component procyanidin B1enhance fatty acid oxidation in fat-loaded models[J].European Journal of Pharmacology,2012,677(1/2/3):147-153.DOI:10.1016/j.ejphar.2011.12.034.
[31]CASTELL-AUVíA,CEDóL,PALLARèS V,et al.Grape seed procyanidins improve beta-cell functionality under lipotoxic conditions due to their lipid-lowering effect[J].The Journal of Nutritional Biochemistry,2013,24(6):948-953.DOI:10.1016/j.jnutbio.2012.06.015.
[32]TERRA X,MONTAGUT G,BUSTOS M,et al.Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet[J].The Journal of Nutritional Biochemistry,2009,20(3):210-218.DOI:10.1016/j.jnutbio.2008.02.005.
[33]LEE Y A,CHO E J,YOKOZAWA T.Effects of proanthocyanidin preparations on hyperlipidemia and other biomarkers in mouse model of type 2 diabetes[J].Journal of Agricultural and Food Chemistry,2008,56(17):7781-7789.DOI:10.1021/jf800639m.
[34]ZHENG S,REN X X,HAN T T,et al.Fenofibrate attenuates fatty acid-induced islet beta-cell dysfunction and apoptosis via inhibiting the NF-kappaB/MIF dependent inflammatory pathway[J].Metabolism:Clinical and Experimental,2017,77:23-38.DOI:10.1016/j.metabol.2017.09.001.
[35]YIN W,LI B,LI X,et al.Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas[J].Food and Function,2015,6(9):3065-3071.DOI:10.1039/c5fo00496a.
[36]HURRLE S,HSU W H.The etiology of oxidative stress in insulin resistance[J].Biomedical Journal,2017,40(5):257-262.DOI:10.1016/j.bj.2017.06.007.
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